Best Unrestricted Grants for Nonprofits in South Carolina

The Incubator Grant, offered by the Society of Interventional Radiology Foundation, supports projects that enhance interventional radiology through clinical research. Eligible applicants must be SIR members and hold relevant degrees. The grant provides funding up to $25,000 for one year, specifically for developing clinical study protocols and proposals. This initiative emphasizes inclusivity and encourages innovative approaches in patient care, aligning with the foundation's mission to advance the specialty and improve patient outcomes.

The Laine - Casey Laine Armed Services Scholarship, established to honor Lieutenant Casey Laine Swakon, supports students from the Coastal Bend area who have participated in JROTC or are part of ROTC programs. Eligible candidates include high school seniors, current college students, and veterans. Applicants must maintain a minimum GPA of 2.5 and complete at least 12 credit hours per semester, ensuring they are well-prepared for their academic pursuits.

The SABIC Innovative Plastics Scholarship supports the children of employees at the Mt. Vernon, Indiana facility, providing financial aid for post-secondary education. Eligible students include graduating seniors from any U.S. high school who are dependents of active employees. Selection is based on academic performance, leadership, and community involvement. Applicants must also submit an essay detailing their goals and achievements, along with an official grade transcript. This scholarship fosters educational advancement for employee families.

Friends of NRA

Friends of NRA is the National Rifle Association’s premier fundraising program, supporting the future of shooting sports. Since day one, Friends of NRA has been a 100% grassroots effort fueled by a united front to secure the Second Amendment and raise money for the shooting sports.

Committee volunteers are appointed to State Fund Committees to make recommendations for local grant funding in areas such as youth education, women-focused clinics, law enforcement training, hunter safety, range improvement, firearms and marksmanship training and safety. Recognizing the impact American youth has on the future of the shooting sports, State Fund Committees frequently recommend grants for youth programs, allocating the most significant portion of monies to this vital area.

Grant awards fund activities and support programs in the United States to promote firearms and hunting safety, to enhance marksmanship skills of those in the shooting sports, and to educate the public about firearms in their historic, technological and artistic context.

Friends of NRA: Capital Improvement Grants

Any request to support a project that seeks to improve a facility is considered a capital improvement. This includes, but is not limited to:

• Range improvements
• Berm improvements
• Clubhouse/Classroom facility improvements
• Shelter structures/covered firing lines/pavilions
• Road improvements
• Commercial-grade trap machines (see section regarding trap machines, below)
• Any other permanent improvement to an organization’s property or facility

The Grant Program considers requests for certain trap machines to be a capital improvement to the facility. Specifically, requests for commercial grade trap machines that have a capacity of 300 clays and up.

Joseph G Markoly Foundation Inc

When Joseph Markoly originally established the foundation more than thirty years ago, its focus was on Alzheimer’s and heart disease support, funded through a number of the larger national disease-related organizations. Over time the focus has shifted to helping small to mid-size organizations in our local communities which support children and seniors in a variety of effective ways. 

Markoly Foundation was established in honor of Joseph G. Markoly, an entrepreneur and philanthropist who wanted to make a positive impact in people’s lives. Joseph’s family was affected directly by both Alzheimer’s and heart disease having lost a family member to each condition. For that reason, the foundation dedicates a majority of their resources to providing grants to organizations that focus on the treatment of each of these diseases. In addition, Markoly Foundation supports a variety of programs dedicated to helping children and seniors by providing services, supplies, programs and research in areas impacting these demographics.

Joseph G. Markoly Foundation Grant Support for Children’s Organizations

Children are the future of this world and the Markoly Foundation is proud to fund local programs dedicated to improving the lives of children and their families. From providing vision services for school kids to classes on parenting, we are proud to do our part to help fund critical community programs for families.

We are dedicated to providing funding for local nonprofit programs that improve the quality of life for all, but particularly for the children and elders in our community.

The LUNGevity Career Development Award supports emerging research leaders focused on lung cancer. It funds innovative projects aimed at enhancing early detection and personalized treatments, including targeted therapies and immunotherapy. With a maximum award of $300,000 over three years, this opportunity is limited to US applicants. The funding is contingent upon annual progress reviews, with the first payment expected after November 1, 2025. This award aims to foster groundbreaking advancements in lung cancer research.

Myasthenia Gravis Rare Disease Network (MGNet)

The Myasthenia Gravis Rare Disease Network (MGNet) is a consortium of academic medical centers partnering with the Myasthenia Gravis Foundation of America and Conquer MG as well as collaborators in other research groups and industry. We are working together to enhance therapeutic development for this rare disease.

Diseases Studied

Myasthenia Gravis (MG) and its subtypes:

• Early-onset acetylcholine receptor (AChR) antibody (Ab) positive MG, which primarily affects women
• Late-onset AChR Ab positive MG with a disease bias towards men
• Paraneoplastic thymoma-associated MG
• Muscle specific kinase (MuSK) Ab positive
• AChR/MuSK antibody negative MG

Goals, Mission, & Vision

The goal of MGNet is to advance therapeutic development. To do so we have four specific aims:

• Improve the tools scientists and doctors have for performing clinical trials through rigorous monitoring of patients over time and evaluate better measures of how patients are doing.
• Identify objective measures (biomarkers) to show how the disease is responding to treatment and better predict treatment response or side effects, to improve the design of clinical trials and care of patients in clinical practice.
• Enhance the education of young investigators focusing their careers on rare diseases and specifically MG.
• Improve the awareness of scientists, physicians, and the public regarding the unique needs of patients with MG through training of clinician scientists and engagement of the patient and scientific communities in clinical research and therapeutic development.

Scholar Awards

Objectives

There is a critical need for investigators prepared to conduct clinical and translational research in myasthenia gravis (MG). The MGNet Scholar Program provides individualized training and mentorship in one of two tracks, Clinical Research or Biomarker Development Research.

Award Description

The MGNet Scholar Program provides mentored research training to prepare Scholars for an independent research career in the field of MG. The MGNet Scholar Program is 1 year in duration and selected Scholars receive up to $100,000 to support salary, research costs and didactics with potential for renewal. The program will provide an additional $3,000 to travel to MGNet sites to learn specific skills and/or to scientific meeting(s) to present the results of their research. If available for renewal, the program requires approval after interim report and is contingent on demonstration of adequate progress on the research and career development plan. Indirect costs are not allowed. Scholars are encouraged to transition to NIH (e.g., K award), departmental, or private foundation support for their research and further career development.Research must constitute at least 50% of each Scholar’s professional effort. Each Scholar must form a 2-3-member advisory committee to include a primary mentor, an additional clinician investigator or collaborator, and a MGNet faculty sponsor. The advisory committee will meet with the Scholar at least quarterly to review progress and each Scholar will develop an individual academic career development plan and renew it with the committee at least every 6 months.

About Pfizer Grants

Pfizer supports the global healthcare community’s independent initiatives (e.g., research, quality improvement or education) to improve patient outcomes in areas of unmet medical need that are aligned with Pfizer’s medical and/or scientific strategies.

Pre-clinical Investigation of anti-TFPI-mediated Rebalancing Mechanisms in Non-Hemophilic Bleeding Disorders

There remains a scientific gap in understanding of the role of anti-TFPImediated hemostatic rebalancing in the context of inherited or non-hemophilic bleeding disorders. This competitive grant program encourages competitive submissions focsed on generating preclinical/foundational data exploring the therapeutic potential and mechanisms of TFPI modulation in bleeding disorders other than hemophilia.

Project Types and Area of Interest

Potential applicants are encouraged to identify and address preclinical/basic science data generation for TFPI modulation/rebalancing in their local setting. This may include:

• Rare bleeding disorders which arise from deficiencies in different clotting factors or pathway components but converge on a common functional endpoint which is an impaired thrombin generation (e.g., Factor II, Factor V, Factor VII, Factor X and Factor XI deficiencies, as well as von Willebrand disease).
• Other diseases such as Glanzmann's thrombasthenia (GT) that have a distinct pathophysiological mechanism.
• Other rare bleeding disorders whose mechanisms are not well understood (e.g., Bleeding Disorder of Unknown Cause, BDUC).

The AGA-R. Robert & Sally Funderburg Research Award in Gastric Cancer aims to support established investigators in gastric cancer research. This award focuses on enhancing the understanding of gastric cancer pathobiology and developing strategies for prevention, treatment, and cure. Eligibility includes holding an MD or PhD, with specific experience requirements. The American Gastroenterological Association encourages applications, particularly from underrepresented groups in biomedical research, to foster diversity in the field.

The Health Equity Innovation Award (U01) aims to support innovative research that enhances minority health and health equity. Key areas include promoting diversity in clinical trials, improving data visibility for underrepresented groups, and amplifying diverse patient perspectives. This initiative, funded by the US Department of Health and Human Services' FDA, seeks to ensure equitable health outcomes and address unmet needs within varied populations.

Marion Community Foundation

Since 1998, area residents have been turning to Marion Community Foundation to make their philanthropic giving as effective as possible. We are a public charity serving thousands of people who share a common concern … improving the quality of life in Marion County. We use distributions from the more than 500 charitable funds — created by generous, local donors — to award more than $2.5 million in grants and scholarships each year to many of the humanitarian, educational and cultural organizations in this remarkable community we call home.

Marion Community Foundation is the area’s leading philanthropic organization, providing charitable donors the opportunity to easily create endowment funds to benefit and support our community through grants and scholarships. We serve communities throughout Marion County through philanthropy, leadership, and civic engagement.

Marion Rotary Club’s Karl W. Schell Scholarship

The Marion Rotary Club was chartered in 1922, as club number 1051, with 23 charter members led by Fred Guthery, the first president. The Marion Rotary Club, along with the Marion Rotary Foundation, which was incorporated in 1959, has contributed to many organizations and scholarships over the years.

The Marion Rotary Club Karl W. Schell Scholarship migrated to Marion Community Foundation in 2017. It honors the late Karl Schell and provides financial support for Marion County graduating seniors. Recipients will have been a resident of Marion County for at least two full years and maintain a cumulative grade point average of 2.5 or higher based on a 4.0 scale.

Special consideration will be given to applicants who intend to pursue an education and career in, or related to, business, management, or the real estate industry.

Agog Open Call: Climate Futures + Immersive Media

This open call supports immersive media projects that help people better understand and respond to climate challenges and imagine what a better world could be.

We are looking for projects that use immersive technologies—including smart glasses, augmented reality, spatial sound, and mixed reality—to create more engaging, experiential forms of climate storytelling and civic participation.

The open call will support projects across a range of stages and formats, from early ideas to more developed work. What matters most is a compelling story or experience, a clear sense of purpose, and a thoughtful approach to bringing the work to life.

Grants may be awarded in denominations ranging from $25,000 to $200,000. In addition to funding, selected projects may receive mentorship, advisor support, and opportunities for partnership and distribution.

The K–12 Educators Grants in American Music, offered by the American Musicological Society, provides $500 awards to K-12 educators with an interest in American music to attend the Teaching Music History Conference. This grant supports educators in engaging with historical pedagogy through workshops and networking opportunities. Participants will explore American music's significance while developing actionable lesson plans, fostering connections among educators and researchers committed to enhancing music education.

The APSF/FAER Mentored Research Training Grant aims to enhance anesthesia patient safety by funding promising anesthesiologists who are within 10 years of their first faculty appointment. This two-year grant, totaling $300,000, supports the development of independent researchers focused on perioperative safety. Recipients must allocate 60% of their time to research and career development. With this initiative, the APSF and FAER seek to cultivate the next generation of safety scientists in anesthesia.

Marion Community Foundation

Since 1998, area residents have been turning to Marion Community Foundation to make their philanthropic giving as effective as possible. We are a public charity serving thousands of people who share a common concern … improving the quality of life in Marion County. We use distributions from the more than 500 charitable funds — created by generous, local donors — to award more than $2.5 million in grants and scholarships each year to many of the humanitarian, educational and cultural organizations in this remarkable community we call home.

Marion Community Foundation is the area’s leading philanthropic organization, providing charitable donors the opportunity to easily create endowment funds to benefit and support our community through grants and scholarships. We serve communities throughout Marion County through philanthropy, leadership, and civic engagement.

Marion Rotary Club’s George Brown Scholarship

The Marion Rotary Club was chartered in 1922, as club number 1051, with 23 charter members led by Fred Guthery, the first president. The Marion Rotary Club, along with the Marion Rotary Foundation, which was incorporated in 1959, has contributed to many organizations and scholarships over the years.

The Marion Rotary Club George K. Brown Scholarship was created in 2020. It honors the late George K. Brown, philanthropist, businessman, and a member of one of Marion’s founding families. His scholarship provides financial support for Marion County graduating seniors who have been a resident of Marion County for at least two full years and maintain a cumulative grade point average of 2.5 or higher on a 4.0 scale. Special consideration will be given to applicants who intend to pursue an education and career in or related to business or management.

The REACHing Communities (REACH) Consortium (U01) Clinical Trials Optional grant aims to advance health equity among racial and ethnic minorities through cooperative agreements. It focuses on research, outreach, and mentoring diverse students and researchers. Although the grant information has not been updated in over six months, it remains under observation for potential updates. The initiative is part of the FDA Office of Minority Health and Health Equity's commitment to improving minority health.

The ChemClub Student Scholarship, offered by the American Chemical Society and the American Association of Chemistry Teachers, supports high school seniors who are active members of a Chartered ChemClub. Eligible students must demonstrate academic excellence and express their commitment to STEM fields. This scholarship provides financial assistance directly to the recipient's chosen college, fostering future leaders in chemistry and related disciplines.

Marion Community Foundation

Since 1998, area residents have been turning to Marion Community Foundation to make their philanthropic giving as effective as possible. We are a public charity serving thousands of people who share a common concern … improving the quality of life in Marion County. We use distributions from the more than 500 charitable funds — created by generous, local donors — to award more than $2.5 million in grants and scholarships each year to many of the humanitarian, educational and cultural organizations in this remarkable community we call home.

Marion Community Foundation is the area’s leading philanthropic organization, providing charitable donors the opportunity to easily create endowment funds to benefit and support our community through grants and scholarships. We serve communities throughout Marion County through philanthropy, leadership, and civic engagement.

Kent A. & Diana C. Morgan Family Scholarship

The Kent A. & Diana C. Morgan Family Scholarship Fund was established in 2019 as a legacy fund. It will provide scholarships for Marion County high school seniors and graduates pursuing a degree in the field of education, with special consideration given to applicants who demonstrate, through the applicant’s application, extraordinary financial need.

The Alzheimer’s Association Research Grant For All (AARGA) Program supports early-career investigators in their first seven years as independent researchers. This grant aims to fund projects that develop preliminary data and test new hypotheses in Alzheimer’s and related dementia research. Areas of interest include disease mechanisms, biomarker development, and health equity. Applications are welcome from both U.S. and international researchers, fostering innovation and collaboration in the fight against dementia.

The MNAF Linda Knauff Clinical Practice Project Grant supports Minnesota Nurses Association members in conducting research that aligns with MNA's organizational goals. It promotes best practices through literature reviews, workgroup convening, policy development, and quality improvement initiatives. Applicants must be MNA members engaged in direct patient care, complete their projects within two years, and submit periodic reports. Preference is given to first-time applicants whose projects meet quality standards.

The AAD Shade Structure Grant Program provides funding up to $8,000 for non-profit organizations and public schools to install shade structures, promoting sun safety for children and teenagers. Applicants must demonstrate a commitment to sun safety, including a year-long awareness program, and submit a letter of recommendation from an AAD dermatologist. The program aims to enhance outdoor safety, supported by donations from members and organizations.

The Beacon Scholarship for Rural America, sponsored by Carrot-Top Industries, Inc., offers $1,000 scholarships to support low-income students from rural areas pursuing higher education. Eligible applicants must be graduating high school seniors, current college students, or adult learners with a GPA of 3.0 or higher, and reside in a rural area. The scholarship aims to empower students by alleviating financial burdens as they enroll in accredited college programs.

Accelerating the Development of Combined CGM–Pump Devices

A combined continuous glucose monitor (CGM) and insulin pump device represents an innovative approach to simplifying diabetes management by integrating two essential technologies into a single device. This approach has the potential to improve quality of life for people with type 1 diabetes (T1D) by reducing the burden associated with wearing and managing multiple devices.

Despite this promise, the development of combined CGM–pump devices presents technical and commercialization challenges. These include the need for further advances in device compatibility and lifespan, system reliability, and scalable manufacturing, while maintaining affordability and broadaccessibility. In addition, a potential insulin dilution effect may require adjustment of the CGM algorithm.

Breakthrough T1D invites applications for research and development projects that address key technical, clinical, and translational challenges related to combined CGM–pump devices, with the goal of accelerating their development and improving outcomes for people living with T1D.

In response to this announcement, applications may request up to a total of $900,000 USD for up to three years. 

The David Perlman Award for Excellence in Science Journalism recognizes outstanding work in science news reporting. Established in 2000, this annual award honors journalists who make Earth and space science accessible to the public. Recipients receive a $5,000 prize, an engraved award, and recognition at AGU's annual meeting. Eligible nominees include journalists from any medium, excluding books, who have not won the award in the past two years. The award encourages diverse representation in science journalism.

The Path to a Cure — Collaborative Research Grant, offered by the Cystic Fibrosis Foundation, aims to support research in developing new therapies for cystic fibrosis, particularly focusing on CFTR gene repair and replacement strategies. This program prioritizes collaborations that integrate new investigators and innovative technologies into CF research. Applicants can request up to $1,000,000 annually for three years, with proposals requiring preliminary data to demonstrate feasibility and potential impact.

About PLTW EngineeringPLTW Engineering students adopt a problem-solving mindset, are engaged in compelling, real-world challenges that help them become better collaborators and thinkers, and are prepared with skills to step into any career path they take.3M has partnered with PLTW to ensure students and teachers have the tools, resources and knowledge they need to succeed in STEM. 3M inspires the next generation of science leaders through the following goals:

• Increasing STEM exposure in K-12 classrooms
• Supporting experiential learning opportunitiesEnhancing the quality of STEM teaching
• Providing professional development opportunities for students

Program Requirements:

• Grantee must use their grant funds to expand their existing PLTW Engineering program.
  • Example expansion activities include but are not limited to adding an additional PLTW Engineering course not previously offered,
  • and/or adding additional class periods of an existing PLTW Engineering courses previously offered,
  • and/or training additional teachers in PLTW Engineering courses for the 2027-2028 academic year. 

Grant Award and Distribution Schedule:

• Total Award: $10,000
  • 2027-2028: $10,000

The Willis C. Helm Charitable Trust, established in 1954, focuses on supporting organizations that work on juvenile delinquency and the development of boys from broken homes. It provides annual grants averaging between $5,000 and $15,000, with a total giving of around $60,000 for five grants each year. Eligible organizations must be 501(c)(3) exempt and preferably located in Minnesota. Applications are accepted year-round, with a deadline of March 31 for annual review.