Best Health and Wellness Grants for Nonprofits in South Carolina

The Global Impact Cash Grants by Cisco Systems Foundation support innovative early-stage solutions aimed at addressing significant social problems. Targeting nonprofit and nongovernmental organizations, these grants focus on four key sectors: crisis response, education, economic empowerment, and climate regeneration. Eligible organizations must demonstrate alignment with these areas, particularly serving underserved communities. The foundation seeks to leverage technology for impactful solutions, ensuring sustainability and community resilience through strategic investments.

State Farm's Good Neighbor Citizenship Company Grants aim to enhance community safety, development, and education. Focused on long-term impact, they support initiatives in auto and home safety, disaster preparedness, affordable housing, and educational programs. Eligible recipients include nonprofits, educational institutions, and government entities. However, funding is not available for individuals, religious programs, or organizations outside the U.S. By addressing critical community needs, these grants foster safer and more resilient neighborhoods.

South Carolina cultural nonprofits offering arts or science programs can access funding through the William Randolph Hearst Foundation for program, capital, and limited general or endowment support. U.S.-based 501(c)(3) organizations with audited expenses over $2 million, strong impact, and broad reach may be eligible, including museums, performing arts groups, and arts education or STEAM initiatives.

The Hearst Foundation's Social Service Grant focuses on tackling chronic poverty by funding direct-service organizations that implement effective solutions for economic independence and family strengthening. With a mission to support diverse nonprofits in the U.S., the Foundation allocates approximately 15% of its total funding to social services, prioritizing scalable programs that serve significant populations. The minimum grant size is $100,000, and special consideration is given to organizations addressing affordable housing, domestic violence, and youth development.

Nonprofit organizations providing health, wellness, education, or community services in South Carolina can apply for funding to support food pantries, healthcare access, STEM programming, and healthy lifestyle initiatives. Labcorp Charitable Foundation provides U.S.-based 501(c)(3) organizations with grants reviewed twice yearly, which may benefit local health and wellness programs serving underserved populations.

Nonprofit 501(c)(3) organizations supporting early childhood education or community economic development in South Carolina communities where PNC operates can seek funding for programs and services. PNC Foundation provides South Carolina nonprofits with support for early learning, health and human services, neighborhood revitalization, arts and culture, and other initiatives serving low- and moderate-income families.

Nonprofit organizations, especially accredited charities, can seek funding for humanitarian, social development, science education, community health, and environmental projects, including wellness initiatives in South Carolina. Focused on impactful, sustainable programs, Roche supports high-quality projects that engage local partners and employees, and are managed locally through its affiliate offices within the same country where activities take place.

South Carolina health and human service 501(c)(3) nonprofits seeking project or capital support can access funding through the Philip L Van Every Foundation; awards range from US $10,000 - US $50,000. Grants prioritize wellness, preventative healthcare, medical education, rehabilitation, and related programs that improve quality of life for residents in North and South Carolina.

South Carolina health-focused 501(c)(3) nonprofits, government agencies, and tax-exempt educational or research institutions can access funding to improve health outcomes and expand care access for economically vulnerable residents. Blue Cross and Blue Shield of South Carolina Foundation supports projects in areas like oral health, mental health, primary care, and community wellness initiatives statewide.

The Hansen Family Foundation Grant seeks to empower organizations that uphold the American values of life, liberty, and the pursuit of happiness. Focused on diverse causes like children, education, animals, environmental conservation, humanitarian efforts, and arts, the foundation is committed to supporting initiatives that create positive change. Eligible applicants must be 501(c)(3) nonprofits, while political campaigns and organizations with high budgets or overheads are ineligible. This grant fosters impactful contributions to society.

Nonprofit organizations with a physical location in South Carolina can seek US $1,000 - US $10,000 to support local health, wellness, and education programs, including pediatric cancer services and life skills education. Central Carolina Community Foundation administers the Aflac Charitable Fund Competitive Grant for groups serving designated Midlands counties.

Nonprofit 501(c)(3) and other charitable organizations serving women and children in South Carolina’s Aiken and Edgefield counties can apply for the Community Foundation for the Central Savannah River Area’s Women in Philanthropy Grant. Funding supports high-impact projects in health, social well-being, arts, and education that improve quality of life for local women and children.

The Robinson Foundation Grant, established in 2016, aims to alleviate hardships faced by individuals and communities, demonstrating God's love through charitable contributions. As a family-operated foundation, it focuses on creating meaningful, long-term impacts in various areas including animal welfare, education, and disaster relief. Organizations eligible for funding must be 501(c)(3) public charities. The foundation prioritizes fiscally responsible projects with the potential for tangible results, while not supporting capital projects.

Nonprofit 501(c)(3) organizations supporting community services in South Carolina can seek philanthropic grants or event sponsorships to advance their service and fundraising goals. With a mission to help communities where employees live and work, Insperity provides eligible charities with financial, volunteer, or in-kind support when they meet its employee, client, or community connection criteria.

Nonprofit 501(c)(3) organizations supporting basic needs, at-risk youth, or domestic violence services near South Carolina TJX locations can seek program funding through The Tjx Foundation. Grants may benefit health and wellness efforts by addressing food, shelter, safety, and enrichment. Applicants must be within 15 miles of a TJX site and meet mission and nondiscrimination criteria.

The Max and Victoria Dreyfus Foundation offers grants to support diverse initiatives, including museums, educational programs, and environmental activities. Aiming to make a significant impact with modest funding, the Foundation targets IRS-qualified non-profits in the U.S. Grants typically range from $1,000 to $20,000, fostering community development and enhancement. Organizations focused on youth, seniors, and individuals with disabilities are particularly encouraged to apply, as the Foundation seeks to empower those in need.

Nonprofit organizations focused on wellness and healthy living in South Carolina communities served by GALLO Giving can apply for up to US $10,000 to support family well-being, the arts, and overall community health. Grants from Stanislaus Community Foundation prioritize 501(c)(3) organizations in Chester County, South Carolina, that align with these giving priorities.

Focused on community vitality, Ameriprise Financial invites South Carolina 501(c)(3) nonprofits to apply for grants supporting basic needs, community development, cultural enrichment, and volunteer-driven causes. U.S.-based organizations working on hunger, shelter, financial literacy, workforce readiness, or arts access that can show measurable outcomes and engage Ameriprise volunteers may be eligible.

Grants from Spartanburg County Foundation help South Carolina health and wellness nonprofits improve quality of life, educational achievement, and economic mobility for Spartanburg County residents. 501(c)(3) and tax-exempt organizations can request up to US $35,000 for programs such as community health initiatives, mental health services, food access, housing stability, and related support services benefiting Spartanburg County.

Nonprofit organizations in South Carolina working on systems change for economic mobility or housing security can apply for Sisters of Charity Foundation’s Systems Change Grants, with awards of US $15,000 - US $20,000. Funding can support general operations, programs, or capacity-building, and may benefit health and wellness initiatives that address poverty’s root causes.

The O'Reilly Automotive Foundation Grant focuses on enhancing community welfare through philanthropic initiatives that support economic stability, workforce development, health services, and disaster relief. Established in 2020, the Foundation seeks to empower underrepresented individuals and organizations in the U.S. by addressing vital community needs. It particularly aims to provide assistance to nonprofits that foster positive change and improve quality of life for those in need, ensuring a lasting impact in local communities.

Health and wellness nonprofits in South Carolina can receive up to US $50,000 for community-focused programs such as healthcare access, illness prevention, mental health, disabilities, and veteran advocacy. BECU Foundation provides funding to 501(c)(3) organizations with a direct impact in Charleston County, nominated by BECU members who support their work.

The True Inspiration Awards, established by Chick-fil-A in 2015, recognizes nonprofit organizations that significantly impact their communities. In 2025, the program will distribute $6 million in grants, ranging from $30,000 to $350,000, to sixteen selected organizations. Categories include Caring for People, Caring through Food, Community, and Caring for our Planet, with a focus on educational initiatives, food security, housing services, and environmental stewardship, honoring the legacy of founder S. Truett Cathy.

South Carolina health and wellness nonprofits addressing adverse childhood experiences and related trauma can access funding through Amerihealth Caritas Foundation for one-year, project-specific initiatives. Eligible 501(c)(3) organizations in AmeriHealth Caritas Medicaid markets may receive US $100,000 - US $150,000 to improve children’s health, promote protective experiences, and support families in high-Medicaid communities.

South Carolina nonprofits and mission-driven housing organizations with proven affordable housing innovations can access funding through Enterprise Community Partners’ national Housing Affordability Breakthrough Challenge. Grants of US $2,000,000 support ready-to-scale solutions in design and construction, finance, or service delivery that expand affordable rental and homeownership options for low- to moderate-income residents.

Health and human services nonprofits in South Carolina and Eastern Massachusetts can access funding through the Yawkey Foundation’s Program and Small Capital Grants, with awards up to US $100,000 for timebound program needs, small projects, or equipment. Grants prioritize direct services addressing unmet basic needs for vulnerable and underserved individuals and families in Georgetown County and designated Massachusetts counties.

Nonprofit organizations working to help disadvantaged people become self-reliant, including those providing health and wellness or human services in South Carolina, can apply for Gupta Family Foundation grants of US $5,000 - US $250,000. With a mission to support focused interventions for disadvantaged individuals worldwide, the foundation prioritizes smaller, non-sectarian organizations with strong founder-led leadership.