Best Sioux Falls Grants for Nonprofits in South Dakota

The 21st Century Museum Professionals (21MP) Program, funded by the Institute of Museum and Library Services, aims to enhance career pathways and professional networks in the museum sector. This initiative focuses on developing current museum staff, recruiting new professionals, and fostering partnerships that promote effective workforce training. By emphasizing peer learning and alternative career pathways, the program seeks to create a robust and diverse museum workforce across the nation.

The Museums for America (MFA) program, funded by the Institute of Museum and Library Services (IMLS), supports museums across the nation in enhancing their educational programs, community partnerships, and collection stewardship. This initiative aims to serve diverse audiences through experiential learning, address community needs, and ensure the proper management of collections. By investing in museums of all sizes, the MFA program plays a vital role in preserving America's cultural heritage for future generations.

The Inspire Grants for Small Museums (2027) initiative, funded by the Institute of Museum and Library Services, aims to empower small museums across various disciplines. This program focuses on project-based funding to enhance public service through educational programs, exhibits, and community partnerships. By supporting small, often underfunded institutions, Inspire seeks to strengthen their capacity to engage communities and improve collections management, fostering experiential learning and discovery.

The Museum Grants for African American History and Culture (AAHC) program, funded by the Institute of Museum and Library Services, aims to enhance the capacity of African American museums. This initiative supports professional development for museum staff and promotes accessibility to collections at these institutions and HBCUs. By fostering institutional growth, the program plays a vital role in preserving and showcasing African American history and culture through museum initiatives.

Museums Empowered (2027) is a professional development initiative by the Institute of Museum and Library Services aimed at enhancing museum staff capabilities. It focuses on three vital areas: digital technology, evaluation, and organizational management. By supporting training and learning opportunities, the program seeks to empower museum professionals to effectively utilize digital tools, improve evaluation methods, and strengthen organizational resilience, ultimately fostering growth within museums of all types.

The Native Hawaiian Health Care Improvement Act Program provides funding to enhance the health status of Native Hawaiians through comprehensive health care services. This initiative supports one administrative award to Papa Ola Lokahi and five awards to certified Native Hawaiian Health Care Systems. The program aims to ensure tailored health promotion and disease prevention services within island communities, addressing specific regional health needs from fiscal years 2027 to 2031.

The SCALE initiative aims to combat injury, violence, overdose, and suicide, the leading causes of morbidity and mortality among individuals aged 0-44. By enhancing implementation and outreach, this funding opportunity seeks to empower organizations to implement effective prevention strategies, especially in underserved communities, including tribal areas. The program encourages collaboration and continuous improvement to achieve sustainable reductions in these critical public health issues.

The Vineyard Family Foundation

The Vineyard Family Foundation is the product of decades of work across three generations and five states. Having enjoyed the benefits of our hard work and community patronage, the Vineyard family has chosen to provide to others what so many have graciously provided to us. 

What Sets Us Apart

The Vineyard family has always been committed to its communities. Whether supporting Boys & Girls Clubs, pediatric hospitals, the Ronald McDonald House, arts organizations, or youth recreation leagues, the family has taken a great interest in the care, health, and education of children and the families that nurture them. We take great pride in personally administering our Foundation’s charitable giving, resulting in fewer expenses and more funding for those organizations aligned with the Foundation’s purpose.

Grants

• Supporting Our Communities and Their Families
• Working Towards the Health, Education, and Overall Well-Being of Parents and Their Children

You are steps away from creating an opportunity to receive full or partial funding of your charitable organization. So that you use your time wisely, we offer the following advice for your efforts:

• As a family foundation, we are prohibited from funding individuals or any entity that is not an IRS-recognized Section 501(c)(3) tax-exempt entity or a Section 509(a)(1), (2), or (3) support organization. Thus, while we cannot award a scholarship to an individual, we can fund a 501(c)(3) charity that provides such scholarships.

• If you qualify as a Section 501(c)(3) tax-exempt organization or a support organization pursuant to Section 509(a)(1-3), we will need the IRS Determination Letter confirming as much, as well as a statement signed by your organization’s President or Chief Executive Officer verifying that your organization’s purposes, structure, and operations have not changed substantially since the date of the IRS’s Determination Letter.

• If you are a “supporting organization” under IRS Code section 509(a)(1-3), please provide a list of the public charities that you support. Please also advise whether you are a Type I, Type II, or Type III supporting organization. If you are a Type III supporting organization, please advise whether you are “functionally integrated” with your supported public charity and provide an explanation of that relationship.

Supported Charities

The Vineyard family has historically provided funding for family-related charities such as the Ronald McDonald House, the Boys & Girls Clubs of America, pediatric hospitals, autism-related organizations, and youth recreational leagues. The Foundation looks forward to continuing this support and extending itself to educational, research, and cultural experiences that focus on the needs of children and their parents.

The Air Force Basic Research Sciences Conference and Workshop Support program encourages proposals from U.S. institutions of higher education and nonprofit organizations for conferences and workshops that promote research and technology interchange. These events are vital for sharing recent findings and educational techniques in key scientific areas. The program specifically invites Historically Black Colleges and Universities, Minority-serving Institutions, and Tribal Colleges to participate, aiming to foster collaboration and knowledge exchange among researchers.

The ROSES 2025: D.4 program by NASA focuses on enhancing theoretical and computational astrophysics through collaborative networks. It aims to address grand challenges in Time Domain Multi-Messenger Astrophysics by integrating diverse expertise from various fields. Researchers from U.S. institutions are encouraged to propose innovative tools for modeling complex multi-messenger phenomena, fostering interdisciplinary collaboration across academic, national laboratory, and private sectors to prepare the next generation of scientists.

The IUSE: Innovation in Two-Year College STEM Education (ITYC) program, funded by the National Science Foundation (NSF), aims to enhance STEM education at two-year colleges. This initiative encourages innovative projects that promote student success in foundational STEM courses. Eligible institutions can request up to $500,000 for three years, with an extra $100,000 for those without NSF funding in the last five years, facilitating a total budget of $600,000 for impactful educational projects.

This grant provides essential support to the Tribal Radioactive Materials Transportation Committee, facilitating engagement with the U.S. Department of Energy. The focus is on planning for the transportation of commercial used nuclear fuel and high-level radioactive waste, ensuring that the concerns of federally-recognized Tribal governments are addressed. By fostering communication and collaboration, the initiative aims to mitigate potential impacts on Tribal areas from large-scale transportation activities.

This grant aims to enhance national immunization programs in the Eastern Mediterranean Region by focusing on capacity building, disease control, and outbreak response. It seeks to eliminate vaccine-preventable diseases, reduce morbidity and mortality, and improve access for under-immunized populations. The initiative will promote sustainability through evidence-based decision-making and program evaluation, aligning with CDC goals to address public health threats and improve overall immunization impact in the region.

This grant aims to enhance global polio eradication efforts through innovative modeling approaches. It focuses on developing effective strategies for cVDPV2 outbreak response and optimizing surveillance following global WPV eradication. The initiative also seeks to build a skilled public health workforce in statistical and mathematical modeling, assess economic impacts of response strategies, and foster capacity among students to address polio and other vaccine-preventable diseases.

The Human Trafficking Youth Prevention Education (HTYPE) Demonstration Program aims to empower local education agencies (LEAs) by funding initiatives that equip school staff to identify and respond to human trafficking signs. Collaborating with nonprofit partners, LEAs will provide students with essential knowledge on avoiding victimization and recognizing trafficking indicators. This program fosters a safer school environment by establishing reporting procedures and safety plans in consultation with local law enforcement, ultimately enhancing awareness and prevention of human trafficking in educational settings.

Burger Family Foundatio

Our Mission

Inspired by our daughter Penelope and the powerful symbolism of the extra 21st chromosome, our foundation is dedicated to creating opportunities for individuals with Down syndrome and their families. Through direct financial assistance, therapy, community, and the healing power of ranch life, we’re building spaces that foster hope, purpose, and belonging.

Pens Pearls

Named after Penelope, Pens Pearls is the financial support arm of our foundation, providing direct assistance to families navigating the unique joys and challenges of raising a child with a disability. From therapy grants to life-changing opportunities, we’re here to lighten the load and ensure every child has the resources they need to thrive.

Through Pens Pearls, eligible families can apply for funding to help cover essential needs, services, or opportunities that make a meaningful impact in their lives. The Burger Family Foundation is a 501(c)(3) organization, and this program is one of the ways we work to create lasting change—one story at a time.

Qualifications for Pens Pearls Grant Program, are deemed by the strict bylaws of the Burger Family Foundation. Funds are paid directly to provider. 

Society of Hospital Medicine (SHM)

The Society of Hospital Medicine (SHM) is dedicated to promoting high-value care and achieving optimal outcomes for acutely ill patients. As part of this mission, SHM seeks to address inequities in acute patient care and contribute to a greater dialogue on this important issue. As the home for hospitalists, SHM activates and engages our community to

• Advocate for our specialty, our members, and the diverse patients we serve.
• Promote high-value care and optimal outcomes for acutely ill patients.
• Meet the evolving educational needs of a dynamic specialty.
• Cultivate an inclusive community for hospitalists and support career growth and wellbeing.
• Advance the research and innovation of healthcare delivery, quality, safety, and experience across the care continuum.

SHM’s Awards of Excellence

SHM’s Awards of Excellence Program honors members who have made exceptional contributions to hospital medicine in a wide variety of categories: 

• Excellence in Research
• Excellence in Teaching
• Excellence as a Partner in Hospital Medicine
• Outstanding Service in Hospital Medicine
• Clinical Leadership for Physicians
• Clinical Leadership for Nurse Practitioners/Physician Assistants
• Excellence in Humanitarian Services
• Excellence in the Care of Vulnerable Populations
• Excellence in Teamwork

Society of Hospital Medicine (SHM)

The Society of Hospital Medicine (SHM) is dedicated to promoting high-value care and achieving optimal outcomes for acutely ill patients. As part of this mission, SHM seeks to address inequities in acute patient care and contribute to a greater dialogue on this important issue. As the home for hospitalists, SHM activates and engages our community to

• Advocate for our specialty, our members, and the diverse patients we serve.
• Promote high-value care and optimal outcomes for acutely ill patients.
• Meet the evolving educational needs of a dynamic specialty.
• Cultivate an inclusive community for hospitalists and support career growth and wellbeing.
• Advance the research and innovation of healthcare delivery, quality, safety, and experience across the care continuum.

SHM’s Excellence in Teamwork Award

This award is presented in recognition of exemplary quality improvement initiatives in hospital medicine that engage the full patient care team. The award is intended to highlight outstanding team approaches to implementing interventions that improve patient care and safety but is particularly interested in projects related to the core competencies in hospital medicine and SHM’s quality improvement resource rooms. 

Recipients of the Excellence in Teamwork in Quality Improvement Award receive recognition at SHM Converge 2026 and complimentary registration for up to 4 team members.

Arnold and Mabel Beckman Foundation

The Foundation was established in September 1977 by Dr. Arnold O. and Mrs. Mabel Beckman to give back to the scientific community.

“The mission of the Foundation is to support leading edge research, in the fields of chemistry and life sciences, broadly interpreted, and particularly to foster the invention of methods, instruments, and materials that open up new avenues of research and application in these sciences and related disciplines. My preference is to favor young investigators, new ideas, and a variety of projects rather than fund large, established ones of long duration.”

Current Foundation Initiatives

Today, the Foundation continues according to the vision laid out by Dr. and Mrs. Beckman:

• Supporting Young Scientists: through our annual grant programs, focused on the most promising young scientists
• Community Support activities: that promote science education and excellence in our local community
• Streamlined operations: so that we don't "spend money to give money away"

"Beckman Family" Awardee Community Support Grants

The Arnold and Mabel Beckman Foundation’s "Beckman Family" Awardee Community Support Grants are open to all current and former Foundation grant awardees and Executive Committee members, specifically from the Beckman Scholars Program, Arnold O. Beckman Postdoctoral Fellowship, Beckman Young Investigator, and Instrument Grants programs.

As a current or former Beckman awardee or Executive Committee member, if you are actively engaged as a volunteer or Board member in a youth STEM or STEAM organization in your local area, you may apply to this program for funding for a particular project with that organization.

Funding Priorities

Projects should be aligned with the Foundation’s aim of “supporting young scientists today for tomorrow’s breakthrough discoveries” and oriented toward achieving positive outcomes in at least one of the Foundation’s current funding priorities:

• Engaging youth in hands-on science and math activities to encourage curiosity and student-driven exploration and learning.
• Using technology to engage youth in STEM/STEAM.
• Promoting the Beckmans’ legacy of technology innovation and leadership amongst youth.

In addition, the following considerations should be addressed in a proposal for funding:

• Where possible, the Foundation’s contribution to a project or activity should help to build capacity within the nonprofit organization to continue the activity beyond the one-time grant.
• The Awardee/Executive Committee member should discuss how the program will increase access to STEM/STEAM opportunities for the target audience.
• The costs associated with the request should relate to a stand-alone STEM/STEAM project, event, or activity and not part of a broader program, event, or target audience outside the Awardee’s or Executive Committee member's local area.
• Youth registration to participate in the STEM/STEAM project, event, or activity should be open to all in the local area, when possible.

Process & Timeline

Grant funds are directly issued to the organization by the Foundation and include for acknowledgement an indication that the gift was made because their volunteer or Board member is a Beckman Awardee or Executive Committee member.

Requests must be submitted by the Beckman Awardee on behalf of a U.S. nonprofit 501(c)(3), or equivalent, organization exclusively serving youth in their local community. As a matter of policy, the Foundation does not provide grants to non-U.S. organizations or institutions. This program defines the terms “youth” and “youths” as individual(s) 17 years of age or younger.

Batten Disease Support, Research, and Advocacy (BDSRA) Foundation

BDSRA is dedicated to funding research for treatments and cures, providing family support services, advancing education, raising awareness, and advocating for legislative action. Founded in 1987, by parents seeking to build a network for those diagnosed with Batten disease, BDSRA is now the largest support and research organization dedicated to Batten disease in North America. BDSRA believes that to effectively unravel the mysteries of Batten disease, the worlds of medical science, research, and families must work together toward a common goal: discover treatments and cures while assuring a better quality of life for those living with the disease.

Batten Family Help Grant

The BDSRA Foundation is committed to supporting families of all CLN types in all aspects of their fight against Batten, including the financial challenges they face. BDSRA understands that families in our community caring for people with Batten disease are often faced with financial challenges that further interfere with their well-being.

We offer grants to help cover the costs associated with battling Batten disease, such as emergency travel, loss of employment, hospital bills, and other challenges our families might face.

31Heroes

On August 6, 2011, a tragedy shook the military community and Americans everywhere. In a single instance, America lost 30 military service members, many of whom were members of the Navy SEAL community—and one military K9– when a CH-47 Chinook helicopter, call sign Extortion 17, was downed in Afghanistan.

Established to honor the 31 Americans killed in action on August 6, 2011, 31Heroes serves to impact the lives of our nation’s heroes and their families, while remembering the fallen, through athletic endeavors and competitive fundraising events.

Our Mission: The mission of 31Heroes is to raise money and awareness through social and athletic events to support the families of Extortion 17 and honor their legacy by funding treatment for Veterans suffering from mental health issues.

Our Focus

Our goal is to create opportunities for the families of Extortion 17 to create healthier lifestyles and to provide financial relief in times of need. We consider it our responsibility to make a positive impact in the lives of each family. Whether through grants we provide, or through partnering with other non-profit organizations that offer programs or services that we do not, we are devoted to the families and creating a legacy the men of Extortion 17 would be proud of.

Guidelines

• Individual limits will not exceed $3750 annually
• Family Grants range from $750 to the maximum range of $1500
• Family members must submit an online application for consideration
• Applications may be submitted at any time during this funding cycle
• Priority and funding will be based on the Primary Next of Kin list

Emergency Grants 

Emergency Grants are aimed at assisting with unforeseen events which cause financial hardship on the family. Limit for this grant is $750.

31Heroes

On August 6, 2011, a tragedy shook the military community and Americans everywhere. In a single instance, America lost 30 military service members, many of whom were members of the Navy SEAL community—and one military K9– when a CH-47 Chinook helicopter, call sign Extortion 17, was downed in Afghanistan.

Established to honor the 31 Americans killed in action on August 6, 2011, 31Heroes serves to impact the lives of our nation’s heroes and their families, while remembering the fallen, through athletic endeavors and competitive fundraising events.

Our Mission: The mission of 31Heroes is to raise money and awareness through social and athletic events to support the families of Extortion 17 and honor their legacy by funding treatment for Veterans suffering from mental health issues.

Our Focus

Our goal is to create opportunities for the families of Extortion 17 to create healthier lifestyles and to provide financial relief in times of need. We consider it our responsibility to make a positive impact in the lives of each family. Whether through grants we provide, or through partnering with other non-profit organizations that offer programs or services that we do not, we are devoted to the families and creating a legacy the men of Extortion 17 would be proud of.

Guidelines

• Individual limits will not exceed $3750 annually
• Family Grants range from $750 to the maximum range of $1500
• Family members must submit an online application for consideration
• Applications may be submitted at any time during this funding cycle
• Priority and funding will be based on the Primary Next of Kin list

Travel Grants

Travel Grants are aimed at assisting with costs of travel for family members to memorials, Arlington National Cemetery, anniversary events, events surrounding the 31. Limit for this grant is $1500.

31Heroes

On August 6, 2011, a tragedy shook the military community and Americans everywhere. In a single instance, America lost 30 military service members, many of whom were members of the Navy SEAL community—and one military K9– when a CH-47 Chinook helicopter, call sign Extortion 17, was downed in Afghanistan.

Established to honor the 31 Americans killed in action on August 6, 2011, 31Heroes serves to impact the lives of our nation’s heroes and their families, while remembering the fallen, through athletic endeavors and competitive fundraising events.

Our Mission: The mission of 31Heroes is to raise money and awareness through social and athletic events to support the families of Extortion 17 and honor their legacy by funding treatment for Veterans suffering from mental health issues.

Our Focus

Our goal is to create opportunities for the families of Extortion 17 to create healthier lifestyles and to provide financial relief in times of need. We consider it our responsibility to make a positive impact in the lives of each family. Whether through grants we provide, or through partnering with other non-profit organizations that offer programs or services that we do not, we are devoted to the families and creating a legacy the men of Extortion 17 would be proud of.

Guidelines

• Individual limits will not exceed $3750 annually
• Family Grants range from $750 to the maximum range of $1500
• Family members must submit an online application for consideration
• Applications may be submitted at any time during this funding cycle
• Priority and funding will be based on the Primary Next of Kin list

Lifestyle Grants

Lifestyle Grants are aimed at improving health and lifestyle via physical fitness, nutrition, holistic treatment, etc. Limit for this grant is $1500

NASA's Solar System Exploration Research Virtual Institute Cooperative Agreement Notice-5 invites multi-institutional proposals aimed at advancing human exploration of the Moon and Mars. This initiative focuses on innovative research to address critical scientific questions and develop technologies for future missions. The program emphasizes community development, training the next generation of scientists and engineers, and fostering partnerships to integrate science with exploration goals.

This project aims to facilitate collaboration between the U.S. Department of Energy's Office of Nuclear Energy and State governments across four regions in the U.S. The focus is on planning for the safe transportation of used nuclear fuel and high-level radioactive waste. By engaging local stakeholders, the project seeks to ensure a transparent and effective transportation program that garners public trust. DOE plans to award four agreements, promoting regional partnerships in this critical area of nuclear waste management.

The FY26 Breast Cancer Research Program's Clinical Research Extension Award aims to enhance breast cancer clinical studies by extending data collection and follow-up. This funding mechanism emphasizes the importance of patient participation and addresses challenges from early trial terminations. Notably, applications must include two breast cancer consumer advocates and can feature either a single Principal Investigator or a duo. This initiative seeks to improve outcomes through comprehensive data analysis and patient engagement.