Best Unrestricted Grants for Nonprofits in Puerto Rico

Spencer Educational Foundation Inc

The Spencer Educational Foundation was founded by the Rims Atlanta Chapter in 1979. To this day, Spencer remains the premier organization funding the education of tomorrow's risk management and insurance leaders.

The Spencer Educational Foundation: awards merit-based scholarships and grants to university students pursuing careers in risk management, insurance, and/or actuarial science; provides grants that create experiential learning opportunities both on and off campus; funds the development of risk management and insurance curricula in colleges and universities; supports Risk Managers by creating internship opportunities within the risk management function of their companies; and operates across the United States and Canada. 

Spencer Educational Foundation: General Grants

Spencer’s goal to help build a talent pipeline of Risk Management and Insurance professionals is achieved in part by our collaboration with Risk Management and Insurance educators across the United States and Canada. Since 2010, Spencer has awarded over $4.5 million in General Grants to support over 225 student-centered experiential learning initiatives at universities and RMI non-profit orgs.

Spencer's General Grants Program supports student-centered initiatives that (1) provide experiential learning opportunities for Risk Management & Insurance students and (2) attract new talent to risk and insurance careers. 

About Lions Club International FoundationLions Clubs International Foundation (LCIF) provides grants that empower the service of our members. Since its inception in 1968, LCIF has awarded more than US$1.3 billion in grant funding.  Mission :Our mission is to empower Lions clubs, volunteers and partners to improve health and wellbeing, strengthen communities, and support those in need through humanitarian service and grants that impact lives globally, and encourage peace and international understanding. And we fulfill it every day, everywhere we serve.Lions Club International Hunger Grant ProgramHunger Grants focus on strengthening infrastructure and providing essential equipment for Lions’ hunger-relief efforts. These grants empower Lions to support vital initiatives such as school feeding programs, food banks and feeding centers, ensuring that those in need receive the nourishment they require. These grants support infrastructure and equipment acquisition for Lions’ projects focused on alleviating hunger.Grant Examples: 

• Construction or expansion of food banks, feeding centers and food storage facilities.
• Purchase of refrigerators and freezers to store perishable food items.
• Vehicles to transport, collect and deliver food.

The Growing Convergence Research (GCR) initiative by the National Science Foundation (NSF) promotes innovative solutions to complex societal and scientific challenges through multidisciplinary collaboration. By integrating diverse expertise, GCR aims to address specific problems and foster new research paradigms. Proposals must outline a five-year plan, divided into two phases, with budgets not exceeding $1.2 million for Phase I and $2.4 million for Phase II. Successful projects are expected to lead to transformative advances in science and technology.

The ASES Research Grant, provided by the ASES Foundation, offers up to $20,000 for innovative shoulder and elbow research projects. It invites applications from principal investigators who are orthopaedic surgeons working in North America. The funding supports projects lasting between 12 to 24 months and aims to foster advancements in patient care through research. Applications are limited to one per principal investigator per year, promoting focused and impactful research initiatives.

The Pulmonary Hypertension Fund, supported by the Patient Advocate Foundation, offers financial assistance for patients dealing with pulmonary hypertension. This fund covers essential healthcare costs, including medication copays and health insurance premiums. Patients must meet specific eligibility criteria, such as having a confirmed diagnosis and appropriate health insurance. Since 1996, the foundation has empowered millions to navigate healthcare challenges, ensuring they receive the care they need without financial burden.

Honor Grants

Supporting organizations that serve victims and families.

Our Honor Grant program provides financial support to 501(c)(3) nonprofits that offer services to victims and families impacted by heinous crimes. Awarded quarterly, these grants help organizations continue vital work in some of the hardest moments families will ever face.

• Grants up to $20,000, with occasional consideration for larger requests
• Open year-round to eligible organizations
• Funding supports a wide range of programs and projects, with a focus on those that are innovative, impactful, and built for long-term sustainability

The CAFE Group 

We resource leaders, invest in their genius, and bring people together to reimagine what philanthropy can do.

Founded by Liz and Don Thompson, The CAFE Group is a national nonprofit transforming how change is resourced. 

With a focus on education equity, social capital, and philanthropic transformation, we pair catalytic funding, community-rooted leadership development, and cross-sector collaboration to strengthen the people and institutions shaping a more just future. Everything we do is grounded in relationship, because we believe the way resources move matters just as much as where they land.

The 1954 Project Luminary Award

The 1954 Project Luminary Award celebrates transformational education nonprofit leaders dedicated to serving Black students and communities through powerful investments in their organizations' ability to create lasting change.

The Luminary Experience

Each Luminary organization gets more than funding. Through The 1954 Project, leaders gain a community, a platform, and space to grow with tailored support over the course of the three year journey.​

• $1 Million, Unrestricted: Catalytic funding to expand what’s working.
• Leadership Coaching + Capacity Support: Guidance from peers and experts who are committed to helping you build a lasting, impactful organization.
• National Network: Luminaries join a powerful community of innovators, change-makers, and visionaries driving systemic progress to support students and communities across the U.S.

The 1954 Project’s Impact Areas

We focus on three interconnected areas critical to advancing equity:

• Innovation in Teaching and Learning: Create education models that center Black students through culturally affirming approaches that challenge traditional structures and transform how learning happens, ultimately serving all students. 
• Diversity in Education: Build pathways that increase and sustain Black educators and education leaders who transform where and how students learn.
• Pathways to Economic Mobility: Build pathways to wealth, ownership, and economic power for Black students, families, and communities through innovative educational programming.

Our Selection Criteria

We seek out extraordinary applicants who embody our values and vision across three categories:

Leader: We look for leaders whose influence and vision contribute to the collective well-being and advancement of the Black community. These leaders:

• Are Visionary: They demonstrate a strategic and pragmatic mindset, articulating a transformative vision for significant, positive change.
• Show Demonstrated Commitment: They embody steadfast dedication to your cause, inspiring and influencing others, and galvanizing community involvement.
• Are Adaptive: They assertively tackle challenges, turning setbacks into opportunities for innovation, while maintaining humility and thoughtfulness in problem-solving.

Organization: We look for organizations that drive significant change, anchored by a deep love for people and driven by the genius within communities of color. These organizations: 

• Have a Defined Problem: They clearly identify the issue they are addressing and explain in detail how your organization tackles root causes. 
• Take a Strategic Approach: They have clear, measurable, and achievable organizational goals with a well-defined strategy informed by thorough analysis. 
• Show Demonstrated Impact: They have a tested model that has produced positive results, incorporating continuous learning and iteration. 
• Have a Transformation Plan: They present a clear plan for using the $1M award to advance your organization's mission, vision, and long-term goals. 
• Embrace Collaboration: They use collaborate to build partnerships based on trust, love, and common goals. 

Radical Imagination: We seek leaders who challenge and redesign societal norms to build a just and equitable future. They demonstrate:

• Community-Rooted Leadership: They maintain and cultivate genuine community ties, integrating professional expertise and personal commitment to drive visionary, impactful strategies. 
• Long-Term Commitment: They are in it for the long haul, committing to sustained impact across generations and prioritizing long-lasting solutions over short-term gains. 
• Collectivism: They embody the philosophy of "I am because we are," actively engaging in collaborative networks and fostering community-reflective solutions. 

Tree and Soil Research Fund for Landscape Architecture Grant Program

The TREE Fund Board of Trustees is launching the new Tree and Soil Research Grant, made possible by a permanently restricted endowment fund supporting areas of research of interest to the landscape architecture community with special focus in the area of trees and the soils that support them. Projects are expected to be completed within one to three years, with a maximum award value of $10,000. No project may receive more than one award from this program. 

Award amount:

• up to $10,000 (minimum $5,000) 

Small Steps in Speech is offering Individual Grants for Speech Therapy, Therapeutic Summer Camps, or Assistive Devices. Effective February 2, 2024, families with a joint household income of up to $125,000 can apply. Eligible applicants are U.S. citizens aged 3-22. Grants are not solely based on financial need, and previous grant recipients from SSIS may not reapply. Detailed eligibility and application requirements are outlined to ensure fair access to necessary support.

This funding opportunity announcement (FOA) aims to support research that advances the development of medical products for preventing, diagnosing, treating, or curing ALS and other rare neurodegenerative diseases. The FDA seeks to address critical knowledge gaps and significantly impact these diseases through this initiative, which targets both adult and pediatric populations. By funding these studies, the FDA hopes to inform current and future product development in this vital area of healthcare.

This funding opportunity by the FDA aims to enhance education and public awareness regarding the risks associated with skin lightening products, such as hydroquinone. The initiative encourages innovative, community-based strategies that engage stakeholders in promoting health equity. Proposals should focus on outreach activities that strengthen the scientific understanding of these products while addressing public health concerns. This is a vital step in ensuring safer use and informed consumer choices.

The Cooperative Agreement aims to enhance the dissemination of clinical practice guidelines, particularly those developed through FDA-supported initiatives. Applicants are encouraged to devise a comprehensive strategy for creating, evaluating, and distributing materials that promote effective dissemination, with a strong emphasis on equity in healthcare access. This initiative seeks to ensure that vital clinical information reaches diverse populations, ultimately improving health outcomes across communities.

The Scott R. MacKenzie Foundation offers grants to support innovative genetic research aimed at advancing cures for diseases like cancer, diabetes, lung, and heart diseases. Only U.S.-based tax-exempt organizations with over five years of operation can apply. The Foundation emphasizes collaboration among research entities to enhance genome sequencing and disease detection. By funding these initiatives, they aim to foster awareness and progress in genetic research for future generations.

The Youth Regional Treatment Center Aftercare Program aims to support American Indian and Alaska Native youth in maintaining safety, sobriety, and success post-discharge from Youth Regional Treatment Centers. This initiative enhances culturally relevant, community-based aftercare by fostering care coordination, building partnerships, and addressing barriers to improve youth outcomes.

The American Academy of Audiology offers the Investigator Research Grant to promote essential research in audiology and balance health care. With a funding limit of $20,000 for one-year projects, the grant aims to support innovative research that enhances the evaluation and management of hearing and balance disorders. Eligible applicants must hold a doctoral degree in audiology or hearing science and be affiliated with a non-profit institution in the U.S. or Canada, fostering collaboration between academia and clinical practice.

The Racial Equity & Women’s Intercultural Ministries Grants and Scholarships, supported by the Presbyterian Mission Agency, aim to empower leaders, congregations, and organizations that promote racial equity and women's rights. This initiative reflects the Presbyterian Church's commitment to justice and inclusivity, fostering an environment where diverse voices can thrive and contribute to the community. By providing these resources, the program seeks to uplift marginalized groups and promote social equity within faith-based settings.

The Patient-Centered Outcomes Research Institute (PCORI) will announce funding for patient-centered comparative clinical effectiveness research (CER) studies focusing on rare diseases. This initiative encourages collaboration and aims to fill critical research gaps affecting approximately 30 million Americans with rare diseases. Applications can request up to $12 million over five years, including coverage for patient care costs. This funding opportunity is set to open on August 12, 2025, with a focus on addressing pressing patient-centered CER questions.

The Hearst Foundation: Education Grant aims to support outstanding nonprofits that promote education across various levels, focusing primarily on higher education. With a minimum grant size of $100,000, the foundation prioritizes organizations demonstrating significant impact and sustainability. They support innovative educational models, professional development, and scholarships, specifically targeting underserved populations. Since the 1940s, the foundation has evolved while maintaining its commitment to fostering healthy and productive lives for all individuals in the United States.

About

Founded in 1971, the Mensa Foundation was established by members of American Mensa to extend the organization’s impact. While connected by a shared purpose, the Foundation operates independently, guided by its own Board of Trustees, strategic plan, and initiatives.

Grants & Fellowships

Fellowships

The Mensa Foundation Fellowship program empowers exceptional individuals committed to advancing the application of intelligence in their respective fields.

Details

Our current fellowship, the Gifted Education Fellowship, is designed to empower educators pursuing graduate studies in gifted education or closely related fields, enabling them to make a transformative impact in their classrooms and communities. The fellowship supports both doctoral and non-doctoral students, with awards and renewal terms tailored to each track.

The Eppley Foundation for Research, established in 1947, supports advanced scientific research in chemistry, physics, and biology. It prioritizes innovative studies, particularly in medical investigations and climate change. The foundation does not fund social sciences or projects with ample existing financial support. Applicants must hold a PhD or MD and be associated with a nonprofit in the US. The foundation aims to foster groundbreaking research that is unlikely to be replicated elsewhere.

The NNLM Region 5 Professional Development Award offers funding for individuals at member institutions to enhance their knowledge and skills in health-related areas. This initiative aims to support meetings, workshops, and training that focus on health literacy, public health, and evidence-based practices. By fostering professional development, the NNLM seeks to improve healthcare services and access to health information across various communities, ultimately contributing to better public health outcomes.

The Howard D. Colman Scholarship supports high school seniors from Boone and Winnebago Counties pursuing degrees in engineering or technology fields. Established in memory of entrepreneur Howard D. Colman, the scholarship offers $2,500 in the first year, with potential renewal up to $10,000 for three additional years, contingent on meeting criteria. Recipients gain hands-on experience through internships with local firms, fostering connections to the Rockford area.

Howard Hughes Medical Institute

More than 70 years ago, the Howard Hughes Medical Institute (HHMI) was founded with a mission to advance basic biomedical research and science education. Today, we invest in exceptional scientists at all career stages, catalyzing breakthroughs, new technologies, and the next generation of transformative clinical therapies. Our pathbreaking science takes place at more than 60 host institutions across the US, and at our Janelia Research Campus.

Cech Fellows Program

The Cech Fellows Program is a paid, nine-week summer research experience for rising college juniors and seniors designed to empower the next generation of scientific leaders through mentorship, hands-on research, and community. 

The Cech Fellows Program gives undergraduate students in the life sciences the opportunity to conduct hands-on research with leading scientists at HHMI laboratories across the US, from universities and research institutions to HHMI’s Janelia Research Campus outside of Washington, DC. Students are matched with HHMI scientists conducting fundamental research that advances our understanding of biology and health. 

This immersive program gives students the chance to contribute to real scientific discovery, receive professional mentorship, explore potential careers in biological and biomedical research, and connect with a community of like-minded peers.  

Gain Hands-On Experience in Research & Lab Work

The HHMI Cech Fellows Program is a 9-week, full-time, immersive research experience running from June 14, 2027 to August 12, 2027. Fellows: 

• conduct cutting-edge basic research in an HHMI lab for their own educational benefit  
• participate in professional development workshops   
• engage with a vibrant scientific community  
• build essential skills for future success in a scientific career   

Funding & Logistics 

As a Cech Fellow, students:  

• receive a $15,000 stipend if placed in an HHMI lab at a host institution, intended to cover travel, housing, meals, and incidentals. (Students are responsible for arranging their own housing.) 
• receive a $12,000 stipend if placed at HHMI’s Janelia Research Campus. (Students placed at Janelia have access to free, on-campus housing.)
• participate in an end-of-summer symposium at the Janelia Research Campus in Ashburn, VA, from August 10–12, 2027, at which they present their research and meet other Cech Fellows from across the country. Food, lodging, and travel to and from the symposium are provided by HHMI. 
• are matched with a local contact from their host lab who will provide suggestions for local housing options. Students are expected to travel to arrive at their host institutions by June 14, 2027.  

The Stout Foundation Grant supports organizations aligned with the values of its founder, Mr. Stout. Grants are awarded exclusively to entities with 501(c)(3) tax-exempt status and focus on charitable, educational, and scientific purposes. Preference is given to organizations with low overhead costs and those located in areas frequented by Foundation members. The Foundation aims to promote effective use of funds while remaining flexible in its grant-making approach.

Foundation of the Federal Bar Association

The Foundation of the Federal Bar Association provides the best way for practitioners to give back to the Federal legal community. Chartered by Congress in 1954, the Foundation serves people in communities across the United States through its generous grants, scholarships, and programming.

Our Mission: The Foundation’s mission is to:

• Promote and support legal research and education;
• Advance the science of jurisprudence;
• Facilitate the administration of justice;
• Foster improvements in the practice of Federal law

Foundation Grants

Foundation grants support community service projects and civics programs which comply with the Foundation’s mission to promote and support legal research and education; advance the science of jurisprudence; facilitate the administration of justice; and foster improvements in the practice of Federal law.

Civics Education Grant

The Civics Grant Program is designed to support projects and initiatives that promote a wider public understanding of democratic principles, the judicial system and the rule of law. Through targeted funding, the program empowers FBA chapters, sections, divisions, national standing committees (FBA entity), and other organizations to develop and support projects in their communities that foster public understanding of the rights and responsibilities of American citizenship, particularly among younger Americans.

Applicants may only receive one (1) Foundation grant per year.

Cherokee Nation Foundation

The Cherokee Nation Foundation is a nonprofit organization serving the Cherokee Nation, a federally recognized tribe of more than 470,000 citizens. Its mission is to provide educational opportunities to Cherokee students so they can reach their full potential. The Cherokee Nation Foundation is a tax-exempt charitable organization under Section 501(c)(3) of the Internal Revenue Code.

Scholarships

Cherokee Nation Foundation offers a diverse range of scholarships to help reverse the trend of rising student debt. Students may receive up to two CNF scholarships per academic year. All opportunities are reserved for Cherokee Nation citizens, unless otherwise noted in the description.

Senior Master Sergeant Texie C. Taylor, USAF Memorial Scholarship

Applicant must be a junior or senior undergraduate or graduate student majoring in physics, chemistry, biology, medicine, nursing (RN), engineering (aerospace, civil, chemical, electrical, mechanical) or mathematics with a minimum 3.0 GPA. This is a one-year scholarship reserved for Cherokee Nation citizens residing within the Cherokee Nation jurisdictional area.

The Guido's Fresh Marketplace Scholarship Fund, established by the Berkshire Taconic Community Foundation, honors the legacy of Guido Masiero, a dedicated educator and entrepreneur. This scholarship aims to support graduating high school students from public schools in Pittsfield, Lenox, or Great Barrington, Massachusetts, who are pursuing higher education in physical education, health, wellness, or business studies. The fund reflects the foundation's mission to enhance community opportunities and economic mobility.