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Search Through Grants for New Nonprofits in South Carolina

The Area Development Grant Program, managed by the Appalachian Regional Commission (ARC), supports economic growth in Appalachia through investments in critical infrastructure and workforce development. Targeting 423 counties across 13 states, the program encourages local communities to collaborate with state governments to identify and implement impactful projects. Key focus areas include enhancing utilities, promoting entrepreneurship, and strengthening local leadership. This initiative aims to uplift the 26 million residents of Appalachia, fostering sustainable economic opportunities.

The Auto Club Group Foundation focuses on creating a positive impact through grants that enhance traffic safety, driver education, and financial literacy across 14 U.S. states and two territories. With a mission rooted in community service, the foundation supports nonprofit organizations and government entities that align with its goals. Grants typically range from $5,000 to $15,000, addressing crucial areas such as traffic safety initiatives, financial literacy for K-12 students, and equitable access to driver education programs.

CSX Charitable Investments provide essential in-kind donations to nonprofit organizations focused on supporting military members and community first responders. Through intermodal transportation services, CSX offers equipment and rail services to help reduce transportation costs for eligible organizations. The program also includes occasional donations of railroad materials and equipment based on availability. CSX prioritizes support for organizations operating within its service areas, promoting community betterment and development.

Grants

Through our grantmaking, we support nonprofits that serve South Carolina at local, regional and state levels to address root causes of poverty while honoring the dignity of every South Carolinian.

Starting in 2026, our grants focus primarily on systems change in the areas of

• economic mobility,
• housing security and
• health care (with health care systems change grants by invitation only).

By focusing our efforts and going deeper on these three issues, we aim to have an even greater impact on the nonprofits and communities we serve.

Systems Change Grants

Systems Change Grants fund organizations and coalitions that are working to change the policies, power structures and mindsets that cause and reinforce poverty in South Carolina. These grants specifically fund systems change that supports economic mobility and housing security.

Through these grants, we aim to generate a larger impact through more intentional funding, highly focused work and alignment across our Foundation’s activities.

What Systems Change Grants Support

• Organizations that are actively working on systems change that impacts people experiencing poverty and addresses economic mobility or housing security. To see how the Foundation defines these terms, visit our Strategic Plan webpage.
• Organizations that are seeking to change systems at the local, regional or state level. Systems Change Grants provide up to $75,000 annually for local or regional work.
  • State-level grants have a $100,000 maximum each year. 
• Organizations addressing systems change in at least one of the following ways:
  • Participating in advocacy and lobbying
    • Focus on changing policies, practices, processes, rules or laws
    • Impacting resource flows (i.e., reallocated and/or new funding streams)
    • Holding systems accountable to their intended purpose through the above as well as through litigation
  • Addressing unequal power
    • Focus on changing the distribution and dynamics of privilege, relationships and tradition
    • Organizing and building connections and coalitions that center community voices and perspectives
    • Civic engagement
  • Affirming the dignity of people experiencing poverty
    • Focus on changing the narrative around poverty
    • Focus on changing attitudes, mindsets, values, belief systems, norms, mental models and paradigms
  • Implementing big impact, scalable, or innovative solutions
    • Focus on changing results, especially for groups experiencing inequitable outcomes as a result of historic and current marginalization

All grants are for one year, with the possibility of renewal up to three years based on meeting reporting requirements and the availability of funding.

The Corporate Giving Program by the Franklin P. and Arthur W. Perdue Foundation supports nonprofit organizations that enhance community welfare. Focus areas include agriculture, education, fighting hunger, and public safety. Eligible applicants must have IRS 501(c)(3) status and a Taxpayer Identification number. Requests are prioritized for programs directly benefiting communities near Perdue facilities across various states. The foundation emphasizes responsible stewardship and community engagement in all funding decisions.

The Corporate Giving Program by the Franklin P. and Arthur W. Perdue Foundation focuses on supporting nonprofit organizations within specific states. They prioritize initiatives that enhance community welfare, especially in agriculture, education, health, and environmental sustainability. Organizations must have 501(c)(3) status to apply, and preference is given to those involving Perdue associates. Ineligible requests include those from religious, political, or individual-focused groups. This program emphasizes broad community benefits over organizational affiliations.

The Professional Development and Artistic Planning Grants, offered by South Arts, support the professional growth of presenters, programmers, and curators in the Southern U.S. These grants facilitate travel to conferences, workshops, and other opportunities to enhance organizational capacity and program design. Emphasizing diversity and inclusion, South Arts encourages applications from organizations led by BIPOC, LGBTQIA+, and disabled individuals. Funding covers travel, training, and related expenses, promoting equitable access to professional development.

The SCAC Term Arts Education Project Grants support quality arts education for preschool and K-12 students during the 2025-2026 academic year. The grants aim to enhance access to arts education, integrate arts with school curricula, and address South Carolina’s educational standards. Eligible applicants include colleges, local governments, and nonprofit organizations. Priority is given to projects serving underserved communities and addressing learning loss caused by COVID-19, ensuring a broad impact on students' educational development.

The Philip L. Van Every Foundation provides grants to 501(c)(3) organizations in North and South Carolina, focusing on education, healthcare, human services, and the arts. With a commitment to strengthen communities and support fiscal responsibility, the foundation aims to enhance lives through meaningful projects. Organizations must demonstrate a track record of success to be eligible for funding, which is generally awarded for special projects and capital needs.

The Building EPSCoR-State/National Laboratory Partnerships program by the DOE aims to foster innovative energy research collaborations between EPSCoR jurisdictions and DOE National Laboratories. This initiative encourages participation from undergraduate and graduate students, as well as postdoctoral fellows, while emphasizing the utilization of DOE user facilities. Eligible applicants include early career faculty from designated states, promoting competitive research and advancing scientific understanding in the energy sector.

The Beaufort Fund, established by the Coastal Community Foundation in 1998, supports nonprofits in Beaufort, Colleton, Hampton, and Jasper counties. With over $11 million distributed, it offers three grant categories: Genesis Grants for strategic growth, Operational Grants for established nonprofits, and First-Time Grants for new applicants. Each category allows organizations to request specific funding amounts based on their needs, fostering community engagement and support.

The Duke Endowment's Child and Family Well-Being Grant provides implementation support to public and private agencies in North and South Carolina. This funding aims to adopt and sustain evidence-based programs that prevent and treat child maltreatment. Eligible organizations must have two years of audited financial statements and work with accredited groups. The grant prioritizes innovative solutions and advocacy to improve child welfare systems, ensuring effective support for children and families at risk.

The CCME Grant Program, administered by the Constellation Quality Health Foundation, aims to enhance health care access and quality in the Carolinas. With grants ranging from $5,000 to $50,000, the program prioritizes nonprofit organizations that focus on measurable health outcomes, especially for underserved populations. Projects funded may include educational initiatives, clinical programs, and services that demonstrate significant improvements in health care delivery. Eligible applicants must have 501(c)(3) status and operate within North and South Carolina.

The Sundt Foundation, established in 1999, supports local communities by offering grants and volunteer opportunities for 501(c)(3) nonprofit organizations. Focused on youth development, hunger and nutrition, and veteran services, the Foundation prioritizes projects in regions such as the Southwest and Southeast United States. However, they do not fund requests exceeding $25,000 or support multi-year pledges, fundraising events, or political causes. Their mission continues to foster community connections and belonging.

The AmeriHealth Caritas Foundation Grant aims to prevent and mitigate adverse childhood experiences (ACEs) to promote healthier outcomes for children. With a focus on empowering families, healing behaviors, and access to healthcare, the foundation supports nonprofit organizations that provide comprehensive care and resources. Grants range from $100,000 to $250,000, totaling up to $1.945 million for project-specific initiatives. Eligible organizations must be 501(c)(3) nonprofits operating in states where AmeriHealth Caritas Medicaid markets exist.

The Community Foundation for the CSRA offers funding to support charitable organizations in Georgia and South Carolina. With a focus on arts, education, health, and services for people in need, the foundation encourages innovative proposals. Grants may reach up to $15,000, supporting impactful community initiatives. Organizations must demonstrate long-term benefits and meet specific eligibility criteria, ensuring funds are used effectively to enhance community welfare and quality of life for residents.

South Arts, Inc. is offering Accessibility Grants of up to $2,500 to nonprofit organizations in the Southeast to enhance accessibility in arts programs for individuals with disabilities. The grants aim to foster inclusivity by supporting projects that engage disabled artists and audiences. Organizations must be located within the South Arts Service region and focus on the arts. Priority will be given to new applicants and those serving BIPOC and LGBTQIA+ communities, with a commitment to rural areas.

The Baltimore Life Community Grants Program, established by the Baltimore Life Foundation, awards grants of up to $500 to nonprofit organizations in various states, including Maryland and Virginia. This initiative aims to enhance community quality of life through projects that focus on family safety and community enhancement. Eligible applicants must be IRS-certified 501(c)(3) organizations, with priority given to those with volunteer support. This program reflects Baltimore Life's commitment to corporate citizenship and community involvement.

The American Honda Foundation provides programmatic support to nonprofit organizations and schools in the U.S., empowering impactful initiatives aligned with community needs. Funding opportunities are available through Honda corporate and Honda USA Foundation, focusing on projects that enhance education and community welfare. Eligible organizations must have nonprofit status or be recognized educational institutions. The application process opens each fall, with funding decisions announced the following spring, ensuring alignment with Honda's commitment to social responsibility.

The Programmatic Support - Education Pillar Award by Honda aims to enhance workforce readiness in the manufacturing sector. It supports nonprofit organizations and schools focused on hands-on programs in design, software/data analytics, and AI/machine learning. Eligible applicants must be US-based and have 501(c)(3) status. The initiative prioritizes projects that train individuals for manufacturing roles, develop technical skills, and introduce automation to prepare for evolving industry demands, ultimately fostering economic prosperity in local communities.

The Environment Pillar Award by Honda supports nonprofit organizations and schools in the U.S. focused on sustainability. Grants aim to reduce environmental impact through programs in decarbonization, clean energy, and efficient resource use. Eligible projects must align with Honda's mission and primarily benefit communities where Honda associates live and work. Organizations can apply for up to two grants, provided they meet specific eligibility criteria, including tax-exempt status under the IRS.

The Honda USA Foundation's Mobility Pillar Award aims to empower individuals with disabilities by funding programs that enhance access and mobility. The foundation supports nonprofit organizations and schools that provide therapeutic, adaptive, and comprehensive care programs, as well as mobility modifications and assistive technology. Applications are accepted from U.S.-based organizations with 501(c)(3) status or fiscal sponsors, ensuring that the joy of mobility is accessible to all.

South Arts, Inc. offers Literary Arts Grants to support Southern independent publishers and small presses with funding up to $5,000. These grants aim to amplify contemporary literary arts and foster community engagement through projects like reading series and festivals. Eligible applicants must be based in the South Arts Region and demonstrate a commitment to advancing literary traditions. This initiative enhances access to the arts and promotes cultural vitality across the Southern states.

The Northern Lowcountry Grants: Lowcountry Unity Fund, established by the Coastal Community Foundation, aims to address systemic racism and economic inequality in Charleston, Berkeley, and Dorchester counties. Following the tragic 2015 attack on Emanuel A.M.E. Church, the fund provides mini-grants up to $5,000 to nonprofits promoting collaborative solutions. Eligible organizations must be 501(c)(3) public charities and focus on partnerships that strengthen community resilience against discrimination.

Midlands Gives, initiated by the Central Carolina Community Foundation, unites the Midlands community to support local nonprofits across 11 counties. Established in 2014, this campaign not only raises awareness but also amplifies donations through an 18-hour online giving challenge held every May. Since its inception, it has successfully raised over $9.3 million, providing nonprofits with a vital platform for outreach and donor engagement, helping them thrive and enhance community welfare.

The Art of Community: Rural SC Grants, offered by the South Carolina Arts Commission, aims to enhance community access to the arts in rural areas. By supporting arts-based projects, this grant encourages public engagement and collaboration among local residents. Eligible applicants include nonprofit organizations, colleges, and government entities. Priority is given to projects that develop artistic skills and foster creativity, addressing specific challenges faced by rural communities in South Carolina.

The Hubert E. Sapp Regular Grant Cycle, by Southern Partners Fund, aims to empower rural communities in the Southeastern U.S. through grassroots leadership and organizing. The fund provides support to nonprofit organizations focused on social, economic, and environmental justice. Eligible applicants are community-based organizations with budgets under $350,000. The initiative honors Hubert E. Sapp's legacy, promoting equitable relationships that drive real transformation and community decision-making.