Best Grants for New Nonprofits in South Carolina

The Area Development Grant Program, managed by the Appalachian Regional Commission (ARC), supports economic growth in Appalachia through investments in critical infrastructure and workforce development. Targeting 423 counties across 13 states, the program encourages local communities to collaborate with state governments to identify and implement impactful projects. Key focus areas include enhancing utilities, promoting entrepreneurship, and strengthening local leadership. This initiative aims to uplift the 26 million residents of Appalachia, fostering sustainable economic opportunities.

The Auto Club Group Foundation focuses on creating a positive impact through grants that enhance traffic safety, driver education, and financial literacy across 14 U.S. states and two territories. With a mission rooted in community service, the foundation supports nonprofit organizations and government entities that align with its goals. Grants typically range from $5,000 to $15,000, addressing crucial areas such as traffic safety initiatives, financial literacy for K-12 students, and equitable access to driver education programs.

The Clancy & Theys 1949 Fund, managed by the Triangle Community Foundation, supports nonprofits in Central Florida, North Carolina, Upstate South Carolina, and Virginia. This donor-advised fund prioritizes initiatives in education, workforce development, youth programming, and community well-being, focusing on measurable impacts. The Foundation seeks to strengthen community ties and enhance quality of life by connecting donors with local organizations that address pressing needs. Both established partners and new applicants are encouraged to apply.

South Arts, Inc. offers Professional Development Grants for Arts Organizations to enhance the skills and knowledge of Southern arts entities. These grants aim to support operational stability and growth, focusing on organizations with budgets of $500,000 or less. Eligible applicants include a range of arts organizations within South Arts' nine-state service area. The program emphasizes first-time opportunities and requires a dollar-for-dollar cash match, ensuring a commitment to professional development in the arts.

The Baltimore Life Community Grants Program, established by the Baltimore Life Foundation, awards grants of up to $500 to nonprofit organizations in various states, including Maryland and Virginia. This initiative aims to enhance community quality of life through projects that focus on family safety and community enhancement. Eligible applicants must be IRS-certified 501(c)(3) organizations, with priority given to those with volunteer support. This program reflects Baltimore Life's commitment to corporate citizenship and community involvement.

The Programmatic Support - Education Pillar Award by Honda aims to enhance workforce readiness in the manufacturing sector. It supports nonprofit organizations and schools focused on hands-on programs in design, software/data analytics, and AI/machine learning. Eligible applicants must be US-based and have 501(c)(3) status. The initiative prioritizes projects that train individuals for manufacturing roles, develop technical skills, and introduce automation to prepare for evolving industry demands, ultimately fostering economic prosperity in local communities.

The Environment Pillar Award by Honda supports nonprofit organizations and schools in the U.S. focused on sustainability. Grants aim to reduce environmental impact through programs in decarbonization, clean energy, and efficient resource use. Eligible projects must align with Honda's mission and primarily benefit communities where Honda associates live and work. Organizations can apply for up to two grants, provided they meet specific eligibility criteria, including tax-exempt status under the IRS.

The Honda USA Foundation's Mobility Pillar Award aims to empower individuals with disabilities by funding programs that enhance access and mobility. The foundation supports nonprofit organizations and schools that provide therapeutic, adaptive, and comprehensive care programs, as well as mobility modifications and assistive technology. Applications are accepted from U.S.-based organizations with 501(c)(3) status or fiscal sponsors, ensuring that the joy of mobility is accessible to all.

The American Honda Foundation provides programmatic support to nonprofit organizations and schools in the U.S., empowering impactful initiatives aligned with community needs. Funding opportunities are available through Honda corporate and Honda USA Foundation, focusing on projects that enhance education and community welfare. Eligible organizations must have nonprofit status or be recognized educational institutions. The application process opens each fall, with funding decisions announced the following spring, ensuring alignment with Honda's commitment to social responsibility.

The Corporate Giving Program by the Franklin P. and Arthur W. Perdue Foundation focuses on supporting nonprofit organizations within specific states. They prioritize initiatives that enhance community welfare, especially in agriculture, education, health, and environmental sustainability. Organizations must have 501(c)(3) status to apply, and preference is given to those involving Perdue associates. Ineligible requests include those from religious, political, or individual-focused groups. This program emphasizes broad community benefits over organizational affiliations.

The Philip L. Van Every Foundation provides grants to 501(c)(3) organizations in North and South Carolina, focusing on education, healthcare, human services, and the arts. With a commitment to strengthen communities and support fiscal responsibility, the foundation aims to enhance lives through meaningful projects. Organizations must demonstrate a track record of success to be eligible for funding, which is generally awarded for special projects and capital needs.

The Duke Endowment's Child and Family Well-Being Grant provides implementation support to public and private agencies in North and South Carolina. This funding aims to adopt and sustain evidence-based programs that prevent and treat child maltreatment. Eligible organizations must have two years of audited financial statements and work with accredited groups. The grant prioritizes innovative solutions and advocacy to improve child welfare systems, ensuring effective support for children and families at risk.

The Corporate Giving Program by the Franklin P. and Arthur W. Perdue Foundation supports nonprofit organizations that enhance community welfare. Focus areas include agriculture, education, fighting hunger, and public safety. Eligible applicants must have IRS 501(c)(3) status and a Taxpayer Identification number. Requests are prioritized for programs directly benefiting communities near Perdue facilities across various states. The foundation emphasizes responsible stewardship and community engagement in all funding decisions.

The BlueCross BlueShield of South Carolina Foundation's Health Priority Grants support initiatives that enhance health access and outcomes for South Carolinians, especially the economically disadvantaged. Established in 2003, the Foundation aims to bridge health and healthcare gaps through innovative partnerships. Eligible applicants include nonprofits with 501(c)(3) status and government agencies. The Foundation prioritizes projects addressing oral health and mental health, among other systemic health issues, to create sustainable, data-driven solutions.

The Resilient and Connected Appalachians Grant Program, offered by The Nature Conservancy, provides up to $100,000 for projects that acquire land and easements throughout the Appalachian region. This program emphasizes equitable conservation, aiming to support historically marginalized communities and enhance access to nature while addressing climate change impacts. Projects must demonstrate community engagement and align with the program's goals to protect vital habitats and foster resilience in the face of environmental challenges.

Midlands Gives, initiated by the Central Carolina Community Foundation, unites the Midlands community to support local nonprofits across 11 counties. Established in 2014, this campaign not only raises awareness but also amplifies donations through an 18-hour online giving challenge held every May. Since its inception, it has successfully raised over $9.3 million, providing nonprofits with a vital platform for outreach and donor engagement, helping them thrive and enhance community welfare.

Grants

Through our grantmaking, we support nonprofits that serve South Carolina at local, regional and state levels to address root causes of poverty while honoring the dignity of every South Carolinian.

Starting in 2026, our grants focus primarily on systems change in the areas of

• economic mobility,
• housing security and
• health care (with health care systems change grants by invitation only).

By focusing our efforts and going deeper on these three issues, we aim to have an even greater impact on the nonprofits and communities we serve.

Systems Change Grants

Systems Change Grants fund organizations and coalitions that are working to change the policies, power structures and mindsets that cause and reinforce poverty in South Carolina. These grants specifically fund systems change that supports economic mobility and housing security.

Through these grants, we aim to generate a larger impact through more intentional funding, highly focused work and alignment across our Foundation’s activities.

What Systems Change Grants Support

• Organizations that are actively working on systems change that impacts people experiencing poverty and addresses economic mobility or housing security. To see how the Foundation defines these terms, visit our Strategic Plan webpage.
• Organizations that are seeking to change systems at the local, regional or state level. Systems Change Grants provide up to $75,000 annually for local or regional work.
  • State-level grants have a $100,000 maximum each year. 
• Organizations addressing systems change in at least one of the following ways:
  • Participating in advocacy and lobbying
    • Focus on changing policies, practices, processes, rules or laws
    • Impacting resource flows (i.e., reallocated and/or new funding streams)
    • Holding systems accountable to their intended purpose through the above as well as through litigation
  • Addressing unequal power
    • Focus on changing the distribution and dynamics of privilege, relationships and tradition
    • Organizing and building connections and coalitions that center community voices and perspectives
    • Civic engagement
  • Affirming the dignity of people experiencing poverty
    • Focus on changing the narrative around poverty
    • Focus on changing attitudes, mindsets, values, belief systems, norms, mental models and paradigms
  • Implementing big impact, scalable, or innovative solutions
    • Focus on changing results, especially for groups experiencing inequitable outcomes as a result of historic and current marginalization

All grants are for one year, with the possibility of renewal up to three years based on meeting reporting requirements and the availability of funding.

The Professional Development and Artistic Planning Grants, offered by South Arts, support the professional growth of presenters, programmers, and curators in the Southern U.S. These grants facilitate travel to conferences, workshops, and other opportunities to enhance organizational capacity and program design. Emphasizing diversity and inclusion, South Arts encourages applications from organizations led by BIPOC, LGBTQIA+, and disabled individuals. Funding covers travel, training, and related expenses, promoting equitable access to professional development.

The Hubert E. Sapp Regular Grant Cycle, by Southern Partners Fund, aims to empower rural communities in the Southeastern U.S. through grassroots leadership and organizing. The fund provides support to nonprofit organizations focused on social, economic, and environmental justice. Eligible applicants are community-based organizations with budgets under $350,000. The initiative honors Hubert E. Sapp's legacy, promoting equitable relationships that drive real transformation and community decision-making.

The AmeriHealth Caritas Foundation Grant aims to prevent and mitigate adverse childhood experiences (ACEs) to promote healthier outcomes for children. With a focus on empowering families, healing behaviors, and access to healthcare, the foundation supports nonprofit organizations that provide comprehensive care and resources. Grants range from $100,000 to $250,000, totaling up to $1.945 million for project-specific initiatives. Eligible organizations must be 501(c)(3) nonprofits operating in states where AmeriHealth Caritas Medicaid markets exist.

Enterprise Community Partners

Enterprise Community Partners is a national nonprofit that exists to make a good home possible for the millions of families without one. Home is where life happens, where plans are made, and futures begin. It is the foundation for dignity, health, education, wealth, and community. Yet rents keep going up, paychecks don’t keep pace, and good homes in strong neighborhoods are increasingly out of reach.

The system doesn’t work. It must be changed, and it must be changed by us.

Enterprise has the breadth, scale, and expertise to do it. We support community development organizations on the ground. We aggregate and invest billions to improve housing and strengthen communities across the U.S. We advance housing policy at every level of government. We build and manage communities ourselves. Everything we do is informed by the residents we serve.

Together with our partners, we focus on the greatest need — the massive shortage of affordable rental homes — to achieve three goals:

• Increase the supply of affordable homes
• Advance racial equity after decades of systematic racism in housing
• Support residents and strengthen communities to be resilient to the unpredictable, and make upward mobility possible

Since 1982, we have invested $92.0 billion and created 1.1 million homes across all 50 states, the District of Columbia, Puerto Rico, and the U.S. Virgin Islands. We do all this to make home and community places of pride, power, and belonging.

National Housing Innovation Grant Competition

Home is foundational. It’s where we plant roots, raise and care for our families, and build community bonds. Yet in every corner of the country, millions of people of all ages and backgrounds need a home they can afford.

Wells Fargo is meeting this moment with a powerful grant opportunity. Together with Enterprise, Wells Fargo has launched the third iteration of the Housing Affordability Breakthrough Challenge. The 2026 cycle of the housing innovation competition will identify and propel proven, ready-to-scale solutions that transform current practices and increase housing choice and access.

Eligible applicants will compete for five individual grants of $2 million to advance their innovation and drive meaningful, systems-level change in the housing and adjacent industries. Winners will gain access to mentorship and coaching from industry leaders and experts and join a powerful network of Breakthrough Challenge innovators.

Focus Areas

This third cycle of the Housing Affordability Breakthrough Challenge aims to meet the nation’s affordable housing challenges across all types of communities: Native, rural, suburban, tribal, and urban.

Proposals must encompass one or more of three focus areas:

• Design and Construction
• Finance
• Service Delivery and Programs

Applicants will be asked to show how their proof of concept or pilot program has achieved clear outcomes and success, and provide a clear pathway to expanding the innovation’s reach and impact

Round 1: Criteria and Scoring

Your innovation must meet the criteria below to advance to the official scoring stage.

Type of Community

Innovations can serve all types of communities:

• Rural
• Urban
• Suburban
• Tribal

Location

Priority scoring will be given to applications from entities that are based in – or whose innovations are designed for – one or more of these 28 states, plus D.C.:

• Alaska, Arizona, Arkansas, California, Colorado, Florida, Georgia, Idaho, Illinois, Iowa, Maryland, Massachusetts, Minnesota, Montana, Nevada, New Jersey, New Mexico, New York, North Carolina, North Dakota, Pennsylvania, South Carolina, South Dakota, Tennessee, Texas, Utah, Virginia, Washington, Washington D.C.

Affordability

Innovations must serve residents at these income levels:

• Rental: 80% AMI or below
• Homeownership: 120% AMI or below
• Workforce housing: 120% AMI or below

The Beaufort Fund, established by the Coastal Community Foundation in 1998, supports nonprofits in Beaufort, Colleton, Hampton, and Jasper counties. With over $11 million distributed, it offers three grant categories: Genesis Grants for strategic growth, Operational Grants for established nonprofits, and First-Time Grants for new applicants. Each category allows organizations to request specific funding amounts based on their needs, fostering community engagement and support.

The Rural Business Development Grants in South Carolina aim to provide technical assistance and training for small rural businesses, defined as those with fewer than 50 workers and less than $1 million in revenue. While there is no maximum grant amount, smaller requests are prioritized. Grant funds can be used for various projects, including training, land acquisition, pollution control, and community development, benefiting rural areas and enhancing economic growth.

The Yawkey Foundation offers Program and Small Capital Grants to nonprofit organizations making meaningful impacts in Health Care, Education, Human Services, Youth and Amateur Athletics, Arts and Culture, and Conservation and Wildlife. Grants can be up to $100,000 and support projects aligned with the nonprofit’s mission. Organizations are encouraged to submit Initial Proposals during designated periods, demonstrating strong leadership and community impact, particularly in underserved regions of Eastern Massachusetts.

South Arts Inc

Headquartered in Atlanta, Georgia, South Arts is a nonprofit regional arts organization empowering artists, organizations, and communities, and increasing access to arts and culture.

In partnership with the National Endowment for the Arts and the State Arts Agencies of Alabama, Florida, Georgia, Kentucky, Louisiana, Mississippi, North Carolina, South Carolina, and Tennessee — with additional funding from other public and private donors such as the Doris Duke Foundation, the Ford Foundation, and Mellon Foundation — South Arts supports artists and organizations through a rich and responsive portfolio of grants, fellowships, and programs. Why? Because South Arts believes that the arts elevate the region, increasing connectedness and inspiring meaningful change in the process.

Our mission: Advancing Southern vitality through the arts.

Arts in Community Grants

Program Description

Arts in Community Grants are designed to support deeper engagements between Southern communities and artists. Through these grants supported by the National Endowment for the Arts, we aim to increase access to the arts, expand audiences for artists, and broaden our reach. Eligible projects require a Southern artist/company visiting another Southern state for public activities, offering access to arts programming by professional artists. Funding supports Southern film directors, traditional artists, visual artists, performing artists, or writers:

• film (documentary, fiction, experimental, and animation),
• traditional arts (music, dance, storytelling, and visual arts/crafts),
• visual arts (crafts, drawing, experimental, painting, photography, sculpture, and mixed media),
• performing arts (theater, music, opera, musical theater, and dance), and
• literary arts (fiction, creative nonfiction, and poetry).

Projects require an artist or artist ensemble and a host or partner organization. Project must include at least two in-person or live, virtual public activities – both a public presentation (a film screening, performance, reading, or exhibition) and an educational/community engagement activity (a workshop, demonstration, lecture, facilitated discussion, or master class). The grant requires a dollar-for-dollar cash match.

Yawkey Foundation

The story of Tom and Jean Yawkey and their impact on the lives of children and families goes back over eight decades to the commitments they made to the people of Massachusetts, New England, and Georgetown County, South Carolina. The Yawkeys’ love for these communities, and their quiet sense of responsibility for those in need, is captured in the careful steps they took to ensure that their legacy would live on through the work of the Yawkey Foundation. The Yawkeys were perhaps best known for their longtime ownership of the Boston Red Sox. More quietly, but with just as much passion and commitment, Tom and Jean Yawkey were also engaged in an unwavering dedication to those most in need.

Today, the Yawkey Foundation remains as committed as ever to continuing to honor Tom and Jean Yawkey and their commitment to those in need. Having awarded more than $620 million to-date in charitable grants to organizations focused on Health Care, Education, Human Services, Youth and Amateur Athletics, Arts and Culture, and Conservation and Wildlife, the Yawkey Foundation is committed to preserving and sustaining the charitable values of the Yawkeys by investing in impactful nonprofits providing resources, opportunity, and dignity to the vulnerable and underserved.

Program and Small Capital Grants

Program and Small Capital Grants support high-impact, strategic, and responsive nonprofit organizations in delivering their core missions through discrete and timebound projects. Program & Small Capital Grants help address an immediate need that is critical to the organization’s work.

Program and Small Capital Grants may fund a discrete timebound program need, one small project, or a piece of equipment aligned with a nonprofit’s purpose. These grants are extremely competitive, and the Yawkey Foundation will receive many more compelling Initial Proposals than it will be able to fund. Initial Proposals should demonstrate an awareness of and alignment with the Yawkey Foundation’s mission and Areas of Giving. Additionally, the most competitive Initial Proposals will reflect a nonprofit’s strong leadership and proven impact in providing direct services and programs for unmet needs in underserved regions aligned with the Yawkey Foundation’s geographic priority areas, including Gateway Cities in Eastern Massachusetts.

Nonprofits may submit only one Initial Proposal to the Yawkey Foundation during a calendar year, irrespective of the Type of Grant. Organizations that have not been previously funded by the Foundation in recent years are encouraged to submit Initial Proposals for Program & Small Capital Grants to familiarize the Foundation with its work before submitting an Initial Proposal for Strategic Investment or Transformational Capital.

Areas of Giving: Human Services; Youth & Amateur Athletics; Education; Conservation & Wildlife; Arts & Culture; and Health Care.

Arts & Culture Support

When he purchased the Red Sox in 1933, Tom Yawkey also bought one of Boston’s greatest attractions: Fenway Park. The Yawkeys worked hard to ensure its preservation and today it remains Major League Baseball’s oldest and most beloved ballpark, a testament to the couple’s appreciation of cultural institutions. Much of the Yawkeys’ early philanthropy in arts and culture revolved around the National Baseball Hall of Fame and Museum, an organization to which Tom and Jean lent early support and where they both served on the Board of Directors. The spirit of baseball history and civic pride is also reflected in the Foundation’s support of the 1967 Impossible Dream exhibit, which commemorates the remarkable Red Sox season that re-energized Boston and united generations of fans.

Their legacy in arts and culture has come to life in recent decades through support to the Boston Children’s Museum, the Museum of Science, and the New England Aquarium. The Yawkey Foundation continues to support cultural institutions and community organizations that enrich the lives of children and families by inspiring curiosity, creativity, and a lifelong sense of wonder and appreciation for the world around them.

Yawkey Foundation

The story of Tom and Jean Yawkey and their impact on the lives of children and families goes back over eight decades to the commitments they made to the people of Massachusetts, New England, and Georgetown County, South Carolina. The Yawkeys’ love for these communities, and their quiet sense of responsibility for those in need, is captured in the careful steps they took to ensure that their legacy would live on through the work of the Yawkey Foundation. The Yawkeys were perhaps best known for their longtime ownership of the Boston Red Sox. More quietly, but with just as much passion and commitment, Tom and Jean Yawkey were also engaged in an unwavering dedication to those most in need.

Today, the Yawkey Foundation remains as committed as ever to continuing to honor Tom and Jean Yawkey and their commitment to those in need. Having awarded more than $620 million to-date in charitable grants to organizations focused on Health Care, Education, Human Services, Youth and Amateur Athletics, Arts and Culture, and Conservation and Wildlife, the Yawkey Foundation is committed to preserving and sustaining the charitable values of the Yawkeys by investing in impactful nonprofits providing resources, opportunity, and dignity to the vulnerable and underserved. The Yawkey Foundation is committed to providing support for program and small capital needs connected to a nonprofit’s established mission and proven program/service delivery connected to the mission.

Program and Small Capital Grants

Program and Small Capital Grants support high-impact, strategic, and responsive nonprofit organizations in delivering their core missions through discrete and timebound projects. Program & Small Capital Grants help address an immediate need that is critical to the organization’s work.

Program and Small Capital Grants may fund a discrete timebound program need, one small project, or a piece of equipment aligned with a nonprofit’s purpose. These grants are extremely competitive, and the Yawkey Foundation will receive many more compelling Initial Proposals than it will be able to fund. Initial Proposals should demonstrate an awareness of and alignment with the Yawkey Foundation’s mission and Areas of Giving. Additionally, the most competitive Initial Proposals will reflect a nonprofit’s strong leadership and proven impact in providing direct services and programs for unmet needs in underserved regions aligned with the Yawkey Foundation’s geographic priority areas, including Gateway Cities in Eastern Massachusetts.

Nonprofits may submit only one Initial Proposal to the Yawkey Foundation during a calendar year, irrespective of the Type of Grant. Organizations that have not been previously funded by the Foundation in recent years are encouraged to submit Initial Proposals for Program & Small Capital Grants to familiarize the Foundation with its work before submitting an Initial Proposal for Strategic Investment or Transformational Capital.

Areas of Giving: Human Services; Youth & Amateur Athletics; Education; Conservation & Wildlife; Arts & Culture; and Health Care.

Health Care Support

Access to high quality health care, particularly for those disadvantaged members of the community, was an issue of great importance to Tom and Jean Yawkey. Tom Yawkey was instrumental in the founding of Georgetown Memorial Hospital, which brought much-needed health care to the rural area of Georgetown, South Carolina. In addition, the Yawkeys first lent their extraordinary support to Dr. Sidney Farber by initiating the Red Sox relationship with Dr. Farber, and laid the groundwork for establishment of The Jimmy Fund in 1953. That relationship lasted throughout both of their lifetimes and continues to this day.

The Yawkey Foundation continues to support medical institutions, including transformational construction and renovation projects to help leading medical institutions expand their footprints and ability to provide expert medical care. Understanding the real link between medical needs and behavioral health needs, particularly in children, the Foundation has also played a leading role in supporting organizations providing access to behavioral and mental health treatment programs.