Best Large Grants for Nonprofit Organizations in Indiana

The NASA ROSES25: A.15 Biosphere program aims to enhance our understanding of terrestrial and aquatic ecosystems through innovative research. This initiative focuses on biogeochemical interactions, biodiversity, and ecosystem function, utilizing satellite data and field studies. The program encourages reproducible and transparent science, fostering collaboration and interdisciplinary approaches. Proposals will undergo rigorous peer review, ensuring high standards and integrity in research outcomes that contribute to our knowledge of global environmental changes.

The Scotts Miracle-Gro Foundation and KidsGardening offer the GroMoreGood Grassroots Grant to enhance community gardens across the U.S. This initiative supports programs that engage under-resourced communities, focusing on youth participation. In 2026, 120 grants of $750 will be awarded, with additional funding opportunities available through specialty awards for programs addressing specific needs, including those serving LGBTQ+ youth and communities of color.

The NASA Earth System Science Research Program (ESSRP) has transitioned to six Earth science research spheres, including Atmosphere, which focuses on understanding atmospheric composition and structure. This program aims to enhance comprehension of phenomena affecting air quality and weather, addressing critical issues like stratospheric ozone recovery and tropospheric dynamics. Through annual ROSES funding opportunities, NASA supports research to improve modeling efforts and observations in atmospheric sciences, ultimately benefiting public health and environmental quality.

The NEA Arts and Artifacts Domestic Indemnity Program provides museums and cultural institutions in the U.S. with financial protection against loss or damage to significant artworks during exhibitions. Established in 1975 and expanded in 2007, the program aims to enhance public access to art by minimizing insurance costs. Managed by the National Endowment for the Arts, it involves thorough evaluations by expert panels to ensure eligibility and compliance, facilitating the safe display of invaluable cultural treasures.

The Clinical and Translational Science Award (CTSA) Program aims to enhance the translation of scientific research into effective health interventions by establishing a national network of academic medical centers. This program supports integrated research and training environments for clinical and translational science, promoting the development of innovative methods and technologies. The reissuance of the CTSA Notice of Funding Opportunity invites eligible organizations to apply, with peer-reviewed applications prioritized for funding.

The ASPCA Right Horse Grants aim to enhance equine adoptions and support community equines by funding programs that boost shelter capacity or assist in keeping owned equines in their homes. Grants between $5,000 and $50,000 are available, with a total funding pool of up to $750,000. Eligible applicants include ASPCA Right Horse Adoption Partners and organizations committed to the welfare of retired Thoroughbred racehorses. Proposals should clearly outline the objectives and expected impacts.

ASPCA Reimagining Racers: Grants for Adopting Out Retired Racehorses Grant

ASPCA Right Horse Adoption Partners, ASPCA Right Horse Industry Partners, and organizations actively participating in the warm-up ring (defined as groups that are actively working to achieve the 13 criteria for Partnership and are participating on myrighthorse.org) are invited to apply for a grant to support an increase in capacity and/or efficiency of programs aimed at adopting out retired Thoroughbred racehorses. 

Funding requests for this grant initiative should focus on:

Activities that increase capacity, decrease length of stay, reduce cost of care or increase efficiencies, and/or improve humane outcomes in other ways. Examples:

• Training programs
• Programs that engage new adopters and grow the market share for adoption
• Medical make-ready or rehabilitation with a focus on innovation and/or sustainability
• Collaborations with other equine industry organizations to increase support for retired racehorses

Proposals will be evaluated on their potential (within the 12-month grant term) to: 

• Increase capacity (the number of horses that can be rehabilitated, trained, and placed)
• Decrease length of stay
• Decrease cost of care
• Reduce risk, harm or suffering for retired racehorses

Requests may be for the creation of new programs or the expansion of existing programs. Programs that test innovative ideas are welcome.

Grant Amounts

Grants will generally range from $10,000-$40,000, with a maximum individual grant amount of $60,000. The total funding amount available for this grant opportunity is $200,000. 

Eligibility

ASPCA Right Horse Adoption Partners, ASPCA Right Horse Industry Partners, and active Warm-Up Ring participants (defined as groups that are actively working to achieve the 13 criteria for Partnership and are participating on myrighthorse.org) whose mission or operations focus significantly on serving retired Thoroughbred racehorses are eligible to apply for this grant opportunity. Adoption organizations must be up to date on reporting data biannually to the Equine Welfare Data Collective (EWDC). If you’re unsure about your eligibility, you may contact therighthorse@aspca.org to confirm before applying.   

The American Society for the Prevention of Cruelty to Animals® (ASPCA®) was founded on the belief that animals are entitled to kind and respectful treatment by humans. We invite all voices to join us in working together to improve the lives of animals in need.

The Chapman Prize, established by the Daniel and Barbara Chapman Trust, honors individuals and organizations making significant contributions to American society. Each year, the award focuses on a theme; in 2025, it will spotlight Economic Prosperity. Eligible applicants include U.S. citizens and nonprofits with three years of charitable work demonstrating impact in the chosen field. Approximately $100,000 will be awarded annually to support endeavors that enhance economic prosperity through various initiatives.

The NIH is set to release a Notice of Funding Opportunity for early to definitive clinical trials across various biomedical fields. This initiative focuses on trials evaluating drugs, devices, and interventions that align with NIH's mission. Utilizing the R61/R33 funding mechanism, projects can span up to 7 years, supporting both planning and trial phases. Interested investigators are encouraged to prepare collaborative proposals, although applications are not currently being solicited.

The URM Travel Grants, established by the American Economic Association (AEA), support junior faculty from underrepresented minority groups in economics, including American Indian, Black, Hispanic, and Pacific Islander individuals. These grants cover up to $1,000 in expenses for meals, travel, lodging, and conference registration to attend the annual ASSA meetings. The initiative aims to enhance the professional development of URM junior faculty and promote diversity within the economics field.

Stark Community Foundation

Since 1963, Stark Community Foundation has been helping individuals, families, businesses and nonprofits like you support the causes you care about.

In addition to personalized donor services, we manage a competitive grantmaking program and award grants to address local needs. Today, the Foundation stewards over 1,000 charitable funds totaling $485 million in assets and has granted more than $300 million to nonprofits in our community and beyond.

Scholarships

Stark Community Foundation is one of the area’s major sources of college scholarship support— thanks to the generosity of caring individuals, families and businesses that have created scholarship funds.

The Foundation currently manages more than 100 scholarship funds that support hundreds of deserving students each year from Stark and Carroll counties.

The Lillian Grace Mahan Scholarship Fund

The Lillian Grace Mahan Scholarship Fund was established to assist graduate and undergraduate students of library science and is available to Stark County residents who have an outstanding academic performance record and/or who are in need of financial assistance to pursue a degree in library science to become a librarian.

This scholarship is renewable.

The scholarships and fellowships provide recipients with the opportunity to attend and explore the operation of the field at the NRPA Annual Conference. A primary focus is to inspire future participation and leadership in NRPA and to develop professional contacts with leadership and members from around the nation. Recipients receive complimentary NRPA Annual Conference registration and a travel stipend.

Young Professional Fellowships

The fellowship provides selected young professionals (up to 4) with the opportunity to explore the operation of NRPA and its governing bodies at the NRPA Annual Conference through the support of Sourcewell. Participants will meet with mentors, be recognized at the awards ceremony and attend various conference sessions and meetings. A primary focus of the program is to inspire future participation and leadership in NRPA and to develop professional contacts.

The BJA FY26 Paul Coverdell Forensic Science Improvement - Formula Grants Program supports state agencies in enhancing forensic science capabilities. The program aims to improve public safety by funding initiatives that strengthen forensic science and support law enforcement efforts. Eligible applicants can submit their full applications through JustGrants by November 6, 2026. This funding is crucial for addressing ongoing challenges in the justice system, including violent crime and public safety concerns.

The BJA FY 2026 Paul Coverdell Forensic Science Improvement- Competitive Grants Program aims to enhance forensic science and medical examiner/coroner services across the U.S. This funding opportunity supports state and local government laboratories in improving their capabilities to ensure justice and public safety. Applications are due by November 5, 2026, at 8:59 p.m. ET, promoting advancements in forensic practices to better serve law enforcement and communities.

The AWWA Larson Aquatic Research Support Scholarships, administered by the American Water Works Association, honor Dr. Thurston E. Larson by providing financial support for graduate students in science or engineering. Annually, two scholarships are awarded: $5,000 for master's students and $7,000 for doctoral students. This initiative reflects AWWA's commitment to fostering future leaders in the water industry while recognizing the contributions of Dr. Larson.

About PLTW Computer SciencePLTW Computer Science students are technology trailblazers who are empowered through transportable skills and prepared to start their career, whether that is in computer science or not.

Lockheed Martin has committed funds to support PLTW grants to schools interested in adding PLTW.Since 2007, Lockheed Martin has partnered with PLTW to address the nation's critical need for future engineers, computer scientists, and math- and science-trained professionals, and to equip all students with the knowledge and skills they need to thrive. Lockheed Martin supports PLTW programs in school districts across the nation and has contributed to the development of PLTW's middle school and high school courses focused on aerospace engineering and flight. Since the first school district partnership in 2014, over 855 PLTW programs have been implemented and more than 145,328 students have gained access to PLTW.Program Requirements:

• Grantee must offer at least one PLTW Computer Science course in the 2027-2028 academic year.
• Grantee may implement any PLTW Computer Science course of their choosing

Grant Award and Distribution Schedule:

• Total Award: $10,000
  • 2027-2028: $10,000

About PLTW Computer SciencePLTW Computer Science students are technology trailblazers who are empowered through transportable skills and prepared to start their career, whether that is in computer science or not.

Lockheed Martin has committed funds to support PLTW grants to schools interested in adding PLTW.

Since 2007, Lockheed Martin has partnered with PLTW to address the nation's critical need for future engineers, computer scientists, and math- and science-trained professionals, and to equip all students with the knowledge and skills they need to thrive. Lockheed Martin supports PLTW programs in school districts across the nation and has contributed to the development of PLTW's middle school and high school courses focused on aerospace engineering and flight. Since the first school district partnership in 2014, over 855 PLTW programs have been implemented and more than 145,328 students have gained access to PLTW.Program Requirements:

• Grantee must use their grant funds to expand their existing PLTW Computer Science program.
  • Example expansion activities include but are not limited to adding an additional PLTW Computer Science course not previously offered,
  • and/or adding additional class periods of an existing PLTW Computer Science courses previously offered,
  • and/or training additional teachers in PLTW Computer Science courses for the 2027-2028 academic year. 

Grant Award and Distribution Schedule:

• Total Award: $10,000
  • 2027-2028: $10,000

Bengier Foundation

After lots of hard work and more than a bit of luck, Gary and Cynthia were able to retire from professional business careers at an early age. They decided then to try to give back a little to their community and to others less lucky than they. So the Bengier Foundation was formed in 2004 to give a helping hand to bright, hardworking young people who need a little help to find their own success.

One of our goals is to help – in a small way – to focus attention on the need to increase our American educational capital. The dropout rate statistics are shocking. We must do more to help the next generation prepare for the increasing demands of our ever-more sophisticated information economy. The Bengier Foundation believes that we must give everyone a chance to achieve their potential.

Bengier Foundation Grants

The foundation's mission is to provide educational experiences that motivate, broaden and qualify bright, hard working young people who have limited means and limited opportunities to enlarge their expectations of what they can accomplish in life.

• By motivate we mean to change a young person’s expectations about themself, by providing experiences which pique their interest, or that let them see themself in a role or career that they never previously imagined.
• By broaden we mean to allow a young person to have experiences that broaden their perspective of the world or cause them to view it and their role in it differently.
• By qualify we mean to help a young person gain the experiences and education that will allow them to succeed in college and in life.

Artis offers exhibition grants to support contemporary artists from Israel, aiming to promote critical dialogue and cultural exchange in international settings. These grants facilitate presentations at renowned organizations globally, focusing on innovative and impactful projects that engage with pressing social and environmental issues. The program prioritizes proposals that demonstrate curatorial ambition and artistic experimentation, fostering collaboration across diverse disciplines. Artis is committed to shaping a sustainable art world while addressing urgent global challenges through artistic practice.

The Capacity Building Grants for Non-Land-Grant Colleges of Agriculture Program, administered by the USDA's NIFA, aims to enhance the capabilities of eligible institutions in agriculture and related fields. By providing financial support, the program encourages institutions to compete for federal funding, disseminate vital information, and foster community engagement in educational and research initiatives. This initiative is crucial for developing infrastructure, promoting faculty development, and establishing graduate assistantships to address national and regional agricultural priorities.

The NRC Research Associateship Grant Program, managed by the National Academies of Sciences, Engineering, and Medicine, provides prestigious research opportunities for postdoctoral and senior scientists at federal laboratories. This program promotes scientific excellence through mentorship and access to advanced facilities. Eligible candidates must hold a relevant doctorate and demonstrate significant research potential. With annual deadlines on February 1, May 1, August 1, and November 1, this initiative aims to enhance the career development of promising researchers.

The Plant America Community Project Grant, offered by the National Garden Clubs, supports initiatives that enhance public spaces and community gardens. Grants of up to $2,000 are available for projects that educate and engage both adults and children in gardening. Since 2017, over 250 grants have been awarded, totaling more than $225,000. Eligible applicants include member clubs, focusing on beautification, restoration, and environmental education.

Armstrong County Community Foundation

The Armstrong County Community Foundation, a public nonprofit corporation,

• Gives grants, scholarships, and organizational support to address the needs of our community.
• Builds a permanent endowment to help our donors create a legacy through this endowment.
• Promotes informed philanthropy to increase and sustain charitable resources for the region.
• Provides leadership and builds partnerships to identify and solve community issues.

Richard and Mary Krauland Scholarship

This scholarship was established to provide scholarship funding to pursue a career in math or engineering.

Scholarship Details

• Available to High School Seniors
• Nonrenewable

All ACCF Scholarships are merit based.

The Association of Legal Writing Directors (ALWD) History Grant is designed to support projects that research, interpret, or celebrate the history of ALWD and its contributions to the legal writing discipline. These grants reflect ALWD’s commitment to preserving the history of ALWD, honoring community contributions, and making ALWD’s history accessible to scholars, teachers, and practitioners into the future.

Types of Fundable Projects

• Oral History & Interview Projects - Projects may include interviews with founders, early leaders, past presidents, award winners, or other members central to ALWD’s history. 
• Archival Preservation & Digitization - A project may include scanning, organizing, and preserving historical materials such as conference programs, newsletters, board minutes, and committee records, accompanied by the creation of searchable digital archives for long-term access.
• Creative Dissemination Projects - Short documentary films, podcasts, interactive digital exhibits, timelines, or “museum-style” digital or physical installations are possible projects.
• Conference Integration  - Projects may include the preparation of history-focused materials for ALWD’s biennial conferences, such as poster sessions, anniversary exhibits, or a temporary “history wall.”
• Publications & Reflections  - Written projects may include essays, case studies, memoir pieces, or historical analyses suitable for publication 

Outstanding Program Award

Recognizing the exceptional programming of AAFP Chapters and Chapter Foundations.

The AAFP Foundation established this award to nationally recognize outstanding philanthropic activities of AAFP Chapters and Chapter Foundations. Each year, one program is selected, and the Award is presented during AAFP FMX at the AAFP Foundation recognition event.

The Outstanding Program Award Recipient will receive up to a $1,000 reimbursement for travel to FMX to accept the award at the AAFP Foundation Donor Recognition dinner.

The FY 2027 Service Area Competition (SAC) aims to enhance health services in underserved communities across the U.S. by providing grants for comprehensive primary and preventive care. This initiative will support health centers in delivering high-quality services, addressing the needs of populations that face barriers to care. Each funding opportunity will specify service areas available for competition, ensuring effective resource allocation to improve community health outcomes.

The Toshiba America Foundation offers grants of up to $5,000 for innovative STEM projects aimed at grades 6-12. These grants support teachers seeking to enhance science and math education through creative project-based learning. Eligible applicants include public and nonprofit private school teachers, with a focus on fostering engaging classroom experiences. Projects must be endorsed by a school official, and funding is not available for general operations or equipment purchases.