Best Brule County Grants for Nonprofits in South Dakota

The Clinical Data, Safety and Statistical Centers (CDSSC) program, supported by the National Institute of Allergy and Infectious Diseases (NIAID), aims to enhance clinical research through comprehensive support. This includes statistical analysis, protocol development, and oversight of safety monitoring in studies related to asthma, autoimmune diseases, and transplantation. By coordinating these efforts, the program seeks to facilitate impactful research outcomes and improve public health outcomes through informed data-driven decisions.

The Translational Transplantation Tolerance Cooperative Study Group, supported by the National Institute of Allergy and Infectious Diseases, aims to advance transplant tolerance strategies that promote long-term graft survival without lifelong immunosuppression. This initiative focuses on developing, optimizing, and evaluating methods to induce immune tolerance in allogeneic transplants through collaborative efforts across multiple centers, utilizing translationally relevant models to ensure effective outcomes.

The NIAID aims to enhance our understanding of the interplay between chronic and infectious diseases through innovative precision systems biology research. By utilizing advanced technologies such as multi-omics and artificial intelligence, the initiative focuses on uncovering critical pathways that connect infections to chronic health issues. This multidisciplinary approach leverages longitudinal patient data to inform and improve prevention and treatment strategies, ultimately seeking to provide insights into disease progression and host-pathogen interactions.

The Asthma and Allergic Diseases Cooperative Research Centers (AADCRC) program, supported by the National Institute of Allergy and Infectious Diseases (NIAID), aims to enhance research on asthma and related allergic diseases. This initiative fosters multi-center, multidisciplinary research to explore disease mechanisms and treatment responses. By promoting clinical trials and observational studies, the AADCRC seeks to advance understanding and improve interventions for conditions such as asthma and food allergies, ultimately benefiting public health.

The National Institute of Allergy and Infectious Diseases (NIAID) is advancing organ transplantation outcomes through the Clinical Trials in Organ Transplantation in Children and Adults (CTOT-CA) program. This initiative supports multicenter clinical trials and mechanistic studies related to heart, lung, kidney, liver, and intestinal transplants, as well as non-hematopoietic cellular transplantation. By exploring immune mechanisms and innovative therapies, the program aims to enhance the success and efficacy of organ transplantation.

The NIAID aims to enhance infectious disease research by supporting human microphysiologic systems (MPS) development. These in vitro platforms mimic human tissue functions, promoting drug and biological product development while reducing animal use. This initiative aligns with NIH’s commitment to innovative research practices and regulatory acceptance. By focusing on MPS in infectious disease contexts, NIAID seeks to streamline therapeutic advancements and establish robust human tissue models, addressing critical challenges in understanding and treating infections.

The Placement and Coordination Program, administered by the Office of Refugee Resettlement, invites eligible organizations to enhance refugee resettlement services. By diversifying service providers, the program aims to strengthen the national resettlement framework. Key responsibilities include managing the Program of Initial Resettlement and Intensive Case Management for vulnerable refugees, ensuring comprehensive support from arrival through initial resettlement, and addressing barriers to self-sufficiency.

The Domestic and Sexual Abuse Program (DASA)

Funds are appropriated through the State of South Dakota general funds annually. Funds are awarded to provide domestic violence and sexual assault prevention and education programs, to provide training programs for the staff and volunteers of the shelter service programs and to provide assistance to shelter programs that serve victims of domestic violence and sexual assault.

South Dakota Department of Public Safety

The South Dakota Department of Public Safety includes 14 agencies with the mission to keep South Dakota a safe place in which to live, work, visit and raise a family.

Victims' Assistance Program Grants

The Victims' Assistance Program provides grant funding for agencies that provide services to victims of domestic violence, sexual assault, stalking and other violent crimes. The Victims' Assistance Program funding includes: VOCA, FVPSA, STOP, SASP and DASA Grants.

Victims of Crime Act (VOCA) Grant

Funds are awarded by the US Department of Justice, Office for Victims of Crime. The funds come entirely from fines and penalties assessed against convicted federal criminals. Funds are awarded to provide direct assistance to innocent victims of violent crime.

Agencies who are currently not funded with Victims’ Assistance grants, but who are considering applying for a grant(s) are strongly encouraged to contact the Victims’ Services Program director prior to grant announcements being released for the upcoming funding cycle.

South Dakota Department of Health

The South Dakota Department of Health (SD DOH) strives to promote, protect, and improve the health of all South Dakotans with information, licensing, and more.

Cardiovascular Disease Prevention and Treatment Funding

The South Dakota Department of Health is pleased to announce a funding opportunity, the Cardiovascular Disease Prevention and Treatment funding. This funding opportunity is intended to support strategies that have a focus on prevention, treatment and/or management of cardiovascular disease. The facilities awarded funding through this opportunity will receive funds and technical assistance to create and expand sustainable programs to help link resources that support self-management and lifestyle changes to address those at increased risk for CVD with a focus on hypertension management.

The South Dakota Department of Health (SD DOH) Heart Disease and Stroke Prevention Program (HDSPP) is offering funding to meet one or both of the following priorities: Priority 1: Self-Measured Blood Pressure (SMBP) Program; and Priority 2: Care Coordination Program.

Priority 1: Self-Measured Blood pressure (SMBP) Program

Self-Measured Blood Pressure (SMBP) Program supports the implementation and expansion of Self-Measured Blood Pressure Monitoring programs through partnerships with local healthcare facilities and clinics. These programs are designed to help individuals with hypertension manage their condition effectively by monitoring their blood pressure at home in conjunction with clinical support.

South Dakota Department of Health

The South Dakota Department of Health (SD DOH) strives to promote, protect, and improve the health of all South Dakotans with information, licensing, and more.

Cardiovascular Disease Prevention and Treatment Funding

The South Dakota Department of Health is pleased to announce a funding opportunity, the Cardiovascular Disease Prevention and Treatment funding. This funding opportunity is intended to support strategies that have a focus on prevention, treatment and/or management of cardiovascular disease. The facilities awarded funding through this opportunity will receive funds and technical assistance to create and expand sustainable programs to help link resources that support self-management and lifestyle changes to address those at increased risk for CVD with a focus on hypertension management.

The South Dakota Department of Health (SD DOH) Heart Disease and Stroke Prevention Program (HDSPP) is offering funding to meet one or both of the following priorities: Priority 1: Self-Measured Blood Pressure (SMBP) Program; and Priority 2: Care Coordination Program.

Priority 2: Care Coordination Program

Care Coordination program supports a patient-centered healthcare delivery model that provides comprehensive, proactive, and coordinated management for individuals with multiple chronic conditions, while explicitly identifying and addressing the non-medical social and environmental factors that impact their well-being.

South Dakota Department of Health

The South Dakota Department of Health (SD DOH) strives to promote, protect, and improve the health of all South Dakotans with information, licensing, and more.

‘South Dakota Walkable Communities’ Active Transportation Assessment Collaboration

The South Dakota Department of Health will provide one South Dakota community (or two communities as an inter-community project) with technical assistance (provided by South Dakota State University Landscape Architect Students) in conducting active transportation assessments and providing recommendations for improving the built environment to increase walkability and bike-ability within that community or joint communities.

Applicants are highly encouraged to consider the specific walkability needs and challenges of priority populations when completing the applications.

The DoW Kidney Cancer Early-Career Scholar Award is a unique initiative by the Academy of Kidney Cancer Investigators, established in FY19. It aims to foster innovative kidney cancer research through a mentoring program that pairs early-career scholars with experienced mentors. This program not only enhances research capabilities but also builds a robust network of kidney cancer researchers. By supporting promising scholars, the initiative aspires to advance the field and improve treatment outcomes for kidney cancer patients.

The FY26 Parkinson’s Research Program Investigator-Initiated Research Award supports innovative, multidisciplinary research projects aimed at advancing the understanding and treatment of Parkinson’s disease. The award encourages collaboration among multiple principal investigators, requiring preliminary data and allowing clinical trials to enhance research outcomes. This initiative is vital for fostering impactful discoveries within the four specified focus areas of the program, ultimately improving patient care and management.

The FY 2027 DoN HBCU/MI Program aims to enhance the research capabilities of Historically Black Colleges and Universities and Minority Institutions. This initiative promotes innovative solutions to naval science challenges while engaging students and faculty in STEM fields. Key objectives include strengthening research infrastructure and fostering collaborative efforts across institutions. White papers are due by September 18, 2026, and should clearly outline the proposed advancements in naval-relevant science and technology.

The FY26 Kidney Cancer Research Program's Idea Development Award supports innovative research that enhances understanding of kidney cancer, aimed at improving patient outcomes. Proposals should feature a strong hypothesis and a detailed research plan, with team members experienced in kidney cancer research. A unique aspect is the Partnering Principal Investigator option, fostering collaboration between two investigators, ensuring comprehensive project development while allowing for distinct submissions. This award emphasizes impactful partnerships to drive advancements in the field.

The FY26 Parkinson’s Research Program (PRP) Early Investigator Research Award supports early-career researchers in Parkinson’s disease (PD) research. It offers two funding levels: Level 1 for fellows requiring a Mentor and Level 2 for independent investigators. The PI must show potential in PD research, with Level 1 emphasizing mentorship and Level 2 needing preliminary data. Research must align with one of the four FY26 PRP Focus Areas, excluding clinical trials.

The Fair Housing Initiatives Program (FHIP), established by Congress in 1988, aims to fund organizations to combat discriminatory housing practices. The Education and Outreach Initiative (EOI) educates stakeholders about their rights under fair housing laws. Key components include the National Media Campaign, which promotes fair housing awareness nationally, and local programs that support community-based outreach. HUD oversees the process, ensuring compliance and monitoring of funded initiatives to enhance fair housing practices.

An award from the George and Viola Hoffman Fund may be made annually for student research toward a master’s thesis or doctoral dissertation on a geographical subject in Eastern Europe. Eastern Europe includes the countries of East Central and Southeast Europe from Poland south to Romania, Bulgaria, and the successor states of the former Yugoslavia. Topics may be historical or contemporary, systematic or regional, limited to a small area or comparative.

The F26AS00104 State ANS Management Plan 2026 aims to combat aquatic nuisance species through pre-proposals followed by full applications. Managed by the US Department of the Interior's Fish and Wildlife Service, this initiative requires a 25% cost-share and limits administrative costs to 5%. Applications are due by October 14, 2026, though the funding opportunity closes on December 16, 2026. The plan is crucial for maintaining biodiversity and supporting a coordinated national approach to invasive species management.

The Child Protection Compact Annual Program Statement invites proposals aimed at combating child trafficking through collaborative efforts between the United States and other countries. This initiative focuses on enhancing the capacity to prosecute traffickers, providing care for victims, and implementing preventive measures. Organizations interested in applying must align with the objectives of the CPC to ensure comprehensive support and effective intervention against all forms of child trafficking.

The TIP Office of the US Department of State invites applications for projects aimed at combating human trafficking, adhering to the Trafficking Victims Protection Act. This initiative prioritizes prosecuting traffickers, protecting victims, and preventing trafficking through strategies outlined in the National Security Strategy, executive orders, and the annual Trafficking in Persons Report, while aligning with America First Foreign Policy priorities.

The DoW Neurofibromatosis Research Academy – Leadership Award supports established neurofibromatosis investigators to lead a virtual research academy. Designed for early-career scholars, this award promotes mentorship and collaboration in neurofibromatosis research. The Academy Director and Deputy Director, both at the Associate Professor level, will oversee pilot research projects that engage scholars and their mentors, fostering a dynamic research environment. This initiative aims to enhance the future of neurofibromatosis research through innovative leadership and collaboration.

Sexual Abuse Services Program (SASP)

Funds are awarded by the US Department of Justice, Office on Violence Against Women. Congress appropriates the funds annually. Funds are awarded to support the establishment, maintenance and expansion of sexual assault services including providing intervention, advocacy, accompaniment (e.g., accompanying victims to court, medical facilities, police departments, etc.), support services and related assistance for adult, youth and child victims of sexual assault, family and household members of victims, and those collaterally affected by the sexual assault.

Violence Against Women Act (STOP VAWA)

Funds are awarded by the US Department of Justice, Office on Violence Against Women. Congress appropriates the funds annually. Funds are awarded to develop and implement effective law enforcement and prosecution strategies to combat domestic violence, dating violence, sexual assault and stalking; and to develop and enhance victim services for cases involving domestic violence, dating violence, sexual assault and stalking through court advocacy and other core services. Funds are also awarded to support services provided to underserved populations.

Family Violence Prevention and Services Act (FVPSA)

Funds are awarded by the US Department of Health and Human Services, Office of Community Services, Administration for Children and Families. Congress appropriates the funds annually. Funds are awarded to prevent incidents of family violence, domestic violence, and dating violence and to provide immediate shelter, supportive services and access to community-based programs for victims of family violence, domestic violence or dating violence and their dependents.

Career and Technical Education

The goal of the South Dakota Department of Education is for all students to graduate college, career, and life ready. The Division of College, Career and Student Success provides support for students' preparations for postsecondary education and the workforce. Services are connected to approved Career & Technical Education (CTE) programs, work-based learning, student organizations and more. In-line with the department's aspiration, DCCSS works to ensure students not only graduate from high school, but that they are prepared to navigate the transitions and life events that come after high school.

Workforce Education Grants

In 2013, the South Dakota Legislature established the Workforce Education Fund through SB 235. Part of that fund was designated to provide grants for Career & Technical Education (CTE) programs in secondary schools.

The Workforce Education Grants provide school districts and private, nonprofit entities who provide specialized training in South Dakota the opportunity to make transformative change in career and technical education programs. High quality CTE programs give students the knowledge, skills and experiences to be well prepared for postsecondary education and the workforce. Partnerships among secondary education, postsecondary education, and business & industry lay the foundation for modern CTE programs.

Grant Purpose & Eligibility

The Workforce Education Grants are designed to demonstrate alignment to postsecondary education and South Dakota workforce needs, developing the state's talent pipeline for workforce development and economic growth. Projects must provide work-readiness training, including technical training. Projects cannot include adult basic education, English learner services, or high school equivalency training programs.

Eligible applicants are private, nonprofit entities that provide specialized career and technical services and education as referenced in SDCL 13-13-89. The entities that are awarded grants will serve as fiscal agents through the completion of their projects. All applications must demonstrate commitment by all grant partners to the grant project and its sustainability following the conclusion of the grant.