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Best Grants for 501(c)(3) in South Dakota

Find the perfect Grants for 501(c)(3) in South Dakota on Instrumentl. 9,000+ Grants for 501(c)(3) in South Dakota in the United States.

9,000+

Available grants

$2.62B

Total funding

$5K

Median grant

9,000+ grants
$2.62B total
$5K median

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9,210 Results based on applied filters

See, Test & Treat Grants

College Of American Pathologists Foundation
Private
United States
US $8,000 - US $50,000
The See, Test & Treat Grants, offered by the College of American Pathologists Foundation, aim to enhance community health by providing free breast and cervical cancer screenings. Since 2011, nearly 9,000 women have benefited from these programs, which will expand in 2026 to reach more underserved populations. This initiative empowers pathologists to reduce healthcare disparities through accessible screenings and follow-up care, ensuring prompt results and comprehensive health education for participants.
Breast Cancer Preventative Healthcare Gynecological Cancers

Development of Medications to Prevent and Treat Substance Use Disorders and Overdose (UG3/UH3 - Clinical Trial Optional) (358937)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $3,000,000
This NOFO invites applications for innovative research aimed at developing and implementing interventions to prevent and treat substance use disorders (SUDs) and overdose. It encourages studies that can rapidly advance candidate solutions towards regulatory approval or clinical use, while also addressing co-morbid SUDs. The initiative supports a wide range of research including basic, clinical, translational, and implementation strategies to tackle drug misuse and related health issues, such as HIV/AIDS.
Pharmacology Addiction & Substance Use Disorders Drug Use Disorder

Dell Scholars Program

Michael & Susan Dell Foundation
Private
United States
Unspecified amount
The Dell Scholars Program, established by the Michael & Susan Dell Foundation, provides scholarships and support to empower students in their journey towards college graduation. It offers flexible funding for tuition, housing, and essential expenses, ensuring students can focus on their education. Alongside financial aid, scholars receive academic coaching, career guidance, and mental health resources, fostering resilience and success. Since 2004, it has helped over 6,000 scholars, including 4,500 graduates, achieve their academic goals.
Mental Health & Psychiatric Diseases Career / College Preparation Financial Literacy +3 more

Aerie Real Foundation: Community Grant

The Aerie Real Foundation
Corporate
Canada, United States
Up to US $10,000
The Aerie Real Foundation™ Community Grant aims to enhance confidence, inclusion, and sustainability among young women while supporting non-profit organizations in the US and Canada. Grants of up to $10,000 are available to programs focused on mental well-being, fostering inclusive communities, and environmental protection. Applications are accepted from certified 501c3 nonprofits, with funding allocated for projects that align with the Foundation's mission. The goal is to empower the next generation and create a positive impact in local communities.
Women & Girl Services Environmental Conservation Environmental Stewardship +2 more

Medication Therapy Management (MTM) Initiative Grant

National Association of Free and Charitable Clinics Inc
Private
United States
US $30,000

NAFC Open Grant/Product Donation Applications

The National Association of Free and Charitable Clinics (NAFC) is the only nonprofit 501c(3) organization whose mission is solely focused on the issues and needs of the medically underserved throughout the nation and the more than 1,400 Free and Charitable Clinics that serve them. The NAFC has earned the Platinum Seal of Transparency from GuideStar and a 4-Star rating from Charity Navigator. Founded in 2001 and headquartered near Washington, D.C., the NAFC is working to ensure that the medically underserved have access to affordable quality healthcare and strives to be a national voice promoting quality healthcare for all. For more information about the NAFC, including how to become a member, please visit https://www.nafcclinics.org.

Medication Therapy Management (MTM) Initiative

The Medication Therapy Management (MTM) Initiative, supported by the McKesson Foundation and administered by the NAFC, aims to improve medication access, adherence, and patient understanding among uninsured and medically underserved populations. Individuals without health insurance often face significant barriers to obtaining prescription medications and receiving the counseling necessary to manage chronic conditions effectively. Through this initiative, NAFC will provide $30,000 grants to member free and charitable clinics and pharmacies to establish or expand Medication Therapy Management programs aligned with recommendations from the American Pharmacists Association. Funding will support activities such as staff certification in MTM, development of standardized protocols, and patient education to help individuals better understand their medications, manage side effects, and support overall treatment plans. By strengthening pharmacist-led care and improving communication between providers and patients, this initiative seeks to enhance medication adherence, improve chronic disease management, and advance better health outcomes for vulnerable patient populations.

Chronic Illnesses Patient Care & Services Health Care Access & Delivery +3 more

Mumford & Keller Grant and Scholarship Program

Indiana Audubon Society Inc.
Private
United States
US $500 - US $5,000
The Mumford & Keller Grant and Scholarship Program, initiated by Indiana Audubon in 2010, offers financial support for projects focusing on natural resources and Indiana's birdlife. With grants ranging from $500 to $5,000, it aims to promote conservation, research, and education. Priority is given to initiatives targeting key species and habitats within Indiana. This program honors the legacy of Russell Mumford and Charles Keller, enhancing bird conservation efforts for future generations.
Ornithology Ornithological Conservation

The Kadel & Gerhardt Internships

Point Foundation
Private
United States
Up to US $7,000
The Kadel & Gerhardt Internships, funded by the Point Foundation, aim to enhance the representation of LGBTQ+ individuals in HIV/AIDS research and advocacy. These internships support academically talented students pursuing unpaid opportunities in the summer of 2025, addressing the critical need for culturally competent care within the community. By investing in future leaders, the program seeks to combat the stigma surrounding HIV and increase access to essential services for those affected.
HIV / AIDS Sexuality & LGBTQIA+ Rights

Ornis Birding x Lost Birds Expedition Grant

Ornis Birding Expeditions
Corporate
Africa, Asia +3 more
Up to US $5,000
The Ornis Birding x Lost Birds Expedition Grant aims to inspire skilled young birders, aged 18-30, to explore remote regions and rediscover species that have evaded scientific detection for over a decade. Funded by Ornis Birding Expeditions, this grant offers up to $5,000 for innovative expeditions, encouraging participants to submit detailed observations and engage with local communities. The initiative seeks to fill critical gaps in ornithological knowledge while promoting conservation and ecotourism.
Ornithology Adventure Travel & Expeditions

Blake-Nuttall Fund Grants

Nuttall Ornithological Club Inc
Private
United States
US $1,000 - US $5,000
The Blake-Nuttall Fund Grants, offered by the Nuttall Ornithological Club Inc, support vital ornithological research, conservation, and education efforts focused on the birds of New England and the Northeast. Eligible organizations must be tax-exempt under section 501(c)(3) of the Internal Revenue Code, while applications from individuals or private foundations are not considered. This initiative aims to foster a deeper understanding and protection of avian species in the region.
Ornithological Conservation Ornithology

Forecast to Publish a Funding Opportunity Announcement for Copy of Integrative Neuroscience Initiative on Alcoholism (INIA) Consortia Research Resource (U24) (Clinical Trial Optional)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The NIAAA Integrative Neuroscience Initiative on Alcoholism (INIA) aims to renew support for two research consortia focusing on the biological mechanisms of excessive alcohol consumption and Alcohol Use Disorder (AUD). By utilizing advanced technologies and fostering collaboration across multiple sites, this initiative seeks to standardize neurofunctional measures and enhance reproducibility in findings. Investigators are encouraged to prepare for future applications to this NOFO, which will utilize the U24 activity code.
Neuroscience Alcoholism

NAFC Capacity Fund

National Association of Free and Charitable Clinics Inc
Private
United States
US $20,000 - US $30,000

NAFC Open Grant/Product Donation Applications

The National Association of Free and Charitable Clinics (NAFC) is the only nonprofit 501c(3) organization whose mission is solely focused on the issues and needs of the medically underserved throughout the nation and the more than 1,400 Free and Charitable Clinics that serve them. The NAFC has earned the Platinum Seal of Transparency from GuideStar and a 4-Star rating from Charity Navigator. Founded in 2001 and headquartered near Washington, D.C., the NAFC is working to ensure that the medically underserved have access to affordable quality healthcare and strives to be a national voice promoting quality healthcare for all. For more information about the NAFC, including how to become a member, please visit https://www.nafcclinics.org.

NAFC Capacity Fund

The NAFC Capacity Fund supports investments that strengthen clinic and pharmacy infrastructure and organizational effectiveness. This funding is designed to help NAFC members build the systems, tools, and capabilities needed to operate more efficiently, improve quality, and expand their ability to serve patients over time.

Medical Education & Professional Training Telemedicine & Telehealth Health Facilities & Clinics +2 more

Physician of Tomorrow Scholarships: Lazarus Family Scholarship in Bioethics and Humanities

American Medical Association Foundation
Private
United States
US $10,000
The Lazarus Family Scholarship in Bioethics and Humanities, offered by the AMA Foundation, supports students engaged in bioethics or the humanities, including art, music, and literature. This scholarship aims to foster the next generation of physician leaders by providing financial assistance to those who are committed to advancing health equity and community service. By recognizing diverse fields of study, it emphasizes the importance of interdisciplinary approaches in medicine and the humanities.
Medical Ethics Music Theater +4 more

EBF: Neighborhood Donations

Eastern Bank Foundation
Corporate
United States
US $100 - US $1,000
The Eastern Bank Foundation (EBF) is dedicated to empowering communities through its Neighborhood Donations initiative. By investing over $16 million in local organizations, EBF aims to support vital services and promote equity in Eastern Massachusetts, Southern New Hampshire, and Rhode Island. This program allows contributions to non-501(c)(3) organizations, reinforcing EBF's commitment to partnership and community-driven solutions, with donations typically ranging from $100 to $1,000.
Employment Services Education Health Care Access & Delivery +5 more

Hawk Watch Fund Grant

Hawk Migration Association of North America
Association/Society
Americas
Up to US $1,000
The Hawk Watch Fund Grant, established by the Hawk Migration Association of North America (HMANA), supports hawk watch sites in North America facing funding challenges. Grants of up to $1000 are available for volunteer-based projects that align with HMANA's mission of promoting raptor conservation and migration study. Funding is sourced from HMANA's annual Raptorthon and donations. This initiative aims to enhance educational resources, equipment acquisition, and operational support for hawk watch groups.
Ornithological Conservation Ornithology

Common Waters: Strengthening Community-based Coastal and Riverine Stewardship

National Geographic Society
Private
Africa, Alaska +25 more
Up to US $75,000

Common Waters: Strengthening Community-based Coastal and Riverine Stewardship

Opportunity Overview

Projects supported by this RFP must be community-based stewardship initiatives (including but not limited to stewardship driven by Indigenous and descendant communities); they should be led by an individual with a strong connection to and/or an existing track record of work in the community(ies) where the project will take place, or by a member of the community themselves, and be designed in response to community needs. Projects can focus on a wide range of specific issues, including (but not limited to) local conservation and ecosystem restoration, climate change adaptation and resilience, or sustainable fishing/agriculture. The RFP will prioritize projects in National Geographic-Lindblad Expeditions destinations, including the Arctic, Asia, Baja California, Costa Rica and Panama, Europe and the Mediterranean, Patagonia, the Peruvian Amazon, the Pacific Northwest, Southeast Alaska and British Columbia, the South Pacific, and the United Kingdom and Ireland. For more detailed information on targeted areas within these regions, please refer to the targeted areas document.

Freshwater Conservation Coastal Conservation Climate Change Resilience & Equity

BSF Research Grants

United States-Israel Binational Science Foundation
Federal Government
Israel, United States
Up to US $300,000
The BSF Research Grants program supports collaborative research between U.S. and Israeli scientists, focusing on basic science projects. Annually, approximately 400 applications are submitted, with around 100 grants awarded. To foster collaboration, joint publications are essential for evaluation. Applications are accepted once per year in mid-November, with results announced the following July. Since its inception in 1972, the BSF has funded over 5,400 high-quality research initiatives, distributing more than $700 million.
Economics Energy Mathematics +12 more

Patagonia’s Grassroots Collaborative Program

Patagonia Org
Corporate
Argentina, Australia +20 more
US $5,000 - US $20,000
Patagonia’s Corporate Grant supports grassroots organizations focused on bold, direct-action campaigns that address the root causes of environmental issues. The program emphasizes equity, inclusivity, and long-term change, targeting communities affected by environmental exploitation. Grants are awarded to innovative groups within the US and Canada, fostering civic engagement and measurable objectives. Patagonia prioritizes funding for initiatives that confront systemic bias and promote environmental justice, ensuring that diverse voices are represented in the environmental movement.
Habitat & Ecosystem Restoration Environmental Health Environmental Justice & Advocacy

Lifetime Contribution to the AAAAI and Allergy / Immunology Specialty Award

American Academy of Allergy, Asthma & Immunology (AAAAI)
Association/Society
United States
Unspecified amount
The Lifetime Contribution to the AAAAI and Allergy/Immunology Specialty Award honors individuals who have made significant and enduring contributions to the AAAAI and the allergy/immunology field. Awardees are recognized for exemplary service, leadership in professional organizations, impactful research, and mentorship of trainees. This prestigious accolade underscores the recipient's dedication to advancing the specialty and improving patient care, emphasizing the importance of community engagement and leadership in the field.
Immune System Diseases Allergies & Allergic Diseases Asthma

Lundbeck US Charitable Fund: Sponsorships

Lundbeck Us Charitable Fund
Private
United States
Unspecified amount
The Lundbeck US Charitable Fund focuses on enhancing brain health through sponsorships that support various initiatives. These sponsorships are available to both non-profit and for-profit organizations, provided they align with Lundbeck's mission. Funds are primarily allocated for educational or awareness events, with an emphasis on community outreach and collaboration to address gaps in care, especially for vulnerable populations. By fostering innovative strategies, the Fund aims to drive meaningful change in the field of brain health.
Military & Veterans Services Cognitive Science Neuroscience +4 more

Lundbeck US Charitable Fund: Charitable Donations

Lundbeck Us Charitable Fund
Private
United States
Unspecified amount
The Lundbeck US Charitable Fund focuses on enhancing brain health through impactful donations. Established to support organizations dedicated to brain health, it addresses pressing needs by funding innovative strategies and community collaborations, particularly for at-risk populations. The Fund aims to transform lives and improve mental health care, with a commitment to responsible giving. With over 20 organizations supported in 2023, it drives meaningful change in communities affected by brain disorders.
Neurological Diseases & Disorders Mental Health & Psychiatric Diseases Cognitive Intervention & Therapy +4 more

Goldberg, Joseph and Ruth, Scholarship

Beatrice Educational Foundation
Association/Society
United States
Unspecified amount
The Goldberg, Joseph and Ruth Scholarship, offered by the Beatrice Educational Foundation, aims to support students pursuing medical professions, such as nursing, dental, and physical therapy. Established in 1987, the Foundation provides over $55,000 annually in scholarships to Beatrice High School seniors. Eligible applicants must be in the top quarter of their class and complete the application independently. This scholarship is part of the Foundation's commitment to enhancing educational opportunities in the Beatrice School District.
Academic Scholarship Programs Education - Higher Education Medical Education & Professional Training +4 more

Earth Rising Foundation Grants

Earth Rising Foundation
Private
United States
US $200 - US $20,000
The Earth Rising Foundation Grants provide financial support ranging from $200 to $20,000 for grassroots climate initiatives. The foundation emphasizes empowering Indigenous communities, advocating for sustainable agricultural practices, and addressing social justice issues linked to climate change. By fostering youth involvement and supporting innovative projects, the foundation aims to create a vision for a sustainable future that respects both people and the planet. Applications must be submitted through a US-based nonprofit organization.
Youth Services Climate Change Resilience & Equity Diversity, Equity & Inclusion +3 more

PMCA Research and Conservation Grant

Purple Martin Conservation Association
Private
Americas
US $500 - US $2,500
The Purple Martin Conservation Association offers the PMCA Research and Conservation Grant to support research on Purple Martins. This grant aims to promote conservation efforts and may cover expenses such as travel and supplies, though it does not fund salaries or overhead. Eligible applicants include students and professionals engaged in Purple Martin research, with a focus on projects that enhance the species' habitat and well-being.
Ornithology Ornithological Conservation

H. Branch Howe Grant

Georgia Ornithological Society
Association/Society
Georgia (Country), North America +2 more
Up to US $15,000
The H. Branch Howe Grant, offered by the Georgia Ornithological Society, supports graduate students conducting ornithological research in Georgia. This grant encourages the scientific study of birds and conservation efforts, providing funding for research that enhances knowledge of avian life. Eligibility is limited to graduate students in Georgia, and preference is given to projects within state boundaries. The GOS aims to foster collaboration and knowledge sharing among those passionate about birds and nature.
Ornithology Ornithological Conservation

SAF National Awards Program: Outstanding Forestry Journalism Award

Society of American Foresters (SAF)
Association/Society
United States
More than US $500
The Outstanding Forestry Journalism Award recognizes exceptional journalistic work that enhances public understanding of forestry and natural resources. Open to all journalists, it encourages submissions in various formats, including articles, documentaries, and ongoing coverage. The award offers a $500 honorarium, complimentary SAF convention registration, and up to $500 for travel expenses. This initiative highlights the crucial role of effective communication in promoting sustainable forestry practices and educating the public about environmental issues.
Forestry Journalism

SAF National Awards Program: W. D. Hagenstein Communicator Award

Society of American Foresters (SAF)
Association/Society
United States
More than US $500
The W. D. Hagenstein Communicator Award honors an SAF member for their outstanding communication efforts in forestry. Recognizing innovative initiatives that enhance public understanding of forestry and natural resources, this award is presented at the SAF National Convention. It includes a $500 honorarium and up to $500 for travel expenses. Nominees must be SAF members and should not have received the Technology Transfer Award in the past five years. This award emphasizes the importance of effective communication in advancing forestry.
Forestry Science Communications

Enterprise Mobility™ Philanthropic Giving

Enterprise Holdings Foundation
Corporate
Canada, France +5 more
Unspecified amount
The Enterprise Mobility™ Philanthropic Giving program focuses on enhancing community engagement through grants aimed at supporting health, education, arts, and disaster relief initiatives. Only Enterprise Mobility team members and their spouses or domestic partners who volunteer with a nonprofit can apply for funding. The program prioritizes sustainable projects that uplift local communities and address pressing social issues, fostering a culture of responsibility and giving back to society.
Disaster Relief / Humanitarian Aid Workforce Preparation & Job Readiness Economic Services & Development +4 more

Grants for 501(c)(3) in South Dakota Highlights

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Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Grants for 501(c)(3) in South Dakota

Grant Availability

How common are grants in this category?

Uncommon — grants in this category are less prevalent than in others.

100+ Grants for 501(c)(3) in South Dakota grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

30 Grants for 501(c)(3) in South Dakota over $25K in average grant size

23 Grants for 501(c)(3) in South Dakota over $50K in average grant size

23 Grants for 501(c)(3) in South Dakota supporting general operating expenses

91 Grants for 501(c)(3) in South Dakota supporting programs / projects

2,000+ Grants on Instrumentl focused on Art & Culture

3,000+ Grants on Instrumentl focused on Education

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for grants for 501(c)(3) in South Dakota?

Most grants are due in the first quarter.

Q1
34.7%
Q2
24.6%
Q3
19.8%
Q4
21.0%

Typical Funding Amounts

What's the typical grant amount funded for Grants for 501(c)(3) in South Dakota?

Grants are most commonly $10,000.

$250 $250 Min.
$10,000 $10 K Median
$89,650 $89.7 K Average
$1,250,000 $1.3 M Max.

Average Grant Size

What's the typical amount funded for South Dakota?

Grants are most commonly $110,621.

$110,621

Total Number of Grants

What's the total number of grants in Grants for 501(c)(3) in South Dakota year over year?

In 2024, funders in South Dakota awarded a total of 6,460 grants.

2022 6,268

2023 6,140

2024 6,460

Top Grant Focus Areas

Among all the Grants for 501(c)(3) in South Dakota given out in South Dakota, the most popular focus areas that receive funding are Education, Human Services, and Philanthropy, Voluntarism & Grantmaking Foundations.

1. Education

2. Human Services

3. Philanthropy, Voluntarism & Grantmaking Foundations

Funding Over Time

How is funding for Grants for 501(c)(3) in South Dakota changing over time?

Funding has increased by 17.48%.

2022 $638,830,994

2023 $606,495,212
-5.06%

2024 $712,509,384
17.48%

South Dakota Counties That Receive the Most Funding

How does grant funding vary by county?

Minnehaha County, Lake County, and Pennington County receive the most funding.

County Total Grant Funding in 2024
Minnehaha County $176,653,145
Lake County $117,647,066
Pennington County $90,630,616
Brookings County $75,457,854
Todd County $56,559,538