Best Unrestricted Grants for Nonprofits in Puerto Rico

The Bayer Fund Health & Wellness Grant Program aims to support organizations that provide education and resources for patients and caregivers facing cancer and cardiovascular diseases. Grants focus on assisting communities, particularly the African American population, in managing these health issues. Funding covers educational services, disease awareness, and access to care, with all activities to commence post-funding decisions. Eligible organizations must hold a 501(c)(3) status and operate within 55 miles of Bayer sites.

The Anderson-Rogers Foundation Grant supports U.S.-based 501(c)(3) organizations focused on environmental protection, animal welfare, climate change mitigation, and social support. Established in 2001, this family foundation prioritizes innovative projects and general operating support for small organizations facing financial constraints. Note that applicants must first submit a letter of inquiry, as the foundation does not fund scholarships or grants to individuals or religious organizations, nor does it support organizations outside the U.S.

The Mazamas is committed to exploring and preserving mountain environments in the Pacific Northwest through research grants. These grants support nonprofit research that aligns with the Mazamas’ mission, encouraging proposals from graduate and undergraduate students. Successful applicants often conduct field studies that enhance understanding of the region's natural features. Notably, the Mazamas also welcome innovative research ideas that may fall outside traditional grant guidelines, promoting a diverse range of scientific inquiry.

The NCCIH Natural Product Mid Phase Clinical Trial (R01 Clinical Trial Required) grant invites applications for mid-phase clinical trials focusing on natural products such as botanicals and dietary supplements. It aims to advance scientific knowledge by determining optimal dosing and patient responses. Applicants must provide preliminary data demonstrating bioavailability and measurable impacts on target engagement. This initiative will not support efficacy trials for cancer treatments and encourages early contact with NCCIH scientific contacts.

The Southeastern Branch John Henry Comstock Award recognizes outstanding Ph.D. students in entomology, promoting interest in the field and supporting attendance at the ESA annual meeting. Awardees receive an all-expenses-paid trip, a $100 cash prize, and a certificate, with additional cash prizes presented by the Southeastern Branch. Eligibility includes being a current member and demonstrating excellence in graduate studies. This award fosters professional development and engagement within the entomology community.

The NCCIH Natural Product Early Phase Clinical Trial Award supports innovative clinical trials of natural products, such as botanicals and dietary supplements, with a strong scientific basis. Applications are encouraged to explore optimal delivery methods and combinations with other treatments. Funding is available for up to three years to assess the impact on target engagement and clinical outcomes, aiming to translate basic science findings into practical clinical applications.

The Kate Stokes Memorial Award, established in memory of CLP Programme Officer Kate Stokes, offers a $5,000 grant annually to an exceptional team of CLP alumni. Focused on supporting young conservationists, the award emphasizes teams demonstrating passion and commitment to conservation efforts. The Conservation Leadership Programme (CLP), initiated in 1985, provides vital support for applied biodiversity projects in less developed countries, helping young leaders gain practical conservation experience.

The NCCIH Natural Product Early Phase Clinical Trial Phased Innovation Award (R61/R33) invites research proposals for early phase clinical trials of natural products, including botanicals and dietary supplements, emphasizing scientific validity for further testing. Applicants may receive up to three years of funding for pharmacokinetics and bioavailability studies, with potential for an additional three years to evaluate clinical outcomes. This initiative aims to optimize natural product delivery through innovative study designs.

Community Finance Initiative 

Advancing the financial resilience of low-income households across the U.S.

This model enables us to engage and support a broad range of organizations across the globe to tackle some of the most pressing social issues of our time.

The Citi Foundation’s 2026 Community Finance Initiative commits $35 million to support programming that bolsters the financial stability, strength and safety of low-income households in the U.S.

Focus Areas

The Foundation seeks to support organizations advancing low-income household financial resilience in the United States across three focus areas:

Stabilize: Programs that help low-income households to build financial skills and confidence to manage daily finances and navigate financial stress.

• Financial coaching on budgeting, credit, debt reduction and savings strategies.
• Digital tools offering personalized financial guidance and product navigation.
• Assistance with public benefits and social safety net programs.

Strengthen: Programs that help low-income households build and repair credit, as well as short- and long-term financial assets.

• Financial products or services for credit building and credit repair.
• Initiatives to increase savings, including emergency funds.
• Support for homeownership, including readiness, preservation and long-term stability (e.g., first-time buyer assistance, preventing displacement and support systems for aging in place resources).

Safeguard: Programs that protect low-income household financial security by preventing and addressing financial losses.

• Education and support for the safe and confident use of digital financial tools.
• Fraud and scam awareness, prevention and recovery initiatives, including protection from identity theft.
• Interventions to help households recover from major financial shocks (e.g., healthcare costs, extended family care, job transitions or natural disasters).

Funding Opportunity

The Foundation plans to award 70 $500,000 (USD) grants (to be disbursed over two years) totaling $35 million to community organizations working in select communities where Citi has a presence.

The grants will be restricted and are anticipated to be disbursed in two annual payments in 2026 and 2027. Proposed projects should be for a term of 24 months, starting no sooner than August 1, 2026 and ending no later than December 31, 2028.

The Strategic Alliance Matching Grant - Division II offers financial support to enhance ethnic minority and gender representation in mid- to senior-level athletics administration roles across NCAA Division II institutions. With an annual budget of $860,000, the grant aims to fund up to 20 schools and conferences each year. Eligible applicants must be active Division II members and are encouraged to collaborate with their human resources departments during the proposal process, ensuring compliance with grant requirements.

The National Institute of Neurological Disorders and Stroke (NINDS) aims to support innovative research for validating therapeutic targets in Alzheimer's Disease-Related Dementias (ADRD). This initiative focuses on overcoming barriers in treatment development by ensuring well-validated targets linked to disease mechanisms. By employing a phased award mechanism, NINDS seeks to enhance the rigor of target validation, facilitating the transition from basic discoveries to clinical applications, ultimately accelerating the development of effective therapeutic strategies.

The National Cancer Institute (NCI) seeks to enhance the validation of biomarkers and assays for cancer detection and treatment through its UH3 funding mechanism. This initiative supports multi-disciplinary collaborations to validate existing assays over three years using clinical trial specimens. Emphasis is placed on harmonizing laboratory tests and validating pharmacodynamic markers. Projects should not focus on early-stage technology development but aim for integration into clinical studies as investigational assays.

The Call for Kindness Grant, offered by Riley's Way Foundation, empowers young leaders aged 13-23 to launch impactful social projects focused on kindness and community connection. With grants up to $5,000, recipients receive essential mentorship, coaching, and community support. This initiative has already benefited over 3,500 youth nationwide, promoting values of empathy and social change. Applicants can pursue projects in diverse areas, including environmental justice, ensuring a broad impact in their communities.

The Clinical and Translational Science Award (CTSA) Program invites applications to enhance clinical and translational science through innovative partnerships and research programs. This initiative aims to accelerate the delivery of treatments to diverse populations by improving clinical research efficiency, creating national resources for public health responses, and providing training for clinical research professionals. Applications are due by 5:00 PM local time, with optional Letters of Intent recommended 30 days prior to the full proposal deadline.

The FY 2027 Notice of Funding Opportunity for the Infrastructure Investment and Jobs Act (IIJA) FAA Contract Tower Competitive Grant Program offers up to $100 million for airport traffic control tower projects. This initiative aims to support airports in modernizing and repairing aging infrastructure, ensuring safety and efficiency in air traffic management. Eligible projects may involve construction, rehabilitation, or installation of essential air traffic control equipment, enhancing the operational capabilities of the nation's airports.

Navigant Credit Union 

Navigant Credit Union is the longest-operating, member-owned credit union in Rhode Island. Since its founding in 1915, Navigant Credit Union has been dedicated to providing its members with unparalleled financial products and services, while working every day to stay committed to the financial well-being of the families, businesses and communities we serve. 

Navigant Credit Union Charitable Foundation Grant

For over a century, Navigant Credit Union has been committed to making a meaningful difference in the community. In 2017, we established the Navigant Credit Union Charitable Foundation to further amplify our impact in five strategic areas:

• Education & Financial Literacy: Organizational and capital support for programs, supplies, building products, sports facilities and teams.
• Social Services: Financial support for programs and organizations for children, veterans, hunger and housing.
• Public Health, Safety & Well-Being: Support for programs addressing public safety, emergency care and eradication of disease.

The Blueprint MedTech Translator program aims to support the advancement of therapeutic and diagnostic devices for nervous and neuromuscular disorders. This initiative encourages clinical feasibility studies and the implementation of clinical prototype devices, along with safety and efficacy testing. Participants will receive funding to conduct research in their own labs, collaborate with NIH consultants, and access contract research organizations for specialized testing, ensuring a comprehensive approach to device development.

The DARPA Tactical Technology Office (TTO) seeks innovative proposals to enhance national security through cutting-edge technology. This initiative focuses on Design/Build/Buy, Surge and Sustain, Long Range Effects, and Disruptive Innovation. By fostering rapid adaptation and sustainable force structures, TTO aims to demonstrate revolutionary systems that are not only effective but also affordable and responsive to emerging challenges.

The Carolyn L. Kuckein Student Research Fellowship, awarded by Alpha Omega Alpha Honor Medical Society, supports first and second-year medical students conducting research over 2 to 12 months. With a total funding of $7,000, students can receive reimbursement for travel expenses up to $1,000 for presenting their findings at national conferences. Eligibility requires enrollment in schools with active AΩA chapters, while those taking a year off for research or holding a PhD are ineligible.

The FY26 Defense Established Program to Stimulate Competitive Research (DEPSCoR) Capacity Building opportunity aims to enhance the capabilities of university researchers in eligible states. Managed by the DoD, this initiative focuses on increasing the number of researchers capable of conducting relevant science and engineering research. The program also seeks to strengthen institutions of higher education and improve their competitiveness for federal research funding, ultimately fostering long-term growth in financial assistance for scientific research.

The BJA FY 2026 Students, Teachers, and Officers Preventing (STOP) School Violence Program aims to enhance school safety by funding initiatives that train staff and students, develop threat assessment teams, and implement technology solutions like anonymous reporting systems. This program supports effective strategies to identify and mitigate risks of school violence, ensuring students have the tools necessary to foster a secure learning environment while adhering to the guidelines set forth by the STOP School Violence Act.

The Prioritization Process Pilot Program (PPPP) Competitive Grant Program, funded by the DOT Federal Highway Administration, offers up to $26 million for innovative transportation planning in FYs 2024-2026. Grants of up to $2 million will support the development of transparent, data-driven prioritization processes for project selection in transportation plans, ensuring that funded projects deliver public benefits and meet community needs.

This funding opportunity aims to advance mechanistic research for precision probiotic therapies. It invites R33 applications focused on characterizing individual differences in probiotic responses, identifying responder subgroups, and enhancing clinical outcomes. The goal is to develop strategies addressing barriers to effective probiotic use, accounting for human variability. Proposals should include innovative studies using animal models or human subjects, supported by preliminary data to test biological patterns and their effects on health outcomes.

The ROSES 2025: A.17 Hydrosphere program by NASA aims to enhance our understanding of Earth's water systems, focusing on Ocean Physics, Precipitation Science, and Terrestrial Hydrology. This initiative invites proposals targeting specific priorities within these disciplines to advance knowledge on water distribution and movement across the Earth. Proposals will undergo rigorous peer review to ensure transparency and scientific integrity, aligning with NASA's commitment to reproducible and collaborative research.

The Park Foundation Grants for Animal Welfare focus on advancing the protection and conservation of wildlife, particularly through policy and advocacy efforts for threatened species. The foundation supports innovative, solution-oriented models that foster systemic change and compassion. Key areas include organizing for endangered wildlife, indigenous management practices, and supporting sanctuaries for great apes. Additionally, the foundation is committed to local efforts, including support for the Tompkins County SPCA, ensuring a compassionate society for all living beings.

The BJA FY 2026 DNA Capacity Enhancement for Backlog Reduction (CEBR)—Formula Grants Program aims to support states and local governments in enhancing their DNA analysis capabilities. By providing funding for existing crime laboratories, this initiative seeks to increase the processing capacity for DNA samples, thereby reducing the backlog in forensic DNA analysis and ensuring timely entry into the Combined DNA Index System (CODIS). Applications are due by November 5, 2026.

The Distressed Cities Technical Assistance (DCTA) Program provides competitive funding for eligible applicants to deliver technical assistance to local governments serving economically distressed communities of 50,000 or fewer residents. Selected awardees collaborate closely with HUD to enhance the capabilities of UGLG officials and staff, ensuring they effectively address community needs. Applicants may focus on broad HUD jurisdictions or specific areas as specified in the program's NOFO.