Best Private Grants for Nonprofits in South Carolina

The Maximizing Investigators' Research Award (MIRA) program, established by NIGMS, aims to enhance research funding efficiency by providing stable financial support to investigators. This allows for greater scientific flexibility and encourages innovative studies. MIRA is pivotal for distributing funding among promising researchers, fostering groundbreaking research. The program invites applications from eligible NIGMS-funded and NIH-defined New Investigators, as well as current MIRA grantees seeking renewal, ensuring a broad and inclusive approach to advancing science.

The Smart Growth Grants program, managed by the National Association of Realtors, aims to enhance community development through educational initiatives aligned with Smart Growth Principles. Available in three levels, the grants support REALTOR Associations in promoting sustainable land use, community planning, and stakeholder engagement. Maximum awards range from $3,000 to $15,000, depending on the grant level. Note that the program is currently not accepting applications for 2025 and will reopen in January 2026.

The National Urban Indian Health Program aims to enhance behavioral health services for Urban Indian communities by fostering awareness, advocacy, and collaboration across the nation. By providing technical assistance and training to Urban Indian Organizations, the program seeks to improve access to culturally relevant behavioral health care for American Indian and Alaska Native populations residing in urban areas, ultimately leading to better health outcomes and community support.

The AAAS Early Career Award for Public Engagement with Science recognizes outstanding early-career scientists and engineers for their significant contributions to public engagement in science. Established in 2010, the award includes a $5,000 prize, a plaque, and recognition at the AAAS Annual Meeting. Eligible nominees must be actively conducting research in STEM fields and demonstrate engagement beyond their job responsibilities, with one awardee chosen annually.

The Camille Dreyfus Teacher-Scholar Awards Program supports talented early career faculty in the chemical sciences by providing an unrestricted research grant of $100,000. Nominees must demonstrate outstanding research achievements and a commitment to education. Each institution can submit one nomination annually. The program emphasizes innovation and leadership in research while considering factors such as awards, publication success, and contributions to education, particularly at the undergraduate level.

The Dressage Foundation

The Dressage Foundation is a 501(c)(3) non-profit, tax-exempt organization, whose mission is to cultivate and provide financial support for the advancement of dressage in the United States.

In 1989, Lowell Boomer founded The Dressage Foundation (TDF) with a vision: to empower dressage across the country. Since then, we've awarded millions of dollars in grants, helping people across our sport, and across the country, achieve their dreams. From grassroots initiatives to high-performance endeavors, we aim to create a strong, inclusive, and vibrant dressage community.

We strive to cultivate dressage excellence by reducing some of the financial barriers of dressage training and education, and we believe that every aspect of our sport deserves help.

George Williams Young Professional Fund

The George Williams Young Professional Fund supports dressage professionals, ages 25-35, who are committed to the sport and have established businesses as instructors and trainers.   

The George Williams Young Professional Fund was established in 2018 to honor his lifelong commitment to dressage. Applicants should have a strong desire to participate in continuing education opportunities, in order to provide higher-quality instruction to their students. 

The Louisville Institute offers the Grant for Researchers to support academic research in North American Christianity and related fields. Grants of up to $55,000 are available for sabbatical leaves, research projects, and necessary resources. This flexible program combines previous grants to meet contemporary academic needs. Applicants can apply individually or as teams of up to three, provided they are based in the U.S. or Canada. Projects bridging scholarship and church life are of particular interest.

The Ray Y Gildea Jr Award, provided by the Royal Geographical Society, offers grants of up to £1,000 to support innovative teaching methods in higher and secondary education. This endowed award aims to enhance geography education by funding projects that develop, research, or pilot new approaches, ultimately benefiting students directly. Eligible applicants must be actively teaching in the higher education or secondary school sectors in the UK or USA.

Seattle Foundation

Seattle Foundation is an agent of change, igniting powerful, rewarding philanthropy to make Greater Seattle a stronger, more vibrant community for all.

At Seattle Foundation, we believe that community is more than a place. It’s the shared understanding that our joy and well-being are tied to one another. Every day we work with nonprofits, philanthropists, and partners like you to strengthen community by igniting powerful philanthropy and advancing long-term solutions. Because it takes all of us to create a joyful region where every person can thrive.

Theresa Earenfight Scholarship

The purpose of the Theresa Earenfight Scholarship is to support undergrad or graduate students who are passionate about the intersection of social justice and animal welfare within a historical context. Applicants should be studying history, in particular how history intersects with animal activism, animal rights, animal liberation, and other related topics. Preference will be given to students with strong financial need, students of color and those from historically marginalized communities, and/or students who may face barriers to receiving other scholarships. This is a $10,000 annual scholarship renewable through the completion of the student’s degree, assuming the student continues to meet the eligibility criteria. The scholarship may be applied to tuition and fees, or other academic expenses payable to the college or university.

The John K. Fairbank Prize in East Asian History, awarded by the American Historical Association, recognizes exceptional scholarly work in the history of East Asia, particularly focusing on books published after 1800. Eligible works must demonstrate high literary merit and can be nominated by authors or publishers. The prize aims to highlight significant contributions to the historical disciplines, with recipients announced in October 2025 and honored at the January 2026 AHA annual meeting in Chicago.

Steven Thayer Hopi Scholarship

This scholarship was established by the family of Steven Thayer to provide scholarship funding for young Hopi artists to develop their talents and artistic skill.

National Main Street Center Inc.

Main Street America (MSA) leads an inclusive, impact-driven movement dedicated to reenergizing and strengthening older and historic downtowns and neighborhood commercial districts through place-based economic development and community preservation. We work in collaboration with thousands of local partners and grassroots leaders across the nation who share our commitment to advancing shared prosperity, creating resilient economies, and improving quality of life.

Main Street America was founded in 1980 as the National Main Street Center®, a program of the National Trust for Historic Preservation. Over the past 40 years the MSA network has helped to generate over $115.27 billion in local reinvestment, rehab 345,801 buildings, create 815,894 new jobs, and start 181,647 new businesses in over 2,000 communities. 

Great American Main Street Awards

Main Street America celebrates communities whose successes serve as a model for comprehensive, preservation-based revitalization efforts in their historic downtowns and commercial corridor districts with the Great American Main Street Awards (GAMSA).

Winners represent the diversity of communities in the Main Street America network — small towns, mid-sized communities, and urban commercial districts from every region in the country — and demonstrate the power of the Main Street Approach™. Since the inception of the Great American Main Street Awards in 1995, 118 Main Street programs have been honored.

Selection Criteria: Semifinalists and winners are selected from a nationwide pool of applicants by a jury of Main Street professionals and leaders in the fields of community and economic development and historic preservation. Criteria for winning GAMSA include: strength of the Main Street program in spurring community transformation, commitment to historic preservation, innovative programming, implementation of cross-sector partnerships, community outreach and stakeholder engagement, and ensuring their downtown districts are for everyone. 

Accolades & Ceremony: Semifinalists are promoted through Main Street America’s digital channels and receive media relations support. Winners also receive a short documentary film, a plaque, communications and media relations support, prominent placement on the Main Street America website for two years, and recognition at the 2027 Main Street Now Conference in Detroit, Michigan.

The AOAP Life Jacket Grant supports aquatic facilities in drowning prevention by offering funds for swim lessons and life jackets. Administered by the Association of Aquatic Professionals, the program aims to provide at least 100 free lessons and distribute 500 life jackets annually. This initiative promotes safety education and awareness of life jacket usage, ensuring that underserved communities have access to vital water safety resources. Applications are open to AOAP members meeting eligibility criteria.

The Collins Medical Trust Grant, established in 1956, supports health-related research and professional education for tax-exempt organizations. Eligible applicants include institutions with approved tax status and a commitment to equal opportunity. Early career investigators are encouraged to apply, but funds cannot be used for individual benefits or political activities. The Trust prioritizes projects in Oregon and does not support product development for industry. Applications are accepted thrice yearly, with specific deadlines for timely consideration.

The Jim and Shirley Cook Scholarship offers a $750 award for graduating high school seniors pursuing higher education at accredited institutions. Applicants must demonstrate financial need through FAFSA-SAI and provide evidence of community service and extracurricular involvement. Preference will be given to candidates with leadership experience in FFA or the GO CAPS program, specifically those studying Mechanical Engineering, CNC programming, Welding, or Machine Tool Technology. This scholarship aims to support students who embody commitment and community engagement.

The BJA FY 2026 Prosecuting Cold Cases Using DNA program aims to enhance public safety and justice by supporting prosecutors in the investigation and prosecution of violent cold case crimes with developed DNA profiles. This funding opportunity, provided by the US DOJ's OJP Bureau of Justice Assistance, facilitates crucial investigative and forensic activities to increase successful prosecutions and provide resolution for victims and their families. Full applications are due by November 5, 2026.

The Outstanding Earth Science Teacher (OEST) Award recognizes exceptional K-12 educators for their contributions to Earth Science education. Established in 1971 by the National Association of Geoscience Teachers, the award aims to stimulate interest in Earth Sciences among students. Eight national finalists are chosen annually, ensuring broad recognition and encouraging teaching excellence. Nominees can apply themselves or be nominated by colleagues, allowing for two awards in an educator's career to honor both early and late career achievements.

The Creation & Development Fund, administered by the National Performance Network, supports the creation and mobility of artistic works that promote racial and cultural justice. It fosters collaboration between artists and communities through financial support, enabling artists to develop meaningful relationships and present their work. The fund emphasizes equity, access, and the importance of public engagement, ensuring that diverse voices are represented while addressing systemic injustices in the arts.

The Community Heart & Soul Seed Grant Program offers $10,000 in startup funding for community-driven groups in small towns to adopt the Community Heart & Soul model. Applications are accepted until 11:59 p.m. EST on the last business day of each month, with funding decisions made the following month. This initiative aims to empower residents to engage in local development and foster community connections.

The ACS-Hach High School Chemistry Classroom Grant aims to enhance chemistry education by providing funding for innovative teaching ideas. Since its inception in 2008, over 700 teachers have benefited from grants of up to $1,800. Eligible applicants are U.S. high school chemistry educators, and the funding can be used for laboratory supplies, instructional materials, professional development, and student-led field studies, fostering a deeper understanding of chemistry.

The Ilpo Martikainen Audio Visionary Scholarship, provided by the Audio Engineering Society Educational Foundation, supports U.S. graduate students dedicated to advancing audio technology. This scholarship honors the legacy of Dr. Martikainen, founder of Genelec, who significantly contributed to loudspeaker innovation. Eligible students must have completed an undergraduate degree and demonstrate a commitment to audio engineering. Grants typically range from $2,000 to $5,000, paid directly to the student's graduate school.

The Ken W. Davis Foundation Grant provides essential funding to nonprofit organizations in the U.S. that align with the Foundation's mission of promoting basic human needs and education in line with Constitutional freedoms. With a minimum grant size of $2,500, the Foundation focuses on supporting human service organizations in Tarrant County, Texas, and the Permian Basin of West Texas and Southeast New Mexico, while also offering national support for grants related to Constitutional freedoms.

The National Institutes of Health (NIH) is continuing support for the Network for Excellence in Neuroscience Clinical Trials (NeuroNEXT), which focuses on clinical trials and biomarker validation studies for neurological disorders. This initiative aims to foster innovation in neurotherapeutics by providing essential infrastructure and expertise. The program encourages the establishment of Clinical Coordinating Centers (CCC) and Data Coordinating Centers (DCC) to enhance collaborative efforts. Note that applications are not currently being solicited.

This grant aims to enhance safety and health in U.S. mining operations through research in automation, robotics, and intelligent systems. It addresses critical issues like emergency communication and self-escape reliability while supporting the development of field-ready solutions. By leveraging advanced technologies, the initiative seeks to improve miner safety and health, reduce hazardous exposures, and foster community engagement. Applicants must be U.S. academic institutions with accredited mining programs, linking project goals to documented health burdens.

The BJA FY 2026 Comprehensive Opioid, Stimulant, and Substance Use Program (COSSUP) Training and Technical Assistance (TTA) aims to enhance the capacity of grantees through dedicated training. It addresses critical operational issues related to overdose responses, targeting illicit opioids and stimulants. The program underscores the U.S. Department of Justice's commitment to public safety, law enforcement support, and the fight against substance misuse. Applications are due by November 9, 2026.

The Civic Experiment Grant by the Trust for Civic Life supports innovative, community-driven projects aimed at enhancing civic engagement. It focuses on rural areas, empowering local leaders to tackle challenges collaboratively. Grants up to $25,000 are available for organizations that are non-partisan and primarily serve rural communities, emphasizing inclusivity and sustainable impact. The next nomination period begins in early 2026, following a closed cycle for 2025. This initiative fosters long-term civic infrastructure and community resilience.

Mission: A non-profit, charitable, Private Foundation established in 1959 by the Long family to support local charities, schools, education events and general community needs.

Grants

Our approach to grant requests focuses on fostering local neighborhood vitality and excellence. The John F. Long Foundation supports local non-profit organizations that promote this objective. The Foundation looks for groups who are working to help themselves, help their own communities, and help others like themselves through self-empowering, community organizing efforts. To be eligible for consideration, the grant request must meet the following criteria:

• Funds’ use must have measurable benefits
• Your organization must have good management, a solid financial background, well-established administration policies and Board of Directors
• The grant request must be precise and complete, providing necessary detail
• The Foundation Questionnaire is to be completed in its entirety
• The grant request amount and time frame must be clearly communicated, i.e. one-time grant, ongoing support, or special project
• If your request is for a particular event or program, providing a budget is always helpful
• Requests for grants of $1,000.00 or more, as well as groups we have not funded within the past two years, must: (i) Provide financial reports/statements for past and current fiscal year; (ii) Provide a list of past donors going back no more than two years.