Best Grants for 501(c)(3) in Kentucky

The ACT on Health Equity Community Solutions Challenge Grant, backed by the Astrazeneca Foundation, aims to enhance health equity by funding community-based nonprofit programs. Since its inception in 2021, it has allocated over $2.6 million to initiatives addressing nutrition, healthcare access, and lung health for historically marginalized populations. Eligible US-based 501(c) organizations can apply, with a focus on projects serving underserved communities and improving health outcomes through targeted support.

The Water & Waste Disposal Loan & Grant Program in Kentucky provides essential funding for clean drinking water systems, sewage disposal, solid waste management, and storm water drainage in eligible rural areas. It supports local governments, nonprofits, and tribes to finance projects such as water treatment and waste collection. Additionally, funds can cover legal fees, land acquisition, and other necessary expenses, ensuring that communities have access to reliable infrastructure.

The Water and Environment Grant Program by the American Water Charitable Foundation supports innovative community projects aimed at improving watersheds, conserving water, and enhancing access to recreation in underserved areas. Eligible applicants include 501(c)(3) organizations and educational institutions located within American Water's service areas. Projects must be completed within 12 months, and applicants should consider budget feasibility when requesting funds. Certain organizations and projects, such as those not classified as 501(c)(3), are ineligible.

The Hope Funds for Cancer Research offers a three-year Postdoctoral Fellowship for innovative research in understanding difficult-to-treat cancers. Candidates with MD, PhD, or equivalent degrees can apply, focusing on novel approaches to cancer mechanisms and treatments. The fellowship provides a stipend starting at $56,000, with annual increases, and a travel grant of $1,500 for conferences. This initiative aims to enhance life expectancy through groundbreaking research in cancer treatment and prevention.

The Appalachian Landscapes Project Capital Grant, offered by the Open Space Institute, supports vital conservation initiatives aimed at preserving biodiversity and enhancing landscape connectivity. Established in 1974, the OSI has protected over 2.5 million acres in the Eastern US and Canada, focusing on land that ensures clean drinking water and wildlife habitats. This grant is specifically for projects within the Appalachian Landscapes Project service area, promoting sustainable community benefits.

Amgen is a leading biotechnology company dedicated to advancing medicine through Independent Medical Education (IME). It funds accredited educational programs that empower healthcare providers to enhance patient care. IME funding supports critical areas such as oncology, bone health, cardiovascular education, and more. Amgen's commitment ensures that these educational activities remain unbiased and compliant with applicable guidelines, fostering innovation and improved health outcomes for patients worldwide.

State Farm's Good Neighbor Citizenship Company Grants aim to enhance community safety, development, and education. Focused on long-term impact, they support initiatives in auto and home safety, disaster preparedness, affordable housing, and educational programs. Eligible recipients include nonprofits, educational institutions, and government entities. However, funding is not available for individuals, religious programs, or organizations outside the U.S. By addressing critical community needs, these grants foster safer and more resilient neighborhoods.

The Truist Foundation Grants aim to empower communities by providing resources for economic mobility and supporting small businesses, particularly those owned by racially and ethnically diverse individuals. The foundation focuses on enhancing job navigation for disadvantaged workers and building sustainable business ecosystems through collaboration and innovation. By addressing barriers to growth and promoting access to capital and education, the Truist Foundation strives to create equitable opportunities for all.

International Paper Grants focus on community engagement, emphasizing education, hunger relief, health & wellness, and disaster relief. They support nonprofit organizations that demonstrate good financial standing and effective management. Eligible organizations must operate in areas where International Paper has facilities. The foundation prioritizes local needs, particularly critical and environmental issues, while encouraging employee involvement. Ineligible entities include private foundations and those without a local presence. Applications are accepted through mid-September in the U.S. and Canada.

The Doris Duke Foundation's Environment Program grants aim to foster a resilient environment through effective conservation efforts. By supporting U.S. nonprofit organizations, the foundation seeks to protect biodiversity, address climate change, and advance equity, particularly for marginalized communities. The program emphasizes land conservation, natural climate solutions, and inclusive practices, ensuring that conservation efforts benefit both wildlife and people. This initiative is pivotal for enhancing the health of ecosystems and communities across the United States.

The HOKC Good Works Program provides over $2.5 million annually in grants to Kentucky nonprofits, aiding over 3.9 million individuals. Established in 1951, it has distributed $68 million through more than 8,900 grants, relying on the support of over 30,000 active Colonels globally. Eligible nonprofits must be 501(c)(3) organizations based in Kentucky, operational for at least five years, and focused on tangible community benefits, aligning with the program's mission to foster community enhancement and support.

The Robinson Foundation Grant, established in 2016, aims to alleviate hardships faced by individuals and communities, demonstrating God's love through charitable contributions. As a family-operated foundation, it focuses on creating meaningful, long-term impacts in various areas including animal welfare, education, and disaster relief. Organizations eligible for funding must be 501(c)(3) public charities. The foundation prioritizes fiscally responsible projects with the potential for tangible results, while not supporting capital projects.

The HOKC Good Works Program provides medium grants ranging from $2,500 to $9,999 to support Kentucky nonprofits. With over $2.5 million distributed annually, the program aims to enhance community services in areas such as education, health, and support for low-income individuals. Eligible organizations must be 501(c)(3) nonprofits operating for at least five years within Kentucky. Ineligible entities include religious organizations and most government bodies. This grant initiative has a strong history of impactful contributions to local communities.

The HOKC Good Works Program offers small grants for newer nonprofit organizations in Kentucky. Grants of up to $5,000 are available for those with 1-5 years of existence, while requests under $2,499 qualify as small grants. Since 1951, the program has distributed over $68 million to support various categories, including community enhancement, education, and health services, benefiting millions of individuals across the state.

Avion Takes Action, a charitable fund by Avion Solutions Inc, empowers community organizations by providing grants to support various quality-of-life initiatives. With a focus on basic needs, education, healthcare, environment, and veterans, the fund has awarded over $250,000 in grants over three years. Eligible non-profits can apply for a minimum of six $5,000 grants every six months, ensuring impactful contributions to local communities where Avion employees live.

The Roy A. Hunt Foundation's Environment Initiative Grants aim to support projects that enhance ecological health and sustainability. With an annual budget of approximately $3.4 million, the foundation prioritizes initiatives that promote responsible environmental practices, clean energy, and waste reduction. Grants between $25,000 and $75,000 are available for projects at various levels, focusing on innovative solutions that foster community partnerships and address root causes of environmental challenges.

Roche Corporate Donations and Philanthropy (CDP) focuses on impactful projects that foster sustainable development, engage employees, and leverage Roche's expertise. Their philanthropic efforts prioritize humanitarian, educational, environmental, and cultural initiatives, aiming to build stronger communities and support innovative projects. Eligibility is limited to local organizations, while ineligible projects include those with political or religious ties. The foundation strives to create a positive societal impact through collaboration and strategic partnerships.

The Sigma Xi Grants-in-Aid of Research Program, celebrating 100 years of supporting research, offers financial assistance to undergraduate and graduate students. Members can receive grants ranging from $500 to $5,000, while non-members can apply for up to $1,000. Additionally, there are specific funds available for astronomy and vision-related research. This program fosters collaboration between students and mentors, promoting scientific excellence through hands-on experience.

Kentucky Cabinet for Health and Family Services

Our mission is to be a diverse and inclusive organization providing programs, services and supports that protect and promote the health and well-being of all Kentuckians and their communities.

Department for Public Health (DPH) - Rural Health Transformation Program Funding Opportunity to Establish or Expand Community Paramedicine Programming

About the Program

This project is 100% funded by the Centers for Medicare and Medicaid Services of the U.S. Department of Health and Human Services (HHS) for a total of $212.9 million in budget year 1 with 100% by CMS/HHS. The RHTF grant spans five budget periods aligned with federal fiscal years (FY2026–FY2030). Funding is disbursed annually by CMS based on achievement of performance metrics.

Funding is designed to support early program development and scaling. Community paramedicine programs are not expected to be fully sustainable during initial funding periods. Awards may vary depending on the proposed budget provided by the applicant and additional funding will be provided in subsequent years.

Program Objectives

Funded programs must demonstrate their willingness and ability to:

• Design and deliver community paramedicine services that address low-acuity, preventative, and high-utilization patient needs in Kentucky’s rural communities.
• Reduce unnecessary emergency department utilization and repeat visits after discharge by supporting community members where they are.
• Strengthen partnerships with rural service sites such as Local Health Departments, Federally Qualified Health Centers, rural clinics, and behavioral health partners, including Community Mental Health Centers (CMHCs).
• Connect community members to the right care before and after emergencies by repositioning EMS as a front-line connector to care.
• Operate in a cost-effective, sustainable, and compliant manner. Compliance is defined as adherence to KBEMS standards for EMS agencies. 

The Kentucky Pride Fund Household Hazardous Waste Management Grant supports projects aimed at developing an integrated recycling infrastructure and managing household hazardous waste in Kentucky. Established in 2006, the program emphasizes regional projects with state-approved cooperative agreements and requires a 25% match. It serves as a crucial resource for public education on recycling and hazardous waste management, promoting efficient use of limited funds for maximum impact.

The Kentucky Pride Fund Composting Grant, established under Senate Bill 50, aims to support eligible applicants in diverting materials from landfills towards composting, reuse, or recycling. This initiative, part of the Recycling and Household Hazardous Waste Management Grants Program, encourages sustainable practices and environmental stewardship in Kentucky. By providing financial assistance, the grant fosters innovative solutions to waste management challenges, ultimately contributing to a cleaner and more sustainable community.

The Central Appalachia Habitat Stewardship Program aims to restore and sustain healthy forests, rivers, and streams to support diverse native bird and aquatic species. Funded by major organizations including the Richard King Mellon Foundation, this initiative focuses on improving forest management and stream health to enhance wildlife populations. Strategies include engaging landowners through education and financial assistance, targeting species like the golden-winged warbler and brook trout to ensure ecological balance and habitat connectivity.

The AW Environmental Grant Program, backed by American Water Works Company, Inc., aims to support community-driven projects focused on water conservation and the protection of vital water resources. Since 2012, the foundation has invested over $15 million in innovative initiatives that enhance access to clean water and promote responsible water usage in underserved communities. Eligible applicants include 501(c)(3) charities and educational institutions committed to environmental stewardship.

The Source Water Protection Assistance Program (SWPAP) aims to enhance public health by safeguarding drinking water supplies. It emphasizes the importance of protecting existing water sources over costly treatment solutions. Eligible applicants include public water systems and nonprofit organizations, while projects must focus on effective source water protection measures. The program encourages collaboration among various stakeholders to prevent contamination and improve water quality. Funding is available for projects that meet specific criteria, including timely completion and demonstrable impact.

The Diminished Tree Species Grant Program focuses on restoring native tree species crucial for biodiversity and forest health. By funding scientific research, seed orchard development, and land preservation, the program aims to combat climate change through effective tree restoration projects. The Oak Hill Fund, a private entity, encourages project-specific applications, prioritizing organizations that meet eligibility criteria under Section 501(c)(3) of the IRS. This initiative is vital for sustaining healthy ecosystems and mitigating environmental impacts.

The United Way of the Bluegrass offers a Basic Needs Grant aimed at supporting low-income and underserved residents in Central Kentucky. This grant focuses on providing essential services such as food, health care, financial assistance, and more. With a funding ceiling of $10,000 per grant year, it ensures targeted support for programs serving single-county residents. This initiative highlights the commitment to fostering education, stability, and basic needs within the community.

The True Inspiration Awards, established by Chick-fil-A in 2015, recognizes nonprofit organizations that significantly impact their communities. In 2025, the program will distribute $6 million in grants, ranging from $30,000 to $350,000, to sixteen selected organizations. Categories include Caring for People, Caring through Food, Community, and Caring for our Planet, with a focus on educational initiatives, food security, housing services, and environmental stewardship, honoring the legacy of founder S. Truett Cathy.