South Dakota Community Development Funding via U.S. Bank Foundation
South Dakota nonprofits working on economic and workforce advancement, affordable housing, or community arts and culture can access funding through U.S. Bank Foundation’s Community Possible Grant Program. 501(c)(3) organizations in designated U.S. Bank communities, especially those led by people of color and addressing multiple pillars of work, home, and play, may be prioritized.
US Bancorp Foundation
Costco Foundation Health Services Grants in South Dakota
Health and human services nonprofits in South Dakota supporting children, education, or related health programs may be eligible for charitable contributions that fund program costs. Grants from Costco Foundation help organizations that are 501(c)(3)s with evidence-based, community-driven initiatives, which can include improving health care access and delivery rather than capital equipment purchases.
Costco Foundation
Creag Foundation Health Innovation Grants in South Dakota
South Dakota 501(c)(3) nonprofits with innovative health care access and delivery programs can seek support for new approaches to social problems. Focused on innovation, Creag Foundation invites organizations with at least one year of 501(c)(3) status to inquire about funding that may help launch or expand medical equipment or related health services initiatives.
Creag Foundation
Youth Welfare Funding for Nonprofits from DanPaul Foundation
501(c)(3) nonprofits worldwide, including those in South Dakota, can apply for DanPaul Foundation grants up to US $15,000 to support youth health, education, development, and welfare programs. Organizations providing child welfare, early childhood development, homelessness, poverty, refugee, or environmental education services may be especially strong candidates.
The Dan Paul Foundation
Tech-Enabled Social Impact Funding from Cisco
Nonprofit and NGO programs using technology for crisis response, education access, or economic empowerment in South Dakota and worldwide can seek Global Impact Cash Grants, with awards up to US $100,000. Cisco Systems Foundation supports innovative, early-stage, tech-enabled solutions serving predominantly economically underserved communities, with applications accepted year-round via an initial LOI.
Cisco Systems Foundation
Community Safety and Development Grants from State Farm
South Dakota nonprofits, educational institutions, government programs, and volunteer fire companies can access funding through State Farm Companies Foundation for safety, education, and community development initiatives. Programs may include auto and home safety, disaster preparedness and recovery, affordable housing, job training, financial literacy, and K-12 or higher education, including STEM and college and career pathways.
State Farm Companies Foundation
Hearst Foundation Culture Grants in South Dakota
South Dakota cultural nonprofits offering arts, science, or arts education programs can access funding through the William Randolph Hearst Foundation; awards are typically more than US $100,000 for program, capital, and limited general or endowment support. U.S.-based 501(c)(3) organizations with audited expenses over $2 million and strong, sustainable impact may be eligible.
William Randolph Hearst Foundation
South Dakota Social Service Funding via Hearst Foundation
South Dakota social service nonprofits addressing poverty, housing, food access, jobs, or related needs can access funding through William Randolph Hearst Foundation for program, capital, or general support. U.S.-based 501(c)(3) organizations with audited expenses over $2 million and strong, scalable outcomes may be competitive for grants over US $100,000.
William Randolph Hearst Foundation
South Dakota Health Funding via Labcorp Charitable Foundation
South Dakota health and community nonprofits can access funding via Labcorp Charitable Foundation to support health and welfare, education, or community-focused programs, including healthcare access and delivery. U.S.-based 501(c)(3) organizations serving underserved populations with medical services, screenings, or related equipment needs may be eligible under the foundation’s health and welfare priority area.
Labcorp Charitable Foundation
Michael & Susan Dell Foundation Health Grants
Organizations serving children’s health and wellness can apply for Michael & Susan Dell Foundation grants of more than US $50,000 to support or scale impactful projects. Eligible entities include nonprofits, social enterprises, schools, and public agencies working in the U.S., India, or South Africa; South Dakota health providers may be eligible if they meet these criteria.
Michael & Susan Dell Foundation
NorthWestern Energy Community Grants in South Dakota
Nonprofit organizations providing education, health, human services, civic, cultural, or conservation programs in South Dakota communities can seek funding for program costs, equipment, or facility improvements. With a mission to build stronger communities, NorthWestern Energy provides 501(c)(3) and 170(c)(2) organizations with charitable support, which may include medical or health-related equipment needs within its service counties.
NorthWestern Energy
Health and Education Funding for Charities via Roche
Focused on humanitarian, educational, community, and cultural projects, Roche invites accredited charities in South Dakota and worldwide to seek support for health, science education, social services, and community initiatives. Eligible projects should promote sustainable development, allow use of Roche’s expertise, and actively involve local partners and Roche employees.
La Roche, Inc.
Health and Human Services Funding from Semnani
Nonprofit organizations providing health care access, humanitarian aid, or social services can apply for support from Semnani Family Foundation, which funds programs in the U.S. and globally. South Dakota providers improving healthcare delivery, women’s and children’s health, or services for vulnerable populations may be eligible for project or program support.
Semnani Family Foundation
Bank of America Support for Community Programs
South Dakota 501(c)(3) nonprofits seeking support for community-focused programs can apply for funding that advances economic mobility and social progress. Bank of America Charitable Foundation backs initiatives in basic needs, workforce development, community development, arts and culture, environment, and diversity and inclusion, which may benefit organizations improving health care access and delivery.
Bank Of America Charitable Foundation Inc
Cowles Charitable Trust Support for Health
Applications due Sep 1, 2026
U.S. 501(c)(3) organizations seeking support for health, medical research, or related operating costs can apply for Cowles Charitable Trust grants of up to US $10,000. While the trust primarily favors Downstate New York and South Florida, South Dakota health providers and clinics may be eligible when their work aligns with its mission and priorities.
Cowles Charitable Trust
Pew Charitable Trusts Support for Biomedical Research
Full proposal due Sep 3, 2026
Grants support early-career biomedical researchers at U.S. institutions to advance independent, high-impact work in human health, including labs in South Dakota. Grants from Pew Charitable Trusts provide US $75,000 - US $300,000 to assistant professors running independent labs at selected institutions, with flexible use for personnel, equipment, supplies, and research-related travel.
Pew Charitable Trusts
Hansen Family Foundation Community Grants in South Dakota
Applications due Sep 11, 2026
South Dakota 501(c)(3) nonprofits seeking program or project support can access funding through the Hansen Family Foundation for work benefiting children, education, animals, the environment, humanitarian needs, or arts and culture. U.S.-based organizations with budgets under $1 million may receive US $1,000 - US $10,000, including those improving health care access within these focus areas.
Hansen Family Foundation
Storytelling Funding for Nonprofits from Couch Foundation
Applications due Sep 25, 2026
Nonprofits and aligned for-profit organizations working in preservation, education, or wellness can receive more than US $50,000 to tell impactful stories about their work, including in South Dakota. Focused on environmental conservation, education, and wellness, the Jesse W Couch Charitable Foundation’s Storytelling Grant may help health-focused organizations highlight medical equipment or care access initiatives.
Jesse W Couch Charitable Foundation
Medical Facility Funding from USDA Rural Development
Applications due Sep 30, 2026
Public bodies, community-based nonprofits, and Federally Recognized Tribes in rural South Dakota can use this program to purchase medical equipment or construct and improve health care facilities. Grants from USDA Rural Development help eligible rural communities develop essential facilities like hospitals, clinics, and telemedicine infrastructure, with support scaled to local population size and median household income.
USDA: Rural Development (RD)
South Healthcare Funding via Robinson Foundation
Applications due Oct 15, 2026
South Dakota health care and medical assistance nonprofits can access funding through Robinson Foundation for programs improving care access, treatment, and related services. Eligible applicants are 501(c)(3) public charities active for over three years that serve communities in the Southern region below the Mason-Dixon line; funding is for single-year, non-capital needs.
Robinson Foundation
Basic Needs Funding for Nonprofits from TJX Foundation
Letter of inquiry due Oct 31, 2026
Nonprofit 501(c)(3) organizations addressing basic needs, youth enrichment, workforce readiness, or domestic violence may be eligible for program support in South Dakota and other U.S. communities. The TJX Foundation supports health, safety, and stability for vulnerable families and children; eligible nonprofits must be within 15 miles of a TJX location and meet its mission and policy criteria.
The Tjx Foundation Inc
Lawrence Foundation Support for Community Services
Applications due Nov 1, 2026
Nonprofit 501(c)(3) organizations, public schools, and libraries seeking support for environmental or human services programs, including work that may involve medical equipment in South Dakota, can apply for grants of US $5,000 - US $10,000. With a mission to support environmental and human services causes, Lawrence Foundation provides unrestricted program or operating funding worldwide.
Lawrence Foundation
Ameriprise Financial Support for Community Vitality
Applications due Jan 15, 2027
Focused on basic needs and community vitality, Ameriprise Financial invites U.S. 501(c)(3) nonprofits to apply for funding that addresses hunger, shelter, adult self-sufficiency, and community development. South Dakota organizations working on food access, supportive housing, workforce readiness, or financial literacy may be eligible, especially where Ameriprise volunteers are actively engaged.
Ameriprise Financial
O'Reilly Automotive Foundation Grants for South Dakota Health
Applications due Apr 15, 2027
Health-focused 501(c)(3) nonprofits providing medical, dental, or related health services in South Dakota communities where O’Reilly Auto Parts operates can seek project, operating, or capital support for equipment and facilities. Grants from O'Reilly Automotive Foundation help organizations addressing health care access, mental health, and other quality-of-life needs for underserved individuals and families.
O'Reilly Automotive Foundation Inc
Chick Fil A Foundation Grants for Community Health
Applications due May 1, 2027
South Dakota health and community nonprofits can access funding through Chick Fil A Foundation to expand programs for youth education, housing, food security, and environmental stewardship. U.S.-based 501(c)(3) organizations may receive US $30,000 - US $350,000 to strengthen services for underserved children and families, which may include projects that improve health, wellness, and related equipment needs.
Chick Fil A Foundation Inc
Community Partnership Funding for Nonprofits from Mutual of America Foundation
Applications due Jul 1, 2027
Nonprofit organizations in South Dakota with strong, replicable community partnerships can apply for Mutual of America Foundation’s national Community Partnership Award to recognize exemplary collaborative leadership and social impact. U.S. nonprofits addressing significant social issues through equal public, private, or social sector partnerships may be eligible for this recognition-focused funding opportunity.
Mutual Of America Foundation