Best Large Grants for Nonprofit Organizations in Wisconsin

The HEAL Initiative: Pain Research Enhancement Program (PREP) supports R15-eligible Principal Investigators in conducting innovative pain research. This program encourages interdisciplinary partnerships and aims to enhance the research environment for health professional trainees. Key application deadlines include November 19, 2024, and October 28, 2025, with specific dates for AIDS-related applications. By fostering collaboration, the initiative seeks to advance understanding and treatment of pain.

About National Fish and Wildlife Foundation (NFWF)

The National Fish and Wildlife Foundation (NFWF) works with partners to foster sustainable and impactful conservation solutions so that people and nature thrive together. Chartered by Congress in 1984, NFWF has grown to become the nation’s largest conservation foundation. Since its founding, NFWF has funded more than 23,900 projects that have generated a total conservation impact of more than $12 billion.About Sustain Our Great Lakes Program

Sustain Our Great Lakes is a public–private partnership designed to sustain, restore and protect fish, wildlife and habitat in the basin by leveraging funding, building conservation capacity, and focusing partners and resources toward key ecological issues. The program achieves this mission, in part, by awarding grants for on-the-ground habitat restoration and enhancement.Funding priorities for this program include:

• Habitat Restoration to Conserve Species and Improve Water Quality
• Expand and Maintain Nature-Based Solutions in Great Lakes Communities
• Invasive Species Control to Protect and Enhance Restored Habitat
• Activate Restored Habitats and Natural Areas

The Union Home Foundation Grant provides financial support to nonprofit organizations that promote economic self-sufficiency through financial literacy and housing initiatives. Established in 2015, this grant has awarded over $2 million to various nonprofits across the U.S. Grants typically start at $1,000 and are available for a one-year period. Organizations must be 501(c)(3) tax-exempt and can only apply once per year, following specific eligibility criteria.

The Higher Education Challenge Grants Program, managed by the USDA's National Institute of Food and Agriculture, aims to enhance institutional capacities in food and agricultural sciences education. This initiative focuses on improving curriculum, faculty, and student recruitment for master's and doctoral programs, particularly in veterinary medicine. By strengthening these educational frameworks, the program seeks to ensure the availability of skilled professionals in critical agricultural sectors.

The Applied Materials Momentum Fund offers emergency financial assistance to students facing unexpected financial obstacles while pursuing degrees in engineering. This initiative supports basic needs such as food, housing, and transportation, ensuring that students can continue their education without interruption. It aims to empower women engineers and underrepresented groups in the semiconductor industry, fostering a diverse and resilient workforce for the future.

The Applied Materials Momentum Fund - Bridge Grants aim to support students facing financial obstacles in completing their computing degrees. This initiative fosters diversity in the semiconductor industry by encouraging women engineers and providing them with career-building opportunities. Eligible candidates include U.S. citizens, DACA recipients, and F1 visa holders pursuing engineering majors. The fund not only alleviates financial stress but also opens doors to internships and full-time positions at Applied Materials, thus enhancing educational progress and career advancement.

The Alice M. Ditson Fund provides organizational support for professional performing ensembles and institutions committed to advancing the work of younger and relatively unknown living American composers. Grants are available for general operating or project support, emphasizing contemporary American classical concert music. Eligibility includes organizations without non-profit status if sponsored by a 501(c)(3) entity, while projects featuring American music are prioritized. This funding opportunity encourages innovative performances and fosters greater recognition of emerging talents in the classical music sphere.

The Friends of Reservoirs: Large Grant supports fish habitat enhancement projects in manmade reservoirs, promoting conservation and partnerships. With approximately $250,000 in Federal funding and $500,000 from Bass Pro Shops, grants up to $75,000 are available. Projects must match funding and can be multi-year, with specific caps on subsequent funding. This initiative aims to address habitat impairments and enrich community quality of life through improved fishing opportunities.

The Applied Materials Momentum Fund is dedicated to enhancing educational opportunities for students in the semiconductor industry, particularly supporting women engineers. This initiative provides essential financial assistance through various grant types, including emergency mini-grants and larger Last Mile grants, aimed at helping students overcome financial barriers in their pursuit of degrees. By fostering diverse and resilient teams, the fund contributes to innovation and growth in technology and engineering fields.

The Friends of Reservoirs: Mossback Grant offers three grants of $1,000 in Mossback products to eligible members of Friends of Reservoirs organizations. Sponsored by Mossback Fish Habitat, these grants aim to enhance structural habitat in public waters. The total retail value is approximately $1,500. Applicants must cover freight costs, and a $25 application fee applies to each submission. This initiative supports habitat restoration efforts across member organizations.

The Limited Competition Small Grant Program for NIDDK K01/K08/K23/K25 recipients offers funding opportunities for pilot studies and feasibility research. This program aims to support researchers transitioning to independent investigator roles by providing resources for small projects that can yield preliminary data for future R01 applications. Key deadlines for applications range from February 2025 through January 2028, with specific dates for standard, renewal, and AIDS-related applications.

The DFO Research, Education, and Conservation Grant supports projects focused on birds and their habitats, prioritizing initiatives in the Denver area and Colorado's Front Range. Established in 1994, the fund encourages research, education, and conservation efforts with grants typically under $2,000. Recent funded projects include studies on owl habitats and educational programs for young birders. The fund aims to advance knowledge and appreciation of avian species through targeted financial support.

The Arthritis National Research Foundation supports early career researchers in their quest to advance understanding and treatment of arthritis and related autoimmune diseases. Annually, the foundation grants 10 to 20 awards of $125,000 each for two years. Focus areas include osteoarthritis, rheumatoid arthritis, lupus, and more. Eligible investigators must hold an M.D. or Ph.D., be affiliated with a U.S. nonprofit research institution, and commit significant research time. Applications from prior grant recipients or those with certain NIH grants are ineligible.

The Cooperative Endangered Species Conservation Fund: Recovery Land Acquisition Grant Program, initiated in FY 2001, aims to foster collaboration between State and Federal entities in conserving listed species. This program provides funding for acquiring critical land parcels to support U.S. Fish and Wildlife Service-approved recovery plans. By securing habitats at risk from development, the initiative directly addresses the primary threat to endangered species, ensuring effective and immediate conservation actions.

The NIDA Research Education Program (R25) aims to enhance the training of a workforce skilled in biomedical, behavioral, and clinical research, particularly regarding substance use disorders. This program supports educational activities that prepare clinicians and clinical researchers. Applications are due by 5:00 PM local time, with optional Letters of Intent encouraged 30 days prior to the full proposal deadline. This initiative does not fund non-research-related clinical training.

The Live Más Scholarship, offered by the Taco Bell Foundation, supports students aged 16-26 pursuing higher education and workforce readiness. Emphasizing passion and impact, applicants showcase how their interests drive positive change in their communities. The foundation is dedicated to breaking down educational barriers, fostering creativity across various fields including arts, technology, and entrepreneurship. This initiative empowers young dreamers to turn their aspirations into actionable goals, creating meaningful contributions to society.

The Affirm Cares Employee Foundation Grant, established by Affirm, aims to support non-profit organizations making a significant impact in financial literacy, community enrichment, and technology education. Grants range from $1,000 to $10,000, focusing on sustainable initiatives that empower communities and alleviate housing insecurity. Eligible applicants must be 501(c)(3) designated non-profits operating within the U.S. The foundation prioritizes measurable outcomes in its funding efforts, fostering civic engagement and vibrant communities.

The NIDDK High Risk Multi-Center Clinical Study Cooperative Agreement (U01 Clinical Trial Not Allowed) invites proposals for high-risk, multi-center observational studies on diseases relevant to NIDDK's mission. Applicants are encouraged to consult with NIDDK staff and must complete planning activities before submission. Key deadlines for applications span from February 2025 to October 2026, with optional Letters of Intent due 30 days prior to full proposals.

Mary Kay Ash Foundation

Guided by Mary Kay Ash’s dream to enrich the lives of women everywhere, the Mary Kay Ash Foundation® raises and distributes funds to invest in breakthrough cancer research and clinical trials to find a cure for women-related cancers and ending domestic violence.

Since 1996, the Mary Kay Ash Foundation®, a 501(c)3 organization, has contributed more than $100 million to organizations aligned with its two-fold mission. In addition, the Foundation supports awareness initiatives, community outreach programs, and advocates for legislation to ensure women are healthy and safe. Through our global charitable foundations in Brazil, Canada, China and the United States, we are collectively making a deeper impact on the lives of women around the world.

Mary Kay Ash Foundation: Cancer Research Grant

The Mary Kay Ash Foundation is a non-profit public foundation, which focuses on funding research for innovative grants for translational research of cancers affecting women (ovarian, uterine, breast, endometrial or cervical cancer among others). Translational research is broadly defined as research that will provide a scientific link between laboratory research and the clinic. Ultimately, such research would lead to improvement in diagnosis, prognosis, prevention, or treatment of the cancer. Each year the Foundation extends invitations to NCI designated cancer institutes and accredited medical schools to apply. Only one application is accepted per institution.

Grant proposals are reviewed by a Scientific Research Review Committee comprised of notable members of the American medical and scientific community. Grants are awarded up to $100,000 (combined direct and indirect costs) for a two-year period. The Foundation anticipates funding between 10 and 15 grants annually. 

The Exploratory Clinical Trial Grants in Arthritis and Musculoskeletal and Skin Diseases (R61 Clinical Trial Required) aim to support clinical trials that can be completed within a limited timeframe. This funding opportunity encourages a variety of exploratory studies that align with the NIAMS mission, focusing on interventions such as drugs, biologics, devices, and various therapies. Applications are due by 5:00 PM local time of the applicant organization.

This funding opportunity encourages applications for clinical observational studies focused on musculoskeletal, rheumatic, and skin diseases. It aims to gather essential data for designing future clinical studies, enhancing understanding of disease symptoms, progression, and patient outcomes. Observational studies supported by this initiative will contribute to the development of objective biomarkers and effective outcome measures. Applicants are invited to address key challenges in clinical project design, ensuring a robust foundation for subsequent clinical trials.

This NOFO invites applications for innovative research aimed at developing and implementing interventions to prevent and treat substance use disorders (SUDs) and overdose. It encourages studies that can rapidly advance candidate solutions towards regulatory approval or clinical use, while also addressing co-morbid SUDs. The initiative supports a wide range of research including basic, clinical, translational, and implementation strategies to tackle drug misuse and related health issues, such as HIV/AIDS.

The Aerie Real Foundation™ Community Grant aims to enhance confidence, inclusion, and sustainability among young women while supporting non-profit organizations in the US and Canada. Grants of up to $10,000 are available to programs focused on mental well-being, fostering inclusive communities, and environmental protection. Applications are accepted from certified 501c3 nonprofits, with funding allocated for projects that align with the Foundation's mission. The goal is to empower the next generation and create a positive impact in local communities.

About Us

advancing the science of water ®

Who We Are

The Water Research Foundation (WRF) is the leading research organization advancing the science of all water to meet the evolving needs of its subscribers and the water sector. WRF is a 501(c)(3) nonprofit, educational organization that funds, manages, and publishes research on the technology, operation, and management of drinking water, wastewater, reuse, and stormwater systems—all in pursuit of ensuring water quality and improving water services to the public.

5426 - Investigation of Non-Point Sources of PFAS in Sewersheds and Potential Mitigation Strategies

Grant Information

Evaluate the impact of non-point or dispersed sources of per- and polyfluoroalkyl substances (PFAS) in the sewershed (including PFAS-contaminated groundwater infiltration) on PFAS mass loading to wastewater treatment plants.

Assess how PFAS loading from non-point or dispersed sources of PFAS in the sewershed may affect treatment efficiency and reuse water quality.

Improve understanding of PFAS precursor contributions.

Identify potential strategies to mitigate PFAS loading from non-point or disbursed sources of PFAS in the sewershed.

The AWWA Jacobs Holly A. Cornell Scholarship, established in 1990, supports graduate students pursuing water supply and treatment studies. Sponsored by Jacobs/CH2M, this $10,000 scholarship is aimed at first-generation college graduates or those who have faced economic disadvantages and significant educational barriers. AWWA, the largest organization of water supply professionals, emphasizes the importance of investing in the future of the water industry through such scholarships.

The Trout and Salmon Foundation Grant offers matching funds up to $5,000 to support projects aimed at restoring and enhancing trout and salmon habitats in North America. Established in 1969, the foundation prioritizes partnerships with local watershed organizations focused on habitat improvement. Grants are provided for projects that physically restore streams and fisheries, with on-site labor recognized in certain cases. The foundation seeks to diversify funding across various watersheds and regions, ensuring a broad impact in conservation efforts.

The NIAAA Integrative Neuroscience Initiative on Alcoholism (INIA) aims to renew support for two research consortia focusing on the biological mechanisms of excessive alcohol consumption and Alcohol Use Disorder (AUD). By utilizing advanced technologies and fostering collaboration across multiple sites, this initiative seeks to standardize neurofunctional measures and enhance reproducibility in findings. Investigators are encouraged to prepare for future applications to this NOFO, which will utilize the U24 activity code.