Best Brule County Grants for Nonprofits in South Dakota

The NIA Genetics of Alzheimer’s Disease Data Storage Site (NIAGADS) aims to create a secure, scalable cloud platform for genetic data related to Alzheimer’s disease. This initiative will enhance data accessibility, promote interoperability, and support rigorous research practices. By facilitating collaboration and providing robust analytical tools, the platform will maximize the scientific impact of AD/ADRD research, aligning with NIH goals for transparent and reproducible science, while addressing recommendations for broad access to high-value datasets.

The Community Development Block Grant Program for Indian Tribes and Alaska Native Villages aims to foster viable communities by providing funding for decent housing, suitable living environments, and economic opportunities for low- and moderate-income individuals. Notably, the program also includes Imminent Threat Grants to address urgent public health or safety issues. These competitive grants are essential for enhancing community welfare and addressing immediate challenges faced by tribal residents.

About The Community Foundation

The Community Foundation of Herkimer and Oneida Counties is a community-based social impact investor whose mission is to engage, invest, and lead—working toward a vision of community vibrancy with opportunity for all. Our team of experienced staff and dedicated trustees is committed to boldly leading and supporting transformational community investments. We channel charitable contributions from donors through nonprofit partners that are meeting current community needs and steward community resources responsibly to ensure greater capacity for the future.

Adirondack League Club Scholarship

Established by Adirondack League Club to award scholarships to students in the Central Adirondack region of the Adirondack Park.

Candidates are identified by a committee.

Saginaw Area Health Care Administrators Scholarship

The Saginaw Area Health Care Administrators Scholarship was established in 1987 to help advance health care for the elderly and ill elderly. The scholarship provides cash awards to assist employees of association members in meeting educational expenses. Each year, employees in the areas of administration, nursing, dietary, maintenance, and other health-related occupations are invited to apply for scholarships.

The Domestic and Sexual Abuse Program (DASA)

Funds are appropriated through the State of South Dakota general funds annually. Funds are awarded to provide domestic violence and sexual assault prevention and education programs, to provide training programs for the staff and volunteers of the shelter service programs and to provide assistance to shelter programs that serve victims of domestic violence and sexual assault.

South Dakota Department of Public Safety

The South Dakota Department of Public Safety includes 14 agencies with the mission to keep South Dakota a safe place in which to live, work, visit and raise a family.

Victims' Assistance Program Grants

The Victims' Assistance Program provides grant funding for agencies that provide services to victims of domestic violence, sexual assault, stalking and other violent crimes. The Victims' Assistance Program funding includes: VOCA, FVPSA, STOP, SASP and DASA Grants.

Victims of Crime Act (VOCA) Grant

Funds are awarded by the US Department of Justice, Office for Victims of Crime. The funds come entirely from fines and penalties assessed against convicted federal criminals. Funds are awarded to provide direct assistance to innocent victims of violent crime.

Agencies who are currently not funded with Victims’ Assistance grants, but who are considering applying for a grant(s) are strongly encouraged to contact the Victims’ Services Program director prior to grant announcements being released for the upcoming funding cycle.

South Dakota Department of Health

The South Dakota Department of Health (SD DOH) strives to promote, protect, and improve the health of all South Dakotans with information, licensing, and more.

Cardiovascular Disease Prevention and Treatment Funding

The South Dakota Department of Health is pleased to announce a funding opportunity, the Cardiovascular Disease Prevention and Treatment funding. This funding opportunity is intended to support strategies that have a focus on prevention, treatment and/or management of cardiovascular disease. The facilities awarded funding through this opportunity will receive funds and technical assistance to create and expand sustainable programs to help link resources that support self-management and lifestyle changes to address those at increased risk for CVD with a focus on hypertension management.

The South Dakota Department of Health (SD DOH) Heart Disease and Stroke Prevention Program (HDSPP) is offering funding to meet one or both of the following priorities: Priority 1: Self-Measured Blood Pressure (SMBP) Program; and Priority 2: Care Coordination Program.

Priority 1: Self-Measured Blood pressure (SMBP) Program

Self-Measured Blood Pressure (SMBP) Program supports the implementation and expansion of Self-Measured Blood Pressure Monitoring programs through partnerships with local healthcare facilities and clinics. These programs are designed to help individuals with hypertension manage their condition effectively by monitoring their blood pressure at home in conjunction with clinical support.

South Dakota Department of Health

The South Dakota Department of Health (SD DOH) strives to promote, protect, and improve the health of all South Dakotans with information, licensing, and more.

Cardiovascular Disease Prevention and Treatment Funding

The South Dakota Department of Health is pleased to announce a funding opportunity, the Cardiovascular Disease Prevention and Treatment funding. This funding opportunity is intended to support strategies that have a focus on prevention, treatment and/or management of cardiovascular disease. The facilities awarded funding through this opportunity will receive funds and technical assistance to create and expand sustainable programs to help link resources that support self-management and lifestyle changes to address those at increased risk for CVD with a focus on hypertension management.

The South Dakota Department of Health (SD DOH) Heart Disease and Stroke Prevention Program (HDSPP) is offering funding to meet one or both of the following priorities: Priority 1: Self-Measured Blood Pressure (SMBP) Program; and Priority 2: Care Coordination Program.

Priority 2: Care Coordination Program

Care Coordination program supports a patient-centered healthcare delivery model that provides comprehensive, proactive, and coordinated management for individuals with multiple chronic conditions, while explicitly identifying and addressing the non-medical social and environmental factors that impact their well-being.

South Dakota Department of Health

The South Dakota Department of Health (SD DOH) strives to promote, protect, and improve the health of all South Dakotans with information, licensing, and more.

‘South Dakota Walkable Communities’ Active Transportation Assessment Collaboration

The South Dakota Department of Health will provide one South Dakota community (or two communities as an inter-community project) with technical assistance (provided by South Dakota State University Landscape Architect Students) in conducting active transportation assessments and providing recommendations for improving the built environment to increase walkability and bike-ability within that community or joint communities.

Applicants are highly encouraged to consider the specific walkability needs and challenges of priority populations when completing the applications.

ASPCA Reimagining Racers: Grants for Adopting Out Retired Racehorses Grant

ASPCA Right Horse Adoption Partners, ASPCA Right Horse Industry Partners, and organizations actively participating in the warm-up ring (defined as groups that are actively working to achieve the 13 criteria for Partnership and are participating on myrighthorse.org) are invited to apply for a grant to support an increase in capacity and/or efficiency of programs aimed at adopting out retired Thoroughbred racehorses. 

Funding requests for this grant initiative should focus on:

Activities that increase capacity, decrease length of stay, reduce cost of care or increase efficiencies, and/or improve humane outcomes in other ways. Examples:

• Training programs
• Programs that engage new adopters and grow the market share for adoption
• Medical make-ready or rehabilitation with a focus on innovation and/or sustainability
• Collaborations with other equine industry organizations to increase support for retired racehorses

Proposals will be evaluated on their potential (within the 12-month grant term) to: 

• Increase capacity (the number of horses that can be rehabilitated, trained, and placed)
• Decrease length of stay
• Decrease cost of care
• Reduce risk, harm or suffering for retired racehorses

Requests may be for the creation of new programs or the expansion of existing programs. Programs that test innovative ideas are welcome.

Grant Amounts

Grants will generally range from $10,000-$40,000, with a maximum individual grant amount of $60,000. The total funding amount available for this grant opportunity is $200,000. 

Eligibility

ASPCA Right Horse Adoption Partners, ASPCA Right Horse Industry Partners, and active Warm-Up Ring participants (defined as groups that are actively working to achieve the 13 criteria for Partnership and are participating on myrighthorse.org) whose mission or operations focus significantly on serving retired Thoroughbred racehorses are eligible to apply for this grant opportunity. Adoption organizations must be up to date on reporting data biannually to the Equine Welfare Data Collective (EWDC). If you’re unsure about your eligibility, you may contact therighthorse@aspca.org to confirm before applying.   

The American Society for the Prevention of Cruelty to Animals® (ASPCA®) was founded on the belief that animals are entitled to kind and respectful treatment by humans. We invite all voices to join us in working together to improve the lives of animals in need.

The ASPCA Right Horse Grants aim to enhance equine adoptions and support community equines by funding programs that boost shelter capacity or assist in keeping owned equines in their homes. Grants between $5,000 and $50,000 are available, with a total funding pool of up to $750,000. Eligible applicants include ASPCA Right Horse Adoption Partners and organizations committed to the welfare of retired Thoroughbred racehorses. Proposals should clearly outline the objectives and expected impacts.

Driving University Impact: Expanding the Public Exchange Network Grant

How the Public Exchange Network Works

No single university – even a large R1 – has enough faculty expertise available to meet the needs of every partner. The Public Exchange Network was designed to help universities work together seamlessly to build robust partnerships and generate more collective impact. Universities joining the network are independent but affiliated members, with full control over their own program and project portfolios. As a national network with local, on-the-ground capacity, Public Exchange Network members can also share approaches that work, scale solutions to common problems, and build cross-regional partnerships together. 

As an institutional partner in the Public Exchange Network, universities will build capacity to develop, test and implement solutions to the most urgent problems in their regions and beyond. Universities joining the Public Exchange Network get:

• The tools, templates and training they need to start right away;
• A shared brand they can plug into on day one;
• A network of faculty, past and potential partners and philanthropic relationships, benefitting everyone in the network. 

Public Exchange Network Expansion grants will cover 75-80% of the minimum estimated annual costs for two years to launch a new Public Exchange. To launch a Public Exchange, universities must have the following in place: (1) a staff executive director with experience launching and leading social impact partnerships, (2) a project seed fund, and (3) a modest operations budget. We also recommend some in-kind project management support from an existing university staff member. The grant includes a two-year Public Exchange Executive Director (ED) compensation subsidy of $300,000 to launch the Public Exchange on campus, and a 2-year license to use the Public Exchange brand. New Public Exchange Network members will also receive ongoing support and guidance from current Public Exchange leadership and staff at USC and WashU, including recruitment support and intensive training for hiring and onboarding an executive director, a sub-site on the Public Exchange website, incubation and project management support from current Public Exchange staff, and a suite of tools for developing and implementing Public Exchange projects.

The NIH Research Evaluation and Commercialization Hubs (REACH) program aims to facilitate the translation of biomedical discoveries into marketable products to enhance patient care. By funding five new academic entrepreneurship hubs, NIH will provide essential resources such as funding, mentorship, and expertise in product development. These hubs will address high-priority technologies and foster public-private partnerships, ultimately supporting the goals of federal research initiatives and addressing local health needs in underserved areas.

About Henry L. Hillman Foundation

Henry L. Hillman Foundation inspires, invests in, and leverages great ideas to improve the quality of life in Pittsburgh and southwestern Pennsylvania.

Backup Power When Your Community Needs It

The Powered & Prepared Initiative seeks proposals from nonprofit and municipal organizations in southwestern Pennsylvania for backup power solutions that allow those organizations to offer essential services during emergencies without disruption.

Southwestern Pennsylvania is increasingly impacted by severe weather events that cause widespread power outages and disruptions. The Powered & Prepared Initiative, supported by Henry L. Hillman Foundation, seeks proposals from nonprofit and municipal organizations for backup power solutions that allow those organizations to offer essential services during emergencies without disruption.

Building the Future Workforce Challenge

Awarding $5 million and the opportunity to test bold, tech‑forward solutions that strengthen the advanced manufacturing and industry technician workforce—today and for the future.

About the Challenge

Caterpillar knows preparing the workforce for the future is urgent. Communities, employers, and industry need new ways to close advancing skill gaps. The Building the Future Workforce Challenge invites fresh perspectives from all sectors to rethink training. Up to five teams will be awarded $1 million each for sustainable, tech‑forward solutions that strengthen today’s—and tomorrow’s—advanced manufacturing and industry technician talent pipelines.

What types of solutions are you looking for?

The Building the Future Workforce Challenge aims to identify, test, and scale innovative, sustainable solutions that will address today’s and tomorrow’s advanced manufacturing and industry technician skill gaps. A core requirement of any solution is that it remains relevant amid evolving technology—ensuring that breakthrough innovation and human potential rise together.

Strong proposals for Building the Future Workforce Challenge will meet four criteria outlined in the scoring rubric, and proposed solutions must focus on one or more of the following solution categories for Building the Future Workforce Challenge:

Pre-clinical Investigation of anti-TFPI-mediated Rebalancing Mechanisms in Non-Hemophilic Bleeding Disorders 

There remains a scientific gap in understanding of the role of anti-TFP Imediated hemostatic rebalancing in the context of inherited or non-hemophilic bleeding disorders. This competitive grant program encourages competitive submissions focsed on generating preclinical/foundational data exploring the therapeutic potential and mechanisms of TFPI modulation in bleeding disorders other than hemophilia.

Geographic Scope

Brazil, China, Europe, Israel, Japan, Saudi Arabia, South Korea, Turkey, USA

Funding Range and Project Length

Individual projects requesting up to $50,000 USD will be considered.

Request for study drug or compound is allowed (max $50,000 USD), additionally to the study project costs.

Maximum project length is 1 year.

Pediatric Hidradenitis Suppurativa Challenge Grant

Hidradenitis suppurativa (HS) is a devastating chronic inflammatory disease that manifests as recurrent painful nodules under the skin in the intertriginous areas of the body. It is associated with significant impacts on quality of life, psychosocial well-being, and long-term health outcomes of patients as well as consequences for families and caregivers. HS is prevalent, affecting between 1 and 4% of the population beginning in adolescence and persisting into adulthood. Despite the impact of HS, it remains underdiagnosed, undertreated, and understudied particularly in the pediatric and adolescent populations. Contributing to this dynamic are unknowns related to a complex disease etiology, stigma associated with HS symptoms (e.g., sweating, itching, and scarring commonly in the genital region), and limited treatment options to date with even fewer available for children under the age of 12.

To address the needs of children and adolescents living with HS, the Pediatric Dermatology Research Alliance (PeDRA), HS Connect, and the HS Foundation are offering the 2026 Pediatric HS Challenge Grant to support an early-to-mid career investigator for a one-year project focused on a high-priority, patient-centric research topic.

Focus

Proposals should address one or more of the following high-priority research topics:

• Predicting treatment effectiveness and risk utilizing real world evidence and/or experience
• Early disease and factors involved in severe disease development
• Optimizing surgical and procedural approaches to minimize pain, shorten healing time, and reduce recurrence
• Improving recruitment of diverse and representative populations for clinical studies, trials and advanced therapeutics

Funding:

• Up to $50,000 to support one year of research
• One award anticipated for this funding cycle

The Alpha Omega Alpha/Pharos Poetry Award

To encourage students to write effective poetry. Winning poems are published in The Pharos.

The Award

Up to 5 poems will receive a $1,500 award. The winning entries will be published in The Pharos.

Summer Medical Internship Program (SMIP)

Fosters an interest in research by funding a summer research project conducted by a medical student.

The SIR Foundation Summer Medical Internship Program introduces medical students to interventional radiology research and medical device development. The goal of this program is to foster an interest in research by funding a summer research project conducted by a medical student.

Students applying for the program must show strong potential for a career in IR with proven academic success. Selected students will have an opportunity to intern with an interventional radiologist research mentor or corporate research and development mentor for 8 weeks during the summer.

SIR Foundation will provide a $6,000 stipend to help ease the financial burdens throughout their internship experience.

• Budget: Up to $6,000
• Grant Length: Eight weeks

Hilcorp Future Leaders of America Scholarship

Benefiting select communities across the United States where Hilcorp operates.

The Hilcorp Future Leaders of America Scholarship Program was developed to give back to the communities in which Hilcorp Energy Company operates to develop future leadership talent as the next innovators, educators, and business leaders.

Award Amount

Multiple scholarships awarded annually. The scholarship is comprised of up to four (4) annual awards of $2,500, for a total award of up to $10,000.

The four annual (4) awards may be received over a period of up to 6 years, allowing for deferment if needed.

Crown Castle Scholarship

Benefiting Crown Castle interns OR dependents of Crown Castle employees.

Award Amount

• Three (3) scholarships awarded annually
• $10,000 divided evenly between the fall and spring semesters
• Recipients may reapply for up to 3 consecutive years.

What can this scholarship be used for?

• The scholarship will be mailed directly to the student's college to be used towards tuition, required academic fees, and/or book expenses.
• Scholarship funding cannot be distributed directly to the student. Funding cannot be used for room and board, rent, meal plans, parking passes, or other similar living expenses.

Behavioral Health Services

Strengthening and supporting children and adults with behavioral health needs. The goal of the continuum of behavioral health services is to foster independent and healthy individuals and families in South Dakota.

The Division of Behavioral Health provides oversight of the publicly funded behavioral health system and supports individuals of all ages with behavioral health needs. The mission of the Division of Behavioral Health is to support quality clinical treatment, recovery supports, prevention and crisis services with integrity to obtain positive outcomes for individuals with behavioral health needs.

Certified Community Behavioral Health Clinics (CCBHCs)

The Department of Social Services, Division of Behavioral Health, is requesting applications from eligible behavioral health organizations to provide Certified Community Behavioral Health Clinic (CCBHC) services for the State of South Dakota. The purpose of this application is to select a cohort of clinics intending to pursue provisional state-level CCBHC certification as soon as December 2027. Successful applicants will be required to meet CCBHC readiness criteria as defined by DBH and complete all required activities of the cohort beginning June 1, 2026. Organizations selected to participate in the 2026 CCBHC Provider Cohort will have access to funding opportunities to support the development, expansion, and sustainability planning of CCBHC-aligned service delivery in any of the nine core service delivery areas:

Crisis Behavioral Health Services

Screening, Assessment, and Diagnosis

Person- and Family-Centered Treatment Planning

Outpatient Mental Health and Substance Use Services

Outpatient Clinic Primary Care Screening and Monitoring

Targeted Care Management Services

Psychiatric Rehabilitation Services

Peer Supports, Peer Counseling, and Family/Caregiver Supports

Community-Based Mental Health Care for Members of the Armed Forces and Veterans

In addition to service delivery expansion, funding is available for the selected cohort to support organizational readiness and capacity building across any of the following goal areas for CCBHC implementation.

Goals for the CCBHC implementation efforts in South Dakota include:

• Develop the capacity to ensure compliance with all aspects of CCBHC Certification Criteria to include service provision either directly or through a Designated Collaborating Organization (DCO).
• Develop data system capacity and Electronic Health Record (EHR) interoperability to meet the data collection and reporting requirements for the CCBHC program.
• Develop financial system capacity to produce necessary cost reports to establish CCBHC Prospective Payment System (PPS) rates, and meet billing, claims encounter data, and cost reporting requirements.
• Achieve provisional and subsequent full CCBHC Certification through the State of South Dakota of at least one CCBHC in each behavioral health region by December 2030.

Sexual Abuse Services Program (SASP)

Funds are awarded by the US Department of Justice, Office on Violence Against Women. Congress appropriates the funds annually. Funds are awarded to support the establishment, maintenance and expansion of sexual assault services including providing intervention, advocacy, accompaniment (e.g., accompanying victims to court, medical facilities, police departments, etc.), support services and related assistance for adult, youth and child victims of sexual assault, family and household members of victims, and those collaterally affected by the sexual assault.

Violence Against Women Act (STOP VAWA)

Funds are awarded by the US Department of Justice, Office on Violence Against Women. Congress appropriates the funds annually. Funds are awarded to develop and implement effective law enforcement and prosecution strategies to combat domestic violence, dating violence, sexual assault and stalking; and to develop and enhance victim services for cases involving domestic violence, dating violence, sexual assault and stalking through court advocacy and other core services. Funds are also awarded to support services provided to underserved populations.

Family Violence Prevention and Services Act (FVPSA)

Funds are awarded by the US Department of Health and Human Services, Office of Community Services, Administration for Children and Families. Congress appropriates the funds annually. Funds are awarded to prevent incidents of family violence, domestic violence, and dating violence and to provide immediate shelter, supportive services and access to community-based programs for victims of family violence, domestic violence or dating violence and their dependents.

Career and Technical Education

The goal of the South Dakota Department of Education is for all students to graduate college, career, and life ready. The Division of College, Career and Student Success provides support for students' preparations for postsecondary education and the workforce. Services are connected to approved Career & Technical Education (CTE) programs, work-based learning, student organizations and more. In-line with the department's aspiration, DCCSS works to ensure students not only graduate from high school, but that they are prepared to navigate the transitions and life events that come after high school.

Workforce Education Grants

In 2013, the South Dakota Legislature established the Workforce Education Fund through SB 235. Part of that fund was designated to provide grants for Career & Technical Education (CTE) programs in secondary schools.

The Workforce Education Grants provide school districts and private, nonprofit entities who provide specialized training in South Dakota the opportunity to make transformative change in career and technical education programs. High quality CTE programs give students the knowledge, skills and experiences to be well prepared for postsecondary education and the workforce. Partnerships among secondary education, postsecondary education, and business & industry lay the foundation for modern CTE programs.

Grant Purpose & Eligibility

The Workforce Education Grants are designed to demonstrate alignment to postsecondary education and South Dakota workforce needs, developing the state's talent pipeline for workforce development and economic growth. Projects must provide work-readiness training, including technical training. Projects cannot include adult basic education, English learner services, or high school equivalency training programs.

Eligible applicants are private, nonprofit entities that provide specialized career and technical services and education as referenced in SDCL 13-13-89. The entities that are awarded grants will serve as fiscal agents through the completion of their projects. All applications must demonstrate commitment by all grant partners to the grant project and its sustainability following the conclusion of the grant.

Career and Technical Education

The goal of the South Dakota Department of Education is for all students to graduate college, career, and life ready. The Division of College, Career and Student Success provides support for students' preparations for postsecondary education and the workforce. Services are connected to approved Career & Technical Education (CTE) programs, work-based learning, student organizations and more. In-line with the department's aspiration, DCCSS works to ensure students not only graduate from high school, but that they are prepared to navigate the transitions and life events that come after high school.

Workforce Education Grants

In 2013, the South Dakota Legislature established the Workforce Education Fund through SB 235. Part of that fund was designated to provide grants for Career & Technical Education (CTE) programs in secondary schools.

The Workforce Education Grants provide school districts and private, nonprofit entities who provide specialized training in South Dakota the opportunity to make transformative change in career and technical education programs. High quality CTE programs give students the knowledge, skills and experiences to be well prepared for postsecondary education and the workforce. Partnerships among secondary education, postsecondary education, and business & industry lay the foundation for modern CTE programs.

Grant Purpose & Eligibility

The Workforce Education Grants are designed to support and align secondary school CTE systems with South Dakota's postsecondary education programs and workforce needs, developing the state's talent pipeline for workforce development and economic growth. Projects are meant to serve middle and high school students.

Eligible applicants are Local Education Agencies (LEAs) with projects designed to serve middle and high school students. The LEAs who are awarded grants will serve as fiscal agents through the completion of their projects. All applications must demonstrate commitment by all grant partners to the grant project and its sustainability following the conclusion of the grant.