Best Large Grants for Nonprofit Organizations in Wyoming

The Ornis Birding x Lost Birds Expedition Grant aims to inspire skilled young birders, aged 18-30, to explore remote regions and rediscover species that have evaded scientific detection for over a decade. Funded by Ornis Birding Expeditions, this grant offers up to $5,000 for innovative expeditions, encouraging participants to submit detailed observations and engage with local communities. The initiative seeks to fill critical gaps in ornithological knowledge while promoting conservation and ecotourism.

The Robotic Research Grant, offered by the American Society of Colon and Rectal Surgeons, provides up to $150,000 over two years for innovative research in colorectal surgery and robotics. Emphasizing education, health equity, and novel techniques, the grant supports projects conducted in the U.S. or Canada, with a focus on scientific rigor. Applications must be submitted by ASCRS members who are principal investigators, ensuring alignment with ethical research standards.

The Research Foundation of the American Society of Colon and Rectal Surgeons offers a Career Development Award to support early career investigators in colorectal surgery. With a funding of $75,000 per year for two years, this award emphasizes mentorship and career growth. Applicants must be within five years of their first faculty position and demonstrate innovative research in colon and rectal diseases. The award aims to enhance academic careers while fostering advancements in surgical techniques.

Biogen General Grants

Funding to support a project or program that does not fit any of the other defined grant categories.

The Eastern Bank Foundation (EBF) is dedicated to empowering communities through its Neighborhood Donations initiative. By investing over $16 million in local organizations, EBF aims to support vital services and promote equity in Eastern Massachusetts, Southern New Hampshire, and Rhode Island. This program allows contributions to non-501(c)(3) organizations, reinforcing EBF's commitment to partnership and community-driven solutions, with donations typically ranging from $100 to $1,000.

The Mike & Sofia Segal Foundation Grant provides vital funding to nonprofit organizations focused on intellectual freedom, medical research for rare diseases, Jewish heritage preservation, elder care, and climate change initiatives. By supporting innovative projects that align with their mission, the foundation aims to uplift communities and foster meaningful societal contributions. Organizations must be 501c-3 compliant and demonstrate a clear plan for engagement with beneficiaries and measurable objectives to be eligible for funding.

The Earth Rising Foundation Grants provide financial support ranging from $200 to $20,000 for grassroots climate initiatives. The foundation emphasizes empowering Indigenous communities, advocating for sustainable agricultural practices, and addressing social justice issues linked to climate change. By fostering youth involvement and supporting innovative projects, the foundation aims to create a vision for a sustainable future that respects both people and the planet. Applications must be submitted through a US-based nonprofit organization.

The David Kelby Johnson Memorial Foundation offers grants to 501(c)(3) organizations focused on sight preservation, children's services, and environmental conservation, primarily in Utah. Established in memory of David Kelby Johnson, who tragically lost his life at a young age, the foundation aims to honor his legacy by supporting impactful charitable initiatives. Grants range from $5,000 to $100,000, with a commitment to improving communities both locally and globally.

The Ralph J. Torraco Food Bank/Shelter Fund Grant, offered by the UNICO Foundation Inc., aims to combat hunger and provide shelter for the homeless and indigent. Eligible applicants include registered non-profit food pantries, soup kitchens, and shelters in 13 U.S. states. The grant focuses on direct services, ensuring that all funds are used for food and shelter, not for operating expenses, thereby promoting effective community support for vulnerable populations.

The Science Policy Fellowship, offered by the American Chemical Society, provides a unique opportunity for trained scientists to engage in public policy. This program enhances understanding of the policy-making process, allowing Fellows to work alongside experienced Government Affairs staff. The Fellowship focuses on key areas such as federal research funding, education in STEM, and environmental policies. Candidates with a strong background in chemical sciences or engineering are encouraged to apply, regardless of holding a doctorate.

The Loretta Morris Memorial Grants support individuals with cystic fibrosis in California who wish to engage in physical activities such as swimming, horseback riding, dance, or golf. Established in memory of Loretta Morris, this fund aims to help recipients enjoy the benefits of an active lifestyle. Applications are welcomed from both children and adults, promoting inclusivity and well-being within the CF community. Note that certain items, like memberships or accessories, are not eligible for funding.

The BJA FY 2026 Smart Reentry Demonstration Program aims to support state, local, and tribal governments in implementing effective reentry strategies for individuals transitioning from correctional facilities back to their communities. This program encourages comprehensive interventions designed to reduce recidivism by addressing various reentry needs, as outlined in the Second Chance Act. Applications are due by October 1, 2026, at 8:59 PM ET, and are submitted through JustGrants.

About Pfizer External Research & Grants

Pfizer External Research & Grants (ER&G) supports independent research, education, and QI initiatives to improve patient outcomes in areas of unmet need. Competitive grants are awarded through transparent RFPs reviewed by independent expert panels.

About ASCP

American Society for Clinical Pathology (ASCP) is the world’s largest professional membership organization for pathologists and laboratory professionals, with more than 100,000 members. ASCP provides excellence in education, certification, and advocacy on behalf of patients and the laboratory workforce. With a portfolio of more than 900 educational activities, ASCP is the worldwide leader in providing CME/CMLE credit for the entire laboratory team.

Quality Improvement in Molecular Testing Pathways for Metastatic Colorectal Cancer (mCRC)

The American Society for Clinical Pathology (ASCP), in collaboration with Pfizer Inc. and with participation from the American Society of Clinical Oncology (ASCO, invites proposals for pathology-centric Quality Improvement (QI) initiatives aimed at optimizing molecular testing pathways in the management of metastatic colorectal cancer (mCRC). This grant opportunity seeks to fund sustainable projects that improve biomarker testing practices, strengthen targeted therapy selection, and support care teams in implementing patient-centered protocols. 

The overarching goal of this program is to advance diagnostic excellence and improve treatment decision-making for patients with mCRC.

The Blake-Nuttall Fund Grants, offered by the Nuttall Ornithological Club Inc, support vital ornithological research, conservation, and education efforts focused on the birds of New England and the Northeast. Eligible organizations must be tax-exempt under section 501(c)(3) of the Internal Revenue Code, while applications from individuals or private foundations are not considered. This initiative aims to foster a deeper understanding and protection of avian species in the region.

The Mayer and Morris Kaplan Foundation Environment Grant aims to support initiatives that combat climate change, prioritizing efforts to reduce fossil fuel consumption and enhance climate education for young adults. The foundation emphasizes innovative solutions and partnerships to address both immediate and long-term environmental challenges. Areas of focus include climate and clean energy policy, as well as providing scientifically accurate climate change education. By leveraging data and research, the foundation seeks to empower organizations dedicated to creating impactful change.

The Aerie Real Foundation™ Community Grant aims to enhance confidence, inclusion, and sustainability among young women while supporting non-profit organizations in the US and Canada. Grants of up to $10,000 are available to programs focused on mental well-being, fostering inclusive communities, and environmental protection. Applications are accepted from certified 501c3 nonprofits, with funding allocated for projects that align with the Foundation's mission. The goal is to empower the next generation and create a positive impact in local communities.

The Healthy American Forests Initiative, led by the National Fish and Wildlife Foundation (NFWF), aims to enhance forest health and resilience through targeted funding. This initiative anticipates awarding 10-15 grants ranging from $250,000 to $2 million, supporting projects up to 2 years in duration. A 20% non-federal match is required, and interested applicants are encouraged to collaborate with NFWF and Native Americans in Philanthropy for potential match funding.

The Enterprise Mobility™ Philanthropic Giving program focuses on enhancing community engagement through grants aimed at supporting health, education, arts, and disaster relief initiatives. Only Enterprise Mobility team members and their spouses or domestic partners who volunteer with a nonprofit can apply for funding. The program prioritizes sustainable projects that uplift local communities and address pressing social issues, fostering a culture of responsibility and giving back to society.

This NOFO invites applications for innovative research aimed at developing and implementing interventions to prevent and treat substance use disorders (SUDs) and overdose. It encourages studies that can rapidly advance candidate solutions towards regulatory approval or clinical use, while also addressing co-morbid SUDs. The initiative supports a wide range of research including basic, clinical, translational, and implementation strategies to tackle drug misuse and related health issues, such as HIV/AIDS.

The U.S. Fish and Wildlife Service's Coastal Program offers vital technical and financial support for projects aimed at protecting and restoring fish and wildlife habitats in priority coastal ecosystems. Collaborating with conservation partners, the program ensures that all projects are scientifically sound and align with the missions of the Department of the Interior. Applicants must contact a local office for guidance before applying, ensuring projects meet strategic conservation goals.

Patagonia’s Corporate Grant supports grassroots organizations focused on bold, direct-action campaigns that address the root causes of environmental issues. The program emphasizes equity, inclusivity, and long-term change, targeting communities affected by environmental exploitation. Grants are awarded to innovative groups within the US and Canada, fostering civic engagement and measurable objectives. Patagonia prioritizes funding for initiatives that confront systemic bias and promote environmental justice, ensuring that diverse voices are represented in the environmental movement.

The FY26 Bureau of Land Management Wildlife Resource Management Program aims to enhance wildlife resource management on public lands across the nation. With a focus on habitat protection, species reintroduction, and collaborative conservation efforts, the program addresses critical ecological needs while supporting the social and economic well-being of communities. Key initiatives include habitat treatments, monitoring efforts, and partnerships with state agencies to ensure effective management and recovery of priority wildlife species.

The Mumford & Keller Grant and Scholarship Program, initiated by Indiana Audubon in 2010, offers financial support for projects focusing on natural resources and Indiana's birdlife. With grants ranging from $500 to $5,000, it aims to promote conservation, research, and education. Priority is given to initiatives targeting key species and habitats within Indiana. This program honors the legacy of Russell Mumford and Charles Keller, enhancing bird conservation efforts for future generations.

Greater Toledo Community Foundation

Greater Toledo Community Foundation transforms generosity into lasting impact. With over $510 million in assets across 1,000+ funds, we've granted more than $370 million to strengthen education, health, arts, and social services throughout our region.

We connect donors with causes they care about while bringing together leaders, organizations, and resources to tackle our community's biggest challenges. What began with Walter E. Terhune's vision in the 1920s continues today as we help individuals, families, and businesses create positive change that will benefit our region for generations.

Ottawa County Community Foundation Grants

The Ottawa County Community Foundation, Inc. (OCCF) is a public charitable organization created by the citizens of Ottawa County to enrich the quality of life for individuals and families in Ottawa County. Grants from unrestricted funds support a variety of programs in the fields of education, health and social services, economic development, natural resources and the arts.

Common Waters: Strengthening Community-based Coastal and Riverine Stewardship

Opportunity Overview

Projects supported by this RFP must be community-based stewardship initiatives (including but not limited to stewardship driven by Indigenous and descendant communities); they should be led by an individual with a strong connection to and/or an existing track record of work in the community(ies) where the project will take place, or by a member of the community themselves, and be designed in response to community needs. Projects can focus on a wide range of specific issues, including (but not limited to) local conservation and ecosystem restoration, climate change adaptation and resilience, or sustainable fishing/agriculture. The RFP will prioritize projects in National Geographic-Lindblad Expeditions destinations, including the Arctic, Asia, Baja California, Costa Rica and Panama, Europe and the Mediterranean, Patagonia, the Peruvian Amazon, the Pacific Northwest, Southeast Alaska and British Columbia, the South Pacific, and the United Kingdom and Ireland. For more detailed information on targeted areas within these regions, please refer to the targeted areas document.

The Catalyze Challenge Grant, managed by Catalyze, is an opportunity for organizations to receive funding for innovative solutions that enhance career-connected learning for youth aged 11-22. With over $4 million available in Round 5, finalists can secure up to $300,000 to implement their ideas. The grant seeks proposals that empower underserved learners through hands-on experiences and meaningful employer partnerships, ultimately impacting over 65,000 young people across the U.S.

Our Mission and Vision

The Wright Foundation for Sustainability and Innovation exists to foster innovative sustainability initiatives that make a positive impact on our planet. We want to find solutions to the complex challenges facing our world today.

Our vision is to facilitate positive action toward sustainable and innovative solutions in agricultural and environmental sectors that reduce carbon footprints and minimize risk for our communities.

Grant Programs

Wright Foundation for Sustainability and Innovation administers projects directly funded by donors that help reduce carbon footprints through carbon positive practices and emission offsetting. The foundation holds open application periods for projects in the contiguous United States, Puerto Rico and Canada that focus on reducing environmental risk through regenerative agricultural practices, habitat restoration and using natural energy sources to make our communities more sustainable.

Reducing Carbon Footprints

The foundation supports projects that work to reduce carbon footprints through the following initiatives.

Habitat Reclamation

• Restoration of habitats creates spaces for native flora and fauna and microorganisms to survive. Natural landscapes are integral to functioning ecosystems and increasing biodiversity, not to mention creating habitats for pollinator species like bees and butterflies that we so desperately need for agricultural success.

Regenerative Agriculture

• Regenerative agricultural practices have a far-reaching impact on the industry and our lives. We aim to reduce carbon emissions by fostering projects that innovate row crop sustainability and dairy, beef, pork and poultry operations to create practices that are sustainable for years to come.

Renewable Energy

• We care about carbon positive practices that harness renewable resources like solar, wind and biomass for improved efficiencies and overall reduction in use. Organic matter often sourced from agricultural production, garbage and tree pruning can be converted to energy in various ways, recycling it back into the agricultural operation that created it or fueling our communities.

Soil

• Soil sequestering practices have wide-reaching benefits like restoring and building organic matter in the soil and increasing biodiversity. It boosts water infiltration and retention and reduces erosion. Through practices like no till, applying organic matter like manure and biochar, and planting cover crops, we improve soil health as well as take CO2 out of the atmosphere.

Tree Planting

• Planting trees is a simple act that makes a huge impact in our urban, suburban and rural communities. They provide shade, release oxygen and improve air quality, improve soil quality and biodiversity, all of which contributes to offsetting carbon emissions.  

• Water
• We want to find ways to protect and restore the integrity of our water resources. We aim to fund projects focused on practices that create efficiencies and reduce the agricultural production impact on water quality and benefit our communities by conserving one of our most important natural resources. 

John Harsch Regenerative Agriculture Grant

Funding for projects adopting best regenerative agricultural management practices that impact one or several of these areas:

• Improve water quality
• Reduce soil erosion
• Increase soil health index
• Reduce synthetic fertilizer use
• Increase effective manure use as a fertilizer
• Increase biodiversity
• Reduce methane and nitrous oxide emissions