Best Addiction and Substance Abuse Grants in North Carolina

Grants from Amerihealth Caritas Foundation help North Carolina 501(c)(3) nonprofits run project-specific programs addressing addiction and substance use disorders, children’s mental health, and related trauma. Organizations with $300,000–$10 million in revenue that serve Medicaid-enrolled communities can apply for US $100,000 - US $150,000 to improve healing behaviors, health care access, and family empowerment.

Nonprofit and community organizations expanding substance use disorder prevention, treatment, services, or supports in North Carolina can apply for up to US $500,000 annually to address access gaps. North Carolina Department of Health and Human Services supports addiction and substance use disorders programs statewide through at least 12 contracts aimed at building an equitable system of care.

Addiction and substance use researchers working with adult populations that experience health disparities can apply for National Institutes of Health funding to test SBIRT/P approaches. Grants from NIH help North Carolina and other U.S. teams evaluate screening, brief intervention, and referral to treatment or prevention in collaboration with healthcare and community partners.

North Carolina nonprofits planning innovative arts or human services projects can apply for the Joy W. Pope Memorial Grant Funds, with awards from US $20,000 - US $100,000 for project-specific work. With a mission to foster innovation, John William Pope Foundation supports capital improvements, program development, equipment, and technology, including initiatives addressing addiction and substance use disorders.

Nonprofit 501(c)(3) organizations in North Carolina working on addiction and substance use disorders can seek project or capital support to improve prevention, treatment, and recovery services. Focused on education, healthcare/rehabilitation, and human and community services, the Philip L Van Every Foundation offers US $10,000 - US $50,000 for established programs with strong leadership and results.

North Carolina research institutions and healthcare or community partners working on addiction and substance use disorders can access funding through the National Institutes of Health to test SBIRT/P approaches for adults facing health disparities. Projects must prospectively evaluate screening, brief intervention, and referral to treatment or prevention for alcohol, tobacco, and other drug use.

Nonprofit and local government organizations working on addiction and substance use disorders, alcoholism, or drug use disorder can apply for funding, including those in North Carolina if they are Native American organizations. Focused on education, health, public safety, treatment, housing, and related services, the Confederated Tribes of Siletz Indians supports charitable programs across the U.S.

The GSK IMPACT Awards in North Carolina honor outstanding nonprofit organizations making a significant impact on community health. This annual program, in partnership with the Triangle Community Foundation, recognizes up to ten organizations for their exemplary contributions to health and wellness. Applicants must demonstrate a commitment to improving community health through innovative and effective programs. Eligible organizations must operate in the Triangle area and meet specific criteria regarding revenue and community impact.

The NIDA Research Education Program (R25) aims to enhance the training of a workforce skilled in biomedical, behavioral, and clinical research, particularly regarding substance use disorders. This program supports educational activities that prepare clinicians and clinical researchers. Applications are due by 5:00 PM local time, with optional Letters of Intent encouraged 30 days prior to the full proposal deadline. This initiative does not fund non-research-related clinical training.

The Rural Opioid Technical Assistance Centers program aims to provide essential training and technical assistance to combat opioid and stimulant misuse in rural areas. With 10 Regional Centers and a National Coordinating Office, the initiative focuses on high-quality prevention, treatment, and recovery support services for substance use disorders. This program anticipates awarding 11 new grants to enhance community health and safety in addressing polysubstance use challenges.

CAREs Flexible Funding

Healthcare Foundation of Wilson (HFW) CAREs about our nonprofit partners that provide CARE (Compassion, Assistance, Responsiveness, and Engagement) for our community. As a response to support the work done by these organizations, the HFW seeks proposals from nonprofit organizations located in Wilson, NC, for an unrestricted funds grant. Funds may be used for general operating support.

Request Range:

• Up to $15,000

As a partner organization, it is essential to note that maintaining compliance with the public support test is the nonprofit’s own responsibility. Please review the information provided on the IRS website. If you are unsure of your public support status, please contact an accounting professional. 

Purpose:

Nonprofits can utilize these funds to support any operating needs within the organization. These funds are not intended for past, present, or future programming needs.

Award Distribution:

Awards will be issued quarterly through a competitive grant process. Up to $50,000 will be issued each quarter.

The nonprofit’s mission and/or vision must align with at least one of our four focus areas.

• Access to Healthcare
• Active Living / Healthy Eating
• Alcohol / Substance Misuse
• Behavioral / Mental Health

Healthcare organizations, 501(c)(3) nonprofits, government agencies, and schools in Wilson County can receive funding to improve healthcare access, behavioral and mental health, and address alcohol and substance misuse among youth. Healthcare Foundation of Wilson prioritizes innovative, evidence-based programs serving residents through age 29 in the greater Wilson, North Carolina community.

The Tobacco, Alcohol, and Cannabis Policy Research for Health Equity grant aims to support research on policies affecting tobacco, alcohol, and cannabis use in the U.S. This initiative focuses on how these policies impact populations facing health disparities. Key components include engaging community organizations to advance equity in cancer prevention. Important deadlines for applications range from February 2025 to October 2027, providing opportunities for both standard and renewal submissions.

The HEAL Initiative's Career Development Awards aim to empower early career researchers and clinicians in implementation science. By providing training and funding, this initiative seeks to address substance use prevention and treatment through research projects that align with the HHS Overdose Prevention Strategy. Focused on vital areas such as opioid prescribing, OUD treatment, and recovery support, the program aspires to cultivate a new generation of experts who will significantly impact addiction clinical practices and mentorship.

The National Institute on Drug Abuse is funding pilot and feasibility studies aimed at preparing for substance use and HIV prevention research trials. The program encourages innovative interventions for substance use disorders and HIV eradication, focusing on stakeholder collaboration and practical application. Projects may include assessment of service models, intervention development, and community engagement. This initiative is designed to fill critical research gaps and enhance partnerships, although applications are not currently being accepted.

This funding opportunity invites Small Business Technology Transfer (STTR) grant applications aimed at developing FDA-regulated medical products for patients with opioid and stimulant use disorders. Projects may focus on pharmacotherapeutics or diagnostic devices, including software. The initiative seeks to address the ongoing opioid crisis by supporting innovations that enhance treatment options for individuals and communities affected by these disorders.

Research institutions studying addiction and substance use policy can apply for NIH R21 funding of up to US $275,000 in the U.S., including North Carolina. Grants from the National Institutes of Health help organizations examine how tobacco, alcohol, and cannabis policies affect use, exposure, and health disparities to advance cancer prevention and health equity.

Universities, research institutions, and similar organizations focused on substance use and addiction can seek funding to provide skills-development courses and hands-on research experiences, including for North Carolina participants. Focused on building a diverse biomedical and behavioral science workforce, the National Institutes of Health offers up to US $1,250,000 for structured research education programs.

Clinician-scientist training programs in addiction and substance use disorders in North Carolina can apply for institutional career development support, with awards up to US $750,000. Grants from the National Institutes of Health help eligible institutions provide intensive, supervised research training that advances substance use and substance use disorder research toward independent clinical research careers.

Research institutions and teams conducting HIV and substance use studies, including addiction and drug use disorders, can apply for up to US $1,500,000 in funding, including projects based in North Carolina. Focused on high-priority HIV research, the National Institutes of Health invites detailed proposals from basic, clinical, and implementation scientists working with people who use drugs.

Research institutions studying addiction and substance use disorders in the U.S. and territories, including work relevant to North Carolina, can seek pilot or exploratory funding for time-sensitive substance use epidemiology and health services research. US Dept. of Health & Human Services: National Institutes of Health supports projects responding to sudden drug issues, policy shifts, and emerging clinical or justice system opportunities, awarding up to US $275,000.

The NIH is offering access to biospecimens from the ABCD, HBCD, and PATH studies to promote research on health and disease across a lifetime. This initiative encourages projects that utilize these samples to deepen understanding of genetic and environmental influences, particularly substance exposure. Researchers can submit proposals to maximize the scientific utility of these resources, in alignment with the goals outlined under federal health regulations.

North Carolina research institutions and clinical trial teams focused on addiction and substance use disorders can access funding through the Food and Drug Administration to study analgesics, anesthetics, and addiction. Awards of US $2,000,000 support clinical trials, outcome measures, neurodevelopmental assessments, and evidence-based plans to improve prescribing for pain, anesthesia, and substance use disorders.

The National Institute on Drug Abuse (NIDA) is launching a specialized entrepreneurship program aimed at life science researchers in the field of substance use disorders (SUD). This initiative will equip researchers with essential skills to transform their innovative ideas into viable products, focusing on aspects such as market evaluation, customer discovery, and intellectual property. The course will be delivered in a hybrid format to engage US-based SUD researchers effectively, fostering collaboration and advancing the field.

The Strengthening Services to Prevent the Infectious Disease Consequences of Drug Use initiative aims to enhance prevention services for infectious diseases among people who use drugs (PWUD). It encompasses two components: a biennial survey to assess service gaps and capacity, and increased support for testing and treatment services. The initiative seeks to improve data utilization in service provision, ultimately increasing testing for HBV, HCV, and HIV, and ensuring more PWUD engage in treatment and care.

The Healthcare Foundation of Wilson (HFW) offers responsive grants aimed at improving health and wellness in the Wilson, NC community. Established in 2014, HFW prioritizes tax-exempt organizations that address healthcare access, active living, and mental health. Funding is directed towards innovative programs, especially those targeting youth, while ensuring eligibility criteria, including three years of operational history, are met. This initiative reflects HFW's commitment to reinvesting resources back into the community.

The Drug-Free Communities (DFC) Support Program, initiated by the Drug-Free Communities Act of 1997, aims to bolster community coalitions dedicated to preventing youth substance use. Funded by the US HHS's Substance Abuse and Mental Health Services Administration (SAMHSA), this program focuses on collaboration among various stakeholders, including government and non-profit entities, to effectively reduce substance abuse among youth and promote protective factors within communities.