Best Large Grants for Nonprofit Organizations in Massachusetts

The Limited Competition: Institutional Mentored Research Career Development Program aims to enhance the CTSA Program by fostering the development of postdoctoral fellows and junior faculty. This initiative focuses on training individuals for independent clinical and translational science careers, ensuring they are well-prepared for research engagement. Funded by the NIH, the program supports a national network of academic centers to facilitate the transition of scientific discoveries into practical health solutions.

The B-INSPIRE program aims to foster behavioral interventions that enhance interest and preparedness for careers in biomedical research. It invites applications that propose innovative studies addressing motivation and persistence in research-oriented individuals. The initiative also encourages analyses of existing data to improve intervention methodologies. Successful projects should yield findings that support the implementation of diverse strategies across academic levels, ultimately enriching the biomedical research workforce.

The Plant America Community Project Grant, offered by the National Garden Clubs, supports initiatives that enhance public spaces and community gardens. Grants of up to $2,000 are available for projects that educate and engage both adults and children in gardening. Since 2017, over 250 grants have been awarded, totaling more than $225,000. Eligible applicants include member clubs, focusing on beautification, restoration, and environmental education.

The Clinical and Translational Science Award (CTSA) Program aims to enhance the translation of scientific research into effective health interventions by establishing a national network of academic medical centers. This program supports integrated research and training environments for clinical and translational science, promoting the development of innovative methods and technologies. The reissuance of the CTSA Notice of Funding Opportunity invites eligible organizations to apply, with peer-reviewed applications prioritized for funding.

The NASA Earth System Science Research Program (ESSRP) has transitioned to six Earth science research spheres, including Atmosphere, which focuses on understanding atmospheric composition and structure. This program aims to enhance comprehension of phenomena affecting air quality and weather, addressing critical issues like stratospheric ozone recovery and tropospheric dynamics. Through annual ROSES funding opportunities, NASA supports research to improve modeling efforts and observations in atmospheric sciences, ultimately benefiting public health and environmental quality.

The NASA ROSES25: A.15 Biosphere program aims to enhance our understanding of terrestrial and aquatic ecosystems through innovative research. This initiative focuses on biogeochemical interactions, biodiversity, and ecosystem function, utilizing satellite data and field studies. The program encourages reproducible and transparent science, fostering collaboration and interdisciplinary approaches. Proposals will undergo rigorous peer review, ensuring high standards and integrity in research outcomes that contribute to our knowledge of global environmental changes.

About McElhattan Foundation

Founded in 2017 following the sale of Industrial Scientific Corporation, McElhattan Foundation invites bold ideas that advance the goals of its four program areas, including Ending Death on the Job.

Zero Electrocution Challenge

Despite decades of regulations, training, and personal protective equipment, workers continue to die from electrical contact every year.

McElhattan Foundation’s Zero Electrocution Challenge seeks breakthrough solutions that present pathways to eliminate life-threatening tasks that lead to fatal electrocution on the job by the year 2050, while increasing enterprise profitability and productivity. This is the inaugural ZERO 2050 challenge, awarding two Winners up to $1 million each.

The ASCFG Research Foundation Grant, offered by the Association of Specialty Cut Flower Growers, aims to support innovative research projects that benefit specialty cut flower growers. The program, open to academia, government, and industry researchers, will distribute up to $30,000 in grants in 2026. Proposed research should last one year or less and can include multi-year projects. Recipients are expected to present their findings at ASCFG meetings, fostering collaboration and advancement in the cut flower industry.

The Yawkey Foundation offers Program and Small Capital Grants to nonprofit organizations making meaningful impacts in Health Care, Education, Human Services, Youth and Amateur Athletics, Arts and Culture, and Conservation and Wildlife. Grants can be up to $100,000 and support projects aligned with the nonprofit’s mission. Organizations are encouraged to submit Initial Proposals during designated periods, demonstrating strong leadership and community impact, particularly in underserved regions of Eastern Massachusetts.

The Johanna Favrot Fund for Historic Preservation, established in 1994, supports public agencies and nonprofit organizations in their efforts to preserve historic environments. With grants ranging from $2,500 to $15,000, this highly competitive funding opportunity aims to foster appreciation for cultural heritage and enhance community livability. Eligible activities include planning, education, and preservation projects. Applicants must match the grant dollar-for-dollar and adhere to specific guidelines to ensure the success of their initiatives.

The Habitable Worlds Observatory (HWO) is a pioneering space mission concept aimed at discovering life beyond our solar system, as highlighted in the Astro2020 survey. The HWO-PSI program seeks to reduce risks for future missions by advancing scientific investigations that inform mission design. As HWO enters its pre-formulation phase, it addresses significant astrophysical questions and technical challenges, ultimately striving for groundbreaking discoveries in our understanding of the universe.

The Vanguard

Remuseum announces The Vanguard, an award and accelerator for innovative leaders in the visual and performing arts, in partnership with the Doris Duke Foundation. The Vanguard’s $100,000 annual award will recognize up to ten leaders who are exploring new ways to strengthen arts institutions, and a year-long accelerator will help them refine, implement, and evaluate their ideas. The first award and accelerator of its kind, The Vanguard celebrates leaders who are ready to center the public in their work in new ways, building models for increased relevance and sustainability in the arts.

The Program

The $100,000 grant that accompanies each award will go to that leader’s institution, to support ideas developed in The Vanguard’s 12-month accelerator program. That program begins with a week-long retreat at Shangri La, the Doris Duke Foundation’s global center for culture and ideas in Honolulu, Hawaii, followed by a year of monthly coaching sessions, regional peer gatherings, and collaborative workshops, culminating in a public presentation of their work and findings to the broader arts community. The accelerator and its curriculum, tailored specifically for cultural leaders, has been designed by Jenny Larios Berlin, entrepreneur in the creative and tech sectors and Lecturer at MIT Sloan School of Management, and will be co-taught with Gregory Bunch, entrepreneur and Adjunct Professor of Entrepreneurship at the University of Chicago Booth School of Business, and will be advised by Ethernet Inventors Professor of Entrepreneurship Bill Aulet, Managing Director of the Martin Trust Center for MIT Entrepreneurship.

By year’s end, members of The Vanguard will have built an intellectual kinship with each other while modeling a spirit of innovative leadership for the field. Remuseum will continue evaluating and sharing their work as case studies for cultural organizations broadly, and future classes will continue expanding a Vanguard of leaders (10, then 20, and on) who build models of success for cultural organizations in the 21st Century, allowing arts & cultural institutions not just to survive but to support a stronger and more pluralistic civil society.

The Lanesborough Initiative For Excellence (LIFE) Grant aims to enhance the educational experience of students and teachers in the Lanesborough School District by funding innovative projects. Eligible applicants include students, teachers, and community members proposing initiatives that foster educational growth. Grants focus on direct project costs, excluding salaries, and preference is given to proposals demonstrating volunteer involvement and additional support. This initiative encourages creativity and resourcefulness in educational settings.

Stark Community Foundation

Since 1963, Stark Community Foundation has been helping individuals, families, businesses and nonprofits like you support the causes you care about.

In addition to personalized donor services, we manage a competitive grantmaking program and award grants to address local needs. Today, the Foundation stewards over 1,000 charitable funds totaling $485 million in assets and has granted more than $300 million to nonprofits in our community and beyond.

Scholarships

Stark Community Foundation is one of the area’s major sources of college scholarship support— thanks to the generosity of caring individuals, families and businesses that have created scholarship funds.

The Foundation currently manages more than 100 scholarship funds that support hundreds of deserving students each year from Stark and Carroll counties.

The Lillian Grace Mahan Scholarship Fund

The Lillian Grace Mahan Scholarship Fund was established to assist graduate and undergraduate students of library science and is available to Stark County residents who have an outstanding academic performance record and/or who are in need of financial assistance to pursue a degree in library science to become a librarian.

This scholarship is renewable.

The CTIA Wireless Foundation's Catalyst Grant Program aims to empower social entrepreneurs leveraging 5G technology to tackle critical challenges in American communities. With over $200,000 in unrestricted grants available, the program supports innovative projects that utilize 5G connectivity for social good. As 5G transforms communication and interaction, the Catalyst Grant seeks visionary leaders who can harness this potential to inspire meaningful change and enhance community engagement.

The Edmond M. Dewan Young Scientist Scholarship for Atmospheric Sciences and Space Physics supports graduate students tackling challenges in atmospheric science and space physics. Funded by the Edmond M. Dewan Young Scientist Scholarship Fund, this scholarship encourages innovative research. Eligible applicants are active AGU student members pursuing graduate studies with a minimum GPA of 3.4. While scholarship recipients do not automatically receive travel grants for AGU’s Annual Meeting, they are encouraged to apply for them separately.

The Academic Career Excellence (ACE) Award (K32) supports early-stage postdoctoral scholars through rigorous research and career development over three years. Applicants must submit their proposals up to a year before or two years after starting their postdoctoral positions. This award emphasizes innovative research ideas and strategic planning for training and mentorship, aiming to cultivate independent investigators in research fields aligned with the missions of NIH Institutes and Centers.

Grand Traverse Regional Community Foundation

The Grand Traverse Regional Community Foundation began in 1992 when a group of community champions came together around a vision to give back to our region then, now, and forever.

This vision lives on within our organization today as we support the people and places of Antrim, Benzie, Grand Traverse, Kalkaska, and Leelanau Counties and the Grand Traverse Band of Ottawa & Chippewa Indians.

Together with our partners, we spark positive change for a variety of local causes, including youth, arts and culture, education, environment, and health and human services, across our region.

Regional Scholarships

We believe that post-secondary education is key to healthy, resilient, and thriving communities and are pleased to partner with generous community donors to create and offer a variety of scholarship opportunities for local students across the region.

Robert Paul Dost Scholarship Endowment (Regional)

Available to graduating high school seniors in Antrim, Benzie, Grand Traverse, Kalkaska and Leelanau Counties who are planning to pursue electrical engineering. 

The NewSchools: Learning Solutions Grant Program aims to empower K-8 students by enhancing their literacy and numeracy skills, crucial for overcoming educational challenges exacerbated by the pandemic. With a focus on innovative learning solutions, the program seeks to fund early-stage ideas that engage students and support educators. By leveraging research and technology, including generative AI, it aims to create equitable educational opportunities, fostering a brighter future for all students.

The Air Force Office of Scientific Research (AFOSR) orchestrates the basic research program for the Air Force Research Laboratory, aligning with technical guidance and Air Force needs. It promotes collaboration among Air Force, universities, and industry, ensuring that research effectively transitions to support military capabilities. AFOSR's focus encompasses significant areas of research organized under two scientific departments, enhancing national defense and peacekeeping operations.

The Lenox Education Enrichment Foundation (LEEF) aims to enhance the educational experience for students and teachers in Lenox Public Schools. They invite grant proposals from the community for projects that can improve educational outcomes, such as independent studies, extracurricular programs, and professional development. Grants range from $100 to $1,000, with a focus on projects that demonstrate volunteer support and collaboration. However, no project can receive funding for more than three years.

The ARS Friends in Research Award, funded by the American Rhinologic Society, offers $25,000 over two years to support innovative research in rhinology. Eligible candidates include members who have completed residency without significant outside funding. The award encourages early and mid-career investigators to explore diverse areas within rhinology. Recipients can publish their findings, with the society retaining first refusal rights for publication. This grant aims to foster career development in the field of rhinology.

Ann Lane Gates Scholarship Fund

Established by Ann Lane Gates to provide scholarships for Project GRAD Akron Public Schools students.

Amount:

• Varies $500-$1,500

Number of awards:

• Varies

Renewal:

• Renewable for three additional years. Must maintain a minimum 2.5 GPA, continue to pursue a degree in education, and reapply annually by submission of a new application.

The CORE Funding: AHNS/AAO-HNSF Translational Innovator Award supports innovative research in head and neck neoplastic diseases with a grant of $100,000 over two years. Eligible applicants include full-time academic head and neck surgeons, who must demonstrate a commitment to developing independent research careers. The award encourages interdisciplinary collaboration and aims to yield significant findings within the funding period, fostering long-term research potential and attracting further funding opportunities.

The National Fund for Sacred Places Grant Program supports historic houses of worship in the U.S. through matching grants ranging from $50,000 to $250,000. This initiative, in collaboration with the National Trust for Historic Preservation, aims to enhance community engagement and preserve culturally significant buildings. Applicants are encouraged to demonstrate their historical relevance and community service, particularly those representing underrepresented groups. The program prioritizes urgent repair needs and projects that foster inclusivity and accessibility.

The Chisholm Foundation offers grants to support arts, education, and religion projects across the United States. Applications for May and November grants should be submitted by March 1st and September 1st, respectively. The Foundation evaluates each application individually and encourages innovative projects that can attract additional funding. Grants may be awarded as lump sums or in installments, and applicants are advised to seek matching gifts to enhance their proposals.

The Gateway Fund Grant aims to enhance the educational experiences of students and teachers in the North Adams Public Schools. This endowed fund supports diverse projects, including independent studies, extracurricular activities, and professional development for educators. Community proposals are encouraged to ensure educational excellence, with a focus on volunteer efforts and additional support. Review criteria include project worthiness, potential impact on the community, and the applicant's ability to complete the project.