Best Large Grants for Nonprofit Organizations in South Carolina

The CSA Grace D. Dreher Memorial Scholarship supports deserving students from Stroudsburg High School. Funded by the Grace D. Dreher Memorial Trust, it offers one-year scholarships for full-time college enrollment at accredited institutions in the U.S. Eligible applicants must demonstrate financial need and have a minimum GPA of 2.0 on a 4.0 scale. Current recipients may reapply, but awards are not guaranteed and depend on the applicant pool each year.

The White-Reinhardt Grant offers funding for projects that enhance agricultural literacy among K-12 students. With grants of up to $1,000 available, state and county Farm Bureaus can initiate new educational programs or expand existing ones. This initiative, supported by the American Farm Bureau Federation and its Women’s Leadership Committee, honors the contributions of Berta White and Linda Reinhardt, aiming to bolster agricultural knowledge across the nation.

In 2025, the Community Foundation of Madison & Jefferson County awarded over $233,000 in scholarships to graduating seniors of the county’s public and private high schools. Nearly 50 different students earned money toward their college costs. Scholarships are available for a variety of applicants. Some are specific to schools, majors, need, or interests.

CFMJC scholarships may be used for tuition and related expenses like fees and required equipment at accredited colleges and universities. Room and board are not covered.

Carolyn Bruce Spicer & Gene E. Spicer Nursing Scholarship (Adult Learner)

Criteria evaluated:

• Academic performance, work history, and financial need

Required materials:

• FAFSA SAI PDF upload

Scholarship amount:

• $1,100 | 1 scholarship

The Ed Dwight Scholarship

The Ed Dwight Scholarship is one of many funding opportunities available to students through NAACP's Inspire Initiatives. We offer scholarships to outstanding and qualified students pursuing undergraduate degrees. Through the generosity of our donors, we advance efforts to ensure equity in educational opportunities that prepare students for success in school, work, and life.

The Ed Dwight Scholarship honors Ed Dwight, a trailblazer in the American space program, author, and sculptor. Ed was the first Black astronaut candidate, the first to enter the program, complete the training and fully qualified as an astronaut. At the age of 90, he finally had the opportunity to see the earth from outside the atmosphere and became the oldest person to go to space.

Scholarship amount:

• $2,500 

This is a non-renewable scholarshipopportunity.

The Procter & Gamble Strategic Fund Grant aims to enhance lives through impactful initiatives such as infant development, hygiene, and oral care. As a highly competitive fund, it supports IRS-designated 501(c)(3) organizations that provide national programs where P&G can uniquely add value. Interested applicants should carefully assess their eligibility and align with the grant's specific focus areas before applying.

The ISF Public Interest Legal Fellowship empowers American Muslims by providing opportunities in public interest law. This fellowship offers a salary of $70,000, professional development workshops, and mentorship to help fellows advance their careers. Applicants must be active members of the Muslim community, have graduated from law school within the last three years, and have secured a host organization for their project proposal. This initiative aims to increase representation and influence in policy-making.

The NIH Pathway to Independence Award (K99/R00) supports the transition of postdoctoral researchers to independent faculty positions. It aims to enhance the number of talented NIH-supported investigators by providing funding during their transition to independent research careers. Key deadlines for applications are set for various dates through 2027. This program is crucial for developing a strong cohort of new independent researchers, fostering innovation in health-related fields.

The National Institute of Environmental Health Sciences (NIEHS) is seeking applications for research coordination and data support under the Health and Extreme Weather initiative. This funding opportunity aims to engage NIH grantees and the broader community by sharing best practices, developing training resources, and facilitating access to health and environmental data. The initiative will enhance collaboration, reduce duplication, and promote data standards to support impactful research and infrastructure activities.

The NIH Pathway to Independence Award (K99/R00) aims to enhance the career development of promising postdoctoral researchers by transitioning them into independent faculty positions. This program supports innovative research during the critical transition phase, enabling awardees to establish successful, independent research careers. Key application deadlines span from June 2024 to February 2027, with specific dates for standard, renewal, and AIDS-related applications. This initiative is vital for fostering a new generation of NIH-supported investigators.

The Research Opportunities for New and At-Risk Investigators (R01 Clinical Trial Optional) program invites applications that promote workforce diversity in health-related sciences. This initiative encourages researchers from underrepresented backgrounds to propose independent research projects in alignment with NIH's mission. Important deadlines for standard and renewal applications range from February 2025 to November 2027. This effort aims to enhance diversity and inclusion within the scientific community.

The EA Infrastructure Fund Grant supports projects that enhance effective altruism by improving access to talent, capital, and knowledge. With grants typically ranging from $5,000 to $200,000, it welcomes applications from individuals, nonprofits, and academic institutions worldwide. However, individuals must ensure their projects conclude by August 31, 2025. The fund aims to amplify the impact of direct charitable work and foster a community committed to effective altruism principles.

The Russell W. Ligon Memorial Engineering Scholarship, offered by the Four County Community Foundation, supports high school seniors and recent graduates from seven school districts pursuing degrees in engineering or computer science. Eligible students can receive up to four awards of $1000 each, contingent upon a GPA of 3.00 or higher, a letter of recommendation, and an essay response. Awardees will be recognized at the Foundation Scholarship Celebration and local high school awards events.

The Sam Noble Foundation Grant aims to uphold the philanthropic legacy of Lloyd Noble by funding agricultural research and supporting charitable initiatives that enhance health, education, and community strength. Geared towards 501(c)(3) nonprofits in the U.S., the foundation prioritizes projects in Oklahoma and does not entertain multiyear commitments or funding for individuals or for-profit entities. The foundation seeks to address agricultural challenges while expanding educational and health services.

The Enhancing Student Mathematics Learning through the Use of Tools and Technology Grants, provided by the National Council of Teachers of Mathematics, aim to promote innovative technology use in teaching mathematics to Pre-K-12 students. These grants encourage proposals that focus on enhancing students' understanding of math concepts through various tools, including professional development for educators. Eligible applicants include current math teachers and full-time coaches, with a focus on impactful evaluation plans.

The Procter & Gamble U.S. Large Site Community Grant supports initiatives that enhance the lives of individuals within 50 miles of P&G facilities. Focused on areas like infant development and hygiene, this competitive grant seeks to partner with organizations aligned with its mission. Interested groups should verify eligibility through the P&G grant portal. While many applications are received, only a select few will be funded due to high demand.

The NIH Mentored Research Scientist Development Award (K01) aims to support early-career researchers in the biomedical, behavioral, or clinical sciences. This program provides three to five years of protected time for intensive career development, paving the way to research independence. Various NIH Institutes leverage this award to assist individuals transitioning into new fields or re-engaging with research after personal challenges. The K01 is a vital resource for cultivating the next generation of scientific leaders.

Marion Community Foundation

Since 1998, area residents have been turning to Marion Community Foundation to make their philanthropic giving as effective as possible. We are a public charity serving thousands of people who share a common concern … improving the quality of life in Marion County. We use distributions from the more than 500 charitable funds — created by generous, local donors — to award more than $2.5 million in grants and scholarships each year to many of the humanitarian, educational and cultural organizations in this remarkable community we call home.

Marion Community Foundation is the area’s leading philanthropic organization, providing charitable donors the opportunity to easily create endowment funds to benefit and support our community through grants and scholarships. We serve communities throughout Marion County through philanthropy, leadership, and civic engagement.

Art & Anne Huggler Memorial Scholarship

The Art & Anne Huggler Memorial Scholarship Fund supports local students pursuing a degree in education or engineering.

Art hailed from Harrisburg, Pennsylvania, graduating with a degree in electrical engineering from Penn State. He was a Navy veteran of World War II and worked for GTE for 35 years. He enjoyed travel and golf and was a licensed pilot. Anne was a teacher and homemaker. They are the parents of two, grandparents of five and great-grandparents of nine. The couple was active with St. Paul’s Lutheran Church, where Art directed Art Market Marion.

The Huggler Scholarship seeks especially to assist Marion area students with substantial financial need. It was established in 2015 by their daughter, Linda Halt.

The Alternative Fuel Foundation Grant aims to support educational institutions in developing programs focused on renewable energy and environmental sustainability. Grants typically range from $250 to $500, with larger amounts considered on a case-by-case basis. Eligible applicants include public or private K-12 schools and universities. The foundation encourages projects that promote alternative fuels and community involvement, with a preference for initiatives that can be completed within a year.

The NIH Pathway to Independence Award (K99/R00) program is designed to support promising postdoctoral researchers in transitioning to independent faculty positions. This initiative aims to maintain a strong cohort of talented investigators by providing independent NIH research funding during this critical phase. Key application deadlines span from June 2024 to February 2027, encouraging applications from diverse fields, including AIDS-related research.

The ROSES 2025: D.4 program by NASA focuses on enhancing theoretical and computational astrophysics through collaborative networks. It aims to address grand challenges in Time Domain Multi-Messenger Astrophysics by integrating diverse expertise from various fields. Researchers from U.S. institutions are encouraged to propose innovative tools for modeling complex multi-messenger phenomena, fostering interdisciplinary collaboration across academic, national laboratory, and private sectors to prepare the next generation of scientists.

The Eastman Foundation Grants promote corporate social responsibility by enhancing the quality of life through sustainable community improvement. By partnering with nonprofit organizations, the foundation focuses on economic success, social well-being, and environmental integrity. The foundation emphasizes creating diverse and inclusive communities, addressing human needs while minimizing environmental impact. Grants are available for qualified organizations that align with these goals, ensuring that funding supports initiatives that foster healthy, vibrant communities where both people and nature can thrive.

The Neag Foundation Grant aims to foster positive change in education, healthcare, and the arts. Supporting initiatives in Pennsylvania and Connecticut, the foundation focuses on enhancing educational opportunities, advancing healthcare interventions, and promoting the arts and humanities. By encouraging innovative projects that receive community support, it seeks to improve the quality of life for individuals and families. Organizations with a 501(c)(3) status are encouraged to apply for funding opportunities that align with these goals.

The NIH Mentored Research Scientist Development Award (K01) supports early-career scientists with up to five years of protected time for intensive research training in biomedical, behavioral, or clinical sciences. This award is tailored for those pursuing independence in research and is particularly beneficial for individuals transitioning fields or returning from a hiatus. Importantly, applicants must not lead independent clinical trials but may participate in trials overseen by mentors.

The Maximizing Opportunities for Scientific and Academic Independent Careers (MOSAIC) program aims to enhance diversity in research by supporting early career investigators from underrepresented backgrounds. This initiative offers a K99/R00 career transition award for postdoctoral scholars and a UE5 cooperative agreement that provides mentorship and professional development. The program's goal is to ensure successful transitions into independent, tenure-track faculty roles in NIH mission areas, ultimately fostering a more inclusive scientific community.

The NIH Mentored Clinical Scientist Research Career Development Award (K08) aims to develop the research careers of individuals with clinical doctoral degrees. This program provides essential support and protected time for intensive, supervised research experiences in biomedical and behavioral fields, including translational research. Important deadlines for applications span from June 2024 to February 2027, accommodating various grant types, including standard and AIDS-related applications.

The NIH Midcareer Investigator Award in Patient-Oriented Research (K24) aims to support mid-career health professionals in conducting patient-oriented research while mentoring clinical residents and junior faculty. This grant offers protected time for research, ensuring participants can focus on impactful studies and foster the next generation of clinical researchers. Key deadlines for applications range from June 2024 to February 2027, with specific dates for standard, renewal, and AIDS-related submissions.

The NIH Midcareer Investigator Award in Patient-Oriented Research (K24) supports mid-career health-professional doctorates by providing protected time for patient-oriented research (POR). This grant also enables recipients to serve as research mentors for clinical residents, fellows, and junior faculty. Key deadlines for applications span from June 2024 to February 2027, ensuring ample opportunities for interested applicants to engage in impactful research and mentoring.