Best Large Grants for Nonprofit Organizations in Alabama

The Nonprofit Security Grant Program (NSGP) in Alabama offers funding to nonprofit organizations at high risk of terrorist attacks. Managed by the Alabama Law Enforcement Agency, the program aims to enhance security through equipment upgrades, training, and collaboration among organizations and local agencies. Eligible applicants must be 501(c)(3) organizations demonstrating a clear risk. This initiative supports a proactive approach to safeguarding vulnerable communities against potential threats.

The Day-End Dough-Nation® Program by Panera Bread exemplifies community generosity through the donation of unsold bakery products to local charities. This impactful initiative supports various organizations that distribute food to those in need, including shelters, health centers, and youth programs. By partnering with thousands of non-profits nationwide, Panera Bread not only reduces food waste but also plays a crucial role in addressing hunger and promoting equality within communities.

The Pratt Family Foundation Grant, established in 1999, supports initiatives in education, healthcare, and community welfare. It prioritizes organizations that aid housing assistance, support for women in crisis, and disadvantaged youth programs, particularly in North Carolina. The Foundation favors established religious and charitable organizations that are tax-exempt and have a local presence. Preference is given to areas connected to the Pratt family, such as Texas and Florida, ensuring impactful contributions to community development.

South Arts Inc. is offering Literary Arts Grants to support writers, independent publishers, and literary organizations focusing on contemporary literature in the Southern U.S. Grants of up to $5,000 will fund projects in poetry, fiction, and other genres. Eligible applicants must be full-time residents of the South Arts region. The initiative aims to amplify the literary traditions of the American South, fostering creativity and community engagement through diverse literary projects.

The NRP Young Investigator Award is designed to support research on optimizing newborn care during delivery using Neonatal Resuscitation Program (NRP) techniques. This grant encourages innovative projects addressing gaps in transitional physiology and resuscitation practices. Eligible applicants include researchers from Canadian and US institutions, particularly those in training or within four years of completing medical training. Awardees may receive up to $15,000 to enhance their skills and knowledge, ultimately improving neonatal outcomes.

Fellowships recognize your artistic career to date and the potential for continued artistic growth, funding exploration and creative production by Alabama's artists. Competitive applications are thoughtful about how a Fellowship award would further personal artistic growth. 

Excellence in the art form is an essential quality of the work of Fellowship recipients. An emphasis is placed on the most recent five years of work in the field. A portfolio of exemplary work is carefully examined by staff, panelists, and the Grants Review Committee

Design Fellowships: for artists working in fashion, graphic, or industrial design.

The California Casualty Thomas R. Brown Athletics Grant aims to support public middle and high school sports programs facing funding challenges due to budget cuts. Established by California Casualty, this grant provides financial assistance for purchasing equipment and covering travel costs for competitions. Eligible applicants must be active employees of public schools and members of affiliated education associations. Awards cannot be used for individual student recognition or fundraising projects.

The Alabama Power Foundation offers Scholar Grants to support public school teachers in grades two to eight, providing funding up to $7,500 for professional development and instructional resources aimed at improving student achievement in math and English language arts. The program prioritizes schools demonstrating financial need, ensuring effective collaboration among teachers to enhance educational outcomes. With a focus on innovative teaching tools and ongoing professional growth, these grants aim to empower educators and foster student success.

The F26AS00104 State ANS Management Plan 2026 aims to combat aquatic nuisance species through pre-proposals followed by full applications. Managed by the US Department of the Interior's Fish and Wildlife Service, this initiative requires a 25% cost-share and limits administrative costs to 5%. Applications are due by October 14, 2026, though the funding opportunity closes on December 16, 2026. The plan is crucial for maintaining biodiversity and supporting a coordinated national approach to invasive species management.

The Patterson Foundation offers Oral Health Grants to support programs that enhance access to dental care for underserved communities. Eligible 501(c)(3) non-profit organizations can apply for funding up to $35,000 for capacity expansion, $10,000 for personnel support, or $10,000 for program support. The foundation prioritizes projects led by volunteer dental professionals and requires follow-up reports for continued funding. Applications are accepted year-round through a two-step process.

The Preschool Development Grant Birth Through Five (PDG B-5) SMART Grant aims to enhance early care and education systems in the U.S. by supporting targeted investments in technology and data analytics. This initiative, led by the Administration for Children and Families, encourages states to improve program quality, family choice, and data-driven decision-making for children from birth to five years old. The funding is designed to create measurable outcomes and strengthen coordination within the mixed-delivery system.

Alabama Rural Health Transformation Program - Simulation Training Initiative

Funding is intended to support the implementation of Simulation Training Initiative projects that advance program goals related to workforce development, access to care, and improved healthcare quality. Depending on the proposed project, funding may support activities such as the development and expansion  of specialty-based simulation training programs, acquisition of simulation equipment, and implementation of training environments designed to improve provider skills and readiness in rural areas.

All funding under this opportunity is expected to be distributed through a competitive subaward process. Selected applicants will be treated as subrecipients and will be required to comply with all applicable federal, state, and programmatic requirements associated with the award. 

Funding Availability

ADECA anticipates making approximately $1,000,000 available under this NOFO, consistent with the CMS-approved Simulation Training Initiative budget. ADECA intends to make awards under the strategy category described in Section I. The number, size, and distribution of awards will depend on application quality, applicant readiness, geographic distribution, and other factors identified in this NOFO. 

The Bonnycastle Fellowship for Wetland and Waterfowl Research supports graduate students in advancing conservation efforts. Offered by Ducks Unlimited, this fellowship provides up to $17,000 annually for research and personal support. The fellowship emphasizes the importance of research originality, ecological contributions, and feasibility. It is open to all North American graduate students, with a preference for doctoral candidates. The award is renewable for PhD students up to two years, and once for Master's students, contingent on satisfactory progress.

The McKesson Foundation Grant provides funding up to $25,000 for organizations focused on improving health outcomes in underserved communities. Established in 1943, the foundation prioritizes health equity through strategic partnerships aimed at reducing cancer burdens, preparing healthcare professionals, and enhancing crisis response efforts. Eligible applicants include national and local nonprofits targeting specific regions in the U.S. and Canada. The foundation emphasizes projects that align with its mission and demonstrate significant community impact.

The High Priority HIV and Substance Use Research funding opportunity aims to support innovative research that addresses the intersection of HIV and substance use. Researchers are encouraged to submit proposals that include a detailed research plan and preliminary data, exploring new avenues for prevention, treatment, and potential cures for HIV among people who use drugs. Applications are due by 5 PM local time, with optional Letters of Intent recommended 30 days prior.

The Critical Needs List by Community Foundation Tampa Bay addresses urgent, unforeseen needs of nonprofits that threaten their ability to serve the community. This innovative program allows nonprofits to submit requests for funding up to $250,000 for critical expenses such as emergency repairs and essential equipment replacement. With a focus on supporting local organizations, the program aims to match funding with community philanthropists, ensuring timely assistance to those in need.

The National Trust Preservation Funds provide grants ranging from $2,500 to $5,000 to support local preservation projects and ongoing work. These funds aim to enhance community engagement in preservation, foster technical expertise, and stimulate financial participation from the private sector. Eligible applicants include public agencies and nonprofit organizations focused on planning and education efforts related to preservation. The program is particularly interested in initiatives that reach new audiences and further the preservation movement.

The Legacy Environmental Education Grant Program aims to cultivate a legacy of environmental stewardship in Alabama. This program funds projects that educate and foster environmentally responsible citizens. Eligible applicants include public and private non-profit organizations in the state, with a focus on feasibility, audience reach, and sustainability of the projects. Grants are evaluated on criteria such as project goals, budget, and public recognition of Legacy’s support, ensuring impactful contributions to environmental education.

Quality Improvement Grant Request for Proposals

Optimizing Maternal RSV Immunization Delivery: A Systems-Based Quality Improvement Initiative to Improve Uptake, Equity, and Newborn Outcomes

Pfizer, in collaboration with the Society for Maternal-Fetal Medicine (SMFM), is pleased to announce a competitive grant opportunity to support independent Quality Improvement (QI) initiatives focused on advancing maternal immunization, with a specific emphasis on Respiratory Syncytial Virus (RSV) vaccination during pregnancy.

This initiative builds upon insights generated from the Maternal Immunization Needs Assessment (MINA) project, a multi-stakeholder collaboration that identified persistent clinical, behavioral, and system-level gaps in the delivery and uptake of maternal vaccines.

We seek to fund projects that implement measurable, evidence-based interventions to improve real-world delivery of maternal RSV immunization across healthcare systems and care settings. Proposed initiatives should aim to optimize access, strengthen provider–patient communication training and tools, enhance care coordination, and address structural and behavioral barriers impacting vaccine uptake and equity.

Pfizer Global Medical Grants (GMG) supports the global healthcare community’s independent initiatives (e.g., research, quality improvement or education) to improve patient outcomes in areas of unmet medical need that are aligned with Pfizer’s medical and/or scientific strategies. Pfizer’s GMG competitive grant program involves a publicly posted Request for Proposal (RFP) that provides detail regarding a specific area of interest, sets timelines for review and approval, and uses an expert review panel (ERP) to make final grant decisions. Organizations are invited to submit an application addressing the specific gaps in clinical practice or care as outlined in the specific RFP.

For all QI grants, the applicant (and ultimately the grantee) will be solely responsible for the design, implementation, and conduct of the proposed initiative. Pfizer will have no involvement in project development, execution, or outcomes.

The Tree Campus Higher Education Program, led by the National Arbor Day Foundation, empowers colleges to cultivate vibrant green spaces while enhancing student well-being. By meeting five essential standards, campuses can achieve recognition for their commitment to sustainability. This initiative not only fosters environmental stewardship but also promotes mental health and physical activity among students, creating a healthier campus environment. Join the movement to enhance your campus and community through tree planting and care.

The Mutual Self-Help Housing Technical Assistance Grants in Alabama provide essential funding to organizations that assist low-income families in constructing their own homes. These grants enable participants to work together, reducing costs and fostering community bonds. Organizations offer technical support, ensuring families can navigate the process of home construction effectively. Eligible applicants include nonprofit organizations and federally recognized tribes. This initiative is crucial in rural areas where housing assistance is often limited.

Mission

The Foundation was established in December 2013 by Kathryn B. McQuade, after retiring from 33 years of working in the business community. I was blessed to have been born into a loving middle class family. My father worked very hard to insure that all of his children were given an opportunity for a good education and my mother, “a stay at home Mom’ was always there for us. My world was safe and comfortable. My life is in stark contrast to how much of the rest of the world lives. I continue to read of the terrible injustices waged against women and children globally and hope that this foundation can provide them the opportunity and resources to succeed. We will support organizations that help us achieve our goal of Striving to make sustainable improvements in women and children’s rights education and welfare.

Kathryn McQuade Foundation Grant

The Foundation will make timely decisions on your grant request and provide clear communications on our expectations of reporting progress.

Women

The Foundation’s goal is to provide women assistance and provide them an opportunity to succeed. Assistance can take many forms, however our goal is to help them become self sufficient and enable them to lift themselves out of poverty and provide for their children. Access to education, job training and professional skills, even access to capital in order to build a business are possible ways we will consider helping women to succeed. Grant requests should focus on enabling the women to sustain financial independence.

We look forward to hearing of the many creative ways organizations are working on helping women succeed through out the world. To help women is to help their children and the communities they live in.

Children

Too many children in the US and across the world live in poverty and lack the access to education. Education and/or appropriate skills training are necessary to break the cycle of poverty and crime. While the assistance to women may take many forms, the foundation’s focus for children will target education and/ or skills training. The Foundation is open to many ideas on how to accomplish this goal and look forward to receiving proposals to help all children achieve their potential.

The Southern SARE: On-Farm Research Grant supports agricultural professionals in collaborating with farmers to conduct innovative on-farm research projects focused on sustainable agriculture. This initiative emphasizes building strong relationships between researchers and farmers while addressing agricultural production challenges. By fostering new practices in production and marketing, it aims to enhance sustainability in the agricultural sector, thereby benefiting local communities and the environment.

The Southern SARE: Professional Development Grants support educational initiatives for agricultural professionals, enhancing outreach and training efforts directly benefiting farmers and ranchers. These grants fund diverse training activities, including workshops and farm tours, aimed at promoting sustainable agriculture through effective participatory methods. Projects are encouraged to involve multi-disciplinary partnerships and the participation of land-grant institutions, ensuring a comprehensive approach to agricultural education. Priority is given to projects with budgets under $80,000, fostering a broad array of impactful initiatives.

About Us

advancing the science of water ®

Who We Are

The Water Research Foundation (WRF) is the leading research organization advancing the science of all water to meet the evolving needs of its subscribers and the water sector. WRF is a 501(c)(3) nonprofit, educational organization that funds, manages, and publishes research on the technology, operation, and management of drinking water, wastewater, reuse, and stormwater systems—all in pursuit of ensuring water quality and improving water services to the public.

5416 - Innovative Approaches to Extend Lifetime and Minimize O&M for Nature-based Installations

Grant Information

• Identify and evaluate innovative design, construction, and management approaches that extend the functional lifetime of nature-based installations and reduce ongoing operations and maintenance (O&M) requirements.
• Develop practical guidance on key factors affecting nature-based solution (NbS) longevity, including hydraulic optimization, engineered media selection and replacement, plant selection, sediment management, and construction-phase best practices.
• Survey utilities and other NbS owners to document current maintenance practices, costs, and hours, and establish benchmarks to inform targets for improvement.

The Toy Foundation Program offers a unique opportunity for nonprofit organizations to apply for toy donations to support children in need. The application period runs from January to June, with approved applicants receiving toys by the end of the year. This initiative, part of the Toy Chest program, has positively impacted over 35 million children since 2003, promoting play as essential for emotional and educational development.

The Alabama State Council on the Arts Literary Grant - Consolidated Project aims to enhance the quality of life and economic vitality for Alabamians by supporting diverse artistic resources. It funds cohesive activities like performance seasons, workshops, and exhibitions, promoting arts education and cultural appreciation. This grant fosters excellence in the arts, providing opportunities for all citizens to engage with and appreciate the rich artistic heritage of Alabama.