Best Operating Grants for Nonprofits in Wisconsin

The Wisconsin Medical Society Foundation is committed to enhancing health in Wisconsin by funding medical education and public health initiatives. Established in 1955, it supports physician-led programs that address health disparities, improve access to mental health services, and promote disease prevention. Preference is given to evidence-based projects with measurable outcomes that foster health equity. The Foundation is a 501(c)(3) nonprofit entity that prioritizes strategic, high-impact initiatives to benefit the community.

The JFNY Grant for Arts & Cultural Exchange supports U.S. non-profit organizations aiming to enhance understanding of Japanese arts and culture. Eligible projects include performances, workshops, and exhibitions, with priority given to those with additional funding and in areas with limited access to cultural events. Applications must be submitted at least one month prior for online projects and three months for others. The grant covers expenses like travel, publicity, and artist fees, and is reimbursed upon project completion.

The CoVantage Cares Foundation Grant supports non-profit organizations in Wisconsin, Michigan, and Illinois that address basic needs and enhance community quality of life. With over $4.2M in funding since its inception in 2015, the foundation prioritizes projects with lasting impact, collaboration, and alignment with its mission. It aims to assist those facing financial challenges while promoting financial literacy and community enhancement initiatives.

The American Electric Power Foundation provides grants to 501(c)(3) organizations focused on educational improvement, particularly in STEM fields, and basic human services such as hunger and housing. Organizations must operate within AEP's service territory or have a broader beneficial purpose. The Foundation also supports social justice initiatives and environmental protection efforts. Eligible applicants must affirm compliance with anti-discrimination policies and demonstrate commitment to diversity and inclusion.

The Bank of America Charitable Foundation focuses on supporting organizations that empower communities through basic needs, income creation, and stable housing. By investing in health and job opportunities, they aim to enhance economic mobility for low- and moderate-income families. Their partnerships target vulnerable populations, ensuring equitable access to resources that foster community vitality and resilience. This initiative emphasizes the importance of stable housing as a foundation for personal and communal growth.

The George F. Moss Foundation Grant supports charitable organizations in the greater Milwaukee area. Established in memory of George French Moss, who dedicated his life to business and philanthropy, the foundation emphasizes local impact. It seeks to fund initiatives that enhance community welfare, reflecting Mr. Moss's lifelong commitment to charitable endeavors. This grant is ideal for organizations aiming to make a significant difference in the lives of Milwaukee residents, ensuring his legacy continues through meaningful contributions.

Investing in Dental Care Technology: Grants to Improve Rural Dental Efficiency and Access

Funding opportunity summary

The Wisconsin Department of Health Services (DHS) is seeking applications for competitive grants to support dental clinics in adopting technologies that improve efficiency and increase access to care in rural and semi-rural communities. Dental practices, particularly in more rural areas of the state, face challenges that result in reduced access to care. These challenges include high rates of uninsured patients, low and unpredictable patient volumes, dental workforce shortages, and limited capital resources to adopt innovative technologies. This funding opportunity seeks to address these challenges through increased access to dental technological innovations, which improve dental services in rural Wisconsin by increasing the speed of appointments while maintaining quality of care. This funding will allow dental practices to purchase technologies to deliver high-quality and efficient services. Applicants may apply to multiple Rural Health Transformation Program (RHTP) funding opportunities for which their organizations are eligible.

About PCORI

PCORI funds patient-centered comparative clinical effectiveness research (CER).

Our Mission

PCORI helps people make informed healthcare decisions, and improves healthcare delivery and outcomes, by producing and promoting high-integrity, evidence-based information that comes from research guided by patients, caregivers, and the broader healthcare community.

Broad Pragmatic Studies PCORI Funding

The Patient-Centered Outcomes Research Institute (PCORI) intends to issue a Broad Pragmatic Studies (BPS) PCORI Funding Announcement (PFA), seeking to fund patient-centered comparative clinical effectiveness research (CER) projects. 

Research Initiative Highlights

CER compares at least two available health treatments, services or care delivery strategies. PCORI seeks proposals that compare clinical interventions (e.g., pharmacological and nonpharmacological treatments, screening and diagnostic approaches) and healthcare delivery system interventions (e.g., workforce, technologies, healthcare service delivery designs) to evaluate potential benefits and harms of different treatment and care delivery options, thus generating evidence that empowers patients, caregivers and the broader healthcare community with information to make informed choices that reflect their needs and preferences.

Special Areas of Emphasis

For Cycle 2 2026, PCORI is particularly interested in submissions that address the following Special Areas of Emphasis (SAE) within the BPS funding opportunity. The purpose of identifying these SAEs is to encourage submissions to these areas, rather than limiting submissions to these topics. Applicants addressing one of the below SAEs should identify the area that is best associated with their research approach:  

• Addressing Obesity
• Diabetes Prevention, Care and Treatment
• Management of Urogynecological and Pelvic Pain
• Pain Management for Individuals Living With Sickle Cell Disease

In PCORI-funded research, patients and other research partners are expected to meaningfully contribute their lived experience or professional expertise to ensure studies are patient-centered, relevant and useful for healthcare decision making. Applicants must address PCORI’s Foundational Expectations for Partnerships in Research — an evidence-based framework supported by tools and resources to guide effective engagement strategies. Applicants are also strongly encouraged to consider the inclusion of a broad range of patient-centered burdens and economic outcomes. 

Broad Pragmatic Studies PFA: Category 1, Category 2 and Category 3 Study Specifications

PCORI will commit up to $120 million in direct costs through this funding opportunity. This funding opportunity contains three categories for funding:

• Category 1: Category 1 will support research projects with direct costs up to and including $5 million.

• Category 2: Category 2 will support research projects with direct costs greater than $5 million and up to a maximum of $12 million. Applications for funding under Category 2 will be required to provide additional information in the Letter of Intent (LOI) and application to justify the size and scope of the proposed research projects and to explain how additional funds are necessary with respect to the scale, scope and complexity of personnel and material resources needed to address the research question.

• Category 3: Category 3 will support research projects with direct costs up to $12 million that utilize PCORnet® to conduct observational studies and/or pragmatic trials that are national in scale. Category 3 PCORnet Studies® must include two or more Clinical Research Networks and share study progress, performance metrics and best practices with the network to promote continuous learning and improvement. PCORnet Studies® will leverage the PCORnet Common Data Model® as appropriate. Additional details about Category 3 can be found on the PCORI website.  

Enterprise Community Partners

Enterprise Community Partners (Enterprise) is a national nonprofit that exists to make a good home possible for the millions of families without one. We support community development organizations on the ground, aggregate and invest capital for impact, advance housing policy at every level of government, and build and manage communities ourselves. Since 1982, we have invested $80.9 billion and created 1 million homes across all 50 states, the District of Columbia, Puerto Rico and the U.S. Virgin Islands – all to make home and community places of pride, power and belonging.

Midwest Asset Management University Program

Operating, maintaining, and preserving affordable housing is complex and requires a specialized set of skills and a deep organizational commitment to asset management. Today, affordable housing providers face a variety of economic, operational, and compliance challenges, including rising operating costs, rental arrears, staffing shortages, and an aging portfolio.

Enterprise is launching its first Asset Management University (AMU) Program in the Midwest (Illinois, Indiana, Wisconsin, Missouri, and/or Minnesota) in March 2026 to support mission-aligned, affordable housing providers in meeting these challenges in their efforts to provide housing stability to residents and preserve the long-term affordability of properties.

The Midwest AMU is a comprehensive, five-month training program that seeks to strengthen the asset and property management capabilities of participating housing providers, improving organizations’ capacity to oversee the financial, physical, and operational health of their housing portfolios.

Midwest Asset Management University Cohort 

Enterprise is excited to offer this application for participation in the Asset Management University (AMU) Cohort (the “Cohort”). Up to fifteen (15) eligible organizations will be selected for this Cohort and will receive access to online training offered by the Consortium of Housing and Asset Management (CHAM), peer learning opportunities, and post-training technical assistance.

Asia-Pacific Network for Global Change Research

The Asia-Pacific region, home to over half the world's population, faces challenges due to its development goals, which strain natural resources, communities, and cultural heritage. These issues are exacerbated by adverse environmental changes. While research has shed light on these problems, it's clear that more challenges lie ahead. The Asia-Pacific Network for Global Change Research (APN) is well-positioned to generate new knowledge and solutions for these evolving global change and sustainability issues by supporting collaborative research and scientific capacity development activities, particularly those aimed at training the next generation of early career professionals.

APN 2025 Call for Proposals: CAPaBLE Programmes

CAPaBLE, our scientific capacity development programme, aims to enhance the capacity of scientists, policymakers and practitioners to assess global change issues, and explore options to resolve issues towards achieving sustainability. Through CAPaBLE, we support activities that enhance capacity at individual, organizational and systemic levels.

Activities of interest under the CAPaBLE Programme

APN supports CAPaBLE activities that enhance existing capacities of developing countries at three levels of individual-based capacity development; group, organisation, network-based capacity development; and societies, governance, and system level capacity development. APN accepts CAPaBLE proposals that engage 1 or more member/approved countries. Proposals must address one or more of the following activities:

SCIENTIFIC CAPACITY DEVELOPMENT ACTIVITIES that promote the following approaches related to one or more of the six thematic areas of APN:

• Utilising and strengthening existing capacity, 
• Creating opportunities to use/instil capacity, 
• Developing new capacity through innovative approaches.

AWARENESS-RAISING AND DISSEMINATION activities through policy- and decision-making communities, civil society, and/or the general public.

SCIENCE-POLICY interfacing in the context of the priority topics.

CAPACITY DEVELOPMENT PARTNERSHIP ACTIVITIES that contribute to the capacity development components of the evolving global change arena, including the UNFCCC Paris Agreement, IPCC, IPBES, post-2015 Sustainable Development Goals, Sendai Framework for Disaster Risk Reduction, and the UN Decade of Ocean Science, and ongoing and new global change and sustainability research programmes.

Activities geared towards using SCIENCE COMMUNICATION to disseminate knowledge generated from projects, particularly to non-science audiences.

Radio Flyer is committed to enhancing the lives of children through charitable giving and community support. Their philanthropic efforts focus on 501(c)(3) nonprofit organizations that promote outdoor play and well-being for children. Key initiatives include partnerships with national charities and local organizations, such as building playgrounds for underprivileged kids. Ineligible requests include those from individuals, political groups, and organizations outside the contiguous United States. This ensures that their contributions create lasting positive impacts.

The US Department of Health & Human Services, through the NIH, invites applications for innovative approaches to implement SBIRT/P for addressing alcohol, tobacco, and other drug use in adults facing health disparities. This funding opportunity encourages research that tests screening, brief interventions, and referrals for treatment or prevention services. Applications are due on specified deadlines from February 2024 through March 2027, fostering collaboration with healthcare and community partners to enhance public health outcomes.

The Kyle R. Long Scholarship, managed by the Community Foundation of North Central Wisconsin, aims to support graduating seniors from the Medford area who have special educational needs or learning disabilities. Scholarships encourage these students to pursue post-secondary education in any field. In total, over $300,000 will be awarded to more than 200 students across north central Wisconsin, reflecting a commitment to enhancing community life through educational opportunities.

The RMEF Grant Program lies at the core of advancing our mission.

RMEF established the program in 1986 to provide financial and logistical support to projects that align with our priorities and goals. Grant funds raised by RMEF members, volunteers and generous donors from across the country translate into significantly more conservation accomplishment when matched with partner funds. The RMEF Grant Program also aims to build recognition for RMEF’s work, grow engagement, and boost local fundraising efforts.

Governed by clear guidelines and criteria, the RMEF Grant Program seeks to foster meaningful collaborations and long-term impacts in the conservation of natural resources and outdoor traditions. Grant project partners include federal, state, local, and tribal wildlife and land management agencies, private landowners and local stakeholders, sportsmen and women, and conservation organizations, universities, foundations and the outdoor industry. Eligible projects primarily focus on habitat stewardship, land conservation and access, wildlife management, and hunting heritage.

We support organizations recognized by the Internal Revenue Service (IRS) as a 501(c)3 entity, federal, state, local, or tribal government entities, sportsmen’s organizations, or educational institutions. All applicants must have a Federal Employer Identification Number (EIN) issued by the IRS. RMEF does not offer grants to individuals.

Wildlife Management and Research

RMEF funds wildlife management and research to keep big game healthy and thriving, including disease surveillance, big game-friendly fencing, road management, and scientific studies that expand our understanding of big game habitat, movement, interactions, and overall herd health.

RMEF’s 2026 priorities include:

• Research on migration + connectivity, critical habitat + nutrition, big game population trajectories, challenges to big game populations, and big game management solutions
• Big Game-Friendly Fencing

The Joyce Foundation's Education & Economic Mobility Grants aim to close income and race disparities in college and career success. The foundation prioritizes equitable access to high-quality education, supporting policies for effective educators, high school graduation, and affordable college credentials. Focused on racial equity and economic mobility, it addresses the needs of historically underserved young people in the Great Lakes region and invests in research, policy development, and advocacy to help them recover from the COVID-19 pandemic.

PCM Credit Union

The PCM Credit Union is a member-owned financial cooperative rooted in the “People Caring More” philosophy, dedicated to helping members achieve personal financial success by providing benefits and advantages over other financial institutions. Its mission emphasizes going above and beyond to support member-owners with a full range of financial services, while its vision focuses on investing in members and growing together through empathetic, reliable, and community-oriented service. The credit union’s funding and community priorities include offering competitive financial products, financial education and wellness resources, and support for local communities through scholarships, volunteerism, and sponsorships that strengthen financial stability and community vitality across its service areas.

PCM Credit Union Scholarship Program

The PCM Credit Union (PCMCU) offers an annual scholarship program to support members pursuing post-secondary education. PCMCU will award three (3) $1,000 scholarships to students who are beginning or continuing their education as full-time students. Applicants must be primary members of PCMCU, enrolled full-time in a post-secondary institution, and must not have previously received a PCMCU scholarship (effective 2026). A completed application and essay response must be submitted. The essay prompt reflects the credit union’s “people helping people” philosophy and asks students to explore how schools and credit unions can collaborate to promote financial confidence and responsible decision-making among young people.

The Steve Brovold Scholarship, offered by the St. Croix Valley Foundation, supports male students pursuing an Elementary Education degree at the University of Wisconsin-River Falls. With a mission to enhance local communities through educational opportunities, this scholarship aims to foster the next generation of educators who will have a meaningful impact in their communities. The foundation, established in 1995, has a rich history of connecting generosity with impactful initiatives across the St. Croix Valley.

Service Objects In-Kind Grants support non-profit organizations dedicated to environmental conservation and sustainability. By leveraging their data validation services, they aim to assist projects that promote ecological health and responsible resource management. The program prioritizes applications with clear, measurable objectives and impactful outcomes within one to three years. Organizations with 501(c)(3) status in the U.S. are eligible, while initiatives lacking detailed plans or focusing on generalized education will not qualify. This grant fosters community involvement in environmental stewardship.

The Great American Cleanup Grants, offered by Keep America Beautiful, aim to enhance community beautification and environmental efforts across the U.S. This initiative encourages KAB affiliates to remove litter, plant greenery, and restore public spaces, contributing to the larger goal of cleaning up 25 billion pieces of litter by 2026. With cash grants available, this program fosters collaboration among communities, promoting sustainable practices and a cleaner, greener future for all.

Asthma-Safe Homes Program Environmental Services Training Provider

This Request for Applications (RFA) is for a partner who can provide training and technical assistance on environmental home assessment, repair, and remediation of asthma trigger sources to organizations delivering the Wisconsin Department of Health Services’ Asthma-Safe Homes Program environmental services. The total available funds is up to $15,000.

Funding opportunity description

The purpose of this request for applications is to seek a partner who can provide training and technical assistance on environmental home assessment, repair, and remediation of asthma trigger sources to organizations delivering the Wisconsin Department of Health Services’ (WI-DHS) Asthma-Safe Homes Program environmental services. This program is a Children’s Health Insurance Program (CHIP) Health Services Initiative (HSI) funded through the Centers for Medicare and Medicaid (CMS). The grant is expected to begin on October 1, 2026.

The Primary Care Program: Allied Health Professional (AHP) Education and Training Grant supports partnerships among hospitals, health systems, and educational institutions to enhance training for allied health professionals. This initiative aims to improve access to high-quality education for vital health positions, particularly in rural areas, while also welcoming applications from urban and suburban partnerships. The grant seeks to foster collaborative efforts that ultimately strengthen healthcare services across Wisconsin.

About Us

Let’s look forward, together.

Wisconsin is known for forward thinking. We’re home to momentum builders, change creators, and what’s next-ers who all have their own visions of success. Starting new businesses. Making the world a better place. Expanding their reach. Revitalizing their communities. Transforming their operations. WEDC is here to help them make it all happen by providing resources, operational support, and financial assistance, and working with more than 600 partners across the state. Our partners include regional economic development organizations, academic institutions and industry clusters.

To strategically invest in Wisconsin to enhance the economic well-being of people and their businesses and communities

An Economy for All, where every Wisconsinite has the opportunity to thrive

Small Business Technical Assistance Program

Strengthening the organizations that support small business

By funding organizations that provide business training, community building, mentorship, and connections to networking, the Small Business Technical Assistance Program from the Wisconsin Economic Development Corporation (WEDC) seeks to increase traditional small business activity across Wisconsin.

The National Forest Foundation's Matching Awards Program connects communities to forests by funding stewardship activities that promote engagement with National Forests and nearby public lands. This program aims to create lasting impacts, ensuring that all communities can benefit from the rich resources of these natural areas. By supporting various projects, the program fosters a deeper relationship between people and the environment, ultimately enhancing conservation efforts and community well-being.

The Chi-Cal Rivers Fund Grant, administered by the National Fish and Wildlife Foundation, aims to enhance the waterways of the Chicago and Calumet region. This initiative focuses on reducing stormwater runoff through nature-based infrastructure, improving fish and wildlife habitats, and promoting community engagement. The program supports projects under three main categories: habitat quality improvement, stormwater solution expansion, and activation of restored natural areas, encouraging strategic investments for ecological resilience.

The Great Apes and Gibbons Program Grant, administered by the Arcus Foundation, supports conservation efforts for great apes and gibbons across 24 priority landscapes in Africa and Asia. The program emphasizes sustainable coexistence between humans and wildlife, having awarded over 2,000 grants to more than 500 organizations globally. Funding is not available for individuals or specific lobbying activities, ensuring resources are directed towards impactful conservation initiatives.

The Ethnic Minorities and Women’s Internship Grant supports entry-level athletics administrative positions for one academic year, promoting diversity in NCAA Division II. It provides $30,000 for intern salaries and $3,000 for professional development, benefiting six schools annually from a total budget of $180,000. Eligible applicants must be active NCAA members, with a focus on enhancing ethnic minority and gender representation in athletics administration. This initiative encourages professional growth and compliance in diverse environments.

About the DNR

Preserving and enhancing the natural resources of Wisconsin

In keeping with our mission, the DNR is dedicated to working with Wisconsinites while preserving and enhancing the natural resources of Wisconsin. In partnership with individuals and organizations, DNR staff manage fish, wildlife, forests, parks, air and water resources while promoting a healthy, sustainable environment and a full range of outdoor opportunities.

Urban Wildlife Damage Abatement and Control (UWDAC) Grants

Urban Wildlife Damage Abatement and Control (UWDAC) grants help urban areas develop wildlife plans, implement specific damage abatement and/or control measures for white-tailed deer and/or Canada geese. They are available to any town, city or village in an urban area.

The following criteria will be used to rank applications for grant awards:

• the extent that the application addresses prevention and abatement of nuisance wildlife problems or wildlife damage to human safety, health, property;
• the extent that the application includes long-term solutions to wildlife problems such as habitat modification or adopting a "no wildlife feeding" ordinance;
• the cost-effectiveness of the plan or project;
• the severity of the wildlife damage or nuisance problem addressed by the application; and
• the likelihood of preventing the specified damage or nuisance.