Best Large Grants for Nonprofit Organizations in California

The National Human Genome Research Institute (NHGRI) is launching a Notice of Funding Opportunity (NOFO) aimed at enhancing genomic research through the development and distribution of high-value resources. This initiative encourages collaborative efforts in genomic resource development and the integration of data science in clinical applications. While applications are not currently being accepted, prospective applicants are urged to prepare meaningful collaborations and projects ahead of the formal solicitation.

The Pride Foundation Scholarship is designed to support LGBTQ+ students who demonstrate leadership in their communities and fields of study. Open to residents of Alaska, Idaho, Montana, Oregon, or Washington, applicants must pursue post-secondary education in the 2025-2026 school year. The scholarship prioritizes those facing systemic barriers, including discrimination and financial need, ensuring resources reach LGBTQ+ students who need them most.

The Helen Elbert Scholarship, administered by the East Texas Communities Foundation, supports graduating seniors planning to major in music, particularly piano. Established in 1989, the Foundation has a strong commitment to education and community support. This scholarship is not based on financial need and will provide one year of assistance to students attending any college in the United States. It aims to empower young musicians to pursue their educational dreams.

The Innovation Grants to Nurture Initial Translational Efforts (IGNITE) support the development of assays and screening processes to identify potential therapeutic agents for neurological disorders and non-opioid analgesics. Sponsored by the NIH, this initiative seeks to foster collaborations and projects that utilize innovative methodologies. Although applications are not currently being solicited, interested parties are encouraged to prepare meaningful proposals that align with the goals of the NIH Helping to End Addiction Long Term initiative.

The RAK Education Foundation Scholarship provides financial assistance to residents of Camden, Chowan, Gates, Pasquotank, or Perquimans Counties who have earned a high school diploma or GED. This scholarship supports students pursuing degrees or certificates in Career and Technical Education fields such as trade education, computer science, business, health science, and more. Applications open on December 16, 2025, and close on March 3, 2026, encouraging eligible students to apply.

Grand Rapids Community Foundation

Connecting people, passion and resources

The Community Foundation is a nonprofit organization that connects people, passion and resources. With our partners, the Community Foundation uses the tools of philanthropy to find solutions to pressing issues. We provide grants to support the work of nonprofits, scholarships to local students and other forms of support to communities working to eliminate barriers to opportunity, prosperity and belonging.

Our Mission is to build and manage our community’s permanent endowment and lead the community to strengthen the lives of its people.

We envision a magnetic and interconnected West Michigan community.

Integrity, Excellence, Inclusion, Sustainability and Bold Aspirations

Give and Receive Openly, Build Trust with Each Other, Create Brave and Safe Space, Embrace Vulnerability, Accountability

Our North Star

For West Michigan to grow and prosper, we must make sure that everyone can apply their talents and creativity to fuel our future. It is only by connecting across perspectives and overcoming inequities that we can build and sustain an inclusive economy and thriving community.

Opportunities for students

Apply for scholarships to support your ambitions

Each year Grand Rapids Community Foundation supports hundreds of students on their college or career training journeys. We are excited to remove barriers to academic success so that students like you can pursue what you're passionate about.

Scholarship Fund Details

Support for West Michigan Students

Attending college or trade school increases opportunity and opens doors to careers. Donor partners who establish a scholarship fund give students a boost on their path to higher education. Students who complete the general scholarship application are considered for these scholarships.

Open to students who are residents of Kent County. Preference to Challenge Scholar students through 2032.

The Carolyn Gallmeyer Scholarship, provided by the Grand Rapids Community Foundation, supports students from Kent County pursuing college or career training. This scholarship aims to remove barriers to education, empowering students to achieve their aspirations. With awards typically ranging from $2,000 to $5,000, it directly contributes to tuition and essential costs. The foundation emphasizes inclusivity, ensuring that all students have the opportunity to thrive in their academic journeys.

The Cancer Care Specialists of Illinois Scholarship offers financial assistance for tuition to high school seniors and healthcare professionals in oncology/hematology within Central and Southern Illinois. The scholarship supports educational pursuits and professional development in these fields. Applications are accepted monthly, with a deadline for 2025 set for December 1st. Eligible candidates must maintain a GPA of 3.0 and reside in specific counties, ensuring support for local talent in healthcare.

The Thomas J Nelson Sr Scholarship, offered by the Community Foundation of North Central Washington, honors the legacy of Tom Nelson, a dedicated community member. This scholarship is available to graduating seniors or past graduates from Chelan, Douglas, or Okanogan counties, who demonstrate financial need and plan to pursue higher education. Eligible students must maintain a minimum GPA of 3.0 for four-year programs or 2.5 for community colleges and trade schools, reflecting Tom's commitment to educational support.

The Vets Serving Vets Scholarship, established by North Central Washington Vets Serving Vets through the Community Foundation of NCW, supports residents of Chelan and Douglas counties who have been honorably discharged from the U.S. Armed Forces. This scholarship is aimed at individuals pursuing full-time college education, helping them achieve their academic goals while honoring their service. Since its inception in 2017, it has played a vital role in assisting veterans in their educational journeys.

The Wenatchee Valley Street Rods Scholarship, managed by the Community Foundation of North Central Washington, aims to support students pursuing education in automotive fields or health sciences at Wenatchee Valley College. Eligible applicants include high school seniors from Chelan County or Eastmont School District, as well as current students in medically related programs. Applicants must demonstrate good citizenship and criminal record eligibility. This scholarship can be renewed with reapplication.

The Women’s Service League of North Central Washington Scholarship, established in 2013, aims to support female students from various high schools in the region. This scholarship prioritizes applicants who demonstrate community involvement, leadership skills, and a minimum GPA of 2.75. Special consideration is given to those who have faced significant challenges and to children or grandchildren of League members, fostering a commitment to volunteerism and community improvement.

The Partners In Education Scholarship Fund, established by Stark Community Foundation, supports Stark County high school graduates pursuing undergraduate degrees. Eligible applicants must be residents of Stark County, Ohio, have completed at least 24 post-secondary credit hours, and maintain a minimum GPA of 2.6. This initiative reflects the Foundation's commitment to enhancing educational opportunities and fostering community development since its inception in 1963.

About Henry L. Hillman Foundation

Henry L. Hillman Foundation inspires, invests in, and leverages great ideas to improve the quality of life in Pittsburgh and southwestern Pennsylvania.

Backup Power When Your Community Needs It

The Powered & Prepared Initiative seeks proposals from nonprofit and municipal organizations in southwestern Pennsylvania for backup power solutions that allow those organizations to offer essential services during emergencies without disruption.

Southwestern Pennsylvania is increasingly impacted by severe weather events that cause widespread power outages and disruptions. The Powered & Prepared Initiative, supported by Henry L. Hillman Foundation, seeks proposals from nonprofit and municipal organizations for backup power solutions that allow those organizations to offer essential services during emergencies without disruption.

The Orran "Buzzy" Calhoun Memorial Scholarship Fund, established by the Stark Community Foundation, supports graduates and current seniors from select high schools in western Stark County. Eligible applicants must maintain a minimum GPA of 3.0, pursue a full-time degree at a college or university, and demonstrate significant academic and extracurricular involvement. This fund reflects a commitment to empowering local students through educational opportunities, fostering community growth and development.

The Altrusa Club of Wenatchee Scholarship supports female graduates of Wenatchee Valley College pursuing further education. Funded by the Community Foundation of NCW, this scholarship aims to empower women through financial assistance based on need and academic merit. Eligible recipients must maintain a minimum GPA of 2.0 and demonstrate commitment to their educational goals. This initiative reflects the club's dedication to promoting women's education and ensuring their successful transition to higher learning institutions.

NAFC Open Grant/Product Donation Applications

The National Association of Free and Charitable Clinics (NAFC) is the only nonprofit 501c(3) organization whose mission is solely focused on the issues and needs of the medically underserved throughout the nation and the more than 1,400 Free and Charitable Clinics that serve them. The NAFC has earned the Platinum Seal of Transparency from GuideStar and a 4-Star rating from Charity Navigator. Founded in 2001 and headquartered near Washington, D.C., the NAFC is working to ensure that the medically underserved have access to affordable quality healthcare and strives to be a national voice promoting quality healthcare for all. For more information about the NAFC, including how to become a member, please visit https://www.nafcclinics.org.

NAFC Response & Emergency Needs Fund

The NAFC Response & Emergency Needs Fund is designed to address urgent and unforeseen challenges that threaten operations or patient access to care within NAFC member organizations. These organizations often operate with limited reserves, making them especially vulnerable to unexpected repairs, equipment failures, workforce disruptions, or community emergencies. This fund provides rapid, flexible support to help stabilize operations and ensure continuity of care for uninsured and underserved patients.

The National Institute of Neurological Disorders and Stroke (NINDS) is launching a collaborative initiative aimed at exploring neurodegenerative mechanisms in Alzheimer’s disease-related dementias (ADRD). This program, termed 'Centers without Walls', encourages interdisciplinary teams to merge diverse expertise, utilizing cutting-edge technologies and clinical insights to uncover novel ADRD pathways. By fostering collaboration and data sharing, the initiative seeks to enhance understanding of ADRD complexities and support the development of innovative therapeutic strategies.

The Pete and Mary Houck Scholarship, established by the Community Foundation of North Central Washington, honors the legacy of Pete and Mary Houck, long-time residents of Wenatchee Valley. This scholarship aims to support local students pursuing healthcare degrees, reflecting the couple's commitment to education and community. Eligible applicants must be residents of Chelan or Douglas County and plan to attend accredited programs in healthcare-related fields, ensuring a brighter future for the community.

The Colonel David Marcus Memorial Scholarship Award supports students from Burlington, Camden, or Gloucester Counties pursuing post-high school education, particularly in military programs. Established by the Jewish Community Foundation, this scholarship prioritizes candidates who embody Col. Marcus's ideals. Eligible applicants must be high school seniors and may apply for multiple awards. The fund has a strong community leadership background, managing over $35 million in assets to support educational initiatives.

The East Bay Fund for Artists Grant Program, initiated by the East Bay Community Foundation, supports individual artists and arts organizations in low-income communities of color. Since 2003, it has partnered with over 300 local artists and secured nearly $3.1 million in funding. The program aims to advance racial justice and social equity through new artistic works. It prioritizes diversity in artistic practices and ensures that BIPOC communities have access to culturally relevant art, promoting resilience and community empowerment.

The Cytokinetics Communications Grant Program provides five grants of $20,000 each annually to patient advocacy organizations focused on hypertrophic cardiomyopathy (HCM) and heart failure. This initiative aims to enhance communication and outreach efforts, helping organizations expand their community engagement and awareness. By supporting crucial marketing initiatives, Cytokinetics fosters improved resources for advocacy groups, ensuring they can effectively address the needs of patients facing muscle performance challenges.

The Nicholas B. Ottaway Foundation's Community Impact Fund Grants aim to enhance community well-being by supporting 501(c)(3) organizations focused on underrepresented populations. Grants range from $3,000 to $20,000 and are intended for projects in areas like disaster relief and sexual health. First-time applicants must submit a letter of intent before applying. The foundation prioritizes projects in regions where its members live and work, ensuring local engagement and impact.

The Gerald E. Robinson Memorial Scholarship, established in 2018 by the Community Foundation of NCW, honors the legacy of Gerald "Jerry" Robinson, a devoted animal lover. This scholarship supports college students pursuing veterinary or pre-veterinary programs, ensuring that Jerry's passion for animals continues through future generations. Eligible applicants include high school seniors from Okanogan, Ferry, or Lincoln Counties, with a minimum GPA of 2.5 and experience in animal care.

CRST Wicozani Wiwokiaye Oyate Scholarship for Nursing

To provide financial support to Native American students pursuing a registered nursing degree.

For a Cheyenne River Sioux Tribe (CRST) member aiming to earn a nursing degree, if there are no eligible CRST candidates, the scholarship will be accessible to another tribal member. Proof of tribal enrollment is required for both applicants. This scholarship is available to students in their second through fifth years who have sustained a GPA of 2.0 or above. When applying for this scholarship, articulate how your nursing education will contribute to enhancing the health outcomes of Native American communities.

(Pronunciation is: Wee-Cho-Zan-Ee, Wee-Woke-Ee-Eye-Aye, Oh-Yah-Tay. Which is Lakota for "Health Helpers Society")

The Mina Powell Scholarship, offered by the Ashland County Community Foundation, supports graduating seniors from any high school who are members of Zion Lutheran Church in Loudonville. This scholarship aims to assist students who have been accepted into accredited two or four-year colleges or universities, providing them with the financial resources needed to pursue their higher education goals.

The Indian Highway Safety Traffic Records Forum Grant is exclusively available for federally recognized tribes without an existing grant for FY 2027. This program, managed by the Bureau of Indian Affairs, supports initiatives aimed at enhancing traffic safety through data collection and analysis. Eligible tribal employees can apply for funding to cover registration and travel expenses for attending the Traffic Records Forum from August 3-5, 2027, promoting improved traffic records and safety measures.