Best Sioux Falls Grants for Nonprofits in South Dakota

New England Foundation For The Arts

Our work at NEFA is simple: to cultivate and promote the arts in New England and beyond. Our programs support artists across many forms of expression and many geographies, connecting them with collaborators and communities, fueling creative exchange and public discourse, and strengthening the arts and culture ecosystem.

Each program and project brought to life at NEFA builds a stronger and more dynamic infrastructure for the arts. Through grants, convenings, and online tools, NEFA continues an almost 50 year history of pioneering partnerships and programs supporting the arts.

Public Art Learning Fund

The Public Art Learning Fund aims to strengthen the field of public art in New England by providing professional development support directly to artists.

The Public Art Learning Fund provides grants to support professional development opportunities for New England artists to strengthen their public art practices. Through the Public Art Learning Fund, NEFA intends to foster the continued development of more equitable, inclusive, and vibrant public spaces and public life throughout New England.

Artists may utilize the Public Art Learning Fund to: pursue a specific professional development opportunity to strengthen their own public art practice in New England and beyond. Examples may include but are not limited to attending a conference, workshop, training, or discussion related to building creative or administrative skills related to their public art practice. 

Program Values & Goals

NEFA’s Public Art programs acknowledge the necessity of addressing the intersectionality of spatial justice and racial justice in cultivating a more vibrant and equitable public art ecosystem.  

The Public Art Learning Fund aims to strengthen the public art field in the region by supporting artists in further developing the skills, resources, and connections they need to build a more vibrant and equitable community of practice in the region. Learning in partnership with grantees, NEFA strives to learn how we may be able to better support a more equitable and sustainable public art ecosystem throughout the region. 

Funding Priorities

Public Art Learning Fund equips artists with skills, resources, and connections to strengthen public art practices that contribute to more equitable, inclusive, and vibrant public spaces and public life throughout New England. 

The Public Art Learning Fund gives priority to timely opportunities that are: 

• Specifically expanding an artist’s public art practice. NEFA will look for clarity on desired learnings and application to artist’s public art practice.
• Equitably contributing to more just and inclusive public artmaking in the region. Artists at various stages in their public artmaking practice from urban, suburban, and rural communities across all six states in New England are welcome to apply.

NEFA values diverse cultural and artistic expressions as essential to more equitable and vibrant public spaces and recognizes that some artists may experience barriers to accessing professional development opportunities due to race, gender, disability, sexual orientation, class, age, and geography. The Public Art Learning Fund intends to prioritize equity in funding opportunities.

Rare Diseases Clinical Research Network

The RDCRN was established by Congress under the Rare Diseases Act in 2002. The network is an initiative of the National Institutes of Health (NIH), led by the National Center for Advancing Translational Sciences through is Division of Rare Diseases Research Innovation (formerly the Office of Rare Diseases Research). It is funded by collaborating NIH institutes, centers, and offices.

Now in its fifth funding cycle, RDCRN supports 20 rare disease research groups (consortia) that partner with 127 affiliated patient advocacy groups. In total, 180 diseases are currently being studied at 273 active clinical sites, both in the United States and internationally.

Developmental Synaptopathies Consortium - Request For Pilot Project Applications

The pilot feasibility core of the Developmental Synaptopathies Consortium (DSC) is pleased to announce that it will fund an estimated $100,000 total costs for a pilot project to stimulate additional research through the DSC NIH grant for one/all of the following disorders: Tuberous Sclerosis Complex (TSC), PTEN Hamartoma Syndrome (PHTS), Phelan-McDermid Syndrome (PMS) and SYNGAP 1-related disorders. The funding will be coordinated, dispersed and evaluated for progress through the DSC infrastructure. This project will be a two-year project with half of the funds ($50,000) allocated in each year, starting in October 2026. 

Rare Diseases Clinical Research Network

The RDCRN was established by Congress under the Rare Diseases Act in 2002. The network is an initiative of the National Institutes of Health (NIH), led by the National Center for Advancing Translational Sciences through is Division of Rare Diseases Research Innovation (formerly the Office of Rare Diseases Research). It is funded by collaborating NIH institutes, centers, and offices.

Now in its fifth funding cycle, RDCRN supports 20 rare disease research groups (consortia) that partner with 127 affiliated patient advocacy groups. In total, 180 diseases are currently being studied at 273 active clinical sites, both in the United States and internationally.

Pilot Grant in Pediatric Fungal Disease

Goal

Invites applications for one-year pilot projects that establish feasibility, refine the analytic design, or generate preliminary data to support future studies addressing critical knowledge gaps or improving patient-centered outcomes for pediatric invasive fungal diseases.

Objectives

• Establish feasibility of proposed pediatric IFD studies
• Refine study design or analytic approaches
• Generate preliminary data to strengthen future large-scale research
• Expand and support a diverse investigator community in pediatric IFD research
• Encourage multi-site collaboration and incorporation of patient/caregiver perspectives

Award Description

Awards will provide up to $30,000 (inclusive of direct and indirect costs) for a one-year period. Applicants are encouraged to pursue co-sponsorship with institutional partners, research networks, industry collaborators, or other stakeholders to expand available resources. To receive the award, investigators must submit their full study protocol for approval by the RDCRN. Award recipients will be offered a project management team that meets quarterly to help ensure that progress is consistent with timelines and benchmarks. Funded investigators will also be required to submit quarterly progress reports and an end-of-project report to be reviewed by the Pilot Project Committee.

Rapid Cancer Grants

Fast Funding for Home Cancer Care Research

We fund healthcare researchers to rapidly explore the feasibility of home infusion as a solution to the ongoing challenges of capacity shortage, site of care management, and financial toxicity in cancer care.

Traditional funding pathways for new care models are too slow to impact patients, so we’ve streamlined the process. By providing funding approvals within 14 days, we enable healthcare teams to quickly launch and evaluate home-based cancer care programs that improve access and affordability.  

What can a Rapid Cancer Grant be used for?

Projects must comprise of research investigating the feasibility, safety, or economic benefit of cancer care at home and must include delivering care to patients via an IRB approved study. IRB approval may be obtained after grant approval. Projects may include assessing suitability of home infusion, enabling access to lab draws at home, or remote care co-ordination to reduce time toxicity for patients.

If you’re a healthcare worker at an oncology practice, hospital or academic institution in the United States and are interested in continuing or launching a new home cancer care initiative, we invite you to apply for a Rapid Cancer Grant.

Outstanding Program Award

Recognizing the exceptional programming of AAFP Chapters and Chapter Foundations.

The AAFP Foundation established this award to nationally recognize outstanding philanthropic activities of AAFP Chapters and Chapter Foundations. Each year, one program is selected, and the Award is presented during AAFP FMX at the AAFP Foundation recognition event.

The Outstanding Program Award Recipient will receive up to a $1,000 reimbursement for travel to FMX to accept the award at the AAFP Foundation Donor Recognition dinner.

About Marion Community Foundation

Since 1998, area residents have been turning to Marion Community Foundation to make their philanthropic giving as effective as possible. We are a public charity serving thousands of people who share a common concern … improving the quality of life in Marion County.

Individuals, families, businesses and organizations create permanent charitable funds that help our community meet its needs and challenges. The Foundation invests and administers these funds.

David G. Wilhelm Memorial Scholarship

The David G. Wilhelm Memorial Fund was created in honor of its namesake in 2020. It supports college students pursuing careers in mental and behavioral health services.  

About Marion Community Foundation

Since 1998, area residents have been turning to Marion Community Foundation to make their philanthropic giving as effective as possible. We are a public charity serving thousands of people who share a common concern … improving the quality of life in Marion County.

Individuals, families, businesses and organizations create permanent charitable funds that help our community meet its needs and challenges. The Foundation invests and administers these funds.

Donald S. & Beulah Mae Williams Scholarship

Created by the late Don Williams in 2016, this scholarship fund initially honored his beloved Beulah Mae, devoted farmer, loving housewife, mother, grandmother and great-grandmother. It now memorializes this Prospect farming couple.

The Williams Scholarship supports Marion County students who participated in either FFA or 4-H for three or more years.

About Marion Community Foundation

Since 1998, area residents have been turning to Marion Community Foundation to make their philanthropic giving as effective as possible. We are a public charity serving thousands of people who share a common concern … improving the quality of life in Marion County.

Individuals, families, businesses and organizations create permanent charitable funds that help our community meet its needs and challenges. The Foundation invests and administers these funds.

Douglas & Elaine Waring Memorial Scholarship

The Douglas & Elaine Waring Memorial Scholarship Fund honors engineer Doug Waring and his wife of 49 years, Elaine. 

Created in 2002, the Waring scholarship supports the education of any Marion County high school student who scored in the upper 50th percentile of the ACT, SAT, or other national standardized test.

The USDA Forest Service's Invasive Species Program funding opportunity invites proposals aimed at enhancing invasive species prevention. By leveraging existing research and knowledge, projects can create actionable solutions to protect American agriculture. This initiative seeks to connect scientific insights with practical regulatory improvements, thereby reducing the introduction and establishment of new invasive pests. Previous research, including horizon scanning and monitoring sentinel trees, serves as a foundation for developing effective strategies.

The Innovative Traffic Safety Enforcement (ITSE) Grant Program aims to develop effective traffic safety enforcement initiatives to reduce motor vehicle crashes caused by risky driving behaviors. It encompasses three evaluation phases, with deadlines from September 2026 to September 2027. This program seeks to fund scalable and repeatable projects that align with the Department of Transportation's mission and executive priorities, enhancing safety across the United States.

The Bill Monroe Memorial Scholarship, managed by the Brown County Community Foundation, offers financial support to graduates of Brown County High School pursuing a full-time baccalaureate degree in music or a related field. This scholarship is open to current and previous graduates, including those participating in Bluegrass music mentoring programs. The foundation has a strong focus on education and has facilitated numerous scholarships, enhancing opportunities for local students since its establishment.

The DHQP Global NOFO aims to enhance the CDC's mission against antimicrobial resistance (AR) by integrating non-research implementation with focused research. This initiative addresses urgent global threats posed by various pathogens and healthcare-associated infections (HAIs). By leveraging existing CDC networks, the NOFO seeks to improve detection, surveillance, and infection control measures, ultimately reducing illness and mortality while protecting healthcare workers and patients, especially in low and middle-income countries.

The FY 2027 State and Regional Primary Care Association (PCA) Cooperative Agreements aim to enhance the technical assistance provided to Health Center Program award recipients and look-alikes. This initiative focuses on improving access to preventive and primary health care, managing chronic diseases, and ensuring a capable health center workforce. By implementing value-based care strategies and leveraging data for operational improvements, the program seeks to support the health of vulnerable communities effectively.

The BETA Scholarship Fund, managed by the Brown County Community Foundation, provides financial support to residents of Brown County, Indiana, under the age of 25. This scholarship is designed for individuals pursuing education or certification at vocational, trade, or skills schools. Since its inception, the Foundation has focused on enhancing educational opportunities for local youth, ensuring that financial barriers do not hinder their academic aspirations.

The Brown County Citizens’ Scholarship, managed by the Brown County Community Foundation, supports graduates of Brown County High School and current residents by providing scholarship grants. Since its establishment in 1993, the Foundation has prioritized education and has awarded numerous scholarships, including full-tuition opportunities through The Lilly Endowment Inc. Eligible applicants include high school graduates and GED recipients, with preference given to those in the upper third of their class and single parents seeking further education.

About Marion Community Foundation

Since 1998, area residents have been turning to Marion Community Foundation to make their philanthropic giving as effective as possible. We are a public charity serving thousands of people who share a common concern … improving the quality of life in Marion County.

Individuals, families, businesses and organizations create permanent charitable funds that help our community meet its needs and challenges. The Foundation invests and administers these funds.

Gary W. Troll Memorial Scholarship

The Gary W. Troll Memorial Scholarship Fund, created in 2002, supports higher education for students who reside in the service area of the Northwest Ohio Educational Service Center, where Gary Troll (1947-2002) served as superintendent.

Recipients of the Troll Scholarship may come from any of the high schools in the Northwest Ohio Educational Service Center’s district, including Marion County—Elgin, Pleasant, Ridgedale, and River Valley; Seneca County—Bettsville, Hopewell-Louden, New Riegel, Old Fort, and Seneca East; and, Wyandot County—Carey, Mohawk, and Upper Sandusky. They will be seniors with a GPA of 2.75 or above.

The Brown County Farm Bureau, Inc. Scholarship aims to provide one-year tuition assistance to two residents of Brown County pursuing a four-year academic degree or a multi-year vocational degree at a trade school or community college. Eligible applicants must be graduates of an accredited high school or G.E.D. program and be members of the Brown County Farm Bureau. The scholarship emphasizes community service, GPA, and personal circumstances.

About Marion Community Foundation

Since 1998, area residents have been turning to Marion Community Foundation to make their philanthropic giving as effective as possible. We are a public charity serving thousands of people who share a common concern … improving the quality of life in Marion County.

Individuals, families, businesses and organizations create permanent charitable funds that help our community meet its needs and challenges. The Foundation invests and administers these funds.

Jeannette Turner Memorial Scholarship

Dorothy Ellen Thew, a lifelong member of the Marion community, left, as part of her legacy, a gift to create three scholarship funds at Marion Community Foundation. A noteworthy person in her own right, Dorothy designated that three scholarship funds be created from her estate to honor beloved members of her family. The Jeannette Turner Memorial Scholarship, created in 2010, honors her aunt’s work as a teacher at the former Silver Street Elementary School.

PetSmart Charities

We’re proud to celebrate over 30 years of being the leading funder of animal welfare in communities across North America. Since 1994, we’ve granted over $600 million to change-making organizations that help transform the lives of pets and those who love them.

Our Mission: We make the world a better place for pets by investing in community partners that advocate and care for the well-being of pets and all who love them.

Adoption Growth Grants 

Purpose

Adoption Growth grants drive lifesaving outcomes by supporting successful, sustainable in-store adoption programs, events, and results in partnership with PetSmart stores.

Funding Support

Funding may be used for costs associated with building or enhancing your organization’s adoption program in partnership with PetSmart stores, including:

• Staff positions supporting in-store adoption programs and events.
• Marketing and advertising for in-store adoption programs.
• Volunteer or foster support, incentives, and recruitment related to in-store adoption events.
• Event supplies, including containment and enrichment materials.
• Shelter software and technology needs.
• Vehicle repairs or transportation to adoption events.
• Innovative in-store adoption ideas and pilot programs.
• Other costs directly associated with facilitating PetSmart adoptions and in-store events.

There are two Cohorts under this funding: Cohort 1-  Accelerating in-store adoptions; and Cohort 2: Capacity Building.

Cohort 2: Capacity Building

Applicants must have completed at least one adoption in a PetSmart store within the last 12 months.

Preference will be given to organizations seeking to build a consistent, sustainable in-store adoption program. Applications should include a clear plan, with examples, for sustaining the program over time.

Four Required Steps

Applicants must complete all four required steps below before submitting a grant application:

• Step 1 - Watch the kick-off video and complete the Adoption Accessibility Questionnaire
• Step 2 - Confirm eligibility and connect with your Adoptions Grant Manager: After completing the questionnaire, you will receive an email confirming your eligibility. Eligible partners will be invited to a call with their Adoptions Grant Manager to discuss the grant opportunity, expectations, and potential fit.
• Step 3 - Engage your PetSmart store partners: Discuss your intent to apply, align on goals, and gain their commitment to support the success of your in-store adoption program.
• Step 4-  Submit your application.

About Us

For over three decades, the Hamilton Education Foundation (HEF) has been sparking innovation and expanding horizons within our classrooms. Since 1991, this community-powered non-profit has channeled more than $2.5 million from passionate individuals, local businesses, and forward-thinking organizations directly into the hands of Hamilton’s students and teachers. 

By funding transformative workshops, creative projects, and classroom grants, HEF doesn't just support education—it inspires students to dream bigger, rewards academic excellence, and builds a stronger, more vibrant community.

Our Vision

The vision of the Hamilton Education Foundation is to assist in achieving creative and academic excellence for the 21st Century through funding activities and projects for students and educators in the Hamilton School District.

Our Mission

Our mission, in partnership with the community, is to fund, Enhanced, Extended, and Enriched learning opportunities for students and educators in the Hamilton School District.

Teacher Grants

Educator Enrichment Grant

The Educator Enrichment Grant funds teacher participation in off-campus professional development, including seminars, workshops, conferences, and externships. 

About Us

For over three decades, the Hamilton Education Foundation (HEF) has been sparking innovation and expanding horizons within our classrooms. Since 1991, this community-powered non-profit has channeled more than $2.5 million from passionate individuals, local businesses, and forward-thinking organizations directly into the hands of Hamilton’s students and teachers. 

By funding transformative workshops, creative projects, and classroom grants, HEF doesn't just support education—it inspires students to dream bigger, rewards academic excellence, and builds a stronger, more vibrant community.

Our Vision

The vision of the Hamilton Education Foundation is to assist in achieving creative and academic excellence for the 21st Century through funding activities and projects for students and educators in the Hamilton School District.

Our Mission

Our mission, in partnership with the community, is to fund, Enhanced, Extended, and Enriched learning opportunities for students and educators in the Hamilton School District.

Student Grants

Evaluation Factors

Applications are reviewed based on:

The AACR June L. Biedler Prize for Cancer Journalism

Prize Summary

The AACR June L. Biedler Prize for Cancer Journalism was established by the AACR in 2015 to raise awareness of the critical role that the media play in educating the public about cancer and cancer research.

Funded by a major bequest to the AACR from cancer research pioneer Dr. June L. Biedler, a scientist, mentor, and former member of the AACR Board of Directors, this prize showcases outstanding examples of cancer journalism and recognizes individual professional journalists who have produced accurate, informative, and compelling stories that enhance the public’s understanding of cancer, cancer research, cancer advocacy, or cancer policy.

The prize provides an unrestricted cash award of $5,000 and a commemorative award.

Categories

Each submission may be considered for only one category, as selected by the candidate on the application form.

Applicants may submit in any of the following categories:

Prize Acceptance

Awardees will be able to accept the prize during the AACR Annual Meeting 2027 in Orlando, April 2-7, 2027.

Friends of NRA

Friends of NRA is the National Rifle Association’s premier fundraising program, supporting the future of shooting sports. Since day one, Friends of NRA has been a 100% grassroots effort fueled by a united front to secure the Second Amendment and raise money for the shooting sports.

Committee volunteers are appointed to State Fund Committees to make recommendations for local grant funding in areas such as youth education, women-focused clinics, law enforcement training, hunter safety, range improvement, firearms and marksmanship training and safety. Recognizing the impact American youth has on the future of the shooting sports, State Fund Committees frequently recommend grants for youth programs, allocating the most significant portion of monies to this vital area.

Grant awards fund activities and support programs in the United States to promote firearms and hunting safety, to enhance marksmanship skills of those in the shooting sports, and to educate the public about firearms in their historic, technological and artistic context.

Friends of NRA State Fund Grant Program - South Dakota

The Friends of NRA State Fund Grant Program provides supplies, equipment, and financial support to a variety of qualified groups and programs at the local level; geared towards youth, women, law enforcement, veterans, the disabled, and the general public, including:

• General shooting programs
• Competitive shooting
• Education, training and safety
• Hunting and conservation
• Community outreach
• Historical education

Grant funding must be used to further a charitable purpose as defined by the Internal Revenue Code under section 501(c)(3) and accompanying rules, regulations, and other IRS law and materials.

Edward E. Ford Foundation

The Edward E. Ford Foundation seeks to improve secondary education by supporting U.S. independent schools and encouraging promising practices. 

• We make Traditional Grants to eligible schools and Associations to help them grow and develop in pursuit of their own missions.
• We make Educational Leadership Grants to eligible schools or groups of schools that consist of larger dollar awards to fewer recipients.
• We encourage collaboration with others in both grant cycles.
• Occasionally, we may make larger, multi-­year Collaborative Innovation Grants in support of projects that have the potential to influence secondary education more broadly and positively affect our democratic society.
• Beyond grant-making, we share what we learn, sponsor strategic meetings, and work with others to identify and respond to the most pressing challenges facing the field of secondary education.

Traditional Grant for Associations

These grants are made in response to requests that can range from $25,000 to $100,000 and that must be matched by additional funds raised by the association at least 1:1.

Associations seeking placement on a Traditional Grant Agenda should be prepared to specify the anticipated dollar value of their proposal when they request placement. This can be months in advance of the date the final version of the proposal will be due, depending on the length of the queue. 

Traditional Grants are awarded based on the quality of the proposal and other considerations in terms of the association’s operation, but it does not identify certain areas of independent school work as favored. That is, you can seek guidance as to what sort of proposals have been funded in the past but association should identify their own greatest institutional need that they think the Foundation can help address.

Step-by-Step Process

• Request Agenda Placement — Please fill out the Agenda Placement form to tell the Foundation a bit more about your association and to help us determine if it is eligible for EE Ford funding.

• Agenda Placement Phone Call — If your association is eligible for Agenda Placement, we will schedule a phone call between your association’s Executive Director and the Executive Director of the EE Ford Foundation. This phone call will serve as an informal introduction and it will determine if Agenda placement is right for your association. No proposal can be considered from associations that have not reserved a place on an upcoming Agenda. If your association is placed on an Agenda, you will receive an Agenda Placement Confirmation email with further instruction.

• Executive Director Meeting — Schedule a 2-3 hour meeting between your association’s Executive Director and our foundation’s Executive Director to be held in our Brooklyn office. The Preliminary Materials will be due one week prior to this meeting (see “Preliminary Materials” under "Required Materials"). 

• Final Submission — Deadline for submission of final materials is January 30 for the April Agenda or April 1 for the June Agenda. When the Board makes its decision about a proposal, the Executive Director communicates this decision within days.

The Substance Abuse Prevention, Treatment, and Aftercare program aims to combat substance abuse in American Indian and Alaska Native populations. It focuses on enhancing care coordination, expanding culturally competent behavioral health services, and implementing early intervention strategies for at-risk youth. By supporting Tribal and community-led initiatives, the program fosters collaboration among families, youth, and community partners to create effective prevention, treatment, and recovery solutions.