Best Health and Wellness Grants for Nonprofits in South Carolina

The Costco Wholesale Charitable Contributions program prioritizes support for children, education, and health services within local communities. Nonprofit organizations seeking assistance must be 501(c)(3) certified and focus on monetary requests. Applications are reviewed within 4-6 weeks, factoring in community needs and collaboration. However, Costco limits grants to 10% of the program budget and typically restricts organizations to one request per fiscal year. They do not fund individuals or direct aid for various specific purposes.

The Draper Richards Kaplan Foundation provides grants to early-stage social entrepreneurs working on scalable solutions to pressing social and environmental issues. By supporting organizations with innovative approaches and proven impact, they aim to uplift underserved communities globally. The foundation offers operational support, funding of up to $300,000 over three years, and fosters a collaborative community among its portfolio organizations. They focus on candidates demonstrating measurable impact and sustainable growth potential.

The Global Impact Cash Grants by Cisco Systems Foundation support innovative early-stage solutions aimed at addressing significant social problems. Targeting nonprofit and nongovernmental organizations, these grants focus on four key sectors: crisis response, education, economic empowerment, and climate regeneration. Eligible organizations must demonstrate alignment with these areas, particularly serving underserved communities. The foundation seeks to leverage technology for impactful solutions, ensuring sustainability and community resilience through strategic investments.

State Farm's Good Neighbor Citizenship Company Grants aim to enhance community safety, development, and education. Focused on long-term impact, they support initiatives in auto and home safety, disaster preparedness, affordable housing, and educational programs. Eligible recipients include nonprofits, educational institutions, and government entities. However, funding is not available for individuals, religious programs, or organizations outside the U.S. By addressing critical community needs, these grants foster safer and more resilient neighborhoods.

The Hearst Foundation: Culture Grant aims to support outstanding nonprofits that enhance cultural engagement and artistic talent in the U.S. With a focus on programs that reach young people, the grant prioritizes organizations that create lasting impacts in the arts and sciences. The Foundation allocates 25% of its funding to cultural initiatives, favoring established organizations with a history of significant results. Eligible nonprofits must encourage inclusivity and sustainability in their programs.

The Semnani Family Foundation, established in 1993, is dedicated to supporting marginalized communities worldwide through health, education, and disaster relief initiatives. Founded by Khosrow and Ghazaleh Semnani, it began by funding an orphanage in Romania. The foundation also operates locally, providing free healthcare through the Maliheh Free Clinic in Utah. Its commitment to human welfare drives impactful partnerships in countries such as Afghanistan, India, and South Africa, focusing on the most vulnerable populations.

The Bank of America Foundation Sponsorship Program aims to enhance economic mobility and social progress in low- and moderate-income communities through partnerships with nonprofit organizations. This initiative focuses on critical areas such as workforce education, basic needs like food and housing, and community development. The Foundation invested $350 million last year and encourages employee volunteerism and giving, supporting nonprofits in various sectors, including arts, culture, and diversity initiatives.

The Robinson Foundation Grant, established in 2016, aims to alleviate hardships faced by individuals and communities, demonstrating God's love through charitable contributions. As a family-operated foundation, it focuses on creating meaningful, long-term impacts in various areas including animal welfare, education, and disaster relief. Organizations eligible for funding must be 501(c)(3) public charities. The foundation prioritizes fiscally responsible projects with the potential for tangible results, while not supporting capital projects.

GALLO Giving

GALLO is committed to making a difference in the communities where their employees live and work and is proud to support a variety of non-profit organizations. Because of the number of deserving requests received each year, donations are primarily directed toward the community where the corporate headquarters is located – Modesto, CA. Donations are also available for organizations in Fresno, Livingston, Napa, and Sonoma in California, as well as in Chester County, South Carolina, and Canandaigua, New York.

GALLO offers corporate donations to nonprofits that support Family Well-Being, the Arts, and Overall Community Health.  

In order to help as many organizations as possible, GALLO appreciates limiting your requests to one (1) donation per year. In an effort to manage their contributions in an equitable and efficient manner, all requests must be submitted via web form. 

Grant applications undergo a thorough evaluation process, which includes assessing the organization's reputation and its adherence to the eligibility criteria listed here. Applying does not ensure the receipt of funds. 

Generally, it is not GALLO’s practice to provide donations to private or public universities, or national disasters (some exceptions may apply).  

The Dudley T. Dougherty Foundation Grant supports nonprofit charitable organizations recognized under section 501(c)(3) of the IRS Revenue Code. Established in 2002, the foundation aims to empower groups committed to positive change, fostering respect for life and the environment. Their vision emphasizes collaboration for a better future, encouraging applicants to embody these values in their initiatives. With a focus on impactful projects, this grant is an opportunity for organizations striving to make a critical difference in our world.

South Carolina health and human service 501(c)(3) nonprofits seeking project or capital support can access funding through the Philip L Van Every Foundation; awards range from US $10,000 - US $50,000. Grants prioritize wellness, preventative healthcare, medical education, rehabilitation, and related programs that improve quality of life for residents in North and South Carolina.

The Max and Victoria Dreyfus Foundation offers grants to support diverse initiatives, including museums, educational programs, and environmental activities. Aiming to make a significant impact with modest funding, the Foundation targets IRS-qualified non-profits in the U.S. Grants typically range from $1,000 to $20,000, fostering community development and enhancement. Organizations focused on youth, seniors, and individuals with disabilities are particularly encouraged to apply, as the Foundation seeks to empower those in need.

The Spark Good: Strengthening Community Local Grants program by the Wal-Mart Foundation empowers local organizations through grants ranging from $250 to $5000. This initiative aims to enhance community welfare by supporting diverse projects, including animal shelters and educational programs. Eligible organizations must have a verified Spark Good account, ensuring funds are allocated effectively to meet local needs and foster community development. Together, we can create lasting impacts through small yet significant actions.

Ameriprise Community Grants focus on supporting nonprofits that enhance community vitality and meet basic needs. With over 120 years of commitment to philanthropy, Ameriprise Financial engages employees in volunteerism and grantmaking. Key giving areas include hunger relief, housing stability, and community development. Priority is given to organizations with active volunteer engagement from Ameriprise advisors and employees, creating a meaningful impact on financial independence and community resilience.

The Dr. Scholl Foundation offers grants annually to IRS 501(c)(3) organizations, primarily focusing on U.S. applicants. The foundation supports projects in education, social services, healthcare, civic and cultural initiatives, and environmental efforts. While the grant cycle runs from October 1 to March 1, it encourages innovative solutions to global challenges. Only one application per organization is accepted each year, and funding is limited to one year. Unqualified organizations, including political entities, are ineligible.

South Carolina health-focused 501(c)(3) nonprofits, government agencies, and tax-exempt educational or research institutions can access funding to improve health outcomes and expand care access for economically vulnerable residents. Blue Cross and Blue Shield of South Carolina Foundation supports projects in areas like oral health, mental health, primary care, and community wellness initiatives statewide.

The Aflac Charitable Fund Competitive Grant supports local nonprofit organizations in South Carolina, focusing on health and education. Priority is given to programs aiding pediatric cancer patients and their families, as well as life skills initiatives. Organizations must comply with state regulations and can only submit one application per cycle. Previous applicants can reapply in future cycles, but declined applications do not carry over automatically. This initiative is managed by the Central Carolina Community Foundation.

The Spartanburg County Foundation's Continuous Improvement Grant aims to enhance the lives of Spartanburg County residents by funding nonprofit organizations that focus on quality of life, educational achievement, and economic mobility. Grants of up to $35,000 are available to eligible 501(c)(3) organizations. The foundation prioritizes projects that demonstrate alignment with its mission, utilize data-driven strategies, and foster community engagement, ensuring diverse populations receive necessary support and resources.

Grants

Through our grantmaking, we support nonprofits that serve South Carolina at local, regional and state levels to address root causes of poverty while honoring the dignity of every South Carolinian.

Starting in 2026, our grants focus primarily on systems change in the areas of

• economic mobility,
• housing security and
• health care (with health care systems change grants by invitation only).

By focusing our efforts and going deeper on these three issues, we aim to have an even greater impact on the nonprofits and communities we serve.

Systems Change Grants

Systems Change Grants fund organizations and coalitions that are working to change the policies, power structures and mindsets that cause and reinforce poverty in South Carolina. These grants specifically fund systems change that supports economic mobility and housing security.

Through these grants, we aim to generate a larger impact through more intentional funding, highly focused work and alignment across our Foundation’s activities.

What Systems Change Grants Support

• Organizations that are actively working on systems change that impacts people experiencing poverty and addresses economic mobility or housing security. To see how the Foundation defines these terms, visit our Strategic Plan webpage.
• Organizations that are seeking to change systems at the local, regional or state level. Systems Change Grants provide up to $75,000 annually for local or regional work.
  • State-level grants have a $100,000 maximum each year. 
• Organizations addressing systems change in at least one of the following ways:
  • Participating in advocacy and lobbying
    • Focus on changing policies, practices, processes, rules or laws
    • Impacting resource flows (i.e., reallocated and/or new funding streams)
    • Holding systems accountable to their intended purpose through the above as well as through litigation
  • Addressing unequal power
    • Focus on changing the distribution and dynamics of privilege, relationships and tradition
    • Organizing and building connections and coalitions that center community voices and perspectives
    • Civic engagement
  • Affirming the dignity of people experiencing poverty
    • Focus on changing the narrative around poverty
    • Focus on changing attitudes, mindsets, values, belief systems, norms, mental models and paradigms
  • Implementing big impact, scalable, or innovative solutions
    • Focus on changing results, especially for groups experiencing inequitable outcomes as a result of historic and current marginalization

All grants are for one year, with the possibility of renewal up to three years based on meeting reporting requirements and the availability of funding.

The J.W. Couch Foundation Grant focuses on supporting Wildlife Conservation nonprofit organizations that align with their mission of community betterment and environmental protection. The foundation seeks partnerships with organizations that promote animal wellbeing, early childhood education, teacher support, and outdoor activities. Eligible applicants must be registered 501(c)3 nonprofits or for-profit entities aligned with their charitable programs. This grant emphasizes collaboration and community engagement to create lasting impacts.

The O'Reilly Automotive Foundation Grant focuses on enhancing community welfare through philanthropic initiatives that support economic stability, workforce development, health services, and disaster relief. Established in 2020, the Foundation seeks to empower underrepresented individuals and organizations in the U.S. by addressing vital community needs. It particularly aims to provide assistance to nonprofits that foster positive change and improve quality of life for those in need, ensuring a lasting impact in local communities.

The BECU Foundation's People Helping People Awards honor exceptional nonprofit work in communities served by BECU. Each year, BECU members can nominate organizations for grants up to $50,000. Eligible nonprofits must be active 501(c)(3) organizations with a direct impact in Idaho, Oregon, South Carolina, or Washington. This initiative highlights the importance of community service and encourages members to recognize local heroes making a difference.

The AmeriHealth Caritas Foundation Grant aims to prevent and mitigate adverse childhood experiences (ACEs) to promote healthier outcomes for children. With a focus on empowering families, healing behaviors, and access to healthcare, the foundation supports nonprofit organizations that provide comprehensive care and resources. Grants range from $100,000 to $250,000, totaling up to $1.945 million for project-specific initiatives. Eligible organizations must be 501(c)(3) nonprofits operating in states where AmeriHealth Caritas Medicaid markets exist.

Enterprise Community Partners

Enterprise Community Partners is a national nonprofit that exists to make a good home possible for the millions of families without one. Home is where life happens, where plans are made, and futures begin. It is the foundation for dignity, health, education, wealth, and community. Yet rents keep going up, paychecks don’t keep pace, and good homes in strong neighborhoods are increasingly out of reach.

The system doesn’t work. It must be changed, and it must be changed by us.

Enterprise has the breadth, scale, and expertise to do it. We support community development organizations on the ground. We aggregate and invest billions to improve housing and strengthen communities across the U.S. We advance housing policy at every level of government. We build and manage communities ourselves. Everything we do is informed by the residents we serve.

Together with our partners, we focus on the greatest need — the massive shortage of affordable rental homes — to achieve three goals:

• Increase the supply of affordable homes
• Advance racial equity after decades of systematic racism in housing
• Support residents and strengthen communities to be resilient to the unpredictable, and make upward mobility possible

Since 1982, we have invested $92.0 billion and created 1.1 million homes across all 50 states, the District of Columbia, Puerto Rico, and the U.S. Virgin Islands. We do all this to make home and community places of pride, power, and belonging.

National Housing Innovation Grant Competition

Home is foundational. It’s where we plant roots, raise and care for our families, and build community bonds. Yet in every corner of the country, millions of people of all ages and backgrounds need a home they can afford.

Wells Fargo is meeting this moment with a powerful grant opportunity. Together with Enterprise, Wells Fargo has launched the third iteration of the Housing Affordability Breakthrough Challenge. The 2026 cycle of the housing innovation competition will identify and propel proven, ready-to-scale solutions that transform current practices and increase housing choice and access.

Eligible applicants will compete for five individual grants of $2 million to advance their innovation and drive meaningful, systems-level change in the housing and adjacent industries. Winners will gain access to mentorship and coaching from industry leaders and experts and join a powerful network of Breakthrough Challenge innovators.

Focus Areas

This third cycle of the Housing Affordability Breakthrough Challenge aims to meet the nation’s affordable housing challenges across all types of communities: Native, rural, suburban, tribal, and urban.

Proposals must encompass one or more of three focus areas:

• Design and Construction
• Finance
• Service Delivery and Programs

Applicants will be asked to show how their proof of concept or pilot program has achieved clear outcomes and success, and provide a clear pathway to expanding the innovation’s reach and impact

Round 1: Criteria and Scoring

Your innovation must meet the criteria below to advance to the official scoring stage.

Type of Community

Innovations can serve all types of communities:

• Rural
• Urban
• Suburban
• Tribal

Location

Priority scoring will be given to applications from entities that are based in – or whose innovations are designed for – one or more of these 28 states, plus D.C.:

• Alaska, Arizona, Arkansas, California, Colorado, Florida, Georgia, Idaho, Illinois, Iowa, Maryland, Massachusetts, Minnesota, Montana, Nevada, New Jersey, New Mexico, New York, North Carolina, North Dakota, Pennsylvania, South Carolina, South Dakota, Tennessee, Texas, Utah, Virginia, Washington, Washington D.C.

Affordability

Innovations must serve residents at these income levels:

• Rental: 80% AMI or below
• Homeownership: 120% AMI or below
• Workforce housing: 120% AMI or below

The Yawkey Foundation offers Program and Small Capital Grants to nonprofit organizations making meaningful impacts in Health Care, Education, Human Services, Youth and Amateur Athletics, Arts and Culture, and Conservation and Wildlife. Grants can be up to $100,000 and support projects aligned with the nonprofit’s mission. Organizations are encouraged to submit Initial Proposals during designated periods, demonstrating strong leadership and community impact, particularly in underserved regions of Eastern Massachusetts.

The Mutual of America Foundation Community Partnership Award honors exemplary nonprofit organizations in the U.S. that foster collaborative partnerships across sectors. Annually, a national competition showcases numerous organizations demonstrating impactful community partnerships. Six organizations receive recognition, including the Thomas J. Moran Award, which offers $100,000, and the Frances R. Hesselbein Award, granting $75,000. Since 1996, the award has acknowledged 262 partnerships, emphasizing Mutual of America's commitment to societal improvement through collaboration.

The CFCSRA: Women in Philanthropy Grant supports organizations that enhance the lives of women and children in Georgia and South Carolina. With over 200 members, the initiative funds high-impact projects while emphasizing collaboration and community engagement. Eligible applicants must be 501(c)(3) organizations or similar entities. The grant does not support individual grants, capital campaigns, or projects typically funded by government sources. This initiative aims to cultivate generosity and strengthen local nonprofits.