Best Large Grants for Nonprofit Organizations in Massachusetts

The CART Fund Grant supports innovative Alzheimer’s Disease research projects in the U.S. with funding up to $500,000 for a two-year period. It invites full-time faculty from public and private institutions to submit Letters of Intent, emphasizing novel concepts that advance biomedical knowledge. Selected finalists will be invited to apply for standard grants. The initiative aims to foster groundbreaking research initiatives lacking extensive preliminary data, ensuring a focus on projects with transformative potential.

The Washington Tree Fruit Research Commission is inviting research proposals aimed at apple crop protection, emphasizing organic practices and pollinator protection. Key areas of focus include the management of pests like Codling Moth and Fire Blight, testing new crop protection products, enhancing soil health, and developing efficient monitoring techniques. Collaboration among institutions is encouraged, and projects should aim for practical industry applications to ensure sustainable and profitable tree fruit production.

The National Cancer Institute (NCI) seeks to enhance the validation of biomarkers and assays for cancer detection and treatment through its UH3 funding mechanism. This initiative supports multi-disciplinary collaborations to validate existing assays over three years using clinical trial specimens. Emphasis is placed on harmonizing laboratory tests and validating pharmacodynamic markers. Projects should not focus on early-stage technology development but aim for integration into clinical studies as investigational assays.

The Abortion Bridge Collaborative Funds, initiated by the Women Donors Network, aim to enhance abortion access across the U.S. in response to the 2022 Dobbs decision. The fund prioritizes support for 501c3 organizations committed to reproductive justice, focusing on immediate community needs and sustainable solutions. Emphasizing grassroots leadership and innovative approaches, the fund seeks to build a robust infrastructure for reproductive care, ensuring equitable access for all individuals in need.

The B-Fund Grant by the Brem Foundation aims to enhance early detection of breast cancer by funding crucial screening and diagnostic tests for women in need. This initiative supports entities in the DC metro area, providing financial assistance for services like mammograms and ultrasounds, while ensuring equitable access regardless of socio-economic status. However, it excludes costs related to post-diagnosis care, employee salaries, and administrative expenses, promoting targeted and effective use of funds in the fight against breast cancer.

The Creative County Initiative Special Projects Grant aims to support innovative arts and culture projects in Essex County. With funding ranging from $2,000 to $5,000, this grant encourages collaborative placemaking and diversity in the arts. It prioritizes projects that foster systemic change and enhance community well-being, ensuring equitable access to resources for local artists and organizations. As a vital initiative, it reflects a commitment to uplifting the creative community through transformative artistic endeavors.

The Jack and Fay Netchin Medical Student Summer Fellowships, offered by the American Brain Tumor Association, provide $3,000 grants to medical students eager to engage in brain tumor research under the guidance of experienced mentors. This initiative aims to inspire the next generation of neuro-oncology researchers, fostering a deeper commitment to advancing treatment and understanding of brain tumors for those affected by this challenging diagnosis.

Pfizer supports the global healthcare community’s independent initiatives (e.g., research, quality improvement or education) to improve patient outcomes in areas of unmet medical need that are aligned with Pfizer’s medical and/or scientific strategies.

Pre-clinical Investigation of anti-TFPI-mediated Rebalancing Mechanisms in Non-Hemophilic Bleeding Disorders

There remains a scientific gap in understanding of the role of anti-TFPImediated hemostatic rebalancing in the context of inherited or non-hemophilic bleeding disorders. This competitive grant program encourages competitive submissions focsed on generating preclinical/foundational data exploring the therapeutic potential and mechanisms of TFPI modulation in bleeding disorders other than hemophilia.

Funding

• Individual projects requesting up to $50,000 USD will be considered. Request for study drug or compound is allowed (max $50,000 USD), additionally to the study project costs.
• Maximum project length is 1 year.

Susan G Komen Breast Cancer Foundation

The mission of Susan G. Komen® is to save lives by meeting the most critical needs in our communities and investing in breakthrough research to prevent and cure breast cancer.

Susan G. Komen Career Catalyst Research (CCR) Grants

Susan G. Komen Career Catalyst Research (CCR) Grants foster promising breast cancer researchers who are in the early stages of their faculty careers by providing support for up to three years of “protected time” for research career development under the guidance of a Mentor Committee. We seek to support those who will emerge as the next key leaders in the fight against breast cancer.

CCR Research Focus: Research projects must be hypothesis-driven, breast cancer-focused studies. They may be considered basic, translational, clinical and/or population science in nature and should align with Komen’s research priorities and mission to save lives from breast cancer. 

The American Heart Association (AHA) is launching the RFP for a Strategically Focused Research Network (SFRN) aimed at enhancing the early detection and delaying the progression of valvular heart disease. This initiative seeks collaborative proposals from researchers to address critical questions and advance understanding in this field. With a maximum budget of $4.4 million and a duration of four years, the AHA plans to award at least three grants based on scientific merit and alignment with its mission.

The National Cancer Institute (NCI) invites applications for the validation of molecular, cellular, and imaging markers for cancer detection and treatment. This funding opportunity supports both analytical and clinical validation phases, emphasizing multi-disciplinary collaboration. The UH2 phase focuses on analytical validation, while the UH3 phase extends to clinical validation using well-annotated biospecimens. Proposals should justify the relevance of assays for clinical use and may include harmonization efforts across laboratories.

The Open Ocean Research Grant Program, funded by Global Fishing Watch Inc, aims to enhance ocean governance through data sharing on human activity at sea. It invites researchers to improve technologies for better governance, offering up to $10,000 for individuals and $20,000 for small groups. This initiative strengthens the community of practice and optimizes Global Fishing Watch datasets to maximize their impact on ocean conservation efforts.

The Peer Education Grant, offered by the Organization for Autism Research, aims to enhance autism acceptance among children by providing educational resources and funding for initiatives. Grants of up to $10,000 support school-wide projects, with smaller grants available for other activities. Eligible applicants include educators and community organization leaders focused on autism awareness, particularly in low-income areas. This initiative fosters inclusive relationships and understanding between children and their autistic peers.

The FY26 Autism Research Program Career Development Award aims to support early-career investigators in conducting innovative research that can significantly impact autism. It encourages applications addressing specific areas of interest and mandates community collaboration for projects involving pilot clinical trials. Proposals must include partnerships with community members for effective planning and implementation, ensuring that the research is grounded in the needs of the autism community.

The FY26 Autism Research Program's Idea Development Award from the US DOD aims to support groundbreaking research that improves outcomes for Autistic individuals. This award encourages innovative, high-risk projects that can lead to significant advancements in autism research. Applications must address specific areas of interest or justify the importance of the research problem. A unique Partnering Principal Investigator option allows two researchers to collaborate on a single project, enhancing the potential for impactful discoveries.

The FY26 Autism Research Program Clinical Trial Award aims to rapidly implement clinical trials that significantly impact autism treatment and management. Projects may range from small proof-of-concept trials to large-scale studies assessing efficacy in relevant populations. Applications are encouraged to partner experienced and early-career investigators and must include community collaborations to enhance research impact. At least one community partner is required to provide ongoing consultation throughout the project.

The Goodridge Brothers Scholarship, offered by the Saginaw Community Foundation, supports residents of Saginaw County pursuing careers in technical education, such as welding or auto mechanics. This initiative recognizes the growing demand for skilled tradespeople and aims to alleviate financial barriers for students. Scholarships typically range from $500 to $4,000, promoting educational opportunities in urban and regional planning and enhancing the community's workforce capabilities.

The Jacques Pepin Foundation (JPF) is dedicated to advancing culinary arts education by supporting community kitchens that provide culinary training to individuals facing employment barriers. Grants of up to $10,000 are available for nonprofits to enhance their culinary programs, including operating costs and facility improvements. Eligibility extends to organizations funded in prior cycles, those that applied but were not funded, and newcomers to JPF funding. This initiative aims to empower underserved communities through culinary skills.

William L. & Mary Ann Brown STEM Endowment Scholarship Program

The William L. & Mary Ann Brown STEM Endowed Scholarship Program was established by William L. and Mary Ann Brown to provide need-based scholarship support to seniors graduating from a high school in Mecklenburg County, North Carolina, enrolled at a UNCF member institution, four-year HBCUs, and four-year institutions.

Successful applicants must be graduating high school seniors entering their first year of college, pursuing a STEM degree, including, but not limited to, fields in physical sciences, mathematics, the biological sciences, the chemical sciences, computer sciences, and engineering. Applicants must be enrolled or planning to enroll as a full-time student.

The Klingenstein Third Generation Foundation's 'Transformation of Mental Health Care Program' seeks innovative research into improving mental health care access for children and adolescents, particularly from under-resourced backgrounds. Applications are invited for studies that build on promising pilot work, focusing on scalable delivery models and technology use. Eligible applicants are academic researchers based in the U.S. who can demonstrate rigorous research capabilities. The foundation plans to award up to two grants of $100,000 each year for two years.

About Us

The John Martinson Honors Program offers Northeastern students the opportunity to engage with our values of challenge, curiosity, and community during their undergraduate career. Through innovative programming, robust funding, and dynamic support, Honors empowers students to make meaningful and lasting change in the world.

Honors Scholarships- George Alden Trust

To complement the scholarships and merit aid that Honors students may receive as they enter Northeastern University, the John Martinson Honors Program offers several awards and scholarships that can be applied towards tuition, global experiences, and research and creative endeavors.

The National Multiple Sclerosis Society offers the Sylvia Lawry Physician Fellowships to support MDs in acquiring essential clinical trial training. This fellowship aims to enhance expertise in conducting complex trials for MS therapies, fostering skills in protocol design, patient recruitment, and data analysis. Applicants must have relevant medical training and be engaged in ongoing MS clinical research. The program is vital for addressing the increasing demand for trained professionals in MS clinical trials, contributing to advancements in treatment.

Jack Beaty Educational Scholarship Foundation Grant

Jack Beaty was a pillar of the community he lived in and loved. He was a successful businessman from an early age having founded two companies. One company supplied food to retail stores throughout New Mexico, where Jack became friends with all his customers and fell in love with the state. He founded an oil and gas company in Farmington, New Mexico as well.

Jack eventually became involved in politics in New Mexico where he served as the Bernalillo County Democratic Chairman and the New Mexico State Democratic Chairman. During the 1960 Presidential campaign, Jack became friends with John F. Kennedy and Robert Kennedy. Jack served as the Western States coordinator for the Kennedy campaign. After the 1960 election, Jack sold his food supply business and moved to Washington, D.C. Jack served in both the Kennedy and Johnson Administrations. Following this service, Jack formed the public relations firm Jack Beaty and Associates in Washington, D.C.

While in Washington, D.C., Jack met and married Rose Marie Beaty Martinez, the personal assistant to Senator Joseph M. Montoya, the United States Senator from Mexico. Jack and Rose Marie retired to New Mexico in 1979 where Jack devoted his time to managing Western Minerals and Oil. Jack desired that upon his and Rose Marie’s death that his estate be used to assist and provide access to education to less fortunate students in New Mexico.

In his estate plan, Jack desired that the Jack Beaty Educational Scholarship Foundation be established to carry out his charitable goal of assisting students to obtain a secondary education.

The National Multiple Sclerosis Society offers a Medical Student Mentorship Program that provides a four-week clinical experience for medical students who have completed at least one year of school. This program aims to raise awareness about the challenges faced by individuals with MS and generate interest in careers focused on MS care. Students gain hands-on experience under the guidance of MS specialists, enhancing their understanding of the disease and its management.

About Us

Our mission is to strengthen our community through philanthropy.

We do this in collaboration with donors and community partners who share our vision for community transformation through stewardship of charitable endowments, superior donor services, effective grantmaking, and leadership to address community needs.

The Community Foundation is governed by a Board of Directors and staffed by a team of local experts, representing diverse backgrounds, interests, and professional expertise. Foundation staff members work closely with donors, grantees, community leaders, government agencies, and businesses to ensure the Community Foundation effectively meets community needs.

Who We Are

Empowering generous people with meaningful giving opportunities

Since 1968, The Community Foundation for the Greater Capital Region (CFGCR) has been dedicated to improving the quality of life in the Greater Capital Region. We work with — and for — all our neighbors across the community because together, we are stronger.

Herbert K. and Isabel C. Liebich Scholarships

Established to honor the founders of Albany Frosted Foods, one of the original companies to form Sysco Corporation, by awarding a scholarship each year to the children of employees or retirees of Sysco Foods of New York, Inc. 

The REI Cooperative Action Fund Grant supports U.S.-based organizations that align with its mission to serve communities, particularly those connecting historically excluded individuals to the outdoors. The fund prioritizes initiatives that promote equitable access to outdoor spaces, enhance community health through nature, and create inclusive outdoor experiences. Eligible applicants must have a 501(c)(3) status and demonstrate a commitment to these values. However, individuals and certain organizations are not eligible for funding.

The Gladys Brooks Scholarship, offered by Northeastern University's John Martinson Honors Program, supports exceptional students with a minimum GPA of 3.5. This scholarship enhances the educational experience by funding tuition, global opportunities, and research initiatives. Honoring academic excellence and leadership, it empowers scholars to make impactful contributions within their communities. Applicants must demonstrate distinguished activity in the Honors Program and a commitment to service and professional growth, ensuring a vibrant and engaged student body.