Best Seed Grants for Nonprofits in Tennessee

The Rural Opioid Technical Assistance Centers program aims to provide essential training and technical assistance to combat opioid and stimulant misuse in rural areas. With 10 Regional Centers and a National Coordinating Office, the initiative focuses on high-quality prevention, treatment, and recovery support services for substance use disorders. This program anticipates awarding 11 new grants to enhance community health and safety in addressing polysubstance use challenges.

The FY25-FY26 Advanced Transportation Technology and Innovation (ATTAIN) grant program aims to enhance transportation through the deployment of innovative technologies. It focuses on improving safety, mobility, and efficiency while fostering economic competitiveness. Projects funded will prioritize core infrastructure improvements and address roadway congestion, aligning with the Trump Administration's goals. The program emphasizes economic opportunities and community benefits, ensuring that selected projects contribute positively to families and communities, ultimately enhancing their quality of life.

Funding Innovative Research

Cannonball Kids’ cancer Foundation (CKc) prioritizes funding clinical trials, research that is nearing translation to a clinical trial, and young investigator grants.

Grants funded by CKc must be innovative and provide better quality of life or symptom relief than current treatments. 

When possible, CKc will prioritize funding research:

• with a focus on cancers that are under-funded or under-researched,
• with a focus on patient populations who are traditionally underserved.

When possible, CKc will prioritize funding researchers of diverse backgrounds.

For CKc, “innovation” means the invention or application of novel methods or treatments, specifically treatments that have fewer side-effects than standard care, increase a child’s quality of life, and/or create an option for care where there otherwise were few or none (either on primary diagnosis, relapse, or for recalcitrant cancers).

Research Grants

Grant Program: Clinical Trial

$200,000 over 3 years

• PI must hold an academic appointment at the Assistant Professor level or higher
• Preclinical studies must be complete
• If an FDA Investigational New Drug (IND) application is necessary for the proposed clinical study, the IND application should already have passed FDA initial review and be active
• If the PI has recruited additional patient enrollment sites, local IRB approval must be obtained for each site.

• How many treatment options would this study provide for children?
• How accessible is this study for children and families to access?

The Smart Growth America Community Connectors Grant Program supports small and mid-sized cities in addressing divisive infrastructure caused by dangerous roads. With funding from the Robert Wood Johnson Foundation, this program aims to reconnect communities through temporary street safety projects while fostering skills and partnerships. Eligible teams must represent populations of 50,000 to 500,000 and include both government and community-based organizations. Priority will be given to projects benefiting low-income communities historically affected by disinvestment.

About Us

advancing the science of water ®

Who We Are

The Water Research Foundation (WRF) is the leading research organization advancing the science of all water to meet the evolving needs of its subscribers and the water sector. WRF is a 501(c)(3) nonprofit, educational organization that funds, manages, and publishes research on the technology, operation, and management of drinking water, wastewater, reuse, and stormwater systems—all in pursuit of ensuring water quality and improving water services to the public.

5432 - Validating Reverse Osmosis Conductivity Profiling for Pathogen Log Reduction Value Credit

Grant Information

• Validate conductivity profiling against pathogen removal by establishing the relationship between conductivity-profile response and MS2 bacteriophage removal under intact and controlled membrane integrity-defect conditions.
• Demonstrate the robustness and applicability of conductivity profiling across representative reverse osmosis conditions, including new and aged membranes, different defect types and severities, operating conditions, variations in feedwater quality/composition/salinity, and temperature.
• Develop a validation implementation framework that defines testing procedures, log removal value calculation methods, sensitivity and performance criteria, continuous monitoring, alarm/response thresholds, and operational requirements needed to support regulatory pathogen log removal values credit for reverse osmosis.

The Rare Impact Fund, founded by Selena Gomez, is dedicated to transforming mental health support for young people. With a commitment to mobilizing $100 million, the fund aims to enhance access to mental health services and promote a stigma-free community. Through public Requests for Proposals, the initiative seeks to strengthen the nonclinical youth mental health workforce, ensuring effective support systems that reflect the diverse backgrounds of youth. This innovative approach fosters lasting change in mental health care.

The Jim Flynn Outstanding Corporation Award, presented annually by NALMS, honors the corporation that has made significant contributions to advancing lake management goals. This award emphasizes the importance of facilitating information exchange, promoting public awareness of lake ecosystems, and supporting management programs at all levels. Eligible nominations can come from any individual or entity, focusing on achievements in lake and reservoir management. Notably, current NALMS board members and awards committee members are excluded from eligibility.

AARP Foundation

AARP Foundation strengthens financial resilience for and with older adults by empowering individuals and improving systems.

AARP empowers people to choose how they live as they age. There are 125 million Americans who are 50 or older, and people want their money, health and happiness to last as long as they do. We are a wise friend and fierce defender, focusing on the priorities of older Americans.

Purpose Prize® from AARP

Honoring extraordinary people 50-plus who put their purpose into action.

Purpose is a powerful force for good. The Purpose Prize from AARP honors extraordinary older Americans who put their purpose into action to support AARP’s mission of empowering people to choose how they live as they age. Winners receive $75,000 and a year of organizational support from AARP to grow the impact of their nonprofits. Examples of organizational support include data and evaluation, governance and succession planning, fundraising strategy, and prospectus development.

The Park Foundation Grants: Media support public interest media that raises awareness of critical environmental and social issues. They prioritize funding for investigative journalism, media policy, public broadcasting, and documentary films to promote a better-informed citizenry. Eligible organizations must be 501(c)(3) certified, and funding is aimed at projects that ensure diverse perspectives and community engagement. The foundation is committed to fostering a robust democracy and independent media, reflecting its mission to advance a just and sustainable society.

The Barney Family Foundation Grant focuses on improving early education and advancing medical research, particularly in cancer and Alzheimer’s. It supports organizations that demonstrate a clear plan to enhance children's life experiences and educational opportunities for those in grades K-8. Grants typically range from $5,000 to $50,000, prioritizing established entities while welcoming startups. Eligible applicants must have 501(c)(3) status, and the Foundation does not fund individual requests or political activities.

The NALMS Achievement Awards: Secchi Disk Award recognizes outstanding contributions to lake management by its members. NALMS aims to unite citizens, scientists, and professionals to ensure the protection and management of lakes and reservoirs. This prestigious award is open to NALMS members, with nominations encouraged from any individual or entity. However, current board and committee members are ineligible. The award celebrates those who significantly advance NALMS's goals and objectives in fostering lake ecosystem awareness and management.

This funding opportunity aims to support urgent research evaluating policies that impact health behaviors related to obesity. It is designed for studies that can only be performed with expedited review due to the time-sensitive nature of the research. Applications must demonstrate a compelling need for immediate funding to explore new policies or programs affecting dietary habits and physical activity, with the expectation that successful proposals will receive funding within four months.

The Thalassemia Patient Incentive Award, sponsored by the Cooley’s Anemia Foundation, aims to support thalassemia patients in pursuing their educational and career aspirations. Awards ranging from $250 to $2,000 will be granted to students at various academic levels, with applications due in March 2026. This initiative not only encourages academic growth but also fosters a positive outlook among patients living with thalassemia, underscoring the Foundation's commitment to improving their quality of life.

The Opioid Crisis Response Program Fellowship, offered by Equal Justice Works, addresses the opioid epidemic by mobilizing public interest lawyers to provide vital civil legal aid to underserved communities affected by Opioid Use Disorder. This two-year fellowship enables attorney fellows to advocate for clients' rights, reduce barriers to treatment, and enhance community education about legal impacts. Through collaboration with various stakeholders, the program aims to improve health outcomes and foster systemic change in the fight against this public health crisis.

The Educational Incentive Award Application by the Cooley’s Anemia Foundation aims to support children of individuals with severe thalassemia in pursuing their educational and career aspirations. With a total funding of $10,000 for the 2025-2026 school year, awards range from $500 for two-year programs to $1,000 for higher degree studies. Eligible applicants must be diagnosed with specific thalassemia types and provide necessary documentation, including a 250-word essay detailing their educational goals.

Disabled Veterans National Foundation

The Disabled Veterans National Foundation (DVNF) was established in 2007 to support veterans facing challenges that traditional systems could not fully address. From its earliest days, DVNF has been focused on closing critical gaps in care and providing resources that help veterans rebuild their lives with dignity and stability.

Guided by this commitment, DVNF developed its Health & Comfort programs, offering emergency financial assistance, housing transition support, food assistance, comfort kits, and wellness initiatives. These programs are designed to meet veterans where they are and to provide practical solutions that restore hope and stability. Today, DVNF continues to grow as a trusted national nonprofit. Every day, our team works with a clear purpose: to change lives for the men and women who have served our country.

Homeless To Housing Program - Household Comfort Support

DVNF is dedicated to assisting disabled and at-risk veterans in their transition from homelessness to permanent housing. Recognizing that securing a home is a significant milestone, DVNF understands that true stability is achieved when a house becomes a home, furnished with essential items that provide comfort and functionality. We help cover essential costs related to securing and creating comfortable housing for at-risk veterans.

The H2H Program offers comprehensive support to veterans by providing: Household Comfort Support of up to $2,000 worth of essential household items to ensure veterans have a stable, safe, and comfortable living environment.

For Financial Assistance: Payments are processed through two payment cycles each month, around the 15th and 30th. For Furniture Assistance: Once the List of Items form is completed, DVNF staff will purchase the requested items, which should arrive within 7-10 business days.

The David Moses Bridges Scholarship honors the legacy of a renowned Passamaquoddy artist and activist, providing essential support for individuals dedicated to the preservation of Wabanaki culture, traditional arts, and environmental stewardship. This scholarship aims to foster connections between master artists and apprentices, promote research on David's impactful life and work, and protect culturally significant natural spaces. It empowers artists and scholars to continue the vital work of preserving indigenous knowledge and practices for future generations.

Harry C. Anthony, Jr. Scholarship

Essay:

• Describe yourself and explain why you are interested in a career in medicine.

Awards:

• One-time award of $2,500

The Core State Injury Prevention Program (Core SIPP) aims to enhance public health infrastructure and partnerships to prevent unintentional injuries through data-driven strategies. Focusing on key areas such as traumatic brain injury, falls among older adults, and drowning, it seeks to improve community safety by strengthening data use and fostering collaborations. This initiative supports states in identifying local injury concerns, thus promoting evidence-based prevention approaches and increasing the capacity for sustained public health actions.

Disabled Veterans National Foundation

The Disabled Veterans National Foundation (DVNF) was established in 2007 to support veterans facing challenges that traditional systems could not fully address. From its earliest days, DVNF has been focused on closing critical gaps in care and providing resources that help veterans rebuild their lives with dignity and stability.

Guided by this commitment, DVNF developed its Health & Comfort programs, offering emergency financial assistance, housing transition support, food assistance, comfort kits, and wellness initiatives. These programs are designed to meet veterans where they are and to provide practical solutions that restore hope and stability. Today, DVNF continues to grow as a trusted national nonprofit. Every day, our team works with a clear purpose: to change lives for the men and women who have served our country.

Homeless To Housing Program - Financial Assistance

DVNF is dedicated to assisting disabled and at-risk veterans in their transition from homelessness to permanent housing. Recognizing that securing a home is a significant milestone, DVNF understands that true stability is achieved when a house becomes a home, furnished with essential items that provide comfort and functionality. We help cover essential costs related to securing and creating comfortable housing for at-risk veterans.

The H2H Program offers comprehensive support to veterans by providing: Financial Assistance of up to $2,000 to cover essential costs related to securing permanent housing, such as security deposits and initial rent payments.

For Financial Assistance: Payments are processed through two payment cycles each month, around the 15th and 30th. If your payment is delayed beyond the expected date, a Promissory Note of Payment will be issued to the vendor, confirming our organization's responsibility and requesting that no penalties be applied to the applicant.

About the ASHFoundation

ASHFoundation supports innovators and sparks innovation in communication sciences. We give early support to promising students, researchers, and clinicians exploring bold ideas to transform the field and improve people's lives.

Frank R. Kleffner Lifetime Clinical Career Award

The Frank R. Kleffner Lifetime Clinical Career Award recognizes an individual’s outstanding contributions to communication sciences and disorders over a period of at least 20 years. The lifetime contribution may have been in clinical service, supervision or administration of clinical service, clinical research, or any other activity that has promoted clinical excellence.

The award is given in honor of Frank R. Kleffner, a former ASHFoundation president and former ASHA president, who worked tirelessly over his lifetime until his passing in 2015 to professionalize and expand the ASHFoundation’s charitable goals.

The awardee receives a commemorative art object with a recognition plaque.

The Dean John A. Knauss Marine Policy Fellowship offers a unique opportunity for early career professionals to engage in marine and Great Lakes science and policy within the U.S. government. This one-year, paid fellowship encourages graduate students from accredited programs to explore impactful coastal resource issues. Interested applicants should connect with their local Sea Grant program or the National Sea Grant Office for guidance, especially if they are from Massachusetts, to ensure a competitive application.

The RMEF Grant Program lies at the core of advancing our mission.

RMEF established the program in 1986 to provide financial and logistical support to projects that align with our priorities and goals. Grant funds raised by RMEF members, volunteers and generous donors from across the country translate into significantly more conservation accomplishment when matched with partner funds. The RMEF Grant Program also aims to build recognition for RMEF’s work, grow engagement, and boost local fundraising efforts.

Governed by clear guidelines and criteria, the RMEF Grant Program seeks to foster meaningful collaborations and long-term impacts in the conservation of natural resources and outdoor traditions. Grant project partners include federal, state, local, and tribal wildlife and land management agencies, private landowners and local stakeholders, sportsmen and women, and conservation organizations, universities, foundations and the outdoor industry. Eligible projects primarily focus on habitat stewardship, land conservation and access, wildlife management, and hunting heritage.

We support organizations recognized by the Internal Revenue Service (IRS) as a 501(c)3 entity, federal, state, local, or tribal government entities, sportsmen’s organizations, or educational institutions. All applicants must have a Federal Employer Identification Number (EIN) issued by the IRS. RMEF does not offer grants to individuals.

Hunting Heritage

Ensuring our hunting heritage is central to RMEF’s mission. Hunters—America’s first conservationists—remain the driving force behind wildlife conservation. RMEF funds hunting heritage and conservation education to help more people experience the outdoors, learn the skills of hunting, and carry forward the traditions that define big game country, including outdoor skills programs/events, hunter or conservation outreach, mentored hunts, and other similar activities.

Hungry for Music

The Hungry for Music story began in 1992, when Founder and Director Jeff Campbell (in photo) organized a street musician concert to benefit the homeless. Within three years, he formed a 501(c)(3) nonprofit organization, dedicated to expanding opportunities in music for children.

Since then, Hungry for Music has placed more than 27,000 instruments into the hands of aspiring musicians. Children whose trajectory has been altered by the uplifting and life-changing gift of music.

We've delivered everything from guitars and trombones to violins and xylophones to kids in 50 states and 35 countries.

We collect and redistribute more than 2,000 instruments annually and, in our 31-year journey, we've become a full-time force for good in the musical community.

Request an Instrument

Hungry for Music collects and distributes instruments including brass, woodwinds, strings, electric keyboards, drums and other percussion, as well as amps and accessories.

Who Hungry for Music Helps

• Music teachers at Title One schools who identify children who cannot participate because of lack of funding.
• Music directors at innovative after-school music programs.
• Social workers who have young clients who would benefit from music therapy.

We only accept requests from public school music teachers, administrators, after-school/summer music program directors, and social workers. 

In our history, we have supported music programs in 40 different countries through stateside sponsors (i.e. business, school, church). We do not accept requests directly from international programs.

After-School & Summer Programs

Hungry for Music supports more than three dozen after-school/summer music programs annually across the United States. To be added to our distribution, a site visit is required.

Quest Diagnostics Foundation

Established as a 501(c)(3) nonprofit organization, the Quest Diagnostics Foundation is committed to addressing the systemic root causes of health disparities. By combining corporate resources with trusted community leadership, we fund and scale evidence-based initiatives that promote wellness, prevent chronic disease, and empower individuals.

We focus our resources on three critical, interconnected clinical and social interventions to build sustainable health improvement:

• Strengthening the community health workforce
• Addressing social drivers of health (SDoH)
• Promoting the prevention, early detection, monitoring, and treatment of disease through diagnostic testing

About Quest for Healthy Communities Champions

The Quest for Healthy Communities Champion award was created to honor, uplift, and support outstanding organizations across the United States that are actively living our core purpose:

Working together to create a healthier world, one life at a time.

Whether you are expanding access to life-saving screenings, supporting maternal and family wellness, or addressing critical social drivers of health, your dedication is moving us closer to an equitable healthcare future. We want to recognize and celebrate your impact.

What we celebrate: Our core impact pillars

The Champions we look to honor are community-first organizations and coalitions tackling critical disparities head-on. We are especially excited to spotlight work that advances health, addresses social drivers of health, fosters community-clinical linkages and develops the community workforce. Examples of this work could include: 

• Programs actively dismantling clinical barriers to ensure every individual—regardless of zip code, background, or income—has access to high-quality care
• Innovators providing creative solutions for food security, transportation, health education, and maternal-child support networks
• Organizations bringing critical care directly to those in need through mobile clinics, community health workers, and localized diagnostic screenings
• Organizations finding creative ways to engage the communities they serve directly into the solutions they are delivering

The award: Selected organization champions will receive a $10,000 grant.

The Strengthening Services to Prevent the Infectious Disease Consequences of Drug Use initiative aims to enhance prevention services for infectious diseases among people who use drugs (PWUD). It encompasses two components: a biennial survey to assess service gaps and capacity, and increased support for testing and treatment services. The initiative seeks to improve data utilization in service provision, ultimately increasing testing for HBV, HCV, and HIV, and ensuring more PWUD engage in treatment and care.

The Gamma Mu Foundation, established in 1988, aims to support the LGBT community in rural and underserved areas through various grants. Initially focused on HIV/AIDS projects, it now funds scholarships and services for diverse LGBT subpopulations. With over $2 million awarded, the Foundation prioritizes initiatives that enhance community support, public education, and health programs. It emphasizes projects that build organizational capacity and provide essential services where resources are limited, ensuring ongoing support for vital health and social services.