Best Large Grants for Nonprofit Organizations in California

The East Texas Estate Planning Council Scholarship, administered by the East Texas Communities Foundation, supports graduating seniors pursuing careers in accounting, law, finance, banking, investments, insurance financial planning, or philanthropic planning. This scholarship reflects a commitment to education and aims to alleviate financial barriers for students in East Texas. Applicants must demonstrate financial need, with FAFSA required, and can attend any college in the United States for one year.

The Focused Technology Research and Development (R01) grant supports innovative projects aimed at developing technologies to enhance biomedical research. This funding opportunity emphasizes the creation of laboratory instruments, algorithms, and biological systems that can significantly improve research capabilities. Key deadlines for applications are set for February, June, and October of 2025 through 2027, ensuring ample time for proposal submissions. The initiative is funded by the National Institutes of Health (NIH), part of the US Department of Health and Human Services.

The Ed & Mildred Schroeder Scholarship, offered by the Coastal Bend Community Foundation, aims to enhance the quality of life in the Coastal Bend through educational support. This scholarship is available to graduating seniors or current college students pursuing a degree in education, demonstrating financial need, and enrolled in at least 12 credit hours. By providing effective grants and scholarships, the foundation fosters community philanthropy and addresses local educational needs.

Project Lead the Way inc.

School and district leaders need a solution that cultivates confidence and career readiness—and PLTW checks all the boxes. As a nonprofit organization founded by educators and driven by education leaders, we've spent more than 28 years equipping students with the technical knowledge, transferable skills, and career confidence they need to thrive—through programs that integrate real-world industry partnerships, best-in-class teacher training, and our proven activity-, project-, problem-based (APB) instructional model. At PLTW, we're on a mission to create a transformative learning environment and empower students to develop in-demand knowledge and skills necessary to thrive in an evolving world. 

PLTW Computer Science

PLTW Computer Science students are technology trailblazers who are empowered through transportable skills and prepared to start their career, whether that is in computer science or not. Empower your students to become creators of the technology all around them. PLTW Computer Science engages students in collaborative projects that help them develop in-demand computer science knowledge as well as transportable skills like creative thinking and communication. And whether they’re creating an online art gallery or using automation to process and analyze DNA-sequence data, PLTW Computer Science students are seeing how their learning connects to the real world.

PLTW Computer Science - New Program (3M)

3M forms lasting partnerships with communities and provides resources to help them succeed and grow – ensuring a more interconnected and thriving world. 3M inspires the next generation of science leaders through the following goals:

• Increasing STEM exposure in K-12 classrooms
• Supporting experiential learning opportunities
• Enhancing the quality of STEM teaching
• Providing professional development opportunities for students

3M has partnered with PLTW to ensure students and teachers have the tools, resources and knowledge they need to succeed in STEM.

The Value Assessment and Health Outcomes Research Postdoctoral Fellowship, funded by the PhRMA Foundation, offers a $60,000 stipend annually for up to two years. This fellowship supports researchers, both U.S. and non-U.S. citizens, engaged in innovative studies aimed at evaluating the effectiveness and value of healthcare interventions. Applicants must be within five years of postdoctoral study and hold a relevant doctoral degree. This opportunity fosters collaboration and patient engagement in health outcomes research.

The Value Assessment and Health Outcomes Research Predoctoral Fellowship, offered by the PhRMA Foundation, supports promising students in their advanced training and thesis research. This fellowship, aimed at U.S. and non-U.S. citizens, provides $30,000 in annual stipend support for up to two years. It encourages research proposals that address the effectiveness, safety, and value of healthcare interventions, emphasizing patient engagement and health equity in the evaluation process.

The 2025 Vilcek Foundation Grants aim to support nonprofit organizations that celebrate immigrant contributions to the arts and sciences. The foundation invites applications from organizations operating under U.S. IRS Section 501(c)(3) that promote diversity and inclusivity. Grants will be prioritized for new partners and those in states without prior funding. This initiative underscores the foundation's commitment to fostering appreciation for immigrant communities and their impact on society.

The Value Assessment and Health Outcomes Research Faculty Starter Grant, offered by the PhRMA Foundation, supports emerging researchers at U.S. universities. With a funding of $100,000 for one year, it aims to advance studies on the effectiveness and value of healthcare interventions. The grant promotes innovative research in areas such as clinical outcomes, health equity, and patient engagement, ensuring that diverse perspectives are included in the evaluation of healthcare solutions.

The CRSJ Racial Justice in Education Grant, administered by the National Education Association, aims to enhance racial equity within education by funding initiatives that promote awareness, leadership development, and solidarity among diverse racial groups. Grants typically range from $10,000 to $75,000, supporting projects that address racism and foster equitable policies in educational settings, thereby accelerating efforts towards social justice.

The National Education Association's Collective Bargaining and Member Advocacy Department offers grants to support affiliates in creating student-centered initiatives through collective bargaining and advocacy. These grants aim to unite educators with communities, enhance transparency in negotiations, and advocate for students' rights, focusing on improving education funding, working conditions, and student outcomes. Affiliates can apply for funding to develop strategies that foster collaboration and promote positive learning environments.

The NeuroNEXT Small Business Innovation program invites small businesses to apply for exploratory clinical trials involving investigational agents, including drugs, biologics, and devices. These trials aim to gather critical data to support the design of future clinical studies, particularly focusing on diseases aligned with the NINDS strategic plan. Applications are due by 5:00 PM local time of the applicant organization, emphasizing the importance of timely submissions.

About Knight Foundation

John S. and James L. Knight believed that a well-informed community could best “determine its own true interests” and was essential to a well-functioning, thriving democracy. They pursued those beliefs, building and leading one of the largest and most successful newspaper companies in American history.

For 75 years, Knight Foundation has supported the people, ideas and insights that lead to thriving communities. The foundation invests in local journalism, arts and culture and community development in the 26 cities and towns where the Knight brothers once published newspapers.

Since our founding in 1950, we have been committed to the communities we serve and to providing those communities with the tools they need for residents to thrive.

Knight Cities Challenge

Knight Foundation is currently accepting applications for the Knight Cities Challenge, a $5 million open call inviting individuals and organizations across its 26 communities to submit new, creative ideas for projects that can spark change and leave a lasting local impact.

Building on a long history of open challenges across programs, Knight democratizes access to grantmaking to unlock the best and brightest ideas. This spring, KCC returns to invest in its first cohort of community-centered solutions to local challenges and help promising ideas take root and grow.

Project ideas must focus on at least one of Knight’s investment areas: strengthening local news and information, creating pathways for economic opportunity or cultivating connection through arts, culture and the places that bring people together.

You may submit one idea, either as an individual or on behalf of your organization. While you are limited to one application as the lead applicant, you may collaborate on other projects submitted by different partners. Each individual or organization may receive funding for only one project.

For large institutions such as universities or city governments, schools or departments are considered separate entities. 

The Game On-Community Places to Play Initiative, led by The DICK’s Sporting Goods Foundation and LISC, offers grants ranging from $50,000 to $100,000 for community organizations to enhance youth sports facilities in under-resourced areas. This initiative focuses on improving safety, accessibility, and quality of athletic spaces for youth aged 6-24. Eligible applicants must have a proven track record in real estate development and ensure community access to the facilities.

Our mission is to enhance quality of life, today and in the future, by:

• Enabling donors to fulfill their charitable desires
• Building a permanent endowment
• Facilitating prudent management and care of funds
• Meeting needs through grants, awards, and scholarships

CFCC: Mark C. and Dorothy I. Morgan Scholarship

Amount

(1) $2,000 scholarship, (2) $1,500 scholarships

This scholarship is not renewable and previous recipients may not reapply.

The Indigo Oak Fund, based in Colorado, is dedicated to enhancing education, the arts, and social justice, particularly through its Equal Justice Under the Law Grant Program. This initiative supports organizations that promote fairness in the justice system, rehabilitation, and civic engagement. By funding programs focused on personal empowerment and equal opportunities, the fund aims to foster lifelong learning and improve lives, particularly for women and children in need.

Scholarships

Since awarding our first $500 scholarship in 1987, the Saginaw Community Foundation has awarded college scholarships to area students totaling more than $13.7 million, thanks to our generous donors. Each year, over 500 college-bound or career and technical education students benefit from our scholarship awards.

Our single application process makes it easy to potentially qualify for one or more of our 260+ scholarships.

JustJane Art Scholarship Fund for Women

Truly unique humans like Jane Marie Ewing do not populate the universe very often, and the JustJane Art Scholarship for Women was created to honor her remarkable spirit.

Jane was an artist at heart, finding joy in countless creative pursuits – whether baking delectable treats, capturing life’s beauty through photography, or expressing her imagination in fashion and digital illustration. Her zest for life was infectious, often bringing laughter through her playful “Jane Pranks”, which will forever live in the hearts of family and friends. Jane shared an inseparable bond with Kyle, each the center of the other’s universe. Tragically, Jane was taken from this world unexpectedly in 2025.

Her vibrant artistic soul touched every aspect of her life – from painting and interior design to crafting costumes for parties and pranks. Though her passion for art wasn’t fully nurtured early on, once she embraced it later in life, creativity flowed freely, illuminating the lives of everyone around her. Jane saw beauty everywhere, and her art became a reflection of that vision.

This scholarship carries forward Jane’s legacy, helping future generations cultivate their own artistic passions. It is a reminder to future generations that art has the power to transform lives.

The SUS Resident Research Scholar Award offers $30,000 for one year to surgical residents engaged in basic or translational research. Eligible candidates must have completed two years of training and commit to full-time research with an SUS member. Notably, applicants must avoid mentors on the exclusion list, ensuring a fair and competitive application process. This funding promotes innovative surgical research and supports the development of future leaders in the field.

The NEA Foundation's Student Success Grants support educators in creating innovative learning experiences that foster critical thinking, problem-solving, and cultural understanding among students. This initiative encourages project-based and personalized learning, enabling students to engage with real-world challenges. Applicants must be members of the National Education Association and can use grant funds for educational materials and experiences. The focus is on enhancing academic skills, communication, and collaboration, ultimately promoting joy in learning.

August Corso Scholarship Fund

Scholarships shall be awarded to residents of Erie County, Ohio pursuing a post-secondary education. Preference shall be given to students pursuing a degree in Horticulture, Environmental Science or Agricultural Business. Financial need is a consideration for the scholarship award.

Scholarships are available for students planning to attend an accredited nonprofit college or university, or planning to receive licensure, accreditation, or a certificate from a nonprofit vocational or apprenticeship program in the United States.

The scholarship may be renewed for a second, third, and fourth year.

The Diana K. Oldfield Memorial Scholarship, offered by the Elk Grove Regional Scholarship Foundation, supports students pursuing degrees in health sciences or medical fields. This scholarship is aimed at full-time students from various high schools in the Elk Grove area, emphasizing the importance of financial need. By providing educational opportunities, the foundation aims to foster community growth and support students in their academic and career aspirations.

The City of Elk Grove Scholarship, offered by the Elk Grove Regional Scholarship Foundation, supports students residing within Elk Grove city limits who are pursuing careers in Public Administration, Government, Public Policy, or Political Science. This scholarship caters to seniors in the Elk Grove Unified School District and aims to enhance educational opportunities by providing financial assistance for higher education, thus fostering community development and engagement.

The Kors, Lois E., Educational Scholarship, established by the Beatrice Educational Foundation, aims to support Beatrice High School graduates in pursuing higher education. With a strong commitment to academic achievement and civic involvement, the Foundation awards over $55,000 annually in scholarships. Applicants must demonstrate financial need, citizenship, and academic merit. This scholarship encourages students to enter the teaching profession, providing essential funds to help them achieve their educational goals.

The SC Ministry Foundation provides annual grants aimed at supporting nonprofit organizations aligned with the mission of the Sisters of Charity of Cincinnati. These grants can be used for core programs, planning, and program expansion. Eligible organizations must demonstrate financial sustainability and avoid duplication of services. The application process starts with a pre-application survey, and funding decisions are typically made by June 30. Priority is given to projects in education, healthcare, and social services.

Feld Entertainment's Charitable Contributions aim to support children in need through various initiatives. Their donations have significantly impacted organizations like St. Jude Children's Research Hospital and the Make-A-Wish Foundation. They offer cash and in-kind contributions to help underserved communities, providing tickets to nonprofit youth organizations and funding educational programs in the performing arts. Employees are encouraged to engage in local charity events, reinforcing the company's commitment to making a difference in the communities they serve.

The Bruce J. Heim Foundation Grant supports organizations that empower young individuals with exceptional potential in academics and the arts. Established in 1986, this private foundation aims to provide financial assistance that fosters skill enhancement and personal growth. The Board evaluates grant requests monthly, assessing the viability and significance of each organization’s project. The Foundation's goal is to inspire recipients to realize their potential and contribute to philanthropic efforts, echoing the support they received.

Beekhuis Scholarship

Award:

• One time award of $4,000.