Best Unrestricted Grants for Nonprofits in Puerto Rico

The National Coastal Resilience Fund (NCRF) aims to protect coastal communities through nature-based solutions, enhancing habitats while addressing the growing threats of climate change. Established in 2018, the fund focuses on restoring vital ecosystems like marshes and reefs to mitigate flooding impacts. With rising sea levels and increasing storm intensity, NCRF invests in community-led projects that foster resilience, ensuring both people and wildlife can adapt to changing environmental conditions.

The CDC has announced funding for FY 2027 to enhance state capacity in alcohol epidemiology and prevent excessive alcohol use through the NOFO CDC-RFA-DP-27-0072. This initiative aims to equip states with essential tools and knowledge for effective public health measures against excessive alcohol use, a major preventable cause of death in the U.S. The program will also provide expert technical assistance and training on effective prevention strategies over a 5-year performance period.

This initiative aims to support research interventions targeting disparities in liver diseases and liver cancer among underserved populations in the U.S. It encourages innovative approaches to reduce health inequities and improve health outcomes. The funding opportunity is available through various deadlines for both standard and renewal applications, promoting multi-level strategies to address these critical health issues effectively.

The Capacity Building for Global, Regional, and National Immunization Programs aims to enhance immunization efforts in key countries, focusing on the prevention and control of vaccine-preventable diseases like polio and measles. By strengthening immunization services and surveillance systems, the program will better address emerging health threats and reach under-immunized populations. Additionally, it will support sustainable practices through National Immunization Technical Advisory Groups and manage the National Stop Transmission of Polio program in Pakistan.

The Asian Cultural Council's Individual Fellowship provides artists, scholars, and arts professionals from Asia and the United States with opportunities for self-directed cultural exchange and research in unfamiliar regions. This program supports activities such as interviews, workshops, and archival research, fostering cultural immersion and collaboration. With a funding limit of $35,000, the fellowship encourages innovative proposals that enhance creative perspectives and relationships among peers, while also ensuring strong eligibility criteria for applicants.

Oncology Nursing Foundation

The mission of the Oncology Nursing Foundation is to support cancer nursing excellence.

Since 1981, the Oncology Nursing Foundation(ONF), through generous contributions from individuals and institutions, has provided more than $33 million in funding to support oncology nursing education, research and leadership development. This funding has translated to career development awards, academic scholarships, research grants, a myriad of specialized educational initiatives, as well as nurse resiliency support. The Foundation’s activities have played a critical role in improving patient care and advancing the oncology nursing profession.

Radiation Oncology Certified Nurse (ROCN™) Exam Scholarship

Recipients receive funding to cover the ONCC ROCN™ Certification exam fee.

Purpose

To support registered oncology nurses who specialize in providing care for adult or pediatric patients with cancer undergoing radiation therapy by providing funding support to cover the ROCN™ Certification exam fee. 

The Alice M. Ditson Fund supports recording projects that aim to document and promote the music of younger, lesser-known American composers. The fund prioritizes living composers of classical concert music, especially those in the early stages of their careers, while also recognizing established composers who deserve greater visibility. Eligible applicants include organizations with a fiscal sponsor or non-profit status, and projects must involve significant contemporary American music.

The National Cancer Institute (NCI) invites applications for the validation of molecular, cellular, and imaging markers for cancer detection and treatment. This funding opportunity supports both analytical and clinical validation phases, emphasizing multi-disciplinary collaboration. The UH2 phase focuses on analytical validation, while the UH3 phase extends to clinical validation using well-annotated biospecimens. Proposals should justify the relevance of assays for clinical use and may include harmonization efforts across laboratories.

The Growing Tribal Economies Through Forest Market Innovations grant program, initiated by First Nations Development Institute, aims to empower Tribes and Alaska Native Villages to engage in emerging markets that enhance forest health and resilience. With funding of $200,000 to $500,000 per grant, this initiative supports projects focusing on sustainability, innovation, and traditional knowledge. Eligible applicants are encouraged to develop forest products, certifications, and practices that contribute positively to biodiversity and ecosystem management.

The NCI Continuing Umbrella of Research Experiences (CURE) Non-Mentored Research Scientist Career Development Award (K22) aims to support postdoctoral fellows from underrepresented backgrounds in transitioning to tenure-track positions. This award provides essential funding for salary and research support for three years, enabling candidates to establish independent biomedical careers. Key deadlines for applications range from February 2025 to October 2027, ensuring ample opportunity for eligible researchers to secure funding for their career development.

The NIDDK Multi-Purpose Resource-Related Research Centers Cooperative Agreement (U2C) invites applications to enhance research capabilities in areas such as obesity and diabetes. These centers provide specialized services, including technical support and data coordination, primarily to clients at other institutions lacking necessary expertise. This initiative aims to bolster high-impact research through collaboration and experiential training, addressing critical health challenges aligned with NIDDK's mission.

The KUH U24 Center Coordinating Hub aims to foster collaboration among funded Centers within the NIDDK/KUHN mission. This initiative encourages the development and sharing of vital research resources, including data, reagents, and expertise, with the broader scientific community. By creating a national network, the program enhances research capabilities and promotes innovative solutions in kidney, urology, and hematology diseases.

The KUH P30 Resource Core Center funding opportunity invites applications for centers aimed at enhancing research in Kidney, Urology, and Hematology diseases. These centers will provide essential resources, including data and tools, to the research community, fostering collaboration through a national network with the Center Coordinating Hub. This initiative by the National Institutes of Health aims to drive innovative research and shared expertise for improved health outcomes.

The OJJDP FY 2026 Community and Schools Youth Drug Prevention Program aims to combat youth substance use through comprehensive prevention strategies. This initiative invites applications from states, local governments, and nonprofit organizations to develop programs that educate and support youth in schools and community settings. By fostering collaboration with law enforcement and community coalitions, the program seeks to build capacity and implement effective interventions to protect the well-being of American youth.

The NIH Research Software Engineer (RSE) Award aims to provide salary support for outstanding Research Software Engineers who play a vital role in creating and sharing biomedical, behavioral, or health-related software and tools. This opportunity encourages RSEs to enhance the development of algorithms and support training for prospective users. Applications are due by 5:00 PM local time, with optional Letters of Intent recommended 30 days prior to the proposal deadline.

The NIDCR Behavioral and Social Intervention Clinical Trial Planning and Implementation Cooperative Agreement (UG3/UH3 Clinical Trial Required) aims to support innovative research in behavioral and social interventions for dental, oral, and craniofacial conditions. This funding opportunity includes a milestone-driven planning phase of up to 2 years, with potential transition to implementation for an additional 5 years, facilitating comprehensive trial development and assessment.

The BJA FY 2026 National Center for Veterans Justice aims to enhance support for veterans in the criminal justice system. By providing specialized training and resources to law enforcement and service providers, the center will address critical gaps in veteran identification and coordination among agencies. This initiative seeks to improve outcomes for veterans experiencing issues like PTSD and military sexual trauma, ultimately strengthening public safety and ensuring effective responses to their unique needs.

The Scholarship America Dream Award, established by Scholarship America Inc, aims to eliminate financial barriers to higher education for students. This program supports U.S. citizens, permanent residents, and DACA recipients, who are at least 17 years old and pursuing their first degree with a minimum GPA of 3.0. By partnering with various organizations, Scholarship America has provided over $5.7 billion in scholarships to millions, ensuring equitable access to education and fostering student success.

Youth Service America

Youth Service America believes that youth, communities, and our democracy thrive when we all work together for the common good. YSA is a leading global nonprofit that activates young people, ages 5-25, to find their voice, take action, and acquire powerful civic and 21st Century skills as they solve problems facing their communities. YSA supports its activation campaigns with grants, training and resources, and recognition programs for young people and their adult champions. Youth-led projects use Awareness, Service, Advocacy, and Philanthropy (ASAP) strategies to create social and environmental change.

We Serve To Remember Grants

Projects that Engage 100 Youth Volunteers

YSA’s We Serve to Remember 9/11 Day of Service Grants are for organizations, schools, and youth changemakers ages 5-25 to lead service projects on or around September 11, 2026. Programming efforts should also honor and pay tribute to those who lost their lives on September 11, 2001, their families, and those who rose in service in response to that tragedy. (We suggest starting with eleven reflections about 9/11/01 and related ideas for service or service-learning projects.)

Grantees are required to engage at least 100 youth as volunteers in planning and implementing the service activities.

What are we looking for?

• Projects must be youth-led;
• Projects must include elements to honor and pay tribute to those who lost their lives on 9/11, their families, and those who rose in service in response;
• Projects must take place on or around September 11th National Day of Service and Remembrance (Friday, September 11, 2026) – between Friday, September 4 and Friday, September 18;
• Project organizers must make their best effort to recruit and engage youth volunteers who are not usually asked to serve;

Grantees are also required to provide evidence of volunteer participation and number of hours served. Approved documention includes sign in sheets, copies of pre-and-post-surveys, or reports from school attendance or volunteer management system. These documents must contain a unique identifier for each volunteer, such as the volunteer’s full first and last name, their full first name and last initial, or a volunteer/student ID number.

Reflecting on the spirit of togetherness that brought people together in the days, weeks, and months after September 11th, we are especially looking for ideas that bring together all members of the community.

The FY26 Vision Research Program's Investigator-Initiated Research Award (IIRA) offers funding for innovative research addressing eye injury and visual dysfunction due to military exposure. This award supports preclinical to early translational studies aligned with specific focus areas. Unique features include two funding levels and a Partnering Principal Investigator Option. Applications undergo rigorous peer review based on research rationale, strategy, and impact, with potential for sharing with the National Eye Institute for additional funding consideration.

The FY26 Vision Research Program Clinical Trial Award supports the swift execution of clinical trials aimed at improving treatments for service-connected eye injuries and visual dysfunction. This award emphasizes the need for regulatory compliance, including IND/IDE submissions, and requires documentation confirming the application's active status by March 1, 2027. Review criteria focus on clinical impact, research feasibility, recruitment strategies, and ethical considerations, ensuring relevance to military health.

The DoW Vision Research Program's FY26 Translational Research Award aims to accelerate the development of innovative drugs, devices, or clinical guidelines ready for clinical trials. It supports preclinical studies and pilot trials, ensuring alignment with specified VRP Focus Areas. Key features include a requirement for regulatory expertise in drug/device development and a unique Partnering Principal Investigator option. Review criteria focus on research rationale, strategy, feasibility, and impact, enhancing military health outcomes.

The Raskob Foundation offers domestic grants to organizations located in the U.S. and its territories. Founded in 1945, this private, non-profit foundation focuses on supporting Catholic institutions. Eligible applicants must be tax-exempt 501(c)(3) organizations, listed in the P.J. Kenedy Official Catholic Directory. However, requests from individuals and certain projects, such as debt reduction or completed projects, are not accepted. The foundation emphasizes its commitment to philanthropy and community support.

The Fetal, Infant, and Child Death Review Program aims to enhance the effectiveness of fetal, infant, and child death review teams across state, local, and tribal levels. By providing essential leadership and technical assistance, the program ensures standardized practices for conducting quality fatality reviews and collecting vital data. These efforts will facilitate the dissemination of findings, ultimately informing prevention strategies and improving outcomes for vulnerable populations.

The Waste Management Charitable Contributions Program supports initiatives that enhance environmental stewardship, sustainability education, and community vitality. With a commitment to civic pride and economic development, the program prioritizes organizations that address local needs and promote sustainable practices. Eligible applicants include 501(c)(3) organizations that focus on public purposes, while ineligible requests include funding for operating costs and individual fundraising events. This initiative fosters a collaborative approach to community betterment.

The NIH is seeking innovative computational approaches to enhance the curation of biomedical research assets at scale. This initiative aims to accelerate access to secure datasets and computational models, facilitating transformative discoveries in biomedical science. Key deadlines for applications range from January 2025 to January 2027, covering standard, renewal, and AIDS-related grants. Applicants are encouraged to submit Letters of Intent 30 days prior to application deadlines to ensure a streamlined review process.

The Alliance for Innovation on Maternal Health (AIM) program aims to enhance maternal health outcomes by providing technical assistance across all U.S. states and territories. This initiative focuses on implementing best practices to improve safety during childbirth, ultimately saving lives. By supporting jurisdictions and birthing facilities involved in AIM, the program seeks to promote quality improvements in maternal health care, ensuring safer births and better health for mothers and infants.