Best Rapid City Grants for Nonprofits in South Dakota

Funding Innovative Research

Cannonball Kids’ cancer Foundation (CKc) prioritizes funding clinical trials, research that is nearing translation to a clinical trial, and young investigator grants.

Grants funded by CKc must be innovative and provide better quality of life or symptom relief than current treatments. 

When possible, CKc will prioritize funding research:

• with a focus on cancers that are under-funded or under-researched,
• with a focus on patient populations who are traditionally underserved.

When possible, CKc will prioritize funding researchers of diverse backgrounds.

For CKc, “innovation” means the invention or application of novel methods or treatments, specifically treatments that have fewer side-effects than standard care, increase a child’s quality of life, and/or create an option for care where there otherwise were few or none (either on primary diagnosis, relapse, or for recalcitrant cancers).

Research Grants

Grant Program: Clinical Trial

$200,000 over 3 years

• PI must hold an academic appointment at the Assistant Professor level or higher
• Preclinical studies must be complete
• If an FDA Investigational New Drug (IND) application is necessary for the proposed clinical study, the IND application should already have passed FDA initial review and be active
• If the PI has recruited additional patient enrollment sites, local IRB approval must be obtained for each site.

• How many treatment options would this study provide for children?
• How accessible is this study for children and families to access?

Grand Rapids Community Foundation

The Community Foundation is a nonprofit organization that connects people, passion and resources. With our partners, the Community Foundation uses the tools of philanthropy to find solutions to pressing issues. We provide grants to support the work of nonprofits, scholarships to local students and other forms of support to communities working to eliminate barriers to opportunity, prosperity and belonging.

Scholarships

Each year Grand Rapids Community Foundation supports hundreds of students on their college or career training journeys. We are excited to remove barriers to academic success so that students like you can pursue what you're passionate about.

Josephine Ringold Scholarship

Open to students who are residents of Kent County. Preference to Challenge Scholar students through 2032.

Grand Rapids Community Foundation

The Community Foundation is a nonprofit organization that connects people, passion and resources. With our partners, the Community Foundation uses the tools of philanthropy to find solutions to pressing issues. We provide grants to support the work of nonprofits, scholarships to local students and other forms of support to communities working to eliminate barriers to opportunity, prosperity and belonging.

Scholarships

Each year Grand Rapids Community Foundation supports hundreds of students on their college or career training journeys. We are excited to remove barriers to academic success so that students like you can pursue what you're passionate about.

Joshua Esch Mitchell Aviation Scholarship

Open to graduating high school seniors from West Michigan Aviation Academy, or to second year undergraduates from any high school, studying Aviation/Flight Science and have a pilot’s license, with a minimum 2.75 GPA.

Grand Rapids Community Foundation

The Community Foundation is a nonprofit organization that connects people, passion and resources. With our partners, the Community Foundation uses the tools of philanthropy to find solutions to pressing issues. We provide grants to support the work of nonprofits, scholarships to local students and other forms of support to communities working to eliminate barriers to opportunity, prosperity and belonging.

Scholarships

Each year Grand Rapids Community Foundation supports hundreds of students on their college or career training journeys. We are excited to remove barriers to academic success so that students like you can pursue what you're passionate about.

Kenneth E. & Shirley J. Morris Scholarship

Open to second year or higher undergraduate or graduate students who are residents of Ionia County studying Nursing and with a minimum 2.0 GPA.

The National Library of Medicine (NLM) is inviting applications for its Coordinating Center within the Network of the National Library of Medicine (NNLM). Established in 1965, the NNLM enhances public access to health information through collaboration with libraries and community organizations. The NCC will oversee network administration and evaluation, fostering partnerships and supporting local clinical research. This initiative aims to expand NIH engagement and improve public understanding of health resources and information available through the NNLM.

The HEAL Initiative Whole Joint Health Program aims to advance research on the biological mechanisms of joint pain by exploring the interactions of various tissues within the joint. This innovative program will support clinical studies that focus on non-pharmacological interventions to enhance healing and improve quality of life for individuals suffering from chronic joint pain. By fostering a comprehensive understanding of joint health, the initiative aligns with the NIH's broader goals to reduce chronic pain and opioid dependency.

The Limited Competition Small Grant Program for the NCATS CTSA Program aims to empower KL2 scholars by funding diverse clinical and translational research projects. These grants support short-term studies, methodology development, and preliminary data collection, facilitating the transition to independent research careers. Applications will undergo NIH peer review, ensuring only high-quality proposals receive funding. This initiative fosters innovation in research methodologies and technology, ultimately enhancing the capabilities of emerging translational scientists.

The NLM Institutional Grants aim to enhance training in biomedical informatics, data science, and AI for predoctoral and postdoctoral researchers. By fostering innovative programs, NLM addresses the urgent need for experts in these fields to tackle complex health challenges. These grants support both new and renewed training initiatives, emphasizing interdisciplinary approaches that combine diverse methods to advance biomedical science and improve health outcomes through advanced computational strategies.

The Collaborative Program Grant for Multidisciplinary Teams, funded by the US Dept. of Health & Human Services: National Institutes of Health (NIH), supports integrated teams of researchers tackling ambitious projects that individual efforts cannot achieve. This program promotes collaboration among experts with complementary skills, aiming for significant advancements in their fields. Teams are encouraged to pursue innovative objectives that have the potential to transform research landscapes.

The HEAL Initiative's new program aims to generate comprehensive datasets on human pain networks through advanced 'omics and physiology research. Utilizing primary human tissues, the initiative promotes collaboration among diverse experts to enhance the understanding of pain mechanisms. This cooperative agreement will foster best practices and data sharing, ensuring integrated approaches across various pain conditions. While applications are not currently being accepted, the initiative encourages multidisciplinary teams to prepare for future opportunities in pain research.

The National Institute on Aging (NIA) is launching a Notice of Funding Opportunity (NOFO) to establish a national consortium focused on improving care for older adults with multiple chronic conditions. This initiative aims to evaluate the effectiveness of integrated primary care interventions through innovative electronic health record (EHR) platforms. By fostering collaborations among researchers and clinicians, the consortium will work to enhance patient outcomes and streamline population health management, paving the way for future advancements in aging care.

The Innovation Grants to Nurture Initial Translational Efforts (IGNITE) support the development of assays and screening processes to identify potential therapeutic agents for neurological disorders and non-opioid analgesics. Sponsored by the NIH, this initiative seeks to foster collaborations and projects that utilize innovative methodologies. Although applications are not currently being solicited, interested parties are encouraged to prepare meaningful proposals that align with the goals of the NIH Helping to End Addiction Long Term initiative.

The Innovation Grants to Nurture Initial Translational Efforts (IGNITE) program, supported by the National Institutes of Health, aims to fund pharmacodynamic and pharmacokinetic studies. These studies will assess the biological activity of therapeutic agents, including small molecules and biologics, for diseases prioritized by participating institutes. The initiative emphasizes the development of non-opioid analgesics with minimal addiction risks. Although applications are not currently solicited, this notice encourages potential applicants to prepare collaborative projects.

The RAK Education Foundation Scholarship provides financial assistance to residents of Camden, Chowan, Gates, Pasquotank, or Perquimans Counties who have earned a high school diploma or GED. This scholarship supports students pursuing degrees or certificates in Career and Technical Education fields such as trade education, computer science, business, health science, and more. Applications open on December 16, 2025, and close on March 3, 2026, encouraging eligible students to apply.

The Robert E. Barnhill, Sr. Scholarship Fund provides financial support for North Carolina high school seniors who plan to attend a four-year college or university as full-time students. Eligible applicants are evaluated on leadership potential, community involvement, academic achievement, and financial need. The scholarship may be renewed for up to three additional years, contingent upon maintaining a 2.0 GPA and continuous enrollment. Applications open on December 16, 2025, and close on March 3, 2026.

The Ruby A. Trivette Ruritan Scholarship, administered by the North Carolina Community Foundation, supports graduating seniors from Ashe and Watauga counties in North Carolina. Eligible applicants must reside in Todd or be active members or children of active members of the Todd Ruritan Club. This scholarship opens for applications on December 16, 2025, and closes on March 3, 2026, providing crucial financial assistance for students pursuing higher education.

The Sammy and Shirley Church Scholarship supports students from Ashe County, NC, including those graduating from the NC School of Science and Math. Eligible candidates must demonstrate academic excellence, physical vigor, and leadership in various activities. Financial need is considered but not the only criterion. Applications open on Dec. 16, 2025, and close on March 3, 2026. Ensure to meet specific eligibility requirements set by the donor for successful application.

The Bertha Sawyer Meiggs & Winfred B. Meiggs Sr. Family Scholarship supports graduating seniors from Camden, Gates, Pasquotank, and Perquimans counties, with a preference for Camden County residents. Eligible candidates must demonstrate strong academic performance, leadership skills, and community involvement while enrolling full-time in a two- or four-year college. The scholarship may be renewed at the discretion of the Scholarship Committee, subject to academic criteria and available funds.

The Reid Sasnett Memorial Scholarship Endowment supports graduating seniors from Pungo Christian Academy and Beaufort County high schools pursuing higher education. This scholarship aims to aid students who exhibit strong character, leadership, and community service, especially those passionate about agriculture and wildlife. Applications open on Dec. 16, 2025, and close on March 3, 2026, with preference for volunteer firefighters and Pungo Academy alumni.

The Scottie W. Cox Memorial Scholarship of NCCCLA supports employees of learning resources centers in North Carolina pursuing advanced degrees in library and information studies. Eligible applicants must have at least a bachelor's degree and be enrolled in accredited programs. This scholarship, administered by the North Carolina Community Foundation, opens for applications on December 16, 2025, and closes on March 3, 2026. It aims to enhance professional development in the library sector.

Bridgestone Americas Trust Fund Grants

Empowering People to Move, Live, Work, and Play

Bridgestone has awarded over $60 million to nonprofit organizations in the United States since 1951, and we are committed to continuing our legacy of giving back by supporting communities around the U.S.

Bridgestone works with grantseekers that offer solutions to keep society moving forward. Strong partners offer a human-centered approach to societal challenges in one or more of the following areas of focus: 

In addition to our three areas of focus, we will consider applications from organizations that have hosted volunteer or community engagement events with Bridgestone volunteers and organizations that have received funding in previous years. 

Adaptive Sports in Schools Mobility Grants

Request for Proposals

More than 7 million students in the U.S. receive special education services for disabilities in public schools. A 2010 study by the U.S. General Accountability Office found that students with disabilities participated in athletics at significantly lower rates than their peers. Currently, 2,490 k-12 public schools in the U.S. are members of the American Association of Adaptive Sports Programs schools and have adaptive sports programs for students.

The Bridgestone Americas Trust Fund seeks public schools pursuing funding to start adaptive sports programs or increase access to adaptive sports and equipment for children and youth. Bridgestone is offering eight $25,000 “mobility” grants to organizations that can establish new athletic programming for students with disabilities. Organizations must articulate a clear plan to provide access to new athletic programs for students with disabilities in one or more public schools for students grades K-12.

The Peter S. Slomianyj Scholarship Fund offers financial assistance to Subway employees and their children who meet specific eligibility criteria, including a minimum of 500 work hours over the past year and a GPA of 2.0 in high school or 2.5 in college. Applications for this scholarship will be open from December 16, 2025, to March 3, 2026. It is part of a broader initiative by the North Carolina Community Foundation to support students pursuing education at various institutions.

The National Quantum and Nanotechnology Infrastructure (NQNI) program by the NSF aims to enhance research in emerging technologies like quantum computing and AI. By establishing a nationwide network of accessible research facilities, NQNI will facilitate innovation and collaboration among researchers. The program emphasizes user facility capabilities and plans for outreach, education, and workforce development, ultimately supporting the nation's quantum and nanotechnology advancements.

The Pathways to Enable Secure Open-Source Ecosystems (PESOSE) program, funded by the National Science Foundation, aims to transform open-source research into sustainable ecosystems that tackle national and societal challenges. This initiative promotes innovation across various sectors, including AI and cybersecurity, by fostering strong governance and broad user engagement. PESOSE invites proposals to establish and enhance open-source ecosystems, ensuring their safety, security, and effectiveness in meeting emergent needs.

The Gabriella Miller Kids First Pediatric Research Program invites applications for whole genome sequencing of pediatric cohorts. This initiative aims to explore the genetic basis of childhood cancers and congenital anomalies, enhancing our understanding of their etiology. Researchers are encouraged to propose sequencing methods, including whole genome and exome sequencing, to investigate genetic contributions and associations with cancer risk. The resulting data will be integrated into the Kids First Data Resource for broader research collaboration.

The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) is launching a Notice of Funding Opportunity (NOFO) under the NIH HEAL initiative to enhance research on joint health and pain. This initiative aims to refine the understanding of joint tissues and pain mechanisms, expand clinical phenotyping, and support preclinical testing of novel therapies. Collaborations among experts in neurobiology, pain science, and rheumatic diseases are encouraged to foster innovative solutions for joint pain management.