Best Operating Grants for Nonprofits in Illinois

Disease Prevention and Chronic Disease Management

Hospital Disease Prevention

• Support critical access hospitals (CAHs) and rural hospitals as designated by CMS in the development, implementation, and monitoring of chronic disease management programs coordinated by or located in the relevant CAHs and rural hospitals as a means to improve patient outcomes and promote population health initiatives in rural communities.
• Participating hospitals are expected to identify local health priorities using resources such as Community Health Needs Assessments (CHNA) or county I-PLANs, which contain data on chronic disease prevalence and high-risk populations.
• Partnership with the facility’s local health department is expected.

Overall Goals of Disease Prevention Grant

Improve patient health outcomes and quality of life through better disease control

Reduce healthcare costs via decreased utilization of high-cost services

Increase access to preventive services in community settings

Empower patients through education and self-management support

Establish sustainable healthcare delivery models aligned with national benchmarks such as Healthy People 2030

Support the identified needs of each region/identified populations

Reduce redundancy

Notice of Funding Opportunity

Violence Against Women Act (VAWA) VAWA – Culturally Specific 2026 NOFO # 1744-0618

The Illinois Criminal Justice Information Authority is requesting proposals for NOFO # 1744-0618, VAWA Culturally Specific grants. A total of $825,000 in funding in Violence Against Women Act (VAWA) is available through this solicitation for use over a period of 12 months.

The Culturally Specific Program Notice of Funding Opportunity (NOFO) will support the development, enhancement, and expansion of culturally specific victim services. This funding opportunity supports efforts to raise public awareness of victim services, particularly for culturally specific communities. The goal of the Culturally Specific Program is to establish, maintain, and expand sustainable, culturally appropriate services that address the unique needs and challenges of victims of domestic violence, sexual assault, stalking, and human trafficking from culturally specific communities.

This funding opportunity addresses an important need and service gap identified in Illinois: culturally specific services for victims of domestic violence, sexual assault, stalking, and human trafficking.

The Old National Bank Foundation offers grants to nonprofit organizations for community impact initiatives across Indiana, Illinois, Kentucky, Tennessee, Michigan, Minnesota, Iowa, and Wisconsin. Focused on four key areas—Affordable Housing, Workforce Development, Economic Development, and Financial Empowerment—the foundation prioritizes programs that support underrepresented communities. Organizations must have 501(c)(3) status and align with the foundation’s funding priorities to qualify for grants, which can be applied for every two years.

Ecolab Foundation

Ecolab Foundation is a philanthropic arm of Ecolab dedicated to advancing community well-being through programs that promote education, environmental stewardship, and public health. Its mission is to create positive social impact by supporting initiatives that strengthen communities and foster sustainable development.

The foundation’s primary areas of engagement include educational programs that enhance learning and workforce readiness, environmental projects that encourage conservation and sustainability, and health-related initiatives that improve hygiene and safety. It focuses on partnerships that deliver measurable benefits and long-term impact.

Ecolab Foundation operates primarily within the United States while also supporting global initiatives aligned with its corporate responsibility goals. Its geographic scope reflects a commitment to addressing local community needs and contributing to broader sustainability efforts.

The foundation collaborates with nonprofit organizations, educational institutions, and community-based groups. It prioritizes partnerships that demonstrate strong governance, clear objectives, and alignment with its mission of education, health, and environmental responsibility.

Ecolab Match Program

Ecolab established the Volunteer and Community Relations programs to encourage and reward Ecolab employee and alumni involvement in the communities where people live and work. There are three programs including the Board Leadership Volunteer Grant.

Board Leadership Volunteer Grant

Ecolab will donate up to $500 USD annually to a qualifying 501(c)3 organization (some restrictions apply) for which an eligible person serves on the Board of Directors. 

Focus Areas of Giving

• Youth and Education: programs that promote youth development, particularly for programs that ensure all students are successful
• Civic & Community Development: affordable housing, work readiness, crisis assistance and hunger relief
• Environment & Conservation: hands-on environmental learning programs, environment and conservation organizations
• Arts & Culture: arts education for children and youth as well as support for museums and the performing arts

The Illinois Racing Board Charity Grant provides essential Wellness Services to individuals working or residing at Illinois' pari-mutuel race tracks. With over $26 million allocated over 30 years, the program ensures access to medical, dental, and counseling services. For 2024, approximately $767,193 is available for grants, supporting non-profit organizations that can demonstrate a commitment to the well-being of backstretch residents. Eligible applicants must meet specific requirements, including prior IRS approval and a solid project plan.

The Illinois Community Canopy: Tree Removal Grant Program, funded by Trees Forever, aims to assist communities in managing their tree canopies by providing grants for the removal of dead, dying, or damaged trees. This initiative is crucial for safety and environmental health, especially in areas affected by the Emerald Ash Borer and natural disasters. Eligible communities can also apply for tree planting grants to replace the removed trees, fostering a sustainable urban ecosystem.

Division of Early Childhood

The Department of Human Services Division of Early Childhood (DEC) was established as a standalone IDHS division in 2021 to help strengthen and centralize the state's existing child care, home visiting, and early intervention programs, as well as operationalize and create administrative capacity to establish sustainable infrastructure needs in order to streamline services.

Working hand-in-hand with local communities throughout Illinois, the Division of Early Childhood provides low-income, working families with access to quality, affordable child care; administers community-based prevention and intervention programs; and helps all children between the ages of birth to three with disabilities or delays, to learn and grow.

480-50-3708 Migrant and Seasonal Head Start

Description

Scope of Work

Provide a full-day, comprehensive Head Start child development program to children, ages six weeks to six years, from migrant and seasonal farm-worker families. Program includes early childhood education, school readiness, developmental assessment, mental health screening, field trips, project work, immunizations, nutritious meal service and medical and dental examinations, completion of dental and medical treatment for children who need it, social-service referrals and transportation services.

Announcement Type: Renewal

The 230 Outpatient Fitness Restoration Grant provides essential outpatient mental health services and fitness education for non-dangerous defendants adjudicated unfit to stand trial. This program focuses on community-based fitness restoration, which includes psychiatric and substance abuse treatment, aimed at reducing the number of individuals on waiting lists for inpatient services. With approximately 16 grants anticipated, the initiative supports both adults and juveniles, ensuring timely access to necessary treatments while upholding fairness and ethical standards in the judicial process.

The Looking Out Foundation Grant supports social justice and humanitarian initiatives, having donated nearly $6 million to various causes globally. With an average donation of $25 per campaign, it aids organizations focused on disaster relief, racial justice, and support for marginalized communities. Eligible applicants must be tax-exempt public charities under Section 501(c)(3). The foundation prioritizes diverse funding sources and encourages organizations to adapt to changing needs, with grant allocations ranging from $5,000 to $25,000.

Lilly Foundation

To extend Lilly’s charitable reach and impact, the Eli Lilly and Company Foundation (Lilly Foundation) was established in 1968 and is supported by donations from Eli Lilly and Company.

The Foundation is a tax-exempt, private foundation supporting programs that align with its philanthropic priorities.

Grantmaking Approach

The Lilly Foundation’s work is guided by a charitable vision of a world where every person has an opportunity to live their healthiest life. Through grantmaking focused on Lilly Foundation’s charitable vision, grants can serve as a catalyst for closing gaps and empowering individuals and communities to thrive.

All proposals should demonstrate clear alignment with at least one focus area and include charitable outcomes that are measurable and consistent with the Foundation’s long-term charitable goals.

Global Health, K-12 STEM Education and Economic Mobility Grant

Focus Areas

Global Health

Lilly Foundation, through its charitable grants, aims to support permissible charitable efforts to improve access to quality healthcare for resource-limited communities in low- and lower-middleincome countries (L/LMICs) and in the United States. Strengthening access to care is essential for enhancing community well-being and supporting economic stability in resource-limited settings.

The Global Health focus area aims to close gaps in quality healthcare by supporting charitable solutions that improve access, bring care closer to where people live, and address the high burden of non-communicable diseases (NCDs) in resource-limited settings. To the extent permissible, the Foundation prioritizes charitable efforts related to cardiometabolic health in resource-limited settings.

K-12 STEM Education

The K-12 STEM Education focus area aims to close the gaps for students from low-income communities by supporting programs that foster new pathways and pipelines to STEM education through focused K-12 efforts, concentrating on the critical middle school years. The Foundation’s K-12 STEM Education grants are focused on initiatives that benefit Marion County, Indiana.

Economic Mobility

The Economic Mobility focus area supports charitable and educational programs that strengthen workforce readiness, postsecondary and skills-based educational pathways, and housing stability to promote long-term prosperity. This support is focused on Marion County, Indiana, with the goal of improving economic opportunity for low-income communities and advancing community well-being.

Historic Preservation - National Maritime Heritage Program for education and preservation projects

The Program provides funding for maritime heritage preservation and education projects designed to reach broad audiences and enhance public awareness and appreciation for the maritime heritage of the United States.

Project funds are disbursed from the Maritime Heritage Program directly to State Historic Preservation Offices (SHPOs), who make subgrants to applicants.

The Business Attraction Prime Sites program, administered by the Illinois Department of Commerce and Economic Opportunity, aims to foster economic growth by supporting large-scale capital investments. This initiative targets companies relocating or expanding in Illinois, promoting job creation through diverse projects, including infrastructure development. Eligible applicants must commit to significant investments and job creation, contributing to a robust economic landscape in the state. The program aligns with strategic industry focuses outlined in the Illinois Economic Plan.

The United Way of Greater St. Louis Targeted Funding aims to provide flexible, one-year grants to nonprofits addressing urgent community needs through emergency, emergent, or innovative approaches. Funding will focus on basic needs, health and wellness, crisis response, and more across 16 counties. Priority will be given to areas identified as having the greatest needs based on recent assessments, ensuring that support is directed where it is most needed.

The Kosciuszko Foundation offers Tuition Scholarships for American students of Polish descent pursuing graduate studies in the U.S. Scholarships can provide up to $12,000 for full-time studies, including master's and Ph.D. programs. Eligible applicants must be U.S. citizens or legal residents with Polish heritage and maintain a minimum GPA of 3.0. This program aims to foster educational exchanges and cultural understanding between the U.S. and Poland, supporting various fields of study.

The Levin Family Foundation Grant supports nonprofits focused on critical issues in Montgomery County, Ohio, such as the opiate epidemic, human trafficking, anti-bullying, and suicide prevention. Established in 1996, the foundation has invested over $12 million globally, emphasizing projects that align with its mission. Eligible organizations must be IRS 501(c)(3) tax-exempt. Priority is given to initiatives in the Greater Dayton Area, fostering positive community impact.

The Guy A. and N. Kay Arboit Charitable Trust Grant, administered by First American Bank, focuses on supporting education for underprivileged individuals, funding cardiac and cancer research, and endorsing religious activities, especially those tied to the Catholic Church. Grants are primarily available to organizations in the greater Chicago area that face challenges in accessing other funding sources, ensuring targeted assistance where it is most needed.

The Japan – U.S. Global Partnership Grant Program aims to foster collaborative projects addressing global issues through partnerships between Japanese and American organizations. It focuses on policy-oriented research and dialogue among diverse professionals, including academia and grassroots practitioners. Key thematic areas include resilience, inclusivity, and advancements in science and technology. Projects outside these themes may also be eligible if aligned with grant goals, covering topics like climate change, public health, and digital transformation.

The Field Foundation of Illinois focuses on funding organizations that address systemic issues in under-resourced communities, particularly prioritizing BIPOC-led initiatives. With a commitment to racial equity, they aim to invest 60% of their portfolio in BIPOC organizations across Chicago, supporting efforts in justice and storytelling. Grant requests typically range from $15,000 to $50,000, fostering local partnerships to create impactful social change.

The Doree Taylor Charitable Foundation supports charitable organizations focused on basic provisions for underserved populations, humane care of animals, health care services, public media, and environmental initiatives. The foundation prioritizes organizations in Boothbay Harbor, Southport, and Brunswick, and encourages requests for general operating support, program support, and capital projects, while maintaining a focus on the impact of their services.

The Illinois Climate Pollution Reduction Grant's Community Geothermal Planning and Pilots Phase One Grants aim to accelerate the deployment of community-scale geothermal energy systems. The initiative focuses on reducing carbon pollution by over 15,000 metric tons by 2030 and serving 1,100 households. With funding for planning and design of projects, this program seeks to create replicable and cost-effective geothermal solutions that contribute to significant greenhouse gas reductions, fostering sustainable energy practices in Illinois.

The Illinois Climate Pollution Reduction Grants - Stretch Code Adoption Grant aims to support local governments in implementing the Illinois Stretch Energy Code. The program provides up to $200,000 for education, community engagement, and technical assistance, facilitating the adoption of the stretch code in 90 municipalities over five years. This initiative seeks to enhance energy efficiency and reduce emissions in both new and existing buildings, ensuring municipalities have the resources needed for successful integration.

The Sachs Family Foundation Grant aims to enhance the quality of life for economically and educationally disadvantaged individuals and families. The Foundation supports self-sustaining charitable organizations focusing on economic and educational opportunities, particularly in low-income communities in the U.S. and developing countries. Grants are available for various initiatives, including education, housing, and job training, with a keen interest in programs that demonstrate clear potential for sustainability.

Request for Proposals: Launchpad Funds

Background

Coefficient Giving is increasing its giving, primarily to prepare for the billions of dollars in new philanthropic capital that may become available in the coming years. Our increased giving in global health and wellbeing is a temporary surge, with two objectives: to smooth funding and pull forward initiatives we expect to be cost-effective, and to help create an ecosystem of regrantors and implementers with the capacity to allocate this new money as cost-effectively as possible. Additional context on our scaling is provided in this blog post. 

With new potential capital on the way, we want to increase the supply of actionable and fundable plans to address some of the world’s hardest problems. We’re looking for specific, credible strategies to convert funding into measurable progress. Our ideal funds are:

However, we are also open to funds that are thematic and don’t have a quantified goal — for example, a fund organized around a promising type of intervention. Such funds still need to be led by a single, identifiable person who is accountable for the fund’s direction.

Through this request for EOIs, we aim to seed or scale Launchpad Funds that can grow to $100m+ over the next few years. We don’t seek scale for its own sake; it is a proxy for the ambition of the fund, and a signal that the problem is large and tractable enough to justify deploying significantly more capital over time.

What we will fund

• We expect to support established ideas that have either not yet secured anchor support or could significantly scale beyond their existing level of funding.
• This funding can cover operating expenses, but we expect most of it to be used for activities that make progress on the fund’s goals — whether through regranting or direct implementation.
• For exceptional proposals, we may consider funding levels beyond $50m. We anticipate higher funding levels will involve more thought partnership from our team.
• While we don’t expect to make grants longer than 36 months, funded proposals may later be considered for additional funding beyond the initial period.

The Max and Victoria Dreyfus Foundation offers grants to support diverse initiatives, including museums, educational programs, and environmental activities. Aiming to make a significant impact with modest funding, the Foundation targets IRS-qualified non-profits in the U.S. Grants typically range from $1,000 to $20,000, fostering community development and enhancement. Organizations focused on youth, seniors, and individuals with disabilities are particularly encouraged to apply, as the Foundation seeks to empower those in need.

The Global Health and Wellbeing Grantmaking program by Coefficient Giving focuses on addressing critical health and welfare issues worldwide. With an emphasis on proactive engagement and evidence-based solutions, the initiative supports projects that improve health outcomes and wellbeing. The program prioritizes funding for organizations tackling neglected global health challenges, advocating for effective philanthropy, and enhancing the lives of both humans and animals in vulnerable communities.

The Workforce Training Support Program aims to assist Illinois manufacturers by providing financial support for workforce training. This initiative addresses the challenges of training and retaining skilled workers in the manufacturing sector. By covering up to 50% of training costs, the program encourages employers to enhance their employees' skills, ensuring a safe and productive work environment. This program supplements existing initiatives, ultimately strengthening the Illinois workforce and supporting local businesses.

What does this program do?

It provides loans and grants to Microenterprise Development Organizations (MDOs) to:

• To help microenterprises startup and growth through a Rural Microloan Revolving Fund.
• Provide training and technical assistance to microloan borrowers and micro entrepreneurs.

Microenterprise Development Organizations must demonstrate experience in managing a Revolving Loan Fund, or:

• Certify that it or its employees have received education and training from a qualified microenterprise development training entity so that the applicant has the capacity to manage such a revolving loan fund.
• Demonstrate that it is actively and successfully participating as an intermediary lender in good standing under the U.S. Small Business Administration (SBA) Microloan Program or other similar loan programs as determined by the Administrator.

 What kind of funding is available?

• Grants are available to provide technical assistance to rural micro-entrepreneurs or microenterprises, up to $205,000 annually.
  • Funding at the requested level is not guaranteed, and at least 15 percent matching funds are required.
• Loans of $50,000 to $500,000 may be used for establishing a Rural Microloan Revolving Fund managed by the Microenterprise Development Organization.
  • Total aggregate debt is capped at $2.5 million.

What are the loan terms?

• Maximum term is 20 years.
• Two-year payment deferral.
• Must establish a loan loss reserve fund.

What terms are required on loans to ultimate recipients?

• Up to $50,000.
• Fixed interest rate.
• Limited to 75 percent of project cost.

How may the funds be used?

Microlenders may make microloans for qualified business activities and expenses including, but not limited to:

• Working capital.
• Debt refinancing.
• Purchasing equipment and supplies.
• Improving real estate.