Best Large Grants for Nonprofit Organizations in Massachusetts

The Columbus Firefighters Foundation Scholarship supports the dependent children of active or retired members of the Columbus Division of Fire. Established by The Columbus Foundation in 1943, this scholarship aims to enhance the educational opportunities for these children. Eligible candidates must attend a public or nonprofit independent college or university in the U.S. full-time, with an award amount of $1,000 to assist in their educational journey.

Anne K. Petry Scholarship Fund

Established by Summit Education Partnership Foundation to provide scholarships for Akron Public Schools students studying special education.

Amount:

• $1,000

Number of awards:

• 1

Renewal:

• No

The MASOT Student Achievement Award, established by the Society of Toxicology, honors exceptional doctoral student members with a $1,000 prize. This award recognizes academic excellence, significant contributions to toxicology, and leadership within the Society and their institutions. Eligible candidates must be current members enrolled in a Toxicology or Pharmacology Doctoral Program and maintain a minimum GPA of 3.5. Recipients cannot reapply in subsequent years, ensuring new talents are acknowledged.

The CAO Legislative Crisis Grant, funded by the National Education Association Staff Organization, is designed to support affiliates in creating and refining student-centered initiatives. Grants can be utilized for contract campaigns, new program development, or enhancing existing practices to improve sustainable learning conditions. This opportunity is exclusive to affiliates, ensuring a focused approach to advocacy and collective bargaining efforts that benefit students.

The MASOT Student Poster Awards, organized by the Society of Toxicology, invite graduate and undergraduate students to showcase their research at the annual meeting on November 5, 2025. Participants can win cash awards for their presentations. Eligible students must submit an extended abstract of up to 500 words and be members of MASOT. This event promotes scientific engagement and recognition for emerging toxicology scholars.

The AO Spine NA Young Investigator Research Grant Award supports early-career surgeons and researchers focusing on clinically relevant spinal or spinal cord research. With funding of $20,000, this initiative encourages new investigators by providing essential start-up capital. Successful applicants are required to present their findings at the Annual AO Spine North America Fellows Forum and submit progress and final reports detailing their research outcomes. This grant aims to foster innovation and excellence in spinal care.

Bass Pro Shops & Cabela's Outdoor Fund supports conservation-focused nonprofits through fundraising events and donation of merchandise or gift cards. Organizations eligible for funding must be registered 501(c)(3) entities in the U.S. or provincially registered nonprofits in Canada. This initiative aims to connect communities to outdoor activities while promoting wildlife conservation and support for military veterans. Grants of up to $1,000 are available to enhance local fundraising efforts.

The Gladys Brooks Scholarship, offered by Northeastern University's John Martinson Honors Program, supports exceptional students with a minimum GPA of 3.5. This scholarship enhances the educational experience by funding tuition, global opportunities, and research initiatives. Honoring academic excellence and leadership, it empowers scholars to make impactful contributions within their communities. Applicants must demonstrate distinguished activity in the Honors Program and a commitment to service and professional growth, ensuring a vibrant and engaged student body.

Alpha Chapter Controlling Corp. of the Delta Theta Sigma Fraternity Scholarship Fund

The purpose of the fund is to provide scholarship awards to deserving high school students who plan to attend an accredited college or university and undertake studies in marketing, communications, journalism, or advertising.

Award Amount:

• The Gene “Duke” Perry Scholarship - $3,000.00
• The Founders Scholarship - $1,500.00
• The Founders Scholarship - $1,500.00

The National Cancer Institute (NCI) invites applications for the validation of biomarkers and assays for cancer detection and treatment. This funding opportunity allows for biphasic or monophasic applications to support both analytical and clinical validation phases. Successful projects will leverage human specimens to develop assays that enhance cancer treatment and prevention, ensuring multidisciplinary collaboration among scientists and clinicians. This initiative aims to improve cancer management through reliable and clinically validated tools.

Retina Research Foundation

Across the nation, there were only a handful of voluntary groups with the will and the means to tackle retinal disdorders. Retina Research Foundation, established in 1969, was one of those organizations. By the 1980s, RRF had become a voice for retina research in an effort to reduce the incidence of retinal disease, which was fast becoming the leading cause of blindness in developing countries.

Undaunted, the Foundation steadily raised funds each year for vision scientists who were nationally recognized for their work in retina research. Government funding for eye research increased dramatically, and the field of retina research matured. As this body of knowledge grew, RRF programs were expanded to include major awards that recognize established retina scientists and contribute to their ongoing research. The Foundation also developed scientific exchange programs to disseminate knowledge of the dramatic advances that were being made in the laboratory.

RRF Pilot Study Grants

The mission of the Retina Research Foundation is to reduce retinal blindness worldwide by funding programs in research and education. As a public charity, RRF raises funds from the private sector and the investment of its endowment funds.

RRF is currently welcoming pilot study grant applications for the 2027 grant period. Each grant application must be signed by the principal investigator and either their Department Chair or Dean of Research.

The Rapid Outcomes from Agricultural Research (ROAR) Grant Program, managed by the Foundation for Food and Agriculture Research (FFAR), provides urgent funding for research addressing unexpected threats to the food supply. This program supports diverse projects related to pest and pathogen outbreaks, facilitating quicker responses than traditional funding avenues. With grants up to $150,000, ROAR aims to enhance agricultural resilience by fostering collaborations among researchers, institutions, and organizations to combat emerging challenges in the food and agriculture sector.

The Emily Hall Tremaine Exhibition Award, established in 1998, supports innovative, thematic exhibitions that present contemporary art within unconventional frameworks. It fosters creativity by offering funding up to $200,000 for curators partnering with non-profit spaces. The award encourages exploration of critical ideas, emphasizing intellectual quality and public impact. Eligible applicants include established curators and institutions, aiming to promote artistic expression while enhancing community engagement and discourse through diverse projects.

Two Joes Scholarship

This fund, named for two local community-minded businessmen, Joe DeRose and Joe Sgro, will support a scholarship for students in Cattaraugus County interested in pursuing technology-, marketing and communications- or business-related degrees.

The St. Baldrick’s Foundation Fellowship Award supports pediatric oncology training through a two-year fellowship, with a potential third year based on need and achievements. This initiative, powered by community fundraising events, aims to advance research for childhood cancer cures. The award provides a salary capped at $97,500 per year, covering salary and benefits for fellows. This fellowship not only fosters professional growth but also contributes significantly to the fight against childhood cancers.

The St. Baldrick’s Foundation Research Grant Award supports innovative research aimed at curing childhood cancers. With funding of $100,000 per year for two years, this grant is designed for hypothesis-driven projects that can be laboratory, clinical, or epidemiological in nature. Established through community-driven fundraising events, the foundation empowers volunteers and donors to make a significant impact in the fight against cancer, ensuring a brighter future for young survivors.

About

What is FOXG1 Syndrome?

FOXG1 syndrome is a rare genetic neurodevelopmental disorder caused by a mutation in the FOXG1 gene. FOXG1 gene is one of the first and most important genes for early brain development and when impaired, causes developmental disabilities as well as medical complexities, including epilepsy.

Every child born with FOXG1 syndrome is unique as FOXG1 manifests as a spectrum where symptoms and severity vary between individuals. Our patient data shows characteristics of children with FOXG1 syndrome include: non-speaking, non-ambulatory, experience seizures, feeding problems, cortical vision impairment, movement disorders, and developmental delays. Less-severely-affected FOXG1 children often present with (ASD) Autism Spectrum Disorder as FOXG1 is an autism related gene. FOXG1 syndrome is found equally among both females and males and is geographically more prevalent where diagnostic testing is more advanced. 

Our Story & Mission

When our children were diagnosed with FOXG1 syndrome, we were told there was nothing we could do. No treatments, no concerted research underway, no roadmap. Just a devastating diagnosis for a disorder few had ever heard of.

But we refused to accept that. 

Research Assets & Grants

FOXG1 Scientific Research Project Grants

The FOXG1 Research Foundation is providing grants to scientists to deepen the understanding of the biology of FOXG1 with the goal of identifying innovative therapeutic strategies and finding a cure.

For the next few years, these are the strategic focus areas:

• Experiments designed to understand when, where, and levels of FOXG1 needed for normal brain development in mice
• Experiments designed to understand the biophysical properties of FOXG1 mutations
• Experiments designed to gain insights into the molecular and cell biological pathways regulated by FOXG1  

The Drs. James and Wanda Trefil Science Scholarship, offered by the Kosciuszko Foundation, supports undergraduate students majoring in natural sciences such as physics, biology, and chemistry. This competitive scholarship awards $5,000 and is available to U.S. citizens of Polish descent who maintain a GPA of 3.5 or higher. Applicants must be full-time students and can only receive the scholarship once, with a deadline for letters of recommendation set for March 3, 2026.

Yawkey Foundation

The story of Tom and Jean Yawkey and their impact on the lives of children and families goes back over eight decades to the commitments they made to the people of Massachusetts, New England, and Georgetown County, South Carolina. The Yawkeys’ love for these communities, and their quiet sense of responsibility for those in need, is captured in the careful steps they took to ensure that their legacy would live on through the work of the Yawkey Foundation. The Yawkeys were perhaps best known for their longtime ownership of the Boston Red Sox. More quietly, but with just as much passion and commitment, Tom and Jean Yawkey were also engaged in an unwavering dedication to those most in need.

Today, the Yawkey Foundation remains as committed as ever to continuing to honor Tom and Jean Yawkey and their commitment to those in need. Having awarded more than $620 million to-date in charitable grants to organizations focused on Health Care, Education, Human Services, Youth and Amateur Athletics, Arts and Culture, and Conservation and Wildlife, the Yawkey Foundation is committed to preserving and sustaining the charitable values of the Yawkeys by investing in impactful nonprofits providing resources, opportunity, and dignity to the vulnerable and underserved.

Program and Small Capital Grants

Program and Small Capital Grants support high-impact, strategic, and responsive nonprofit organizations in delivering their core missions through discrete and timebound projects. Program & Small Capital Grants help address an immediate need that is critical to the organization’s work.

Program and Small Capital Grants may fund a discrete timebound program need, one small project, or a piece of equipment aligned with a nonprofit’s purpose. These grants are extremely competitive, and the Yawkey Foundation will receive many more compelling Initial Proposals than it will be able to fund. Initial Proposals should demonstrate an awareness of and alignment with the Yawkey Foundation’s mission and Areas of Giving. Additionally, the most competitive Initial Proposals will reflect a nonprofit’s strong leadership and proven impact in providing direct services and programs for unmet needs in underserved regions aligned with the Yawkey Foundation’s geographic priority areas, including Gateway Cities in Eastern Massachusetts.

Nonprofits may submit only one Initial Proposal to the Yawkey Foundation during a calendar year, irrespective of the Type of Grant. Organizations that have not been previously funded by the Foundation in recent years are encouraged to submit Initial Proposals for Program & Small Capital Grants to familiarize the Foundation with its work before submitting an Initial Proposal for Strategic Investment or Transformational Capital.

Areas of Giving: Human Services; Youth & Amateur Athletics; Education; Conservation & Wildlife; Arts & Culture; and Health Care.

Education Support

The Trustees of the Yawkey Foundation are committed to providing educational opportunities for degree-aspiring individuals who are working to achieve their academic and career goals. The Foundation partners with nonprofits with missions dedicated to higher education access, persistence and success for young adults living in Greater Boston and Georgetown County, SC, with special focus on individuals from circumstances and communities that may lack resources and pathways to opportunities.

Yawkey Foundation

The story of Tom and Jean Yawkey and their impact on the lives of children and families goes back over eight decades to the commitments they made to the people of Massachusetts, New England, and Georgetown County, South Carolina. The Yawkeys’ love for these communities, and their quiet sense of responsibility for those in need, is captured in the careful steps they took to ensure that their legacy would live on through the work of the Yawkey Foundation. The Yawkeys were perhaps best known for their longtime ownership of the Boston Red Sox. More quietly, but with just as much passion and commitment, Tom and Jean Yawkey were also engaged in an unwavering dedication to those most in need.

Today, the Yawkey Foundation remains as committed as ever to continuing to honor Tom and Jean Yawkey and their commitment to those in need. Having awarded more than $620 million to-date in charitable grants to organizations focused on Health Care, Education, Human Services, Youth and Amateur Athletics, Arts and Culture, and Conservation and Wildlife, the Yawkey Foundation is committed to preserving and sustaining the charitable values of the Yawkeys by investing in impactful nonprofits providing resources, opportunity, and dignity to the vulnerable and underserved.

Program and Small Capital Grants

Program and Small Capital Grants support high-impact, strategic, and responsive nonprofit organizations in delivering their core missions through discrete and timebound projects. Program & Small Capital Grants help address an immediate need that is critical to the organization’s work.

Program and Small Capital Grants may fund a discrete timebound program need, one small project, or a piece of equipment aligned with a nonprofit’s purpose. These grants are extremely competitive, and the Yawkey Foundation will receive many more compelling Initial Proposals than it will be able to fund. Initial Proposals should demonstrate an awareness of and alignment with the Yawkey Foundation’s mission and Areas of Giving. Additionally, the most competitive Initial Proposals will reflect a nonprofit’s strong leadership and proven impact in providing direct services and programs for unmet needs in underserved regions aligned with the Yawkey Foundation’s geographic priority areas, including Gateway Cities in Eastern Massachusetts.

Nonprofits may submit only one Initial Proposal to the Yawkey Foundation during a calendar year, irrespective of the Type of Grant. Organizations that have not been previously funded by the Foundation in recent years are encouraged to submit Initial Proposals for Program & Small Capital Grants to familiarize the Foundation with its work before submitting an Initial Proposal for Strategic Investment or Transformational Capital.

Areas of Giving: Human Services; Youth & Amateur Athletics; Education; Conservation & Wildlife; Arts & Culture; and Health Care.

Youth & Amateur Athletics Support

Tom and Jean Yawkey loved baseball. Tom grew up around the game, played while at Yale University, and understood its value in bringing players, fans and communities together. He purchased the Boston Red Sox in 1933 and as much as being the team owner, he also took great joy in participating in batting practice at Fenway Park and sitting alongside fans in the bleachers to watch a game. Tom and Jean Yawkey were committed to supporting youth athletics so that all young people had the opportunity to play and enjoy the game of baseball. The Yawkeys recognized that team sports, particularly baseball and softball, build important skills that would benefit players off the field – such as cooperation, respect, sharing, and discipline.

This tradition of supporting quality youth recreation programs, particularly baseball and softball programs, continues today through the work of the Yawkey Foundation. In many instances, funding from the Yawkey Foundation supports the very things Tom and Jean Yawkey provided many years ago – quality fields, new equipment, and programs providing ample opportunities for teamwork, sportsmanship and play.

Please be advised that the Yawkey Foundation is currently focusing its Youth & Amateur Athletics category Program & Small Capital on baseball and softball. The Foundation does not support any athletic programs specific to individual towns, districts, or counties.

The Student Research Fellowship Awards program provides financial support of up to $2,500 for students conducting research on Inflammatory Bowel Disease (IBD) for a minimum of 10 weeks. Aimed at undergraduate, medical, and graduate students, the initiative encourages research interest in IBD. Up to 16 awards are available, and research must be conducted under a qualified mentor at an accredited institution, ensuring a professional academic environment for the study of this critical health issue.

The Crohn’s & Colitis Foundation awards Research Fellowship Awards to support post-doctoral individuals pursuing innovative research in inflammatory bowel disease (IBD). With a maximum award of $70,000 per year for up to three years, the program encourages research aimed at understanding and preventing IBD progression. Eligible applicants must hold an MD or PhD and demonstrate relevant research experience. This initiative fosters the development of future independent researchers in the field of IBD.

The 1Fur1 Foundation Grant supports U.S.-based 501(c)(3) charities that engage in animal-assisted programs. Eligible organizations can apply for grants ranging from $500 to $7,500 to support Animal Assisted Therapy, Activity, and Service Dog programs. The foundation focuses on charities that align with its mission and does not fund individual requests, for-profit businesses, or initiatives that promote animal cruelty. Applications are reviewed within 90 days.

The Frederic C. Collin Trust Grant supports 501(c)(3) organizations in promoting polo and tennis, especially among youth. Established under Frederic C. Collin's will, it offers grants ranging from $2,000 to $3,800, with an annual total giving of approximately $9,000. Applications are accepted year-round for consideration during the annual grant meeting. This initiative aims to enhance participation in these sports, fostering talent and interest among young players.

The Alliance Global Partners Scholarship, established in August 2022 by the Community Foundation of the Lowcountry, offers post-secondary financial aid to graduating students from southern Beaufort County high schools. This scholarship aims to support those pursuing business education at accredited institutions. With a commitment to enhancing educational opportunities, this initiative reflects the foundation's mission to empower local communities and ensure that students can thrive in their academic and professional pursuits.

William L. & Mary Ann Brown STEM Endowment Scholarship Program

The William L. & Mary Ann Brown STEM Endowed Scholarship Program was established by William L. and Mary Ann Brown to provide need-based scholarship support to seniors graduating from a high school in Mecklenburg County, North Carolina, enrolled at a UNCF member institution, four-year HBCUs, and four-year institutions.

Successful applicants must be graduating high school seniors entering their first year of college, pursuing a STEM degree, including, but not limited to, fields in physical sciences, mathematics, the biological sciences, the chemical sciences, computer sciences, and engineering. Applicants must be enrolled or planning to enroll as a full-time student.

The Fanny Vought Fink Memorial Scholarship, established by Louise Van Vliet in 2007, supports single mothers pursuing education at accredited institutions. Funded by The Dayton Foundation, a key philanthropic organization in Greater Dayton, Ohio, this scholarship aims to empower women by easing financial burdens associated with higher education. With a focus on promoting equitable opportunities, it is a vital resource for those seeking to improve their lives through education.