Best Seed Grants for Nonprofits in Puerto Rico

The Preschool Development Grant Birth Through Five (PDG B-5) SMART Grant aims to enhance early care and education systems in the U.S. by supporting targeted investments in technology and data analytics. This initiative, led by the Administration for Children and Families, encourages states to improve program quality, family choice, and data-driven decision-making for children from birth to five years old. The funding is designed to create measurable outcomes and strengthen coordination within the mixed-delivery system.

Mayo Family Foundation

The Mayo Family Foundation, founded by Simer and Vicki Mayo in 2019, is dedicated to creating a lasting impact across the globe. With a focus on eradicating food insecurity, empowering at-risk youth, and advancing women’s equality, the Foundation strives to transform lives and foster a brighter future for all.

Domestic Focus

We envision a world where concerns about the next meal, a safe place to sleep, or access to healthcare become a thing of the past. Our goal is to provide long-term solutions that will build stronger, more resilient individuals and communities.

A child at risk is less likely to transition to adulthood successfully. Our mission is to equip our youth with the tools needed for academic achievement and job readiness. These tools are key to securing a future marked by financial stability and high hopes of becoming a positive member of society.

Grant Application

The Mayo Family Foundation (MFF) is dedicated to creating a lasting impact. Its focus is on eradicating food insecurities, women’s equality issues, and empowering at-risk youth. The foundation strives to transform lives and foster a brighter future for all.

This grant has been created to provide the funding needed to make a significant impact in two key areas: combating food insecurity and empowering at-risk youth.

We believe that by supporting dedicated nonprofit organizations like yours, we can create a lasting positive impact in our community. Together, we can ensure that no one goes hungry and that every young person has the opportunity to thrive.

The Pratt Family Foundation Grant, established in 1999, supports initiatives in education, healthcare, and community welfare. It prioritizes organizations that aid housing assistance, support for women in crisis, and disadvantaged youth programs, particularly in North Carolina. The Foundation favors established religious and charitable organizations that are tax-exempt and have a local presence. Preference is given to areas connected to the Pratt family, such as Texas and Florida, ensuring impactful contributions to community development.

The State Occupational Safety and Health Surveillance Program (U60) aims to enhance state-level occupational safety and health (OSH) surveillance capacity. Funded by NIOSH, this initiative supports various state programs, fostering partnerships among health departments and universities. By utilizing diverse data sources, these programs assess workplace health impacts and develop tailored interventions, ultimately ensuring better health and safety for workers across the U.S. This collaborative approach addresses critical gaps left by regulatory programs.

The Teiger Foundation's Curatorial Research and Development Grant offers support for innovative curatorial practices within the contemporary visual arts sector. Designed to address gaps in funding, this grant provides up to $50,000 for curatorial research projects, including travel and collaborative investigations. It emphasizes the importance of experimentation and creativity while aligning with values of racial justice and environmental sustainability. The next Call for Proposals will open in Fall 2026, with funding opportunities available to U.S.-based curators.

The National Institute on Aging intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for the Coordinating Center (CC) of the Claude D. Pepper Older Americans Independence Centers (OAIC) program. The CC serves as a facilitator for OAIC site interactions and as a conduit for translating OAIC objectives and findings to both scientific and general audiences. The proposed CC must demonstrate an ability to work cooperatively with all OAIC sites and possess sufficient scientific expertise in geriatrics and related areas to serve the national coordination functions of the OAIC program. Applicants should have a demonstrated ability to coordinate multi-site projects.Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the U24 activity code. Investigators with expertise and insights into this area of aging research are encouraged to begin to consider applying for this new NOFO.

The Teiger Foundation's Hosting Grant provides up to $75,000 for US-based curators or artistic directors to present contemporary visual art exhibitions that originated in different contexts. This grant encourages resource-sharing and collective learning, allowing institutions to expand their programming sustainably. It prioritizes projects affiliated with established non-profits, fostering community-building and positive change in the field of visual art while addressing issues of racial justice and climate crisis.

The Innovative Traffic Safety Enforcement (ITSE) Grant Program aims to develop effective traffic safety enforcement initiatives to reduce motor vehicle crashes caused by risky driving behaviors. It encompasses three evaluation phases, with deadlines from September 2026 to September 2027. This program seeks to fund scalable and repeatable projects that align with the Department of Transportation's mission and executive priorities, enhancing safety across the United States.

The National Institute on Aging (NIA) is launching a funding opportunity for outstanding graduate students interested in aging research. The Transition to Aging Research Award for Predoctoral Students will support late-stage doctoral students in completing their dissertation projects. This two-phase award aims to ensure a smooth transition into postdoctoral positions focused on aging, promoting the recruitment and retention of new investigators in the field. Applications are currently not being solicited, allowing time for potential applicants to prepare collaborations.

The Teiger Foundation Programming Grant supports innovative visual arts projects led by curators at smaller non-profit organizations with budgets under $3.5 million. Grants of up to $150,000 are available for three years, funding development, realization, and documentation of exhibitions and related programs. The foundation emphasizes community engagement, racial justice, and artistic experimentation while encouraging collaboration with other cultural institutions. Note: The next Call for Proposals opens in Fall 2026.

The McKesson Foundation Grant provides funding above $25,000 to support health equity initiatives across North America. Founded in 1943, its mission focuses on removing barriers to quality healthcare for vulnerable communities. The foundation prioritizes projects that align with strategic pillars: reducing cancer burdens, preparing the healthcare workforce, and enhancing crisis response. Eligible organizations include national and local nonprofits. Funding is limited to specific regions and assessed based on demonstrated need and expected impact.

The Southern SARE: Professional Development Grants support educational initiatives for agricultural professionals, enhancing outreach and training efforts directly benefiting farmers and ranchers. These grants fund diverse training activities, including workshops and farm tours, aimed at promoting sustainable agriculture through effective participatory methods. Projects are encouraged to involve multi-disciplinary partnerships and the participation of land-grant institutions, ensuring a comprehensive approach to agricultural education. Priority is given to projects with budgets under $80,000, fostering a broad array of impactful initiatives.

The Teiger Foundation Single Project Grant supports innovative visual arts projects at non-profit exhibition spaces with annual budgets exceeding $3 million. Focused on curatorial practices, the grant encourages experimentation and creativity, aiming to drive positive structural change in contemporary art. Eligible expenses include artist fees, publication costs, and coalition-building efforts. The next Call for Proposals opens in Fall 2026, with funding of up to $150,000 available for selected projects.

The Opportunities for Collaborative Research at the NIH Clinical Center aims to foster high-quality translational research partnerships between NIH intramural and extramural investigators. This program supports projects that bridge basic biological discoveries with clinical applications, ultimately enhancing patient-centric research. By facilitating collaborations, the program seeks to accelerate scientific advancements leading to improved health outcomes through innovative therapeutic interventions and diagnostic strategies.

The Gerber Foundation provides research grants focused on enhancing the health and nutrition of infants and young children, particularly those aged 0-3. The foundation seeks innovative projects that address critical health issues and improve developmental outcomes. Grants support applied research, diagnostic tools, and treatment regimens that promise significant advancements in pediatric health. Eligible applicants include tax-exempt organizations, emphasizing a commitment to projects with a direct impact on children's well-being in the U.S.

The Veterans Cemetery Grants program, administered by the US Department of Veterans Affairs, provides funding to establish, expand, and improve Veterans cemeteries across the United States. With over $910 million awarded, the program supports state and tribal governments in maintaining 120 cemeteries, ensuring they meet VA standards. Grants cover up to 100% of development costs, facilitating the dignified interment of Veterans and their families in accessible locations.

The Tree Campus Higher Education Program, initiated by the National Arbor Day Foundation, encourages colleges and universities in Puerto Rico to enhance their campus environments through tree planting and maintenance. This program fosters a commitment to sustainability, providing students with educational opportunities and promoting physical and mental well-being. By achieving recognition, institutions can showcase their dedication to green initiatives, ultimately benefiting both the community and the planet.

The MPS Mathematical Sciences Research Programs (MPS MathSci) by the NSF supports diverse research initiatives in theoretical and applied mathematical sciences. Key areas include Algebra, Applied Mathematics, Combinatorics, and Mathematical Biology. The program encourages groundbreaking foundational research with flexible budgets and durations. Proposals do not need to promise immediate outcomes, allowing researchers to explore innovative concepts without the pressure of commercial viability.

The Illuminations Grant for Black Trans Women Visual Artists, a $10,000 annual grant, supports early-career Black trans women artists in the U.S. whose contributions to visual arts are often overlooked. Established in partnership with notable figures, this grant not only provides funding but also offers professional development resources. In its fifth year, it aims to address systemic barriers and enhance representation in the arts, with additional awards for finalists to further their artistic journeys.

The Silicon Carbide Cladding Lead Test Rod Development-Phase 1 project aims to advance the use of silicon carbide cladding for nuclear fuel rods. It focuses on the research, development, and fabrication of cladding specimens for reactors, with testing planned for both unirradiated and irradiated samples. The project is poised to provide critical performance data for future commercial lead test rods, enhancing safety and efficiency in light water reactors.

The Health Policy Research Scholars program, funded by the Robert Wood Johnson Foundation, aims to develop leadership among doctoral students from diverse, nonclinical disciplines. This four-year initiative focuses on aligning research with community health needs, emphasizing equity and collaboration across sectors. Scholars will receive $30,000 annually for up to four years, complemented by mentorship and training. The program targets second-year doctoral students who are committed to influencing health policy and fostering a Culture of Health in their communities.

The Mid Atlantic Tours Grants program supports presenters in the mid-Atlantic region who engage Roster Artists during their project periods. Eligible presenters can receive up to a 50% subsidy for artist compensation, which includes fees, housing, and travel. The application process is straightforward and non-competitive, but early engagement with the artist's tour manager is advised due to limited funding. This initiative fosters a diverse range of performances and community engagement.

The Infant-Toddler Court Program State Awards empower states and communities to enhance child welfare practices by integrating courts, social services, and families. This initiative promotes safety, healthy development, and nurturing relationships for young children involved in child welfare. Awardees implement the evidence-based ITC approach, sharing lessons learned with local teams, tracking outcomes, and training to ensure effective program expansion across targeted communities.

The Infant-Toddler Court Program's National Resource Center (NRC) focuses on enhancing child welfare practices across the United States. By collaborating with courts, social services, and families, the NRC aims to improve the safety and healthy development of young children involved with the child welfare system. This initiative not only supports families but also fosters nurturing relationships essential for child growth and well-being, making it a crucial resource for communities.

The NRP Young Investigator Award is designed to support research on optimizing newborn care during delivery using Neonatal Resuscitation Program (NRP) techniques. This grant encourages innovative projects addressing gaps in transitional physiology and resuscitation practices. Eligible applicants include researchers from Canadian and US institutions, particularly those in training or within four years of completing medical training. Awardees may receive up to $15,000 to enhance their skills and knowledge, ultimately improving neonatal outcomes.

The National Foundation for the Centers for Disease Control and Prevention offers funding to support administrative expenses that bolster CDC's mission. This initiative enhances partnerships to address health threats both domestically and globally. Projects funded through this grant align with CDC's strategic goals, focusing on measurable outcomes such as program support and participation from various CDC Centers and Offices. Importantly, this grant only supports non-research activities.

The NSF State and Regional AI Infrastructure Hubs program seeks to enhance access to computational resources essential for AI-driven scientific exploration. By forming flexible consortia among government, academia, and industry, these hubs aim to foster innovation and workforce development in AI. The initiative aligns with national R&D priorities, emphasizing the critical role of AI in advancing scientific discovery and expanding infrastructure to support this mission across various disciplines.