Best Worcester Grants for Nonprofits in Massachusetts

Takeda Oncology offers grant funding opportunities aimed at addressing unmet educational and research needs in the medical community. They prioritize support for programs in hematology, thoracic, and gastrointestinal cancers, including lymphoma, leukemia, and previously treated metastatic colorectal cancer. Takeda encourages partnerships that enhance patient outcomes and provide tangible benefits through donations, grants, and sponsorships. Applications must be submitted at least 60 days prior to the program start date for timely review.

The Overwatch Alliance Grants support non-profit organizations with annual revenues of $500,000 or less that aid military members, veterans, and their families. Grants of up to $15,000 are available for impactful projects such as emergency financial assistance, transitional housing, and employment support. Eligible organizations must be IRS-designated 501(c)(3) entities. The Alliance encourages applications from those addressing crucial veteran community needs while reinforcing the importance of community backing for capital projects.

The Myelodysplastic Syndromes (MDS) Research Fund Grant, established by the Vera and Joseph Dresner Foundation, aims to enhance research and treatment of MDS and related blood disorders. This fund supports innovative projects addressing etiology, biology, genetics, prognosis, treatment, symptom management, and quality of life. It offers up to $125,000 for Early Career Awards and $250,000 for Established Investigator Awards, facilitating significant advancements in the field.

The SC Ministry Foundation provides annual grants aimed at supporting nonprofit organizations aligned with the mission of the Sisters of Charity of Cincinnati. These grants can be used for core programs, planning, and program expansion. Eligible organizations must demonstrate financial sustainability and avoid duplication of services. The application process starts with a pre-application survey, and funding decisions are typically made by June 30. Priority is given to projects in education, healthcare, and social services.

Stealth Biotherapeutics offers grants and sponsorships aimed at enhancing healthcare education for providers and patient communities. These funding opportunities focus on innovative programs that address rare genetic disorders, neurodegenerative conditions, and ophthalmic disorders. To apply, requests must be submitted 60 days prior to the funding start date, ensuring alignment with the therapeutic interests of the organization while providing valuable insights for healthcare professionals.

Stealth Biotherapeutics is dedicated to supporting innovative programs that enhance disease awareness and therapeutic management. Their charitable contributions focus on accredited institutions, promoting educational initiatives for health care providers and patient communities. Funding is prioritized for unique and cost-effective projects that align with their therapeutic interests, including rare genetic disorders, neurodegenerative diseases, and ophthalmic conditions. By fostering community awareness, they aim to make a significant impact in the healthcare landscape.

Who We Are

The Unitarian Universalist Funding Program (UUFP) is a denominational grantmaking program of the Unitarian Universalist Association. Inspired by the richness and diversity of our liberal religious tradition, the mission of the UUFP is to promote the influence of Unitarian Universalist principles through grantmaking.

With funds generously provided by the Unitarian Universalist Veatch Program at Shelter Rock, the UUFP awards grants to Unitarian Universalist (UU) and non-UU projects and organizations. Grants are made that:

• Support the work of social justice.
• Strengthen Unitarian Universalist institutions.
• Transform gratitude for being into generosity of living.

Get Out The Vote - 2026

The Fund for UU Social Responsibility has increased funding for grants to UU congregations and organizations working to Get Out The Vote in 2026. Grants of up to $1,000 will be made on a rolling basis until funds are depleted.  

Please note that funds must go to a UU congregation or organization for the work by UUs of the organization. The funds may not be passed through to another organization. Collaboration and partnerships are encouraged.

UU congregations and organizations frequently support the democratic process in an election cycle in a non-partisan* manner by participating in voter registration drives, organizing to stop voter suppression, providing non-partisan educational materials or forums for voters, or by volunteering to help registered voters get to the polls on election day.

The Officers’ Research Grants on Reducing Inequality support studies aimed at understanding and addressing inequalities affecting youth ages 5-25 in the U.S. This initiative funds descriptive, intervention, and measurement development studies focused on academic, social, behavioral, and economic outcomes. The William T. Grant Foundation encourages research that identifies specific inequalities and explores effective programs or policies to mitigate these disparities while addressing systemic issues such as racism and structural inequality.

The McKnight Endowment Fund for Neuroscience offers Scholar Awards to early-career neuroscientists focusing on learning and memory disorders. The awards provide up to $225,000 over three years, emphasizing research that could lead to significant clinical advancements. Eligible candidates must work as independent investigators at U.S. non-profit institutions, hold an Assistant Professor position for less than four years, and demonstrate their research program's potential. The program aims to foster innovative solutions in neuroscience.

The IECA Foundation Grant offers up to $5,000 to nonprofit organizations in the U.S. that assist underserved youth and young adults in achieving their educational goals. The Foundation prioritizes projects that demonstrate measurable impact and align with its mission of fostering positive outcomes through personalized support and community engagement. Eligible organizations must be 501(c)(3) nonprofits with an annual budget of $1 million or less, focusing on innovative, project-based initiatives.

The Charles F. Bacon Trust Grant supports educational, human services, and health care programs for underserved populations, with a focus on elderly women. Established in 1928, the trust encourages grant requests for operating and program support, including small capital expenses. Most grants are awarded for one year, but multi-year support may occasionally be granted. This initiative aims to enhance the quality of life for vulnerable communities through targeted assistance and resources.

The AWS Imagine Grant Program aims to empower U.S.-based nonprofit organizations by prioritizing technology in their projects. This initiative offers three award categories: The Pathfinder Award for innovative generative AI projects, the Go Further, Faster Award for cloud-based solutions, and the Momentum to Modernize Award for foundational tech projects. Each category provides significant financial support, AWS promotional credits, and implementation guidance to help nonprofits achieve their mission-driven goals.

Nikon USA is dedicated to supporting innovative initiatives that align with its marketing strategies and community impact. They seek sponsorship proposals that demonstrate unique ideas, enhancing brand engagement and consumer reach. However, applicants must be over 18 and submit requests at least six months prior to their program. Nikon prioritizes USA-based entities and cannot support individual projects or certain causes. For more details, please submit your request through their designated online form.

The True Inspiration Awards, established by Chick-fil-A in 2015, recognizes nonprofit organizations that significantly impact their communities. In 2025, the program will distribute $6 million in grants, ranging from $30,000 to $350,000, to sixteen selected organizations. Categories include Caring for People, Caring through Food, Community, and Caring for our Planet, with a focus on educational initiatives, food security, housing services, and environmental stewardship, honoring the legacy of founder S. Truett Cathy.

The Covenant Foundation's Signature & Ignition Grants celebrate excellence in Jewish education by funding innovative projects that enhance educational practices. The Foundation supports diverse institutions across North America, inviting applications for creative programs that can adapt and disseminate effective practices. While Signature Grants may reach up to $150,000 over three years, Ignition Grants focus on untested ideas with funding up to $20,000 for one year. One application per cycle is permitted.

The Wadsworth Golf Charities Foundation Program Grants aim to promote self-discipline, culture, and etiquette through golf, enriching lives and fostering charity. The foundation focuses on providing grants exclusively to 501(c)3 organizations, ensuring that only one application per organization is accepted each year. By encouraging youth and individuals of all ages to engage with the game, the foundation aspires to instill valuable life lessons and a sense of community, making golf a powerful teacher.

The Barbara McDowell and Gerald S. Hartman Foundation Grant supports social justice litigation in the U.S. by providing funding to organizations involved in systemic legal cases. Since 2009, the foundation has awarded over $1.4 million to 49 organizations, enhancing the lives of disadvantaged groups through impactful legal advocacy. The foundation prioritizes cases that align with its focus areas, including children's rights, discrimination, and homelessness, ensuring comprehensive support for societal improvement.

The Life Comes From It Grant, funded by the Tides Foundation, supports grassroots initiatives focused on restorative, transformative, and indigenous justice. It prioritizes projects led by communities of color, emphasizing alternatives to incarceration and community-led solutions. Applicants must be 501c3 organizations based in the United States. This grant fosters a collaborative approach to healing and justice, aiming to shift power dynamics and promote inclusive practices across generations.

The Highland Street Foundation Grant supports critical needs for children and families in Massachusetts and California. Focused on education, housing, health care, and the arts, it awards grants based on established relationships with nonprofit partners. The foundation does not accept unsolicited proposals and limits submissions to one letter of inquiry per organization each year. Organizations outside the U.S. are not eligible for funding, ensuring support remains local.

The Humanity United Grant focuses on addressing human exploitation and violent conflict through a strategic approach. It emphasizes support for registered charities and initiatives globally, particularly in regions like Asia-Pacific and South Sudan. The grant fosters collaboration among partners to promote human dignity, racial justice, and peacebuilding. Interested organizations are encouraged to align their proposals with the outlined themes and engage with the funder for potential support.

The Native American Agriculture Fund (NAAF) offers grants to support Native farmers and ranchers through business assistance, agricultural education, technical support, and advocacy services. Established from the Keepseagle v. Vilsack settlement, NAAF is committed to providing essential resources to eligible organizations, including 501(c)(3) nonprofits, educational institutions, and tribal governments. Special focuses include inflation assistance and market access, ensuring a holistic approach to agricultural support.

The Security and Preparedness (SAP) Program, supported by the National Science Foundation, promotes fundamental research addressing global and national security issues. It emphasizes intellectual merit and broader impacts, encouraging projects that are methodologically sound and empirically driven. Research areas include international relations, political violence, and peace science, among others. The program also fosters undergraduate research experiences and methodological innovations, while strictly avoiding applied research.

The Civic Engagement Microgrant Grant Program, funded by Research!America, aims to enhance public engagement skills among early-career scientists. By providing financial support for innovative projects, this initiative encourages collaborations across various STEM disciplines. Grantees will develop essential skills in communication and policy-making to strengthen community ties and promote science as a national priority. This program addresses the critical need for scientists to connect with local communities and policymakers to ensure the relevance and impact of scientific research.

The Rachael Ray No-Kill Excellence Grants, funded by the Rachael Ray Foundation, support Best Friends Network partners in maintaining a 90% Save Rate for animals. These grants encourage innovative projects that enhance community partnerships and mentorships, helping organizations achieve sustainable lifesaving outcomes. Eligible organizations can apply for grants up to $60,000, with a focus on scalable programs that benefit animals and promote no-kill initiatives across the United States.

Preserving American Historical Treasures

The 1772 Foundation was named in honor of its first restoration project, Liberty Hall in Union, New Jersey. Built in 1772 by William Livingston, New Jersey’s first elected governor, the residence was home to generations of the Livingston and Kean families, including Stewart Barney Kean, who founded the 1772 Foundation in 1984. Liberty Hall has since been converted into a museum and the Foundation, thanks to Mr. Kean, continues to provide ongoing support for it and many others like it across the country. Upon Mr. Kean's death, in 2002, the Foundation grew from a $2.1 million private foundation to one with over $80 million in assets. In the twenty years since then, the foundation has granted more than $50 million for historic preservation work throughout the United States. After learning of the Kean Family's ties to slavery, the 1772 Foundation has committed to increased funding to racial justice and African American history funding.

Massachusetts Historic Preservation Matching Grants

The 1772 Foundation has announced that funding in the form of 1:1 matching grants of up to $10,000 will be made available for the following historic preservation projects: exterior painting, finishes and surface restoration, fire detection/lightning protection/security systems, repairs to/restoration of porches, roofs and windows, repairs to foundations and sills, and chimney and masonry repointing.

To demonstrate the sustainability of historic sites, applicants maybe required to submit a cyclical maintenance plan, condition assessment, restoration plan or stewardship plan that has been prepared or updated within the last five years. If an appropriate plan does not exist, the Foundation will consider providing support for development of a plan on a case-by-case basis

The Foundation will consider the following: 

• Matching grants for exterior painting, finishes and surface restoration
• Matching grants to install or upgrade fire detection, lightning protection and security systems
• Matching grants for repairs to/restoration of porches, roofs and windows
• Matching grants for structural foundation and sill repair/replacement
• Matching grants for chimney and masonry repointing

The Brave Heart Foundation Grant aims to uplift underserved populations, focusing on children and families through education, health, and community action. With a commitment to funding impactful programs in Indiana, the Foundation prioritizes organizations that demonstrate clear community benefits. Larger funding requests are accepted from previously funded agencies, ensuring continuity and accountability. This grant serves as a vital resource for initiatives that enhance the well-being of those in need, fostering positive change within local communities.

The Monsignor Leo Adamiak Trust Grant provides financial assistance to Ukrainian Catholic parishes in the U.S. and Ukraine, aiming to support their educational and operational needs. Eligible organizations must demonstrate a commitment to community service with a history of at least three years. The trust favors projects with measurable impacts and sustainable outcomes, while not supporting general operating costs or for-profit entities. Interested parishes should contact for application materials, as online applications are not accepted.