Best Large Grants for Nonprofit Organizations in Massachusetts

The Harry Shwachman Clinical Investigator Award, offered by the Cystic Fibrosis Foundation, supports clinically trained physicians transitioning to independent researchers in cystic fibrosis. It provides up to $133,000 per year for three years to facilitate research tailored to individual interests. The funding covers personnel costs and supplies, promoting a strong mentorship during this critical stage of their academic careers.

The Path to a Cure (PTAC) - Postdoc-to-Faculty Transition Award by the Cystic Fibrosis Foundation supports postdoctoral fellows in advancing their research careers in cystic fibrosis. This program offers up to five years of funding, including 3 years for research training and 2 years for transitioning to an independent faculty position, with a maximum support of $110,000 per year. It aims to foster innovative research that develops new therapies for cystic fibrosis.

Accreditation Sustainability Learning Community RFA

The Association of State and Territorial Health Officials (ASTHO), through the Public Health Infrastructure Grant (PHIG), is currently accepting applications for participation in a learning lab that will foster health department capacity to build a sustainable public health accreditation culture within their agencies. This opportunity is open to applicants from direct PHIG awardees at the state-, big city-, and county-level.

The Cystic Fibrosis Foundation offers the Path to a Cure (PTAC) Postdoctoral Research Fellowship Award to support innovative research training in cystic fibrosis (CF). Aimed at enhancing scientific knowledge and facilitating the transition to independent careers, this program funds projects targeting the development of new therapies for CFTR variants. Awards can reach up to $75,000 in the first year and $76,000 in the second year, fostering foundational research that could lead to breakthroughs in CF treatment.

About

Central Carolina Community Foundation is a nonprofit organization that helps generous people give back to the Midlands of South Carolina in ways that matter. Since 1984, we’ve been a trusted partner, helping individuals, families, and businesses make smart, meaningful contributions that support local nonprofits, scholarships, and community projects.

Wesley United Methodist Church Scholarship ($1,000)

This scholarship is for graduating high school students who are members of Wesley United Methodist Church located in Columbia, South Carolina. 

Robert B. Tonjes Scholarship

Amount

• $1500
• Active
• Renewable

Applicant must be a graduating senior of a Henderson County public high school or the equivalent who is pursuing a four-year degree in nursing or another medical related field. Applicant must demonstrate financial need to attend an institution of higher learning.

The Pizza Hut Foundation is offering scholarships for students demonstrating financial need and community leadership. Eligible applicants must be U.S. residents aged 17-26, enrolled in accredited post-secondary education for Spring 2026, and maintain a minimum GPA of 2.5. Scholarship amounts range from $500 to $5,000, with distribution to be made in Spring 2026. The application period runs from July 8 to September 5, 2025, with notifications for recipients by November 17, 2025.

William Elliott Frye Memorial Scholarship

Funding Amount:

• $1000
• Active

This scholarship is to assist a student seeking a higher education at an accredited community college or technical school. Students must be a resident of Western North Carolina that include, but not limited to, graduating seniors, current college students, and returning adult education students who are focused on a career and technical education field. Students may be either full-time or seeking a certification to advance their education. Students must demonstrate financial need and meet all requirements of the attending education institution.

The Anna Fuller Fund Grant provides year-round support for organizations dedicated to alleviating suffering caused by cancer. Established in memory of Egbert C. Fuller’s wife, the fund prioritizes applications that focus on cancer research and education initiatives. Eligible applicants must be 501(c)(3) organizations or equivalent charities outside the U.S. Grant funds cannot be used for direct treatment, ensuring that resources are allocated to research and public education.

Community Foundation of Henderson County

Community Foundation of Henderson County was incorporated in 1982 by a group of fourteen dedicated and compassionate local leaders with the immediate need to manage two funds - the William C. Armstrong Scholarship Fund and the Charlie Renfrow Scholarship Fund, in addition to providing a permanent vehicle for citizens to give back to their community.

Our Mission is to help people who care make lasting contributions to causes that matter. The Community Foundation of Henderson County is a highly visible, philanthropic leader directed by an engaged and committed board, staffed by qualified employees, empowering donors at all levels to invest in professionally managed charitable funds that address community needs.

Bryce A. Malsbary (BAM) Scholarship

The purpose of the Fund is to provide a scholarship for a person seeking higher education at an accredited institution, including but not limited to: vocational, technical, trade, college, or university levels of education. Assistance is for a resident of Henderson County or Polk County, North Carolina, leading to a degree. Candidate must show financial need, GPA 3.0 or higher, and have community service, work, or school activities. Student must be a legal resident of North Carolina.

The Genentech Foundation supports innovative projects that address systemic inequities in healthcare. They fund tax-exempt organizations, including public charities and governmental entities, located in the U.S. Grant requests must be submitted at least 60 days before the project start date. Notably, projects must align with Genentech's commitment to advancing health equity and diversity in the medical workforce. Applications for funding will be accepted starting January 2, 2026, after a temporary closure.

The AWS Welding Workforce Grants aim to enhance welding programs by providing up to $50,000 for essential resources such as new equipment and training. This initiative addresses the growing demand for skilled welders while supporting educational institutions. Eligible applicants include secondary schools, community colleges, and post-secondary programs. Preference is given to proposals that significantly increase welding graduates and address geographic areas with high needs. Note: Applications are currently closed and will reopen in January 2026.

The Coastal Resilience Grant Program, managed by the Massachusetts Department of Energy & Environmental Affairs, aims to support coastal communities facing challenges from storms, flooding, and climate change. This program offers financial and technical assistance for projects that enhance understanding of climate impacts, conduct vulnerability assessments, and implement adaptation strategies. Eligible applicants include municipalities, nonprofits, and recognized tribes, focusing on proactive planning, public outreach, and shoreline restoration to ensure resilience against future climate threats.

The Arthritis National Research Foundation (ANRF) offers grants for research focused on Psoriatic Arthritis (PsA). With funding of up to $125,000 over two years, the ANRF encourages innovative projects that reveal the underlying mechanisms of PsA. Eligibility includes M.D. or Ph.D. qualifications and affiliation with a U.S. nonprofit research institution. Preference is given to senior post-doctoral researchers transitioning to independent status and new assistant professors. Applications without a Co-PI or those who have previously received ANRF funding will not be accepted.

The Diversity, Equity, and Inclusion (DEI) Initiative Grant aims to promote innovative educational programs and enhance diversity within the nurse anesthesia profession. This grant supports efforts such as workshops, lectures, and online learning modules that address DEI issues. By funding these initiatives, the AANA Foundation seeks to foster an inclusive environment and advance the understanding of equity and diversity in the anesthesia community, benefiting both current and future practitioners.

The Stinn & Oebser Scholarship, offered by the St. Croix Valley Foundation, supports students from Pierce Counties (Wisconsin) and the Harlan Community School District (Iowa) pursuing trade schools, colleges, or universities. Eligible applicants are high school seniors with a minimum GPA of 3.0. Selection is based on financial need, work experience, and extracurricular involvement. This scholarship aims to empower local students to achieve their educational goals and contribute positively to their communities.

Community Foundation of Henderson County

Community Foundation of Henderson County was incorporated in 1982 by a group of fourteen dedicated and compassionate local leaders with the immediate need to manage two funds - the William C. Armstrong Scholarship Fund and the Charlie Renfrow Scholarship Fund, in addition to providing a permanent vehicle for citizens to give back to their community.

Our Mission is to help people who care make lasting contributions to causes that matter. The Community Foundation of Henderson County is a highly visible, philanthropic leader directed by an engaged and committed board, staffed by qualified employees, empowering donors at all levels to invest in professionally managed charitable funds that address community needs.

Arthur and Lois Jean Stuenkel Scholarship

This scholarship provides financial support to a graduating senior seeking to further his or her education beyond high school. The recipient must be in the top 25% of his or her graduating class and demonstrate financial need. This scholarship is for a worthy student who has participated in sports or extracurricular activities. 

The scholarship is renewable.

The Small Business Transition Grant for New Entrepreneurs, funded by the NIH, aims to support early-career scientists as they transition into entrepreneurship. This program invites eligible small business concerns to apply for STTR Phase I and Fast-Track grant applications, which include funding for research and development, as well as essential entrepreneurial training and mentorship. It is designed for first-time Principal Investigators, emphasizing the importance of industry mentorship in project development.

The Emerging Scholars in Family Planning Grant, offered by the Society of Family Planning, aims to support early-career researchers in developing a family planning research portfolio. This grant provides funding for publishable scholarly research projects, including thesis or dissertation work, fostering the next generation of scholars in abortion and contraception research. By promoting diversity and inclusion, the grant seeks to build a multidisciplinary community dedicated to advancing family planning science.

The Anonymous Scholarship for Franklin County, established by The Columbus Foundation, aims to support students in financial need within the community. This scholarship provides $1,000 annually for up to five years, covering the duration of a first degree. Eligible candidates include graduating seniors residing in Franklin County with a minimum GPA of 2.0, who plan to attend a two- or four-year college in the U.S. This initiative reflects a commitment to enhancing educational opportunities for local youth.

The Pathway to Stop Diabetes Accelerator Award supports innovative early-career researchers tackling diabetes-related challenges. It offers flexible funding up to $325,000 annually for transformative research. Candidates must have independent faculty status and demonstrated productivity in diabetes research. The program aims to inspire groundbreaking discoveries by providing essential resources and mentorship, thereby improving the lives of those affected by diabetes. Nominations focus on translational research that bridges basic science with practical benefits for patients.

The Pathway to Stop Diabetes Initiator Award (INI) aims to support early career researchers in diabetes research by providing funding and mentorship. With a focus on innovative and transformational ideas, this initiative encourages researchers to develop groundbreaking solutions for diabetes prevention and management. The award offers up to $100,000 annually in Phase 1 and $325,000 in Phase 2, fostering a new generation of leaders committed to improving the lives of those affected by diabetes.

The McKnight Clinical Translational Research Scholarship supports young investigators focusing on cognitive aging and age-related memory loss. Funded by the McKnight Brain Research Foundation, this scholarship offers $65,000 annually for two years, plus an education stipend. Eligible applicants should have completed their PhD or residency within the last five years and conduct their research in accredited U.S. institutions. The award emphasizes rigorous training and aims to foster careers in human cognitive aging research.

The Alzheimer’s Foundation of America Bi-Annual Grant aims to support nonprofit organizations in their efforts to enhance the lives of individuals impacted by Alzheimer’s disease and related dementias. Each grant, valued at $6,000, is awarded twice a year, focusing on innovative programs and services. AFA emphasizes partnership and collaboration, enabling grantees to manage their own policies and programs while adhering to specific funding guidelines. This initiative underscores AFA's commitment to compassionate care and ethical standards.

The RFA: Biology to Prevention Award (CRUK) aims to foster innovative translational research that enhances understanding of cancer biology, ultimately leading to effective prevention strategies. Joint applications from UK and US research teams are encouraged, with a focus on equal partnerships and complementary expertise. The funding provides up to £600,000 for UK costs and up to $946,000 for US costs, supporting projects of 1 to 5 years duration that address critical research questions in cancer prevention.

The Burton E. Stevenson Endowment Scholarship, established by The Columbus Foundation, supports underprivileged children in Ross County, Ohio. Named after the influential librarian and author Burton E. Stevenson, this scholarship aims to alleviate the challenges faced by these children, promoting access to education regardless of race, sex, or religion. Applicants must be graduating seniors from Ross County high schools and plan to attend a public or nonprofit college in the U.S. Awards range from $500 to $6,500.

The Kevin & Rita Vance Family Scholarship, offered by the St. Croix Valley Foundation, supports students from St. Croix County, WI, pursuing trade degrees. This scholarship is aimed at individuals demonstrating financial need and a commitment to vocational training. The Foundation, a key philanthropic organization in the region, aims to foster community growth and prosperity through support for educational initiatives and charitable funds. This scholarship exemplifies their dedication to investing in local talent and future careers.