Best Private Grants for Nonprofits in South Carolina

The Behavioral Health Integration Initiative aims to enhance the health of American Indian and Alaska Native individuals by expanding access to integrated behavioral health care. It supports Tribal and Urban Indian Organization health systems in providing culturally responsive and trauma-informed services. The initiative focuses on improving care coordination, promoting early identification of mental health issues, and integrating various health services to improve overall health outcomes and quality of life for AI/AN communities.

The Substance Abuse Prevention, Treatment, and Aftercare program aims to combat substance abuse in American Indian and Alaska Native populations. It focuses on enhancing care coordination, expanding culturally competent behavioral health services, and implementing early intervention strategies for at-risk youth. By supporting Tribal and community-led initiatives, the program fosters collaboration among families, youth, and community partners to create effective prevention, treatment, and recovery solutions.

The Rural Communities Opioid Response Program - Evaluation aims to assess the effectiveness of behavioral health strategies in rural settings. By developing evaluation tools and resources, this initiative seeks to empower local communities in their health initiatives, ensuring that future programs are informed by comprehensive evaluations. Funded by the Health Resources and Services Administration, the program highlights the importance of tailored approaches to address opioid-related challenges in rural areas.

The Breast Cancer Community Education Grants, funded by the Oncology Nursing Foundation through AstraZeneca HealthCare Foundation, aim to enhance breast cancer awareness through nurse-led community education programs. Grants of up to $1,000 are available to ONS Chapters in the U.S., enabling them to implement impactful educational initiatives. Eligible activities must focus on community outreach and education, fostering a broader understanding of breast cancer.

The Periodic Paralysis Grant, offered by the Patient Advocate Foundation, assists individuals diagnosed with periodic paralysis in managing out-of-pocket healthcare costs. Eligible applicants must be in treatment or planning to begin treatment for this rare muscle disease. The fund covers various expenses, including medication copays and insurance premiums, ensuring that patients can afford essential care. With a mission to empower and support patients, this grant plays a crucial role in navigating healthcare challenges.

About Patient Advocate Foundation

Patient Advocate Foundation is the nation’s most comprehensive nonprofit dedicated to helping patients navigate, access, and afford the care they need—while improving the healthcare system for all.

Who we are and our impact

Patient Advocate Foundation provides financial assistance to help patients afford treatment and cost of living needs, personalized case management to navigate complex healthcare and social needs challenges, and a wide array of resources to empower people to take charge of their health. Since our founding in 1996—and joining forces with the PAN Foundation in 2026—we have helped 3.8 million patients navigate and access care, granted over $7 billion in financial assistance, served 350,000 people through personalized case management and elevated the patient’s voice to drive improvements in the healthcare system.

Paroxysmal Nocturnal Hemoglobinuria (PNH)

Help with healthcare costs for Paroxysmal Nocturnal Hemoglobinuria (PNH)

This TotalAssist fund helps you pay for out-of-pocket healthcare costs, including medication copays, coinsurance, and deductibles, health insurance premiums, and other expenses.

About the disease

Paroxysmal Nocturnal Hemoglobinuria (PNH), also known as Marchiafava– Micheli syndrome, is a rare disease that is characterized by impaired bone marrow function and destruction of red blood cells. PNH is a rare disease that affects the circulatory system.

The U.S. Hillman Prize for Broadcast Journalism, awarded by the Sidney Hillman Foundation, recognizes outstanding journalism that serves the common good. Open to global journalists, the contest honors work accessible to U.S. audiences, with no entry limits per outlet. Winners receive a $5,000 honorarium and a certificate at a ceremony in New York City. This prestigious award highlights impactful stories across various media platforms, emphasizing the importance of journalism in addressing social issues.

The NCAA Postgraduate Scholarship for Winter Sports awards up to 126 scholarships of $10,000 annually to outstanding student-athletes who excel both academically and athletically. Eligible candidates are in their final year of NCAA competition and must have a minimum GPA of 3.2. The scholarships are available for men and women in various winter sports and are intended for use in accredited graduate programs, emphasizing the importance of academic achievement and community involvement.

The Hyperkalemia Grant, provided by the Patient Advocate Foundation, offers crucial financial assistance to patients struggling with hyperkalemia. This grant covers out-of-pocket healthcare costs, including medication copays and health insurance premiums. Eligible applicants must have a confirmed diagnosis and meet specific income and residency requirements. Since its inception, the foundation has supported millions of patients, ensuring they can access the necessary treatment and resources for their health needs.

The Hypercholesterolemia Grant by the Patient Advocate Foundation offers financial assistance to individuals diagnosed with hypercholesterolemia, helping cover out-of-pocket healthcare costs such as medication copays and insurance premiums. This nonprofit aims to improve patient access to necessary care while supporting over 3.8 million patients since its inception. Eligible applicants must have health insurance and meet specific income requirements to receive assistance in managing their healthcare expenses effectively.

The LEGO Foundation Fellowship

Advancing the science and practice of supporting children to thrive

The LEGO Foundation Fellowship is a global initiative supporting researchers working to deepen our understanding of how children thrive. Spanning disciplines from education and psychology to public health, data science, and humanitarian studies, the fellowship brings together early- and mid-career scholars whose work has the potential to generate evidence that matters for children’s lives.

Fellows receive three years of flexible support to pursue rigorous, practically relevant research, and join a cohort of peers working across the fellowship’s themes. In addition to funding research, the program fosters a community of scholars engaged in meaningful exchange with one another and with research, policy, and practice audiences.

The LEGO Foundation Fellowship is developed in partnership with the LEGO Foundation, and administered by SSRC as part of its commitment to supporting scholars whose work bridges research and real-world impact.

Research themes

The LEGO Foundation Fellowship welcomes research proposals that advance understanding of children’s thriving through one of the following three themes: the youngest children in crisis and conflict settings; inclusion and wellbeing of neurodivergent children; and children’s learning and development in an AI-enabled world. Applicants may explore the role of play where it is relevant to the research question. The consideration of play is optional and not a condition of eligibility.

The Limited Competition: Clinical and Translational Science Award (CTSA) Program's Collaborative and Innovative Acceleration Award aims to enhance translational research by fostering collaboration in developing and implementing innovative solutions. This funding opportunity invites applications focused on new approaches and technologies that will improve research impact across various diseases and expedite treatment availability. Eligible applicants include organizations with active CTSA hub prime or partnering awards.

Fall 2026 Early Childhood Education Funding Cycle

Overall Early Childhood Education Program Blueprint

The Stranahan Foundation’s Early Childhood Education grant program supports efforts to improve access to high-quality early care and education for young children (birth to five), especially those from low-income families. We do this by investing in strategies that strengthen, support, and retain a high-quality, thriving early educator workforce.

The Foundation has a history of supporting professional development (PD) and learning systems through its Provider strategy (). We believe strong professional development systems are essential for building a skilled early childhood workforce and creating positive learning environments for young children.

The Fall 2026 funding cycle is available for organizations that align with this Provider strategy.

Funding Opportunity

This funding opportunity will provide up to $750,000 to support early childhood education providers in strengthening existing professional development (PD) systems. Funding is intended to improve a specific area of an established PD system—not to build a brand-new system from scratch or put the foundational elements in place.

What kind of improvements can funding support?

Organizations should focus their projects on strengthening their professional development systems. The Stranahan Foundation defines a strong professional development system as one that includes:

• Connect learning opportunities that build on one another over time.
• Use adult learning best practices.
• Align staff learning to educator competencies, credentials, career growth, or compensation.
• Provide learning experiences that are individualized, scaffolded, and responsive to educators’ needs, experience, and goals.
• Have dedicated leadership and organizational capacity to support ongoing implementation.

• Gather regular feedback from staff and families.
• Use standardized assessment and evaluation tools to understand what is working and where improvements are needed.
• Make ongoing improvements based on what is learned.
• Support reflective practice, peer learning, and collaborative inquiry among educators.

• Offer both individual and group learning opportunities, such as training, professional learning communities, coaching, and mentoring.
• Provide learning opportunities on an ongoing basis rather than in a one-and-done situation.
• Connect internal and external learning opportunities to make the best use of available resources.
• Support classroom implementation through observation, modeling, feedback, and continuous improvement cycles.

• Provide learning experiences that are practical, relevant, and easy to apply in daily work.
• Include fundamental topics such as family engagement, effective instruction, developmentally appropriate practice, and classroom management.
• Align with established standards, research, and effective practices in the early childhood field.
• Equip educators to support all learners, including multilingual learners, children with disabilities, and children impacted by trauma or adverse experiences.

About Us

advancing the science of water ®

Who We Are

The Water Research Foundation (WRF) is the leading research organization advancing the science of all water to meet the evolving needs of its subscribers and the water sector. WRF is a 501(c)(3) nonprofit, educational organization that funds, manages, and publishes research on the technology, operation, and management of drinking water, wastewater, reuse, and stormwater systems—all in pursuit of ensuring water quality and improving water services to the public.

5413 - Comparison of PFAS Contributions to Agricultural Systems

Grant Information

• Report per- and polyfluoroalkyl substance (PFAS) concentrations from a variety of agricultural inputs, including animal manures, fertilizers, pesticides, composts, soil amendments, seed coatings, and biosolids-based products.
• Compare the impact of the various agricultural inputs on PFAS concentration in the soil profile over varying timeframes.
• Evaluate the fate and transport of different inputs to PFAS contributions in agricultural systems at field-scale.
• Determine the relative contributions from biosolids-based products and other inputs to help develop and prioritize risk management strategies.

The ScotiaRISE initiative by Scotiabank aims to foster economic resilience among disadvantaged groups over ten years, with a budget of $500 million. By focusing on enhancing educational opportunities, facilitating employment for newcomers, and removing barriers to career advancement, ScotiaRISE seeks to create a more inclusive society. This program highlights the importance of collective efforts in supporting individuals and communities to thrive, ensuring everyone has the chance to rise above challenges and contribute positively to their environments.

The Herbek Humanitarian Award honors a CAP member pathologist for significant contributions to the See, Test & Treat® program, which offers free cancer screenings to underserved women. Established in 2011, it commemorates Gene N. Herbek, MD, FCAP, who pioneered this initiative for Native Americans. Nominees must have led or significantly contributed to the program, with submissions due by May 3, 2024. Self-nominations or incomplete entries will not be accepted, ensuring high standards in recognition.

The Alkermes Pathways Research Awards program aims to foster research in neuroscience, specifically targeting schizophrenia and bipolar disorder. With grants up to $100,000, it supports early-career investigators exploring critical areas, including sleep and circadian disturbances related to these conditions. This initiative addresses the urgent need for innovative solutions in mental health research, empowering the next generation of scientists to make impactful contributions in understanding and treating these complex disorders.

The ABPN Dorthea Juul, PhD, Education Research Award offers up to $100,000 for research projects aligned with the ABPN's mission of enhancing lifelong learning and certification standards for psychiatrists and neurologists. Two awards each in psychiatry and neurology are available annually, with projects lasting up to two years. Eligible applicants must hold faculty appointments or have confirmed offers, comply with conflict of interest policies, and, if MDs or DOs, maintain ABPN certification and licensure.

The National Parks Business Plan Internship aims to enhance the operational health of national parks through a graduate-level program that trains students in business management and NPS operations. Participants will engage in substantive analysis, gain insights into park management, and promote federal careers in conservation. This initiative seeks to involve underrepresented graduate students from disciplines such as business administration and public policy, fostering a commitment to stewardship of public lands.

BAE Systems offers community investment grants aimed at enhancing the well-being of military families and supporting future workforce development in STEM fields. As a U.S. subsidiary of a global defense and aerospace leader, they require applicants to be recognized 501(c) organizations. The initiative underscores a commitment to charitable partnerships that uplift local communities and contribute positively to society.

The Heiser Program for Research in Leprosy, established by Dr. Victor G. Heiser, focuses on innovative biomedical research to combat leprosy. Since 1975, it has funded over 200 grants totaling more than $20 million, supporting early-career researchers and significant projects. The program aims to enhance diagnostic tools, improve treatments, and implement effective surveillance strategies. With a dedicated Scientific Advisory Committee, it ensures rigorous proposal reviews and fosters collaboration among grantees, ultimately advancing leprosy elimination efforts.

The National Breastfeeding Support Initiative aims to enhance maternity care quality by engaging diverse partners and providing training to healthcare organizations. It focuses on implementing evidence-based practices to support breastfeeding, ensuring safe and effective maternity care in hospitals across the U.S. and territories. By fostering collaboration and utilizing data for quality improvement, the initiative seeks to create a sustainable impact on maternal and infant health.

The BJA FY 2026 Tribal Justice Training and Technical Assistance Program aims to enhance Tribal justice systems through specialized technical support. This funding opportunity addresses critical issues such as violent crime and substance-use related crime, including opioids. By assisting federally recognized Indian Tribes, the program promotes the development of sustainable legal and corrections infrastructure while fostering collaboration with federal, state, and local partners. Applications are due by October 28, 2026, at 8:59 p.m. ET.

The Harry Sudakoff Foundation Grant supports qualified charities in Sarasota, Florida, focusing on arts, community, education for youth, environment, human services, and science. Established by builder Harry Sudakoff, the foundation prioritizes organizations with a history of support. Grants are restricted to 501(c)(3) entities, excluding individuals and certain funding types like endowments and operating expenses. A commitment to impactful contributions is central to the foundation's mission.

The National Institute of Allergy and Infectious Diseases (NIAID) is advancing Type 1 diabetes research by exploring the innate immune system's role in disease onset. This initiative aims to identify genetic and environmental factors contributing to Type 1 diabetes through multidisciplinary teams. By employing innovative methodologies, the program seeks to determine how immune responses affect pancreatic tissues, potentially leading to early detection and prevention strategies for at-risk individuals.

The TIRBEE funding opportunity supports federally-recognized Tribes and Tribal Entities in establishing or enhancing Institutional Review Boards. This initiative aims to strengthen the capacity for biomedical research involving human participants within these communities by improving review and oversight capabilities. Eligible organizations are invited to apply, with applications subject to NIH's standard peer-review process to ensure only the most meritorious proposals are considered.

Disabled Veterans National Foundation

The Disabled Veterans National Foundation (DVNF) was established in 2007 to support veterans facing challenges that traditional systems could not fully address. From its earliest days, DVNF has been focused on closing critical gaps in care and providing resources that help veterans rebuild their lives with dignity and stability.

Guided by this commitment, DVNF developed its Health & Comfort programs, offering emergency financial assistance, housing transition support, food assistance, comfort kits, and wellness initiatives. These programs are designed to meet veterans where they are and to provide practical solutions that restore hope and stability. Today, DVNF continues to grow as a trusted national nonprofit. Every day, our team works with a clear purpose: to change lives for the men and women who have served our country.

Veterans Food Assistance Program

It is our goal to ensure that no veteran goes hungry by providing essential food assistance and household support, fostering stability and well-being in the lives of our veterans and their families.

The Veterans Food Assistance Program (VFAP) is designed to provide a one-time grant of essential food and household support to veterans and their families, ensuring no veteran goes hungry. With the rising cost of living, especially food prices due to inflation, this program offers a much-needed lifeline to those who have served our country. Once approved, the DVNF program team will handle the shopping for you.

The Veterans Food Assistance Program provides a one-time grant per household to support different family sizes, given the rising cost of food:

• Married Veterans Grant Allowance
  • Married - No Children up to $250
  • Married - 1 Child up to $300
  • Married - 2 Children up to $450
  • Married - 3+ Children up to $500
• Single Veterans Grant Allowance
  • Single - No Children up to $200
  • Single - 1 Child up to $300
  • Single - 2 Children up to $350
  • Single - 3+ Children up to $450