Best Operating Grants for Nonprofits in Illinois

The Robert J. Keown Trust, established in 1934, provides financial assistance to needy Christians through grants to charitable organizations. Managed by Wells Fargo Bank N.A., the trust focuses on supporting organizations that benefit residents of Los Angeles County. Eligible organizations must be 501(c)(3) exempt. Preference is given to requests aiding needy Christians and elderly women. The trust awards an average of four grants per year, fostering community support and outreach.

The SHC Student Research Grant supports research utilizing herbarium resources across various taxa, including plants, fungi, lichens, and algae. Eligible projects may involve fieldwork, data collection, or meta-analysis of herbarium data, with an emphasis on enhancing herbarium collections. Three grants are awarded annually: two for $500 and one specifically for undergraduates for $250. Applicants must be student SHC members with projects likely to lead to publication.

The Lynn E. Poffenberger Memorial Scholarship Fund, established by the Middle Paxton Lions Club, honors the legacy of Mr. Poffenberger by providing annual scholarships to two graduating seniors. Eligible applicants must reside in Middle Paxton Township or Dauphin Borough, demonstrate financial need, and show active community involvement. This one-time scholarship aims to support deserving students in their educational pursuits, reflecting the values of service and commitment to the community.

TryMarine Grant

The Reservoir Fish Habitat Partnership (RFHP) is seeking candidate pilot sites for evaluating two water quality treatment technologies—TryMarine and Oase Water Technology—in small urban fishing lakes (1–3 acres).

Urban fishing lakes are important community resources, providing accessible angling opportunities and supporting local outdoor recreation. Many of these lakes experience nutrient‑driven water quality impairments such as algal blooms, low dissolved oxygen, and reduced water clarity. These issues degrade fish habitat and diminish angler satisfaction.

This pilot initiative aims to identify lakes where these technologies can be tested to determine their effectiveness, feasibility, and potential for broader application across the RFHP network.

Objectives

Water Quality & Habitat Objectives

• Reduce nutrient concentrations (total phosphorus, total nitrogen).
• Improve water clarity and reduce turbidity.
• Reduce harmful algal blooms (HABs).
• Increase dissolved oxygen stability to support sportfish populations.
• Improve habitat conditions for stocked and naturally occurring fish species.
• Reduce internal nutrient loading from sediments.

RFHP Program Objectives

• Demonstrate scalable tools for improving fish habitat in small urban lakes.
• Support community‑based fisheries enhancement.
• Provide case studies and data for future RFHP guidance.
• Strengthen partnerships among agencies, municipalities, NGOs, and angling groups.

The Rockefeller Family Fund's Climate Grant focuses on reducing fossil fuel production to combat climate change. It supports initiatives that hold polluters accountable and fosters citizen engagement for climate action. The fund prioritizes programs that seek to limit oil and gas production, enforce climate damages in court, and promote sustainable energy solutions. By addressing the fossil fuel industry's resistance, the grant aims to create meaningful progress towards climate goals and ensure that those responsible for climate disruption contribute to adaptation efforts.

The NIH Research Evaluation and Commercialization Hubs (REACH) program aims to facilitate the translation of biomedical discoveries into marketable products to enhance patient care. By funding five new academic entrepreneurship hubs, NIH will provide essential resources such as funding, mentorship, and expertise in product development. These hubs will address high-priority technologies and foster public-private partnerships, ultimately supporting the goals of federal research initiatives and addressing local health needs in underserved areas.

The IUSE: Innovation in Two-Year College STEM Education (ITYC) program, funded by the National Science Foundation (NSF), aims to enhance STEM education at two-year colleges. This initiative encourages innovative projects that promote student success in foundational STEM courses. Eligible institutions can request up to $500,000 for three years, with an extra $100,000 for those without NSF funding in the last five years, facilitating a total budget of $600,000 for impactful educational projects.

The GEMSSTAR for Emergency Medicine Supplemental Funding Program provides up to $25,000 over two years to support emergency medicine physicians who have received the NIA GEMSSTAR grant. This program aims to enhance the Professional Development Plan of GEMSSTAR awardees, ensuring they receive the necessary funding for their research endeavors. Eligibility is limited to those who have completed their clinical specialty training and are based at U.S. institutions, with funding contingent upon available resources.

Beckley Area Foundation

Beckley Area Foundation was established in January 1985 by ten community-minded citizens. It began with a gift of $1.1 million from the Dr. Thomas Walker Memorial Health Foundation as “seed” money for this Raleigh County project. BAF assets have grown to over $70 million with over 500 different funds managed by our three trustee banks. Today, Beckley Area Foundation is one of West Virginia’s largest community foundations.

Since its inception, BAF has distributed over $23 million to charities and other worthy projects in the fields of education, public recreation, health & human services, the arts, animal services and beautification.

Scholarships

The Beckley Area Foundation proudly manages scholarship funds established by individuals, businesses, and organizations dedicated to helping students pursue higher education. Many of these scholarships are tailored for specific schools, fields of study, or graduates from local high schools, while others offer broader opportunities. No matter the path, our scholarships aim to support students from our region as they work toward achieving their educational goals.

Most of these scholarships must be awarded to students from our geographic area or at least preference given to such students. While the majority of scholarships benefit Raleigh County applicants there are others designated for Fayette, Summers, Webster, and Wyoming students. 

The File Girls Cystic Fibrosis Scholarship

Weighted for educational merit, personal achievement and financial need; West Virginia high school matriculating senior with a confirmed diagnosis of Cystic Fibrosis. Recipient will provide physician’s letter affirming a diagnosis of Cystic Fibrosis as part of the application process; The scholarship is to be awarded for post-secondary education through college, vocational or technical schools.

This scholarship is renewable.

Who We Are

Buiding a stronger, More Vibrant Community

For over 70 years, the Scranton Area Community Foundation has served Northeastern Pennsylvania as a steward of charitable resources, a grantmaker, and a catalyst for positive change. Guided by our core values of collaboration, trust, integrity, innovation, and inclusivity, we work to ensure that our communities thrive with opportunities for all.

This scholarship is awarded to a graduating senior who has demonstrated the qualities of honesty, care, trustworthiness, and personal integrity, and who is active in sports and shows an interest in working with children or the elderly.

The Clinical Data, Safety and Statistical Centers (CDSSC) program, supported by the National Institute of Allergy and Infectious Diseases (NIAID), aims to enhance clinical research through comprehensive support. This includes statistical analysis, protocol development, and oversight of safety monitoring in studies related to asthma, autoimmune diseases, and transplantation. By coordinating these efforts, the program seeks to facilitate impactful research outcomes and improve public health outcomes through informed data-driven decisions.

The Asthma and Allergic Diseases Cooperative Research Centers (AADCRC) program, supported by the National Institute of Allergy and Infectious Diseases (NIAID), aims to enhance research on asthma and related allergic diseases. This initiative fosters multi-center, multidisciplinary research to explore disease mechanisms and treatment responses. By promoting clinical trials and observational studies, the AADCRC seeks to advance understanding and improve interventions for conditions such as asthma and food allergies, ultimately benefiting public health.

The Skyler James Wenger Scholarship, established in 2012 in memory of Skyler, a 14-year-old who tragically lost his life, supports graduating seniors from Cedar Cliff or Red Land High School. Eligible applicants must plan to attend college or trade school, come from a single-parent household, be athletes, and demonstrate financial need. This one-time award aims to honor Skyler's legacy by helping deserving students achieve their educational goals.

The Bill Monroe Memorial Scholarship, managed by the Brown County Community Foundation, offers financial support to graduates of Brown County High School pursuing a full-time baccalaureate degree in music or a related field. This scholarship is open to current and previous graduates, including those participating in Bluegrass music mentoring programs. The foundation has a strong focus on education and has facilitated numerous scholarships, enhancing opportunities for local students since its establishment.

The Cook County Community Development Block Grant (CDBG) offers funding opportunities for municipalities and non-profits to enhance urban communities. Projects can focus on infrastructure improvements or public services, with funding caps of $500,000 for infrastructure, $150,000 for public facilities, and $100,000 for public service initiatives. The program aims to support low- and moderate-income individuals by providing decent housing, suitable living environments, and expanded economic opportunities.

The Cook County Emergency Solutions Grant (ESG) aims to enhance homeless assistance through funding ranging from $25,000 to $125,000. This grant supports a variety of activities, including homeless prevention, rapid re-housing, emergency shelter services, and street outreach. It emphasizes collaboration between recipients and the Continuum of Care to improve service delivery and performance outcomes, ensuring effective use of resources to combat homelessness in the community.

The George C. Cotzias, MD, Memorial Fellowship, established by the American Parkinson Disease Association, supports young neurologists in their research and treatment of Parkinson's disease and related disorders. Funded at $125,000 annually for three years, this fellowship encourages recent graduates to develop their careers in neurology, ensuring they have the mentorship and resources necessary for success. The fellowship aims to honor Dr. Cotzias' legacy and inspire the next generation of leaders in neurology.

Scott Cornelius Memorial Scholarship (Piedmont)

To honor the memory of Scott Cornelius by supporting students pursuing careers in sales, marketing, insurance or related business fields who demonstrate leadership and integrity.

The Burroughs Wellcome Fund's Next Gen Pregnancy Initiative Grants aim to enhance research on pregnancy outcomes, addressing issues such as preterm birth and maternal health. With an emphasis on fostering diverse scientific collaboration, the initiative supports innovative proposals from researchers across various disciplines. Each grant offers up to $500,000 over four years, encouraging groundbreaking studies that explore the biological and environmental factors affecting pregnancy. This initiative seeks to improve health outcomes through informed research and interdisciplinary partnerships.

The Health Equity and Inclusiveness Research Fellow Award by LUNGevity supports physician-scientists conducting lung cancer research aimed at addressing health disparities. Funded projects will focus on early detection and improved outcomes for lung cancer, particularly among underserved communities. Awards can reach up to $100,000 over two years, with payments contingent on project milestones. This initiative aims to foster innovative research and enhance individualized treatment approaches for lung cancer.

The Section 5310 – Enhanced Mobility of Seniors and Individuals with Disabilities Grant, administered by the East-West Gateway Council of Governments, aims to enhance transportation access for seniors and individuals with disabilities in the St. Louis region. This federal funding supports projects that improve mobility, including vehicle acquisition, travel training, and barrier removal at bus stops. Eligible applicants include non-profits and government entities focused on serving these communities.

The Family Unification Program (FUP) aims to assist families and youth at risk of homelessness by providing Housing Choice Voucher (HCV) assistance. It targets families facing housing issues that could lead to out-of-home placement for children and youth aged 18-24 who have aged out of foster care. The program offers flexible voucher durations, with extensions available under specific conditions, ensuring support for those in need of stable housing.

The Steven C. Leuthold Family Foundation Grants support 501(c)(3) non-profits in areas such as land conservation, environmental protection, human services, and animal welfare. Founded in 1991 by philanthropist Steven C. Leuthold, the foundation prioritizes organizations that align with its giving preferences. Applications are due by June 30, 2025, with grants distributed by December 2025. Note that incomplete applications will not be accepted.

The Childhood Asthma in Urban Settings Clinical Research Network (CAUSE) aims to enhance asthma prevention and treatment in economically disadvantaged pediatric populations. Funded by the NIH, CAUSE supports multi-site clinical studies to identify innovative strategies and treatment targets for asthma. Utilizing systems biology, the network seeks to discover specific disease endotypes suitable for new therapeutic approaches, addressing the high burden of asthma in urban settings.

Justamere Foundation

Our goal is to remove barriers that are keeping hard working people from being fully self-sufficient. We support programs that are addressing these obstacles, big and small, in a way that opens a path to self-reliance.

The Justamere Foundation is dedicated to working with our community partners to find innovative ways to help our neighbors through education, coaching, and connections.

Small solutions can result in enormous change. The Justamere Foundation’s mission is to find those needs and connect them to the right resources to make the biggest impact.

Areas of Need We Support

The Justamere Foundation’s mission is to find those areas that are underserved by traditional resources and see if we can make a bigger difference with direct involvement. Solutions might involve grants, non-traditional scholarships or simply making the right connection.

We focus on four main areas of need in our community:

• Trade Education: Individuals working towards obtaining a family-sustaining income encounter many small barriers that can impede their progress. We’ve partnered with local community colleges and organizations that work to eliminate the barriers.
• Veterans Resources: Veterans entering the civilian workforce can struggle to find the right fit. We’re working with organizations to support veterans with this process.
• Childhood Literacy: Reading is essential. Fostering a love of reading and learning opens so many doors as children grow up. We support organizations with programs that focus on education and literacy resources for children in underserved areas.
• Arts Education: Arts programs inspire and help children express themselves. We support summer and after-school programs in music, art, and theatre.

How do we support these areas?

• Non-Traditional Scholarships
• Grants that make a real impact

Non-Traditional Scholarships

There are many traditional Scholarship and Financial Aid resources for high school kids going on to college. This is great but it leaves a whole lot of people out of the solution. Kids who couldn’t go directly to college or didn’t finish highschool – Adults who are in a job that cannot effectively support their family and want to make a change – or anyone simply looking for a better life. The resources available to them are limited. We want to work with organizations that are addressing those challenges and see if there’s a connection to be made, an existing program to utilize or even a new program to be developed.

The OJJDP FY 2026 Strategies to Support Children Exposed to Violence program aims to implement effective violence reduction strategies targeting juvenile offenders. This initiative focuses on enhancing community capabilities to assist children affected by violence in various environments, including homes and schools. By strengthening local responses to child victimization, the program seeks to diminish the incidence of violence and alleviate the long-term adverse effects that such exposure can have on children's well-being.

Society of Hospital Medicine (SHM)

The Society of Hospital Medicine (SHM) is dedicated to promoting high-value care and achieving optimal outcomes for acutely ill patients. As part of this mission, SHM seeks to address inequities in acute patient care and contribute to a greater dialogue on this important issue. As the home for hospitalists, SHM activates and engages our community to

• Advocate for our specialty, our members, and the diverse patients we serve.
• Promote high-value care and optimal outcomes for acutely ill patients.
• Meet the evolving educational needs of a dynamic specialty.
• Cultivate an inclusive community for hospitalists and support career growth and wellbeing.
• Advance the research and innovation of healthcare delivery, quality, safety, and experience across the care continuum.

SHM’s Awards of Excellence

SHM’s Awards of Excellence Program honors members who have made exceptional contributions to hospital medicine in a wide variety of categories: 

• Excellence in Research
• Excellence in Teaching
• Excellence as a Partner in Hospital Medicine
• Outstanding Service in Hospital Medicine
• Clinical Leadership for Physicians
• Clinical Leadership for Nurse Practitioners/Physician Assistants
• Excellence in Humanitarian Services
• Excellence in the Care of Vulnerable Populations
• Excellence in Teamwork