Best Grants for Small Nonprofits in Iowa

The Jeffris Heartland Fund Grant, provided by the Jeffris Family Foundation, supports significant historic preservation projects across several Midwestern states, including Iowa and Wisconsin. Grants range from $5,000 to $50,000, covering 50% of costs for Historic Structure Reports, requiring a dollar-for-dollar match. Eligible applicants include 501(c)(3) organizations and government agencies, focusing on projects with historical significance, architectural merit, and strong community ties. Applications are accepted anytime, with decisions made approximately 30 days after submission.

The DDIF: Toothbrush Donations program, supported by the Delta Dental of Iowa Foundation, aims to improve oral health by providing essential dental supplies like toothbrushes, toothpaste, and floss. Nonprofit organizations are encouraged to apply year-round, emphasizing the importance of including an oral health education component in their projects. This initiative not only addresses immediate dental care needs but also promotes long-term oral hygiene practices.

PFund Foundation supports LGBTQ+ communities in the Upper Midwest by providing event sponsorship funding for various gatherings, including fundraisers and pride festivals. Organizations eligible for funding must align with the foundation's mission, serve LGBTQ+ individuals, and be registered as 501c3 nonprofit entities. Events must be located within the foundation's service area and be scheduled at least 60 days in advance. This initiative aims to foster community engagement and support.

The High Priority HIV and Substance Use Research funding opportunity aims to support innovative research that addresses the intersection of HIV and substance use. Researchers are encouraged to submit proposals that include a detailed research plan and preliminary data, exploring new avenues for prevention, treatment, and potential cures for HIV among people who use drugs. Applications are due by 5 PM local time, with optional Letters of Intent recommended 30 days prior.

The Iowa Department of Health and Human Services is inviting proposals for Round 2 Opioid Settlement Funding (RFP BHTHPTR26113) to support local opioid abatement strategies across seven districts. Eligible applicants may propose new projects distinct from previous funding. The agency aims to enhance health and resiliency in communities through innovative services. Preference will be given to applicants who have not previously received funding, ensuring a diverse range of strategies to combat opioid-related issues.

The Pratt Family Foundation Grant, established in 1999, supports initiatives in education, healthcare, and community welfare. It prioritizes organizations that aid housing assistance, support for women in crisis, and disadvantaged youth programs, particularly in North Carolina. The Foundation favors established religious and charitable organizations that are tax-exempt and have a local presence. Preference is given to areas connected to the Pratt family, such as Texas and Florida, ensuring impactful contributions to community development.

The Outcomes Innovative Pharmacy Grant Program supports innovative pharmacy initiatives in Iowa. It offers funding up to $10,000 for projects aiming to enhance pharmacy practices. Eligible applicants include Iowa licensed pharmacists and researchers who are active members of the Iowa Pharmacy Association. The program encourages collaboration and requires a presentation of the grant proposal along with final reports detailing project outcomes and fund distribution.

The Patterson Foundation offers Oral Health Grants to support programs that enhance access to dental care for underserved communities. Eligible 501(c)(3) non-profit organizations can apply for funding up to $35,000 for capacity expansion, $10,000 for personnel support, or $10,000 for program support. The foundation prioritizes projects led by volunteer dental professionals and requires follow-up reports for continued funding. Applications are accepted year-round through a two-step process.

The McKesson Foundation Grant provides funding up to $25,000 for organizations focused on improving health outcomes in underserved communities. Established in 1943, the foundation prioritizes health equity through strategic partnerships aimed at reducing cancer burdens, preparing healthcare professionals, and enhancing crisis response efforts. Eligible applicants include national and local nonprofits targeting specific regions in the U.S. and Canada. The foundation emphasizes projects that align with its mission and demonstrate significant community impact.

The NRP Young Investigator Award is designed to support research on optimizing newborn care during delivery using Neonatal Resuscitation Program (NRP) techniques. This grant encourages innovative projects addressing gaps in transitional physiology and resuscitation practices. Eligible applicants include researchers from Canadian and US institutions, particularly those in training or within four years of completing medical training. Awardees may receive up to $15,000 to enhance their skills and knowledge, ultimately improving neonatal outcomes.

The Land & Water Conservation Fund (LWCF) provides crucial federal funding for outdoor recreation projects in Iowa, supporting 50% cost share for development and land acquisition. It has facilitated popular projects such as skate parks, playgrounds, and multipurpose trails since its establishment in 1964. Applicants should anticipate a timeline of 12-24 months from application to the start of construction, ensuring thorough planning and execution of their recreational initiatives.

The Miccio Foundation offers Standard and Mini Grants to organizations in Iowa dedicated to animal welfare. Eligible groups include shelters and humane societies with 501c3 status. Grants can fund projects like spay/neuter programs and facility renovations, aiming for immediate, measurable impacts in local communities. Standard grants may reach up to $10,000, while Mini grants offer up to $1,500. The Foundation prioritizes projects that enhance animal health and operational efficiency.

The Jean M. Walker Grant, administered by The Miccio Foundation, aims to enhance public awareness regarding the humane treatment of animals, focusing primarily on companion animals. It supports educational initiatives and actions to end inhumane treatments, such as workshops and media campaigns. Projects that demonstrate measurable impacts on animal welfare and can be replicated in other communities are particularly encouraged. Grants are available to qualifying organizations dedicated to animal welfare.

The St. Croix Valley Foundation serves six counties bordering the St. Croix River through local partnerships and place-based philanthropy. We serve:

• Minnesota: Chisago County, Washington County
• Wisconsin: Burnett County, Pierce County, Polk County, St. Croix County

Since our founding in 1995, we’ve:

• Grown to 500+ charitable funds and $100M+ in assets
• Facilitated $100M+ in grants and scholarships, including $5.8 million in 2024
• Partnered with local community affiliates led by volunteers who help guide grantmaking, grow local endowments, and connect donors to opportunities close to home.

Humane Organization Grant Program 

Mission

To enhance the quality of life of shelter/ rescue animals and to increase their chances for adoption. 

The St. Croix Valley Foundation (SCVF) Humane Organization grant program funded by the Compassionate Animal Fund, is accepting applications (invitation only) from Managed Open Admission humane organizations located in the upper Midwest. The grants, ranging up to $3,000, can cover items on your “wish list” including food, supplies, infrastructure needs, and veterinary cost. 

Funding Criteria

Grants are intended to provide funds for items such as food, supplies, medicine, spay/neuter programs (for in-house animals to aid in adoption) newsletters, or other needs and/or programs that most benefit the humane organization.

​We understand that shelters may differ in the services or alternatives they offer during the waiting period prior to intake. If your facility is at capacity, you must provide a clear statement outlining how emergency surrenders and stray animals are handled, including the procedures your organization follows to operate as an Open Admission shelter.  

The McKesson Foundation Grant provides funding above $25,000 to support health equity initiatives across North America. Founded in 1943, its mission focuses on removing barriers to quality healthcare for vulnerable communities. The foundation prioritizes projects that align with strategic pillars: reducing cancer burdens, preparing the healthcare workforce, and enhancing crisis response. Eligible organizations include national and local nonprofits. Funding is limited to specific regions and assessed based on demonstrated need and expected impact.

Alliant Energy’s Community Tree Planting Program, part of the One Million Trees Initiative, is a recognized program aimed at enhancing community and environmental health. Collaborating with Trees Forever, this initiative supports communities in Iowa and Wisconsin to plant trees, fostering energy efficiency and stewardship. Grants of up to $5,000 are available for purchasing local landscape-sized trees. The program helps ensure a greener future by engaging citizens in tree planting efforts, thereby improving local ecosystems and community vitality.

The CHS Foundation supports initiatives that benefit the agriculture industry, focusing on 501c3 organizations within specific states. Their funding is aimed at empowering cooperative growth and sustainable practices. Local projects may also be eligible through the CHS Seeds for Stewardship program. However, funding is not available for individuals, sports teams, or religious groups, ensuring that the support remains directed towards community and cooperative development.

The Dunkin' Joyful Spaces Grant supports children's hospitals and community health centers in creating joyful environments for pediatric patients. Launched in 2022, this initiative helps fund play areas, healing gardens, and other kid-friendly spaces, enhancing the hospital experience. Grants typically range from $25,000 to $65,000 annually, with a maximum of $150,000 over three years. This opportunity encourages creativity in designing spaces that provide comfort and joy to children and their families during hospital stays.

Project Lead The Way is offering a rolling grant for schools to implement the PLTW Biomedical Science program for the 2026-2029 academic years. Eligible schools can receive up to $14,000 to cover participation fees and training costs. This grant encourages public, private, and charter schools across the U.S. to enhance their science curriculum, supporting students with engaging, hands-on learning experiences. Schools must commit to offering specific courses during the grant period to qualify for funding.

The National Trust Preservation Funds provide grants ranging from $2,500 to $5,000 to support local preservation projects and ongoing work. These funds aim to enhance community engagement in preservation, foster technical expertise, and stimulate financial participation from the private sector. Eligible applicants include public agencies and nonprofit organizations focused on planning and education efforts related to preservation. The program is particularly interested in initiatives that reach new audiences and further the preservation movement.

The Growing Justice Fund provides grants ranging from $25,000 to $250,000 to support community-led initiatives that enhance equitable food procurement. This initiative aims to empower Tribal, Indigenous, Black, Latinx, Asian, and immigrant communities by facilitating access to institutional contracts and promoting local economic viability. With a focus on health, environmental justice, and collective action, these grants are designed to foster sustainable food systems and build wealth in historically marginalized communities.

The Girls with Goals Fund, established by Women Lead Change, aims to empower girls in Iowa from Kindergarten to 8th Grade. This fund supports non-profit organizations that inspire girls to recognize their strengths, celebrate individuality, and stimulate interest in traditionally male-dominated fields. Organizations with 501(c)(3) status are eligible to apply for funding to foster mentorship and leadership skills among young girls, ensuring they have the resources needed for personal and academic growth.

The Ashland County Wildlife Conservation League David McClure Memorial Scholarship supports graduating seniors from Ashland County high schools and alternative education programs pursuing a degree in wildlife-related fields. Applicants must maintain a GPA of 3.0 or higher and be accepted into accredited colleges or vocational programs. This scholarship fosters educational growth while promoting conservation efforts, reflecting the commitment of the Ashland County Community Foundation to enhance community development and support future leaders in wildlife conservation.

PFund Foundation

PFund Foundation builds equity with LGBTQ+ communities across the Upper Midwest by providing grants and scholarships, developing leaders, and inspiring giving.

Community Grants

PFund Community Grants are for LGBTQ+ serving nonprofits in the Upper Midwest. These grants range from $1,000-$20,000+ and include organizational membership to the PFund Leadership Institute, a monthly cohort based learning and networking opportunity.

• PRISM Fund

PRISM (Promoting Rural Interconnections for Sexual Minorities). Fund supports rural LGBTQ+ serving nonprofit organizations. Grants are made possible by the Northwest Area Foundation.

• TRANScend Fund

TRANScend Fund supports Trans & gender nonconforming serving nonprofit organizations and programs. Grants are made possible by Drop Deadlift Gorgeous and donors.

• Bi+ Fund

Bisexual Fund supports noprofit organizations primarily serving the bisexual community, including but not limited to bisexual, omnisexual, pansexual, polysexual, or sexually fluid. Grants are made possible by an endowed fund. 

The Operations and Program Grant by the Quad Cities Community Foundation provides essential operating and program support to nonprofits, enhancing their long-term sustainability. Eligible organizations must be located in specific counties in Illinois and Iowa, with a focus on diverse fields such as health, education, and community development. This grant favors applications for general operating support and those from successful existing programs. Grant amounts range from $5,000 to $20,000, allowing for flexible funding options.

The Bonnycastle Fellowship for Wetland and Waterfowl Research supports graduate students in advancing conservation efforts. Offered by Ducks Unlimited, this fellowship provides up to $17,000 annually for research and personal support. The fellowship emphasizes the importance of research originality, ecological contributions, and feasibility. It is open to all North American graduate students, with a preference for doctoral candidates. The award is renewable for PhD students up to two years, and once for Master's students, contingent on satisfactory progress.

The F26AS00104 State ANS Management Plan 2026 aims to combat aquatic nuisance species through pre-proposals followed by full applications. Managed by the US Department of the Interior's Fish and Wildlife Service, this initiative requires a 25% cost-share and limits administrative costs to 5%. Applications are due by October 14, 2026, though the funding opportunity closes on December 16, 2026. The plan is crucial for maintaining biodiversity and supporting a coordinated national approach to invasive species management.