Best Small Grants for Nonprofits in Puerto Rico

The Limited Competition Small Grant Program for ORIP SERCA K01 Recipients provides funding to early-stage veterinary scientists to enhance their research capabilities and transition to independent investigator status. This initiative addresses challenges faced by these researchers, including reliance on funding from senior investigators. Grants support pilot studies, secondary data analysis, and development of research methodologies, aiming to foster independence within a two-year timeframe without funding clinical trials.

The Clinical and Translational Science Award (CTSA) Program aims to enhance the translation of scientific research into effective health interventions by establishing a national network of academic medical centers. This program supports integrated research and training environments for clinical and translational science, promoting the development of innovative methods and technologies. The reissuance of the CTSA Notice of Funding Opportunity invites eligible organizations to apply, with peer-reviewed applications prioritized for funding.

The Leadership Education in Adolescent Health (LEAH) Program, funded by the US HHS: Health Resources & Services Administration, aims to enhance the quality of care for adolescents and young adults. By establishing graduate training programs, LEAH prepares healthcare professionals to effectively address chronic disease prevention and improve access to team-based healthcare services for this population, ultimately fostering better health outcomes and empowering future leaders in adolescent health.

The Limited Competition for High Impact Specialized Innovation Programs aims to enhance clinical and translational science by funding unique capabilities and addressing critical gaps through the Clinical and Translational Science Award (CTSA) Program. This initiative fosters collaboration across a national network of academic medical centers, facilitating the transition of scientific discoveries into impactful health interventions. Applications are peer-reviewed, ensuring funding is directed towards the most promising proposals.

The National Fund for Sacred Places Grant Program supports historic houses of worship in the U.S. through matching grants ranging from $50,000 to $250,000. This initiative, in collaboration with the National Trust for Historic Preservation, aims to enhance community engagement and preserve culturally significant buildings. Applicants are encouraged to demonstrate their historical relevance and community service, particularly those representing underrepresented groups. The program prioritizes urgent repair needs and projects that foster inclusivity and accessibility.

This funding opportunity from the NIH encourages groundbreaking research to enhance, develop, and preserve animal models and related biological materials for studies impacting human health. The program seeks innovative methodologies that can improve the diagnosis and management of diseases affecting animal use in biomedical research. Projects must demonstrate relevance across multiple NIH Institutes to align with broader research goals, emphasizing diverse body systems and disease categories.

The Limited Competition Research Education Program for the Clinical and Translational Science Awards Program aims to enhance the training of a workforce to meet the nation's biomedical and clinical research needs. It supports educational activities that facilitate the translation of scientific discoveries into practical health interventions. Funded by the NIH, this program invites applications from eligible organizations, and only those with meritorious proposals will be considered for funding.

The Institute of Education Sciences (IES) offers a grant to support state education agencies in utilizing longitudinal data systems to inform policies and programs for learners with disabilities. This initiative aims to enhance evidence-based decision-making at both state and local levels, ensuring better educational outcomes for at-risk students. The grant encourages collaboration and effective use of data to promote informed policymaking in special education.

The CTIA Wireless Foundation's Catalyst Grant Program aims to empower social entrepreneurs leveraging 5G technology to tackle critical challenges in American communities. With over $200,000 in unrestricted grants available, the program supports innovative projects that utilize 5G connectivity for social good. As 5G transforms communication and interaction, the Catalyst Grant seeks visionary leaders who can harness this potential to inspire meaningful change and enhance community engagement.

The Peggy Barber Tribute Grant, offered by the American Library Association, supports libraries facing budget constraints by providing $2,500 to three selected libraries. The 2025-2026 cycle focuses on programming that strengthens community ties through libraries as third spaces, promoting gatherings and connections among individuals. Eligible proposals may include intergenerational gardening programs, play-based activities for adults, or visual arts performances. Applicants must have ALA or ARSL membership and demonstrate how their program will foster community engagement.

The B-INSPIRE program aims to foster behavioral interventions that enhance interest and preparedness for careers in biomedical research. It invites applications that propose innovative studies addressing motivation and persistence in research-oriented individuals. The initiative also encourages analyses of existing data to improve intervention methodologies. Successful projects should yield findings that support the implementation of diverse strategies across academic levels, ultimately enriching the biomedical research workforce.

Charlie's Heart Foundation Annual Grant Program supports small nonprofits focusing on mental well-being for families in underserved communities. Grants between $5,000-$30,000 are available, prioritizing organizations based in North Carolina. Eligible applicants must be 501(c)(3) tax-exempt and demonstrate alignment with the Foundation's mission, organizational need, and program sustainability. The Foundation does not fund individuals, private foundations, or religious organizations, ensuring a strong focus on impactful community programs.

The Habitable Worlds Observatory (HWO) is a pioneering space mission concept aimed at discovering life beyond our solar system, as highlighted in the Astro2020 survey. The HWO-PSI program seeks to reduce risks for future missions by advancing scientific investigations that inform mission design. As HWO enters its pre-formulation phase, it addresses significant astrophysical questions and technical challenges, ultimately striving for groundbreaking discoveries in our understanding of the universe.

The HDR Foundation Grant Cycle supports community organizations aligned with HDR's values, focusing on education, healthy communities, and environmental stewardship. This employee-funded initiative emphasizes the importance of employee engagement in grant proposals, requiring a clear scope of work and completion within a year. Eligible applicants include U.S.-based nonprofits, educational institutions, and tribal governments, while grants are not provided for faith-based organizations or individual support.

The National Science Foundation (NSF) is funding initiatives to enhance the value of scientific datasets through innovative artificial intelligence (AI) methods. This program aims to facilitate interdisciplinary research and unlock new insights by applying AI for feature extraction, metadata generation, and dataset integration. Proposals should ensure data security and promote collaboration with various sectors to advance AI-driven scientific discovery. By aligning with NSF priorities, researchers can contribute to cutting-edge science and technology for broader participation in STEM.

The Medical Scientist Training Program (MSTP) aims to cultivate a diverse group of physician-scientist leaders to address the nation's biomedical research needs. This program supports institutions in creating integrated dual-degree training that results in both medical and research doctorate degrees. By combining clinical practice with scientific research, MSTP graduates will advance health-related research, focusing on improving training effectiveness, alumni retention in research careers, and workforce diversity. NIGMS emphasizes comprehensive training elements for impactful careers.

The American Bar Endowment's Opportunity Grant Program provides funding for innovative, boots-on-the-ground initiatives that address urgent legal needs of the public. This grant focuses on increasing access to justice for underserved populations, improving the justice system, and enhancing public understanding of legal rights. Eligible applicants include public charities and organizations directly impacting local communities, with a strong emphasis on projects that leverage technology and address immediate legal challenges.

The National Biomedical Research Centers (NBRCs) aim to enhance biomedical research by providing advanced equipment, scientific expertise, and innovative human-based models. Supported by NIH and other federal agencies, this initiative focuses on reducing reliance on live animal models through the development of New Approach Methodologies (NAMs). The program invites applications that propose actionable plans to refine and replace animal use, promoting innovative research at centers with existing nonhuman primate colonies.

The NSF Expeditions in Computing program aims to foster transformative research in computer and information science. By funding projects up to $15 million over seven years, it encourages multidisciplinary teams to tackle ambitious research agendas that redefine the future of computing. The program supports innovative areas such as new architectures for intelligence, advanced robotics, and next-generation communication, emphasizing the importance of collaboration across various fields to achieve groundbreaking advancements.

The Centers of Biomedical Research Excellence: Development Phase (COBRE-D) program aims to enhance biomedical research capacity in IDeA states, which historically receive low NIH funding. By providing critical support for early-career investigators and essential infrastructure, COBRE-D facilitates a long-term vision for institutions. This initiative not only supplements start-up packages for new hires but also establishes research facilities and improves administrative services, paving the way for less-resourced institutions to transition into the COBRE E/S program.

The JetBlue Foundation is dedicated to enhancing aviation-related education and STEM initiatives, aiming to inspire future aviation leaders. Offering grants up to $50,000, it supports educational organizations that focus on aviation technology, engineering, operations, and maintenance. The foundation prioritizes programs benefiting under-represented communities in aviation, including veterans, women, and diverse groups, ensuring a broader range of voices in the industry.

The Advancing Oil and Natural Gas Production and Delivery initiative, led by the United States Department of Energy, seeks innovative proposals that enhance the efficiency and resilience of the oil and gas supply chain. This funding opportunity aims to improve resource utilization, modernize infrastructure, and promote digital transformation. Key objectives include increasing natural gas utilization, reducing economic losses, and optimizing operational costs through advanced technologies and predictive maintenance strategies.

The NIAID Physician-Scientist Pathway to Independence Award (K99/R00) aims to support new independent physician-scientists by facilitating their transition from postdoctoral research to tenure-track faculty positions. This program provides essential research funding to help awardees establish their careers in biomedical research, addressing the national shortage of physician-scientists. Applicants must propose research that does not lead an independent clinical trial, but may include mentorship in clinical trials.

The Limited Competition: High Impact Specialized Innovation Programs in Clinical and Translational Science (RC2 Clinical Trials Optional) aims to foster unique hub capabilities and research platforms to tackle critical gaps in clinical and translational science. Open to eligible organizations involved in the CTSA Program, this funding opportunity is crucial for laying groundwork for future advancements across CTSA Program Hubs. Applications are due by 5:00 PM local time, with Letters of Intent encouraged 30 days prior to the deadline.

The Maximizing Investigators’ Research Award (MIRA) for Early Stage Investigators (ESI) by NIGMS aims to enhance research productivity and flexibility for early career scientists. This program consolidates funding into a single award, allowing investigators to pursue ambitious projects while reducing administrative burdens. By supporting diverse research initiatives, MIRA helps cultivate a new generation of innovative researchers, ensuring essential breakthroughs in fundamental science.

The Amgen Foundation, established in 1990, focuses on enhancing science education and strengthening communities. It supports nonprofit organizations that align with its mission, emphasizing teacher development and hands-on science experiences. Grants are awarded annually, with a commitment of $180 million to impactful programs. Eligible organizations include public schools and libraries, while ineligible requests involve individual support, religious organizations, and political activities. This approach aims to inspire the next generation of innovators through quality educational opportunities.

The National Science Foundation (NSF) Directorate for Engineering (ENG) fosters groundbreaking research in electrical, communications, and computing systems through programs like Electronic, Photonic, Magnetic, and Quantum Devices (EPMQD) and Circuits and Systems for Communications and Sensing (CSCS). These initiatives emphasize innovative foundational research, particularly in power and energy systems, while being open to transformative ideas without immediate commercial outcomes. Funding availability will shape the portfolios of ECCS awards.