Best Grants for Charities in South Carolina

South Carolina agricultural producers, forest landowners, Tribes, and water management entities can access funding through USDA Natural Resources Conservation Service to implement conservation practices on working lands. Support covers technical and financial assistance to improve water and air quality, soil health, wildlife habitat, and climate resilience, which may benefit charities partnering with local producers.

Charitable 501(c)(3) organizations in the greater Chicago area can seek McGraw Foundation support for education, human services, conservation, health, and cultural programs, including general operating, projects, or occasional capital needs. Grants from McGraw Foundation may benefit South Carolina charities that partner or operate in this region, with typical awards of US $2,000 - US $10,000.

USDA: Natural Resources Conservation Service of South Carolina provides South Carolina agricultural and forest producers with funding to enhance conservation practices on working lands. Eligible individuals, entities, joint operations, and Tribes can receive more than US $4,000 annually to improve soil, water, wildlife habitat, climate resilience, and overall environmental stewardship across their entire operation.

Charitable 501(c)(3) organizations providing community services in South Carolina can receive up to US $50,000 for programs in areas like education, basic needs, health, environment, arts, and community development. Grants from BECU Foundation help South Carolina charities nominated by BECU members expand their direct impact in Charleston County and other eligible service areas.

Graduate students conducting research in drinking water quality, environmental science, or public health can receive US $3,000 to advance projects with practical benefits for the water industry. Focused on water-related research, the American Water Works Association invites applicants, including those studying at institutions serving South Carolina communities, to pursue timely, actionable solutions.

Registered 501(c)(3) public charities with over $500,000 in private contributed revenue working in South Carolina or North Carolina can seek funding for education, healthcare, human services, and Jewish values programs. With a mission to foster lasting change, Leon Levine Foundation provides multi-focus support to strong, sustainable nonprofits serving Carolinians.

With a mission to support environmental sustainability, American Honda Motor provides South Carolina charities and schools with US $25,000 - US $100,000 for programs in decarbonization, clean energy, and efficient use of natural resources. Eligible 501(c)(3) organizations and public or private schools must serve communities where Honda associates live and work.

South Carolina charities and public entities serving a Weyerhaeuser community can seek grants for housing, education, environmental stewardship, human services, culture, workforce development, and inclusion. Weyerhaeuser Giving Fund supports U.S. and Canadian communities with awards of more than US $1,000, favoring impactful, broadly serving, well-supported local projects.

Charities and nonprofits in South Carolina working on humanitarian aid, child welfare, education, health care, or disaster relief can access funding through The Father's Table Foundation. Grants up to US $750,000 support programs that build self-sufficiency for women and children, including employment assistance, homelessness services, microfinance, food security, and water and sanitation projects.

South Carolina 501(c)(3) charities running education, environmental, health, arts, or community development programs can seek US $1,000 - US $15,000 to support specific projects. With a mission to strengthen communities, Dominion Energy Charitable Foundation provides grants twice yearly to organizations in its South Carolina service areas, primarily for programmatic rather than capital needs.

Undergraduate-focused higher education institutions in South Carolina can seek NIH funding for small-scale biomedical research projects that engage primarily undergraduate students and strengthen their research environment. The U.S. Department of Health and Human Services National Institutes of Health provides up to US $375,000 for institutions awarding baccalaureate science degrees that have limited prior NIH support.

Charitable organizations in South Carolina seeking support for humanitarian, educational, environmental, or arts initiatives can apply for Roche Corporate Donations and Philanthropy. La Roche supports accredited charities with innovative, high-quality projects in areas like human and social services, STEM education, disaster relief, community development, and contemporary arts, managed locally through its affiliate offices.

Early-career health research scientists at low- or middle-income country institutions conducting clinical trials can apply for the Emerging Global Leader Award, which provides approximately US $140,000 for mentored career development. Grants from the National Institutes of Health help South Carolina-based charities collaborating with LMIC investigators or institutions participate in global health research projects.

Early-career research scientists in eligible low- or middle-income countries, including those from South Carolina–based institutions with LMIC appointments, can apply for the Emerging Global Leader Award from the National Institutes of Health. This program offers approximately US $140,000 for three to five years of mentored health-related research and career development aligned with their country’s health priorities.

Focused on education and related community programs, 501(c)(3) charities in South Carolina and other U.S. regions can seek grants of US $5,000 - US $20,000 for scholarships, tutoring, youth initiatives, arts education, and basic needs services. The John Ben Snow Memorial Trust favors new or enhanced programs and short-term support to stabilize funding.

South Carolina charities and related organizations can seek funding for medical congresses, educational events, and similar initiatives that offer Biogen Foundation tangible recognition or marketing benefits. Biogen Foundation provides support to programs focused on neurological and immune-related diseases, with decisions based on topic alignment, event details, and the geographic location of the activity.

Regions Bank provides South Carolina charities with matching gift funding when recent Regions retirees donate to eligible 501(c) or 170(c) organizations. Nonprofits focused on community and economic development, education and workforce readiness, financial wellness, arts and culture, veterans, or individuals with disabilities can receive up to US $1,000 per retiree per year through this program.

Charitable 501(c) or 170(c) organizations in South Carolina can benefit when full-time Regions associates request matching gifts to support eligible programs in economic and community development, education and workforce readiness, financial wellness, arts and culture, veterans, or disability services. Accredited educational institutions may be located anywhere in the U.S. and still receive matches.

South Carolina charities, 501(c)(3) nonprofits, government agencies, and tax-exempt educational or research institutions can seek funding for projects that improve health outcomes and expand care access, especially for economically vulnerable residents. Health-focused organizations may be eligible for Blue Cross Blue Shield of South Carolina Foundation support in areas like oral health, mental health, primary care, and community health initiatives.

Charities and 501(c)(3) organizations in South Carolina working on environmental conservation, sustainable agriculture, healthy food access, or climate justice can seek general operating support through the Clif Family Foundation Open Call. Focused on grassroots, community-based efforts in the U.S., this program offers US $5,000 - US $50,000 grants, reviewed twice annually.

The Data Center Community Grants Program (US-CBF) supports nonprofit organizations that enhance their local communities surrounding Google data centers. Funding is available for projects focused on education, economic opportunity, bridging the digital divide, sustainability, health, and arts. Grants typically range from $5,000 to $50,000, prioritizing measurable community benefits and innovative approaches. Eligible projects must demonstrate long-term impact, while operational expenses are generally ineligible. This initiative aims to empower underserved groups and foster collaboration within local ecosystems.

The William and Helen Thomas Charitable Trust provides funding to nonprofit organizations focused on education, environmental protection, medical research, and support for the underprivileged. This trust, based in Florida, primarily serves communities in Palm Beach, Martin, and St. Lucie Counties, along with select areas in Appalachia. It seeks to assist public charities classified under Section 501(c)(3) of the Internal Revenue Code, ensuring support for impactful charitable initiatives.

The AmeriHealth Caritas Foundation Grant aims to prevent and mitigate adverse childhood experiences (ACEs) to promote healthier outcomes for children. With a focus on empowering families, healing behaviors, and access to healthcare, the foundation supports nonprofit organizations that provide comprehensive care and resources. Grants range from $100,000 to $250,000, totaling up to $1.945 million for project-specific initiatives. Eligible organizations must be 501(c)(3) nonprofits operating in states where AmeriHealth Caritas Medicaid markets exist.

The Soil and Water Stewardship Scholarship, sponsored by the Community Foundation of Northern Illinois, provides financial support to students pursuing careers in natural resources. Applicants must reside in specific Illinois counties and plan to enroll in a full-time program related to fields such as ecology, hydrology, and conservation. Academic performance is a key consideration in the selection process. For more details, contact the Winnebago County Soil & Water Conservation District.

NAFC Open Grant/Product Donation Applications

The National Association of Free and Charitable Clinics (NAFC) is the only nonprofit 501c(3) organization whose mission is solely focused on the issues and needs of the medically underserved throughout the nation and the more than 1,400 Free and Charitable Clinics that serve them. The NAFC has earned the Platinum Seal of Transparency from GuideStar and a 4-Star rating from Charity Navigator. Founded in 2001 and headquartered near Washington, D.C., the NAFC is working to ensure that the medically underserved have access to affordable quality healthcare and strives to be a national voice promoting quality healthcare for all. For more information about the NAFC, including how to become a member, please visit https://www.nafcclinics.org.

NAFC Healthcare Services Expansion Fund

The NAFC Healthcare Services Expansion Fund supports the launch or expansion of clinical programs and new service areas that increase access to care for underserved patients. This funding is designed to help NAFC members introduce new services or grow existing programs that address unmet community health needs and improve access to comprehensive, patient-centered care.

The Spartanburg County Foundation offers Nonprofit Effectiveness Grants of up to $10,000 to enhance the internal capacity of community-based organizations in Spartanburg County. These grants aim to strengthen governance, financial management, and overall organizational effectiveness. Eligible organizations must be recognized 501(c)(3) nonprofits serving Spartanburg residents, demonstrating alignment with the Foundation's mission and measurable impact. The Foundation seeks to promote philanthropy and community engagement, ensuring that funds are utilized to benefit local residents directly.

The Frances P. Bunnelle Foundation offers the Grants for the Common Good in Fall to support organizations in Georgetown County, SC. Grants of up to $15,000 can fund general operations or special projects addressing poverty, basic human needs, economic vitality, and environmental preservation. Eligible entities include IRS-certified 501(c)(3) charities and government bodies, with a limit of one grant per year. Applications must demonstrate impactful use of funds within a nine-month term.