Creag Foundation Health Innovation Grants in South Carolina
South Carolina 501(c)(3) nonprofits with innovative health and human services programs can seek invitation-only support to pilot or expand new approaches. Focused on creative solutions to social problems, Creag Foundation invites organizations with at least one year of 501(c)(3) status to submit a letter of inquiry for potential funding.
Creag Foundation
Youth Health and Welfare Grants from DanPaul Foundation
501(c)(3) organizations supporting youth health, education, and welfare in South Carolina can apply for DanPaul Foundation grants, with awards up to US $15,000. Funding may support early childhood development, child advocacy, homelessness and poverty services, refugee enrichment, environmental health education, and related wellness and healthy living programs for children and youth.
The Dan Paul Foundation
William Randolph Hearst Foundation Culture Grants in South Carolina
South Carolina cultural nonprofits offering arts or science programs can access funding through the William Randolph Hearst Foundation for program, capital, and limited general or endowment support. U.S.-based 501(c)(3) organizations with audited expenses over $2 million, strong impact, and broad reach may be eligible, including museums, performing arts groups, and arts education or STEAM initiatives.
William Randolph Hearst Foundation
South Carolina Health Programs Funding via Labcorp
Nonprofit organizations providing health, wellness, education, or community services in South Carolina can apply for funding to support food pantries, healthcare access, STEM programming, and healthy lifestyle initiatives. Labcorp Charitable Foundation provides U.S.-based 501(c)(3) organizations with grants reviewed twice yearly, which may benefit local health and wellness programs serving underserved populations.
Labcorp Charitable Foundation
Early Education and Community Grants from PNC Foundation
Nonprofit 501(c)(3) organizations supporting early childhood education or community economic development in South Carolina communities where PNC operates can seek funding for programs and services. PNC Foundation provides South Carolina nonprofits with support for early learning, health and human services, neighborhood revitalization, arts and culture, and other initiatives serving low- and moderate-income families.
PNC Foundation
Community Health Funding for Nonprofits from Roche
Nonprofit organizations, especially accredited charities, can seek funding for humanitarian, social development, science education, community health, and environmental projects, including wellness initiatives in South Carolina. Focused on impactful, sustainable programs, Roche supports high-quality projects that engage local partners and employees, and are managed locally through its affiliate offices within the same country where activities take place.
La Roche, Inc.
Health and Humanitarian Funding from Semnani Family Foundation
Nonprofit organizations providing health, education, or disaster relief services to marginalized communities, including those in South Carolina, can seek support from the Semnani Family Foundation. The foundation funds global initiatives such as healthcare access, women’s and children’s health, humanitarian aid, and related human and social services across multiple countries and the U.S.
Semnani Family Foundation
Sidney Stern Memorial Trust Grants for Health
Nonprofit 501(c)(3) organizations in South Carolina seeking support for charitable, scientific, medical, or educational programs can apply for funding that must be used in the U.S. With a mission to strengthen charitable, scientific, medical, and educational work, Sidney Stern Memorial Trust provides flexible support that may benefit health and wellness initiatives serving broad populations.
Sidney Stern Memorial Trust
South Carolina Human Services Funding via Gupta Family Foundation
Applications due Jul 31, 2026
Nonprofit organizations working to help disadvantaged people become self-reliant, including those providing health and wellness or human services in South Carolina, can apply for Gupta Family Foundation grants of US $5,000 - US $250,000. With a mission to support focused interventions for disadvantaged individuals worldwide, the foundation prioritizes smaller, non-sectarian organizations with strong founder-led leadership.
Gupta Family Foundation
South Carolina Systems Change Funding via Sisters of Charity Foundation
Letter of inquiry due Aug 4, 2026
Nonprofit organizations in South Carolina working on systems change for economic mobility or housing security can apply for Sisters of Charity Foundation’s Systems Change Grants, with awards of US $15,000 - US $20,000. Funding can support general operations, programs, or capacity-building, and may benefit health and wellness initiatives that address poverty’s root causes.
Sisters of Charity Foundation of South Carolina
Blue Cross Foundation Support for South Carolina Health Programs
Letter of inquiry due Aug 7, 2026
South Carolina health-focused 501(c)(3) nonprofits, government agencies, and tax-exempt educational or research institutions can access funding to improve health outcomes and expand care access for economically vulnerable residents. Blue Cross and Blue Shield of South Carolina Foundation supports projects in areas like oral health, mental health, primary care, and community wellness initiatives statewide.
Blue Cross and Blue Shield of South Carolina Foundation
Philip L Van Every Foundation Health Grants in South Carolina
Full proposal due Aug 10, 2026
South Carolina health and human service 501(c)(3) nonprofits seeking project or capital support can access funding through the Philip L Van Every Foundation; awards range from US $10,000 - US $50,000. Grants prioritize wellness, preventative healthcare, medical education, rehabilitation, and related programs that improve quality of life for residents in North and South Carolina.
Philip L Van Every Foundation
Central Carolina Community Foundation Support for Health Programs
Applications due Sep 15, 2026
Nonprofit organizations with a physical location in South Carolina can seek US $1,000 - US $10,000 to support local health, wellness, and education programs, including pediatric cancer services and life skills education. Central Carolina Community Foundation administers the Aflac Charitable Fund Competitive Grant for groups serving designated Midlands counties.
Central Carolina Community Foundation
Community Foundation Support for South Carolina Wellness
Applications due Oct 3, 2026
Nonprofit 501(c)(3) and other charitable organizations serving women and children in South Carolina’s Aiken and Edgefield counties can apply for the Community Foundation for the Central Savannah River Area’s Women in Philanthropy Grant. Funding supports high-impact projects in health, social well-being, arts, and education that improve quality of life for local women and children.
Community Foundation for the Central Savannah River Area
Insperity Community Services Grants in South Carolina
Applications due Oct 16, 2026
Nonprofit 501(c)(3) organizations supporting community services in South Carolina can seek philanthropic grants or event sponsorships to advance their service and fundraising goals. With a mission to help communities where employees live and work, Insperity provides eligible charities with financial, volunteer, or in-kind support when they meet its employee, client, or community connection criteria.
Insperity
Dudley T Dougherty Foundation Support for Health
Applications due Oct 31, 2026
Nonprofit 501(c)(3) organizations working on community services, environmental conservation, or peacebuilding in South Carolina may be eligible for this flexible program funding. Focused on broad social and environmental impact, the Dudley T Dougherty Foundation invites nonprofits whose work supports wellness and healthy living to apply.
Dudley T Dougherty Foundation Inc
South Carolina Community Funding via Georgia-Pacific Foundation
Applications due Oct 31, 2026
Nonprofit 501(c)(3) organizations, public schools, and qualified local government entities in South Carolina can apply for Georgia-Pacific Foundation’s grants to support education, entrepreneurship, community enrichment, and environmental initiatives. Eligible applicants must be within 30 miles of a Georgia-Pacific manufacturing community and serve communities where the company operates, which may include health and wellness-related programming.
Georgia-Pacific Foundation
Youth and Family Support Grants from TJX Foundation
Letter of inquiry due Oct 31, 2026
Nonprofit 501(c)(3) organizations supporting basic needs, at-risk youth, or domestic violence services near South Carolina TJX locations can seek program funding through The Tjx Foundation. Grants may benefit health and wellness efforts by addressing food, shelter, safety, and enrichment. Applicants must be within 15 miles of a TJX site and meet mission and nondiscrimination criteria.
The Tjx Foundation Inc
Lawrence Foundation Support for Community Services
Applications due Nov 1, 2026
Nonprofit 501(c)(3) organizations, public schools, and libraries in South Carolina seeking support for environmental or human services programs can apply for grants of US $5,000 - US $10,000. With a mission to back environmental and human services work, Lawrence Foundation provides unrestricted operating or program funding, including reasonable indirect costs, for U.S.-headquartered organizations.
Lawrence Foundation
Stanislaus Community Foundation Wellness Grants in South Carolina
Applications due Nov 15, 2026
Nonprofit organizations focused on wellness and healthy living in South Carolina communities served by GALLO Giving can apply for up to US $10,000 to support family well-being, the arts, and overall community health. Grants from Stanislaus Community Foundation prioritize 501(c)(3) organizations in Chester County, South Carolina, that align with these giving priorities.
Stanislaus Community Foundation
Ameriprise Financial Support for Community Vitality
Applications due Jan 15, 2027
Focused on community vitality, Ameriprise Financial invites South Carolina 501(c)(3) nonprofits to apply for grants supporting basic needs, community development, cultural enrichment, and volunteer-driven causes. U.S.-based organizations working on hunger, shelter, financial literacy, workforce readiness, or arts access that can show measurable outcomes and engage Ameriprise volunteers may be eligible.
Ameriprise Financial
Dr Scholl Foundation Grants for South Carolina Health Programs
Letter of inquiry due Jan 31, 2027
Health and wellness nonprofits in South Carolina can seek project funding for education, social services, health care, civic, cultural, and environmental initiatives. Grants from Dr Scholl Foundation help U.S. 501(c)(3) organizations with one-year projects, awarding US $5,000 - US $25,000 through an annual cycle running from October 1 to March 1.
Dr Scholl Foundation
Spartanburg County Foundation Support for Wellness
Letter of inquiry due Mar 17, 2027
Grants from Spartanburg County Foundation help South Carolina health and wellness nonprofits improve quality of life, educational achievement, and economic mobility for Spartanburg County residents. 501(c)(3) and tax-exempt organizations can request up to US $35,000 for programs such as community health initiatives, mental health services, food access, housing stability, and related support services benefiting Spartanburg County.
Spartanburg County Foundation
BECU Foundation Community Grants in South Carolina
Letter of inquiry due Apr 24, 2027
Health and wellness nonprofits in South Carolina can receive up to US $50,000 for community-focused programs such as healthcare access, illness prevention, mental health, disabilities, and veteran advocacy. BECU Foundation provides funding to 501(c)(3) organizations with a direct impact in Charleston County, nominated by BECU members who support their work.
BECU Foundation
US $100,000 - US $150,000
South Carolina Childhood Health Funding via Amerihealth Caritas Foundation
Letter of inquiry due May 13, 2027
South Carolina health and wellness nonprofits addressing adverse childhood experiences and related trauma can access funding through Amerihealth Caritas Foundation for one-year, project-specific initiatives. Eligible 501(c)(3) organizations in AmeriHealth Caritas Medicaid markets may receive US $100,000 - US $150,000 to improve children’s health, promote protective experiences, and support families in high-Medicaid communities.
Amerihealth Caritas Foundation
South Carolina Housing Innovation Funding via Enterprise
Applications due May 16, 2027
South Carolina nonprofits and mission-driven housing organizations with proven affordable housing innovations can access funding through Enterprise Community Partners’ national Housing Affordability Breakthrough Challenge. Grants of US $2,000,000 support ready-to-scale solutions in design and construction, finance, or service delivery that expand affordable rental and homeownership options for low- to moderate-income residents.
Enterprise Community Partners Inc
Yawkey Foundation Support for Human Services
Letter of inquiry due Jun 19, 2027
Health and human services nonprofits in South Carolina and Eastern Massachusetts can access funding through the Yawkey Foundation’s Program and Small Capital Grants, with awards up to US $100,000 for timebound program needs, small projects, or equipment. Grants prioritize direct services addressing unmet basic needs for vulnerable and underserved individuals and families in Georgetown County and designated Massachusetts counties.
Yawkey Foundation