Best Sioux Falls Grants for Nonprofits in South Dakota

About the ASHFoundation

ASHFoundation supports innovators and sparks innovation in communication sciences. We give early support to promising students, researchers, and clinicians exploring bold ideas to transform the field and improve people's lives.

Frank R. Kleffner Lifetime Clinical Career Award

The Frank R. Kleffner Lifetime Clinical Career Award recognizes an individual’s outstanding contributions to communication sciences and disorders over a period of at least 20 years. The lifetime contribution may have been in clinical service, supervision or administration of clinical service, clinical research, or any other activity that has promoted clinical excellence.

The award is given in honor of Frank R. Kleffner, a former ASHFoundation president and former ASHA president, who worked tirelessly over his lifetime until his passing in 2015 to professionalize and expand the ASHFoundation’s charitable goals.

The awardee receives a commemorative art object with a recognition plaque.

Purpose

This call for proposals (CFP) provides support to health equity research centers at MSIs to strengthen research infrastructure and capacity-building. Capacity-building will help develop staff, skills, culture, resources, and systems that enable research to happen effectively. Specific work that RWJF may fund under this CFP includes specific skill or methodology training; faculty release time; support for research assistants, advisors, and project staffing; mentoring, professional development and collaboration, and more.

Through this CFP, RWJF will expand its efforts to transform deeply rooted beliefs about which data and research methods are valued, whose perspectives are prioritized, and which populations deserve resources. By supporting the infrastructure and capacity-building needs of MSIs, this opportunity strengthens their ability to generate critical evidence and to cultivate transformative, actionable solutions toward health equity. 

RWJF believes in health equity research that is grounded in systems thinking; supports and disseminates evidence identifying and implementing structural solutions to racial and health inequities. This CFP seeks mission-aligned institutions to participate in cohort-style peer learning to advance their ability to engage in health equity research and apply for competitive funding opportunities in the future.

Although no single philanthropy can fill the gap left by federal funding cuts, this CFP demonstrates strong support for research, historically underrepresented researchers, and research centers that are positioned to pave the way toward a future where health is not a privilege, but a right.

Total Awards

• Type of Award: Awards funded under this opportunity will be structured as grants. 
• Number of Awards: Up to eight awards will be funded. 
• Amount of Award: Each award will be up to and including $350,000.
• Award Duration: Awards will be 24 months.  

Disabled Veterans National Foundation

The Disabled Veterans National Foundation (DVNF) was established in 2007 to support veterans facing challenges that traditional systems could not fully address. From its earliest days, DVNF has been focused on closing critical gaps in care and providing resources that help veterans rebuild their lives with dignity and stability.

Guided by this commitment, DVNF developed its Health & Comfort programs, offering emergency financial assistance, housing transition support, food assistance, comfort kits, and wellness initiatives. These programs are designed to meet veterans where they are and to provide practical solutions that restore hope and stability. Today, DVNF continues to grow as a trusted national nonprofit. Every day, our team works with a clear purpose: to change lives for the men and women who have served our country.

Homeless To Housing Program - Financial Assistance

DVNF is dedicated to assisting disabled and at-risk veterans in their transition from homelessness to permanent housing. Recognizing that securing a home is a significant milestone, DVNF understands that true stability is achieved when a house becomes a home, furnished with essential items that provide comfort and functionality. We help cover essential costs related to securing and creating comfortable housing for at-risk veterans.

The H2H Program offers comprehensive support to veterans by providing: Financial Assistance of up to $2,000 to cover essential costs related to securing permanent housing, such as security deposits and initial rent payments.

For Financial Assistance: Payments are processed through two payment cycles each month, around the 15th and 30th. If your payment is delayed beyond the expected date, a Promissory Note of Payment will be issued to the vendor, confirming our organization's responsibility and requesting that no penalties be applied to the applicant.

Better Food Policy Fund 

Since its inception, the Better Food Policy Fund has set its strategic direction in a participatory fashion. We are intentionally building capacity for engagement to ensure the Fund aligns with the needs of food policy council stakeholders.   

Thus far, the Fund has engaged 300+ food policy council stakeholders to help co-develop the Fund. We are immensely grateful for the individuals who helped shape the initial direction of this fund. We view this growing stakeholder audience as the people to whom the Fund’s governing body, the Independent Advisory Committee, is ultimately accountable.

Grantmaking

The Better Food Policy Fund invests in US-based food policy councils, empowering community and government collaboration for progressive food policy. We utilize participatory processes to enhance equity and redistribute power in the funding landscape. We seek to celebrate and uplift the work of food policy councils, and believe every food policy council is worthy of financial support.

We define “food policy councils” as councils, networks, coalitions, or other groups working across boundaries at the tribal, municipal, county, state, or regional level.  

We support actions aimed at ensuring an enabling environment for policy change, such as: 

• increasing levels of inclusive and equitable stakeholder engagement in public processes
• engaging systems thinking when tackling complex food system challenges
• facilitating collaboration with and across local government agencies and departments 
• developing or revising local policies and plans  

We define “better food policy” as practices, procedures, ordinances, laws, etc. of governing institutions which strengthen community-based food systems.

We define “civic collaboration” as people joining together at the intersection of community and government to address public issues.

The Air Force Fiscal Year 2027 Young Investigator Program (YIP) is designed to support early career scientists and engineers who have recently obtained their Ph.D. This initiative aims to promote innovative basic research in science and engineering while enhancing the professional growth of promising investigators. Awards are available to U.S. institutions where the principal investigator is a full-time employee. Eligible candidates must be U.S. citizens, nationals, or permanent residents.

The Impact Aid Discretionary Construction Grant Program (84.041C) offers $19M in funding to Local Educational Agencies (LEAs) to address urgent school facility needs. This initiative supports repairs, renovations, or replacements required to maintain safe educational environments. Grants cover projects that improve accessibility in compliance with the Americans with Disabilities Act (ADA) and ensure that facilities meet health standards. The program aims to enhance learning conditions by responding effectively to emergency situations.

The John Lewis NIMHD Research Endowment Program aims to enhance research infrastructure and training at higher education institutions to address health disparities. Key objectives include improving physical infrastructure, acquiring research equipment, developing technical expertise, expanding academic science programs, and recruiting accomplished researchers. This limited competition invites applications from eligible organizations, with a rigorous peer-review process to ensure only high-quality proposals receive funding.

Wind Creek Hospitality Community Support

Our communities are like family. That’s why Wind Creek is dedicated to giving back and helping others thrive in the places we call home (and beyond). We’re always looking for creative ways to lift up our neighborhoods and make life better for us all.

Sponsorships, Donations and Giveaways

Wind Creek Hospitality Community Relations actively builds partnerships with service organizations, non-profits, educational organizations and more. If you’d like to partner with us, please submit an application at least 90 days before your event or donation is needed.

About Us

Children’s Cancer Research Fund is a national nonprofit dedicated to ending childhood cancer. Our main focus is to support the research of bright scientists across the country whose ideas can make the greatest impact for children fighting cancer. We also fund resources and programs that help kids and families as they navigate the difficult experience of cancer treatment and survivorship.

Since 1981, we’ve contributed over $235 million to research, support programs for children and families, and awareness and education outreach. In 2024, over 81 percent of funds raised went directly to these program services areas.

Children’s Cancer Research Fund (CCRF) is a national nonprofit committed to finding safer, more effective therapies for kids battling cancer. Thanks to donors and partners around the country, we have contributed over $235 million to research, education and awareness, and quality-of-life programs for childhood cancer families. We believe kids deserve safer, less toxic treatments, and we’re committed to funding groundbreaking research and services that enhance healing and care.

In 2026, Children’s Cancer Research Fund will focus our research funding efforts on three main areas:

• Hard-to-Treat Cancers
• Survivorship
• Health Disparities

Accelerating Hope: Clinical Trials for Hard-to-Treat Cancers Award

This funding opportunity is limited to support for clinical trials focused on hard-to-treat cancers, prioritizing Phase 0 – Phase 2 studies. Learn more about eligibility criteria and other key details below.

The Healthy After Cancer Award, offered by the Children's Cancer Research Fund, focuses on enhancing the quality of life for childhood cancer survivors. This funding supports research aimed at addressing the long-term effects of cancer therapy, prioritizing survivorship interventions over new treatment development. With a commitment to improving health outcomes for young survivors, this award underscores the importance of addressing unique challenges faced by this population.

The Development of Fiscal Year 2027 Commercial Vehicle Safety Plans aims to enhance national safety goals by reducing incidents involving commercial motor vehicles. This initiative, funded by the US Department of Transportation's FMCSA, provides crucial financial support to states and territories. Through the Motor Carrier Safety Assistance Program, the focus is on minimizing crashes, injuries, and fatalities associated with commercial vehicle operations, ensuring safer roads for all.

The DARPA PINPOINT program seeks innovative proposals focused on the physics and nonlinear control of inertial measurement units (IMUs) for tactical and unmanned missions. The initiative aims to break the performance plateau of MEMS IMUs by exploring novel sensor architectures like electromagnetically levitated proof masses and non-linear resonators. This program emphasizes co-designing sensor packages with advanced adaptive control systems to manage complex dynamics, encouraging revolutionary advances in science and technology.

The National Foundation for the Centers for Disease Control and Prevention offers funding to support administrative expenses that bolster CDC's mission. This initiative enhances partnerships to address health threats both domestically and globally. Projects funded through this grant align with CDC's strategic goals, focusing on measurable outcomes such as program support and participation from various CDC Centers and Offices. Importantly, this grant only supports non-research activities.

The Domestic Violence Prevention grant aims to enhance access to forensic healthcare services for American Indian and Alaska Native victims of domestic violence and related issues. By fostering multidisciplinary partnerships, this initiative promotes trauma-informed care and improves victim support across IHS Areas. The focus is on developing comprehensive, culturally sensitive services that ensure timely interventions and coordinated responses to vulnerable populations, thereby enhancing overall victim well-being and safety.

The Tribal Epidemiology Centers initiative aims to support currently unserved areas through a new cohort of TEC sites. Funded by the US Dept. of Health & Human Services: Indian Health Service, this program seeks to enhance public health capacity within tribal communities, ensuring access to essential health services and resources. The initiative underscores a commitment to addressing health disparities and promoting wellness among Native populations.

The Public Health Nursing initiative aims to enhance the health and wellness of American Indian and Alaska Native men by implementing a culturally sensitive case management model. Through this program, Public Health Nurses will provide preventive health services, facilitate access to care, and encourage healthy lifestyle choices. By promoting early identification and management of health issues, the initiative strives to improve overall community health outcomes through targeted, collaborative interventions.

The National Urban Indian Health Program aims to enhance behavioral health services for Urban Indian communities by fostering awareness, advocacy, and collaboration across the nation. By providing technical assistance and training to Urban Indian Organizations, the program seeks to improve access to culturally relevant behavioral health care for American Indian and Alaska Native populations residing in urban areas, ultimately leading to better health outcomes and community support.

The NIH Common Fund Data Ecosystem aims to enhance the reusability of biomedical data through collaboration between Common Fund programs and external data resources. This funding opportunity encourages projects that connect various biomedical data ecosystems, including the HEAL Data Ecosystem and the BRAIN Initiative. By fostering partnerships, the initiative seeks to improve the accessibility and interoperability of valuable datasets, ultimately advancing research efforts. Note that clinical trials are excluded from this funding opportunity.

The Domestic Violence Prevention (DVP) grant from the IHS aims to enhance the capacity of Tribes and Urban Indian Organizations to combat domestic and sexual violence. This initiative promotes culturally appropriate, trauma-informed services, focusing on victim advocacy and collaboration across sectors. It addresses critical issues like human trafficking and child maltreatment, ensuring long-term sustainability through evidence-based practices and data sharing, ultimately improving community health and safety for AI/AN populations.

The Urban Indian Health 4-in-1 Program is designed to enhance the health and well-being of urban Native Americans through targeted initiatives in immunization, health promotion, disease prevention, mental health support, and addressing alcohol and substance abuse issues. Funded by the US Dept. of Health & Human Services, this program aims to improve access to essential health services and foster healthier communities among urban Indian populations.

The Youth Regional Treatment Center Aftercare Program aims to support American Indian and Alaska Native youth in maintaining safety, sobriety, and success post-discharge from Youth Regional Treatment Centers. This initiative enhances culturally relevant, community-based aftercare by fostering care coordination, building partnerships, and addressing barriers to improve youth outcomes.

The Urban Indian Health Program - Education & Research collaborates with the US Dept. of Health & Human Services to enhance educational and research opportunities for urban Indian populations. This initiative aims to address health disparities and ensure that urban Indians have access to quality health services and information. By partnering with various urban Indian organizations, the program fosters community engagement and empowers individuals through education and research, ultimately improving health outcomes.

The Suicide Prevention, Intervention, and Postvention program aims to reduce suicide rates among American Indian and Alaska Native populations. By enhancing care coordination and culturally relevant behavioral health services, it targets at-risk youth with early intervention strategies. This initiative emphasizes community engagement and collaboration among families, youth, and partners, fostering a comprehensive approach to prevention and support for those affected by suicide.

The Tribal Self-Governance Planning and Negotiation Cooperative Agreements are designed to assist tribes in planning and preparing to manage healthcare services for their members through the Tribal Self Governance Program. The Indian Health Service will provide three awards under this initiative, aiming to empower tribal organizations in their efforts to enhance healthcare delivery and self-determination.

The Tribal Management Grant program is designed to empower tribes and tribal organizations by enabling them to take over functions and services of the Indian Health Service. Under the Public Law 93-638, this initiative aims to enhance their health management capabilities, fostering self-determination and improved healthcare delivery. The Indian Health Service plans to provide between five and sixteen awards to support this vital development in tribal health management.

The Tribal Self Governance - Planning program provides essential support for tribes to prepare for managing healthcare services for their communities. Through the Cooperative Agreements, the Indian Health Service aims to empower tribal organizations to take charge of their health needs, facilitating a smoother transition to self-governance in healthcare. This initiative reflects a commitment to enhancing tribal autonomy and improving health outcomes, with three awards available to eligible applicants.

Chick-fil-A Impact Accelerator

With the goal of helping organizations sustain their purpose and scale their impact, the Chick-fil-A Impact Accelerator brings together hundreds of nonprofit leaders to learn from influential national thought leaders through a one-day conference and a 12-month cohort program. By providing training, support, and resources – and fostering connections with fellow nonprofit leaders and change makers - Chick-fil-A Impact Accelerator invites nonprofit organizations to greater long-term impact as we serve and contribute to our communities together.

Cohort Program: 12-Month Accelerated Growth Program

Nonprofit Founders and Executive Directors are invited to apply for in-depth training, development, and networking by Plywood People through a grant-funded 12-month cohort program sponsored by Chick-fil-A.

• In-Person Kick-off Training Session
• 3-Day Retreat near Atlanta
• 9 Half-Day Monthly Group Coaching Sessions