Best Large Grants for Nonprofit Organizations in Tennessee

The Sachs Family Foundation Grant aims to enhance the quality of life for economically and educationally disadvantaged individuals and families. The Foundation supports self-sustaining charitable organizations focusing on economic and educational opportunities, particularly in low-income communities in the U.S. and developing countries. Grants are available for various initiatives, including education, housing, and job training, with a keen interest in programs that demonstrate clear potential for sustainability.

The Doree Taylor Charitable Foundation supports charitable organizations focused on basic provisions for underserved populations, humane care of animals, health care services, public media, and environmental initiatives. The foundation prioritizes organizations in Boothbay Harbor, Southport, and Brunswick, and encourages requests for general operating support, program support, and capital projects, while maintaining a focus on the impact of their services.

The James Avery Fundraising Support provides limited cash contributions, sponsorship of special events, and in-kind support to organizations enriching community life within 50 miles of a James Avery retail location. Eligible organizations must be 501(c)(3) certified and focus on arts, community improvement, veteran support, and wellness. Requests must be made at least 60 days prior to events, and organizations can receive support only once per year.

The Japan – U.S. Global Partnership Grant Program aims to foster collaborative projects addressing global issues through partnerships between Japanese and American organizations. It focuses on policy-oriented research and dialogue among diverse professionals, including academia and grassroots practitioners. Key thematic areas include resilience, inclusivity, and advancements in science and technology. Projects outside these themes may also be eligible if aligned with grant goals, covering topics like climate change, public health, and digital transformation.

James Avery Corporate Grants support 501(c)(3) organizations located within 50 miles of a James Avery retail or corporate location. The foundation prioritizes projects that enrich community life, focusing on arts, veteran services, and wellness. Grants typically range from $10,000 to $25,000, with applications accepted once per year. Organizations must demonstrate community impact, effective management, and provide necessary documentation for eligibility. Note that certain types of funding, such as for individuals or for-profit organizations, are excluded.

The Max and Victoria Dreyfus Foundation offers grants to support diverse initiatives, including museums, educational programs, and environmental activities. Aiming to make a significant impact with modest funding, the Foundation targets IRS-qualified non-profits in the U.S. Grants typically range from $1,000 to $20,000, fostering community development and enhancement. Organizations focused on youth, seniors, and individuals with disabilities are particularly encouraged to apply, as the Foundation seeks to empower those in need.

The Global Health and Wellbeing Grantmaking program by Coefficient Giving focuses on addressing critical health and welfare issues worldwide. With an emphasis on proactive engagement and evidence-based solutions, the initiative supports projects that improve health outcomes and wellbeing. The program prioritizes funding for organizations tackling neglected global health challenges, advocating for effective philanthropy, and enhancing the lives of both humans and animals in vulnerable communities.

Request for Proposals: Launchpad Funds

Background

Coefficient Giving is increasing its giving, primarily to prepare for the billions of dollars in new philanthropic capital that may become available in the coming years. Our increased giving in global health and wellbeing is a temporary surge, with two objectives: to smooth funding and pull forward initiatives we expect to be cost-effective, and to help create an ecosystem of regrantors and implementers with the capacity to allocate this new money as cost-effectively as possible. Additional context on our scaling is provided in this blog post. 

With new potential capital on the way, we want to increase the supply of actionable and fundable plans to address some of the world’s hardest problems. We’re looking for specific, credible strategies to convert funding into measurable progress. Our ideal funds are:

However, we are also open to funds that are thematic and don’t have a quantified goal — for example, a fund organized around a promising type of intervention. Such funds still need to be led by a single, identifiable person who is accountable for the fund’s direction.

Through this request for EOIs, we aim to seed or scale Launchpad Funds that can grow to $100m+ over the next few years. We don’t seek scale for its own sake; it is a proxy for the ambition of the fund, and a signal that the problem is large and tractable enough to justify deploying significantly more capital over time.

What we will fund

• We expect to support established ideas that have either not yet secured anchor support or could significantly scale beyond their existing level of funding.
• This funding can cover operating expenses, but we expect most of it to be used for activities that make progress on the fund’s goals — whether through regranting or direct implementation.
• For exceptional proposals, we may consider funding levels beyond $50m. We anticipate higher funding levels will involve more thought partnership from our team.
• While we don’t expect to make grants longer than 36 months, funded proposals may later be considered for additional funding beyond the initial period.

The External Collaborative Research (ECR) program by Boehringer Ingelheim invites academic and community scientists to propose collaborative studies aimed at protocol development and result publication. This program offers potential drug and financial support, excluding direct salary for the Principal Investigator. Budgets must represent fair market value and will be negotiated further. Research interests span therapeutic areas including Cardio-Renal-Metabolic, Mental Health, Dermatology, and Oncology, encouraging innovative solutions to unmet medical needs.

South Arts, Inc. offers Professional Development Grants for Arts Organizations to enhance the skills and knowledge of Southern arts entities. These grants aim to support operational stability and growth, focusing on organizations with budgets of $500,000 or less. Eligible applicants include a range of arts organizations within South Arts' nine-state service area. The program emphasizes first-time opportunities and requires a dollar-for-dollar cash match, ensuring a commitment to professional development in the arts.

The Postdoctoral Grant Program at the University of Wisconsin School of Medicine and Public Health aims to support the growth and professional development of postdoctoral trainees, fellows, and associates. With funding up to $20,000 for one year, recipients can engage in independent research projects, attend workshops, or cover open-access publication fees. This initiative enhances research capacity and promotes health equity in Wisconsin, addressing critical health challenges while fostering career advancement in the medical field.

The Resilient and Connected Appalachians Grant Program, offered by The Nature Conservancy, provides up to $100,000 for projects that acquire land and easements throughout the Appalachian region. This program emphasizes equitable conservation, aiming to support historically marginalized communities and enhance access to nature while addressing climate change impacts. Projects must demonstrate community engagement and align with the program's goals to protect vital habitats and foster resilience in the face of environmental challenges.

What does this program do?

It provides loans and grants to Microenterprise Development Organizations (MDOs) to:

• To help microenterprises startup and growth through a Rural Microloan Revolving Fund.
• Provide training and technical assistance to microloan borrowers and micro entrepreneurs.

 What kind of funding is available? 

Grants are available to provide technical assistance to rural micro-entrepreneurs or microenterprises, up to $205,000 annually. Funding at the requested level is not guaranteed, and at least 15 percent matching funds are required.

Loans of $50,000 to $500,000 may be used for establishing a Rural Microloan Revolving Fund managed by the Microenterprise Development Organization. Total aggregate debt is capped at $2.5 million.

Are there other requirements?

Microenterprise Development Organizations must demonstrate experience in managing a Revolving Loan Fund, or:

• Certify that it or its employees have received education and training from a qualified microenterprise development training entity so that the applicant has the capacity to manage such a revolving loan fund.
• Demonstrate that it is actively and successfully participating as an intermediary lender in good standing under the U.S. Small Business Administration (SBA) Microloan Program or other similar loan programs as determined by the Administrator.

What are the loan terms?

• Maximum term is 20 years.
• Two-year payment deferral.
• Must establish a loan loss reserve fund.

What terms are required on loans to ultimate recipients?

• Up to $50,000.
• Fixed interest rate.
• Limited to 75 percent of project cost.

How may the funds be used?

Microlenders may make microloans for qualified business activities and expenses including, but not limited to:

• Working capital.
• Debt refinancing.
• Purchasing equipment and supplies.
• Improving real estate.

Tennessee Department of Transportation

The Department of Transportation provides citizens of Tennessee and travelers with one of the best transportation systems in the country. TDOT consistently wins awards for its projects, highway design and innovative approach to transportation.

TDOT is a multimodal agency with responsibilities in aviation, public transit, waterways, railroads and cycling and walking. Our involvement ranges from airport improvements to funding transit buses to planning for river ports.

Transportation Planning Grants

The Transportation Planning Grant (TPG) is intended to assist jurisdictions (both municipalities and counties) with transportation planning efforts that determine strategies to support improvements in traffic flow, safety, mobility, and overall efficiency of the transportation system. Since 2015, TDOT has awarded 145 planning grants across the state, many of which have resulted in implementation funding.

The TPG funds transportation plans only.

Goals of the Transportation Planning Grant

• Assist Tennessee communities with multimodal transportation planning
• Bridge the gap between land use planning and transportation planning
• Aid with the creation of planning documents that support improvements in traffic flow, safety, and overall efficiency of the transportation system
• Provide planning resources to achieve community visions that promote future economic growth

Matching

• The TPG is 80% federal, 10% state, and 10% local match
• Distressed and At-Risk Counties as determined by TNECD (and municipalities within) as of FY26 qualify for 0% local match

Planning Opportunities

Planning opportunities include, but are not limited to: Complete Streets Plans; Bicycle and Pedestrian Master Plans; Transportation System Management and Operations (TSMO) Plans; Corridor Studies; Resurfacing Plans; Community Mobility Plans

We also welcome any creative and innovative transportation planning ideas.

Bicycle and Pedestrian Master Plans

A Bicycle & Pedestrian Plan can assist communities in prioritizing non-motorized transportation investments. As demand for alternative transportation options continue to grow, communities are increasingly recognizing the need for these facilities to help achieve their desirable quality of life. See more here.

Administrative Process

Through the Transportation Planning Grant program, your community will be paired with a consultant currently under contract with TDOT that will guide you through the planning process and bring your plan to life. The community is responsible for actively participating in the plan by establishing a Steering Committee, providing the match, and ensuring local support for the proposed study recommendations.

The Hearst Foundation: Culture Grant aims to support outstanding nonprofits that enhance cultural engagement and artistic talent in the U.S. With a focus on programs that reach young people, the grant prioritizes organizations that create lasting impacts in the arts and sciences. The Foundation allocates 25% of its funding to cultural initiatives, favoring established organizations with a history of significant results. Eligible nonprofits must encourage inclusivity and sustainability in their programs.

The O'Reilly Automotive Foundation Grant focuses on enhancing community welfare through philanthropic initiatives that support economic stability, workforce development, health services, and disaster relief. Established in 2020, the Foundation seeks to empower underrepresented individuals and organizations in the U.S. by addressing vital community needs. It particularly aims to provide assistance to nonprofits that foster positive change and improve quality of life for those in need, ensuring a lasting impact in local communities.

SITKA Ecosystem Grants support projects that enhance ecosystems and promote conservation efforts. These grants encourage both grassroots initiatives and larger organizational projects, aiming to improve habitat restoration, biodiversity, and the hunting experience. With funding ranging from $3,000 to $20,000, applicants must be 18 years or older and have relevant experience. The review process is ongoing, and projects should emphasize collaboration and measurable impacts on environmental goals, benefiting both society and ecosystems.

The FastTrack Infrastructure Program, administered by the Tennessee Department of Economic & Community Development, provides grants to local governments for essential public infrastructure projects. These funds are aimed at supporting new or expanding companies and require local matching contributions. Eligible projects include improvements to water, sewer, and electrical systems, fostering job creation and economic growth in the community.

The FastTrack Economic Development Fund provides crucial grants to local communities in Tennessee for public infrastructure projects that support job creation and significant capital investments. These grants necessitate local matching funds and are aimed at enhancing community development. The program promotes strategic investments that lead to long-term economic growth, helping to offset costs for companies as they expand or establish operations in the state.

Medtronic is a global leader in medical technology, dedicated to enhancing healthcare access and supporting the communities it serves. Through its Grants and Donations program, Medtronic provides financial assistance for medical education, independent conferences, and charitable events, emphasizing collaboration with healthcare stakeholders. The program aims to alleviate pain, restore health, and extend life, positively impacting millions of patients worldwide. For more information, visit Medtronic's FAQs on grants and donations.

The Corporate Giving Program by the Franklin P. and Arthur W. Perdue Foundation supports nonprofit organizations that enhance community welfare. Focus areas include agriculture, education, fighting hunger, and public safety. Eligible applicants must have IRS 501(c)(3) status and a Taxpayer Identification number. Requests are prioritized for programs directly benefiting communities near Perdue facilities across various states. The foundation emphasizes responsible stewardship and community engagement in all funding decisions.

The Women’s Fund, part of the Community Foundation of Middle Tennessee, is dedicated to empowering women and girls by funding long-term solutions that enhance economic self-sufficiency, promote health, and prevent violence. With a commitment to collective philanthropy, the Fund prioritizes support for organizations with budgets under $3 million and a focus on women's issues. Grants can reach up to $20,000 for established organizations and $5,000 for newer ones, ensuring impactful contributions to the community.

Friends of NRA

Friends of NRA is the National Rifle Association’s premier fundraising program, supporting the future of shooting sports. Since day one, Friends of NRA has been a 100% grassroots effort fueled by a united front to secure the Second Amendment and raise money for the shooting sports.

Committee volunteers are appointed to State Fund Committees to make recommendations for local grant funding in areas such as youth education, women-focused clinics, law enforcement training, hunter safety, range improvement, firearms and marksmanship training and safety. Recognizing the impact American youth has on the future of the shooting sports, State Fund Committees frequently recommend grants for youth programs, allocating the most significant portion of monies to this vital area.

Grant awards fund activities and support programs in the United States to promote firearms and hunting safety, to enhance marksmanship skills of those in the shooting sports, and to educate the public about firearms in their historic, technological and artistic context.

Friends of NRA State Fund Grant Program - Tennessee

The Friends of NRA State Fund Grant Program provides supplies, equipment, and financial support to a variety of qualified groups and programs at the local level; geared towards youth, women, law enforcement, veterans, the disabled, and the general public, including:

• General shooting programs
• Competitive shooting
• Education, training and safety
• Hunting and conservation
• Community outreach
• Historical education

Grant funding must be used to further a charitable purpose as defined by the Internal Revenue Code under section 501(c)(3) and accompanying rules, regulations, and other IRS law and materials.

Catholic Extension's Enhancing Pastoral and Social Ministry Grants aim to empower the church to broaden its outreach and foster societal transformation through targeted pastoral and social initiatives. This program supports specific elements of the church's ministerial efforts, including funding for catechetical resources, marriage and family ministries, and social outreach for vulnerable populations. By investing in these areas, Catholic Extension seeks to enhance the church's role in communities, especially following disasters.

The David, Helen and Marian Woodward Fund, established by Marian Woodward Ottley in 1974, aims to support non-profit organizations in Georgia and neighboring states. The fund prioritizes capital projects and educational programs that enhance graduation rates, particularly those with religious affiliations. Grants are awarded exclusively to 501(c)(3) organizations, while governmental agencies can also apply. The foundation's mission underscores a commitment to improving the world for future generations.

The Norfolk Southern In-Kind Donation Grant supports organizations seeking physical donations of materials that align with their focus areas, including safety, sustainability, workforce development, and thriving communities. This grant is available year-round, with no application deadline. Recipients must be located within Norfolk Southern territory and are encouraged to apply for resources that will enhance their community projects and initiatives, fostering growth and resilience.

The Middle Tennessee Fund Grant, offered by the HCA Healthcare Foundation, supports nonprofits in addressing community needs related to basic necessities, healthcare, education, and the arts. Since its inception in 1997, it has prioritized organizations with established relationships with HCA Healthcare. Eligible applicants must be 501c3 organizations with a minimum budget of $250,000, serving the Middle Tennessee area, and demonstrating engagement with HCA Healthcare through board involvement or volunteerism.