Best Small Grants for Nonprofits in Massachusetts

The CURE Childhood Cancer: Translation to CURE (T2C) award provides funding for groundbreaking research to improve outcomes for children with cancer. Offering up to $150,000 per year for two years, this grant supports innovative projects led by full-time faculty at nonprofit institutions. The initiative seeks to foster collaboration among researchers at all career stages, ensuring that promising ideas can take root and flourish, ultimately driving advancements in pediatric oncology.

The CURE Childhood Cancer Early Investigator Award supports emerging scientists in the fight against pediatric cancer. This grant offers up to $150,000 per year for two years, totaling $330,000. It is designed for early-career researchers at US-based nonprofit institutions, particularly those at the Instructor or Assistant Professor level. The award aims to foster innovative research that can lead to effective treatments for childhood cancer, emphasizing the importance of collaboration and scientific advancement.

The BJA FY 2026 Adult Treatment Court Program aims to enhance Adult Treatment Court operations, focusing on preventing overdoses and reducing substance use among high-risk adults in the criminal justice system. The program integrates judicial supervision, substance use disorder treatment, and recovery support services to improve outcomes for participants. This funding opportunity from the U.S. Department of Justice highlights the commitment to public safety and addressing critical issues like the opioid crisis.

The BJA FY 2026 Capital Case Litigation Initiative aims to enhance legal representation in state capital cases. By providing essential funding, this initiative supports both prosecutors and defense attorneys to ensure equitable legal processes for indigent defendants. The U.S. Department of Justice emphasizes the importance of upholding the rule of law and protecting citizens' rights. Applications are due by November 5, 2026, at 8:59 p.m. ET, marking a critical opportunity for improvement in capital case litigation.

The George I. Alden Trust, established in 1912, focuses on promoting education in vocational and independent secondary schools primarily located in Worcester. With a commitment to evolving community needs, the Trust provides capital support through outright and challenge grants. It seeks to enhance philanthropic engagement and educational opportunities, particularly in industrial and vocational sectors, following Alden's vision to benefit the greatest number of individuals in the community.

The Leonard-Litz Foundation's LGBTQ+ Advocacy Fund Grant aims to empower LGBTQ+ individuals by funding organizations that advocate for their rights and well-being. With a focus on health, wellness, and racial justice, the fund supports projects that require significant investment for impactful change. Prioritizing partnerships that serve vulnerable communities, including people of color and transgender individuals, this grant fosters equality and addresses systemic inequalities faced by LGBTQ+ people, especially in the northeast U.S.

The Teagle Foundation's Knowledge for Freedom initiative aims to empower underserved high school students through transformative experiences in the humanities. Grants ranging from $100,000 to $300,000 over 36 months support programs that foster civic responsibility and personal purpose. Colleges can also apply for planning grants of $10,000 to $25,000 to develop tailored programs. The initiative emphasizes intensive summer seminars led by faculty, with continued support for college applications and civic engagement.

The Norman R. Tilford Field Studies Scholarship Fund, established in 1998 by the AEG Foundation, honors the contributions of Norman R. Tilford. It provides grants to undergraduate and graduate students undertaking field studies in geology. Awards include $1000 for undergraduates and $1500 for both Master’s and doctoral candidates, based on academic merit and potential contributions to the field. This fund promotes hands-on learning and professional development in geosciences.

The Toshiba America Foundation offers grants to K-5 teachers in public and nonprofit private schools, funding innovative projects in math and science education. Designed to support teachers in implementing hands-on learning experiences, these grants encourage creativity and community involvement. Applicants can propose projects that enhance student engagement and foster scientific inquiry. The foundation prioritizes teacher-led initiatives, making it a valuable resource for educators aiming to enrich their classrooms and inspire young learners.

The Sanofi-Regeneron Diversity, Equity and Inclusion Mid-Career Award, funded by the Dermatology Foundation, supports exceptional researchers committed to addressing dermatological issues affecting underrepresented groups. Offering $100,000 annually for up to three years, this award emphasizes projects that enhance understanding and improve health equity in dermatology. Eligibility includes a strong research commitment, relevant training, and a faculty appointment within 12 years of becoming an Assistant Professor. It encourages minority applicants to foster diversity in medical research.

The East Boston Foundation

The foundation was formed in 1998 to administer a generous $9.6 million commitment from the Massachusetts Port Authority as part of community mitigation and to offset the impacts associated with Massport's $4.4 Billion Logan Airport Modernization Program.

Categories of Grants

The Board of Trustees of the East Boston Foundation has identified the following categories of grants, which in the discretion of the Board may be amended from time to time. Grant requests and applications shall be grouped into various categories and identified as follows:

Business /Enhancement Grants (BDE)

The Foundation is committed to preserving initiatives, which are beneficial to the continued economy of the East Boston community and recognizes that the promotion of business objectives within the community, especially as they may relate to and benefit from the airport will help to serve as a means of minimizing various economic impacts that might be associated with the operations of Logan International Airport.

The Foundation will consider applications for business enhancement, which meet the following criteria:

• The proponent identifies an issue affecting the business community which specifically relates to enhancing business opportunities in all of East Boston’s business districts, including opportunities relating to Logan Airport;
• The proponent develops a plan to address the needs of the business community created by this issue and which is designed to provide education, assistance, and resources to the business community at large;
• The proponent receives at least 50% of its funding from sources other than the East Boston Foundation; (e.g. matching funds) and the Grant sought from the Foundation shall not exceed 50% of the applicant’s average total cash revenue (excluding in kind support) for the two (2) years preceding the application as demonstrated by the Applicant’s 990/990EZ filing or Form PC filed with the Massachusetts Attorney General
• The allocation of the Foundation’s grant money may be used for expenses related to salaries, wage benefits, and professionals, however the amount allocated may not exceed 50% of the amount granted.
• The applicant adequately demonstrates an ability to generate the remaining revenue as contemplated under its proposed budget

The Cancer Research Education Grants Program (R25) aims to enhance research education in areas crucial to the NIH mission. This program supports innovative courses that develop skills in cancer research, covering topics such as prevention, diagnosis, and treatment. Grant applications are encouraged to be creative and state-of-the-art, addressing the needs of patients and their families. Key deadlines for applications span from January 2024 to September 2026, ensuring ongoing support for educational initiatives.

The Medical Student Research Supplement Award by the Dermatology Foundation supports medical students' research in dermatology, encouraging diversity and inclusion. This award offers $5,000 for direct research expenses, fostering the involvement of full-time students from underrepresented backgrounds. Eligible applicants must be current or former DF career development awardees and must recruit medical students pursuing MD or DO degrees who meet specific academic criteria. The award enhances research participation and strengthens the academic workforce in dermatology.

The Dermatology Foundation offers Career Development Awards to support the academic growth of emerging investigators in various dermatologic fields. With an annual stipend of $55,000, these awards foster research addressing significant health issues, including public health, diversity, and women's health. Eligible applicants must demonstrate strong institutional support and meet specific educational requirements. The awards can be renewed for up to three years, contingent on the recipient's progress and commitment to advancing dermatological science.

The East Boston Foundation

The foundation was formed in 1998 to administer a generous $9.6 million commitment from the Massachusetts Port Authority as part of community mitigation and to offset the impacts associated with Massport's $4.4 Billion Logan Airport Modernization Program.

Categories of Grants

The Board of Trustees of the East Boston Foundation has identified the following categories of grants, which in the discretion of the Board may be amended from time to time. Grant requests and applications shall be grouped into various categories and identified as follows:

Youth/Senior Recreation Support Grants (YSRS)

The Foundation recognizes the need to further promote, encourage and support youth and senior recreation programs in the community.

Participation in such programs should be encouraged for the community’s youth and seniors and the costs of participation should be minimal so as to not be cost prohibitive.

The Foundation will consider applications for youth recreation programs, which meet the following minimum criteria:

• The proponent have at least two (2) years of demonstrated experience in the successful coordination of such events or can demonstrate to the satisfaction of the Board its ability to carry out such objectives;
• The program is open to and is capable of providing a substantial benefit on the residents of the East Boston community regardless of gender, race, religion, ethnicity, national origin or handicap and seeks to encourage participation through outreach and/or registration drives as well as needs assessments;
• The Grant sought from the Foundation shall not exceed 50% of the applicant’s average total cash revenue (excluding in kind support) for the two (2) years preceding the application as demonstrated by the Applicant’s 990/990EZ filing or Form PC filed with the Massachusetts Attorney General;
• The allocation of the Foundation’s grant money may be used for expenses related to salaries and or wage benefits, however the amount allocated from the grant may not exceed 50% of the grant awarded.
• In certain circumstances, the proponent provides reasonable assistance to disadvantaged individuals who experience financial hardship and who would otherwise be prohibited from participation.
• A grant to the organization shall not result in the creation of a general
• unrestricted surplus for the program’s operating budget.
• The applicant adequately demonstrates an ability to generate the remaining revenue as contemplated under its proposed budget

The East Boston Foundation

The foundation was formed in 1998 to administer a generous $9.6 million commitment from the Massachusetts Port Authority as part of community mitigation and to offset the impacts associated with Massport's $4.4 Billion Logan Airport Modernization Program.

Categories of Grants

The Board of Trustees of the East Boston Foundation has identified the following categories of grants, which in the discretion of the Board may be amended from time to time. Grant requests and applications shall be grouped into various categories and identified as follows:

Sports and Athletic Support Grants (SAS)

The Foundation recognizes the need to promote, encourage, and fund seasonal to year long youth sports programs in the community as another means of achieving part of the Foundation’s stated mission. Participation in such programs should be encouraged for the community’s youth and the cost of participation should be equivalent to similar programs in the metropolitan area. In any case, costs per participant shall be kept to an absolute minimum.

The Foundation will consider applications for general funding of sports and athletic programs which meet the following minimum criteria:

• The proponent have at least two (2) years of demonstrated experience in the successful coordination of such events or can demonstrate to the satisfaction of the Board its ability to carry out such objectives;
• The program is open to both boys and girls with demonstrated ability to participate without regard to race, ethnicity, nationality, or religion, and seeks to encourage broad participation through outreach and/or registration drives that encompass the entire community;
• Administrative fees are less than 15% of the entire operational budget and shall be directed towards compliance . The allocation of the Foundation’s grant money shall be used for expenses unrelated to salaries, wage benefits or expenses unrelated to the operation of the organization;
• The Grant sought from the Foundation shall not exceed 20% of the applicant’s average total cash revenue (excluding in kind support and prior Foundation grants) for the two (2) years preceding the application as demonstrated by the Applicant’s 990/990EZ filing or Form PC filed with the Massachusetts Attorney General;
• In certain circumstances, the proponent provides reasonable assistance to disadvantaged individuals who experience financial hardship and who would otherwise be prohibited from participation;
• A grant to the organization does not result in the creation of a general unrestricted surplus for the program’s operating budget.
• The applicant adequately demonstrates an ability to generate the remaining revenue as contemplated under its proposed budget

The East Boston Foundation

The foundation was formed in 1998 to administer a generous $9.6 million commitment from the Massachusetts Port Authority as part of community mitigation and to offset the impacts associated with Massport's $4.4 Billion Logan Airport Modernization Program.

Categories of Grants

The Board of Trustees of the East Boston Foundation has identified the following categories of grants, which in the discretion of the Board may be amended from time to time. Grant requests and applications shall be grouped into various categories and identified as follows:

Community Activity Support Grants (CAS)

The Foundation recognizes that the promotion and encouragement of civic and community pride as well as cultural awareness serves to mitigate various socioeconomic impacts commonly experienced in the East Boston Community. Therefore, the Foundation will consider applications for programs and activities fostering or promoting civic and community pride and cultural awareness, which meet the following minimum criteria:

• The proponent have at least two (2) years of demonstrated experience in the successful coordination of such events or can demonstrate to the satisfaction of the Board its ability to carry out such objectives;
• Admission and/or the cost of participation is free of charge to any East Boston resident who wishes to participate;
• The Grant sought from the Foundation shall not exceed 15% of the applicant’s average total cash revenue (excluding in kind support and prior Foundation grants) for the two (2) years immediately preceding the application as demonstrated by the Applicant’s 990/990EZ filing or Form PC filed with the Massachusetts Attorney General;
• The allocation of the Foundation’s grant money shall be used for expenses related only to direct costs of the event. Notwithstanding the foregoing, no portion of the funds shall be used for salaries, wage, or benefits, or costs associated with general administration of the event including payments to third parties for service fees. The total payment to third parties for services fees rendered to the Applicant for general administration of the program or event shall be no more than 25% of the event’s total proposed budget.
• The applicant adequately demonstrates an ability to generate the remaining revenue as contemplated under its proposed budget;

The Macy Faculty Scholars Program, funded by the Josiah Macy Jr. Foundation, supports early-career educators in medicine and nursing, promoting their development as future leaders. Scholars receive substantial financial support, mentorship, and access to educational resources, including funding for professional development activities and participation in a Harvard Macy Institute course. This initiative aims to enhance the educational landscape by nurturing diverse talent in the healthcare education field.

The Covenant Foundation's Signature & Ignition Grants celebrate excellence in Jewish education by funding innovative projects that enhance educational practices. The Foundation supports diverse institutions across North America, inviting applications for creative programs that can adapt and disseminate effective practices. While Signature Grants may reach up to $150,000 over three years, Ignition Grants focus on untested ideas with funding up to $20,000 for one year. One application per cycle is permitted.

The Dr. Harvey Young Education & Development Foundation’s Young Guts Scholars Program supports undergraduate students from underrepresented groups in biomedical research. The program encourages students to pursue careers in science or medicine by offering a stipend, AGA membership, and travel funds for Digestive Disease Week®. Eligible applicants must have a mentor and commit to a minimum of 12 hours of research per week. This initiative aims to expand the pipeline of investigators in digestive disease research.

The Aman Armaan Ahmed Family SURF for Success Program offers summer undergraduate research fellowships for students from underrepresented groups in biomedical research. Awardees engage in 10 weeks of research related to digestive diseases under expert mentorship, receiving a stipend of $6,200. This initiative aims to inspire students to pursue careers in science and medicine, enhancing diversity in the field of gastroenterology and hepatology.

The Schlumberger Foundation's Faculty for the Future Grant Program aims to empower women from developing countries to pursue advanced STEM research abroad. By providing fellowships of up to $50,000 for PhD candidates and $40,000 for postdoctoral researchers, the program supports women's education and encourages their return to home countries to advance local STEM fields. Since 2004, it has awarded 863 fellowships, fostering gender equality in STEM and enhancing community development through increased female participation in scientific careers.

The Francis R. Dewing Foundation Grant provides seed money to support innovative projects in early childhood education, benefiting children up to sixth grade. Founded by Frances R. Dewing in 1963, the foundation aims to stimulate intellectual growth in young children through unique educational methods. Grants typically range from $1,000 to $25,000, with a focus on projects that demonstrate a broad impact on the educational community. Applications are accepted from 501(c)(3) nonprofit organizations and government entities across the United States.

The Combined Pilot Research Grants by the AAPPS and PSF aim to promote innovative research in pediatric plastic surgery and hand surgery. With funding up to $15,000 for one-year pilot projects, these grants support the development of surgeon scientists and encourage applications that will enhance the scientific understanding and improve care for children with deformities requiring reconstructive surgery. This initiative fosters collaboration among various subspecialty organizations dedicated to advancing surgical research.

The ASTR Po-Hsien Chu International Scholar Award Fund aims to support international scholars facing unique challenges in the U.S. due to their visa status. This initiative offers annual research awards to up to two scholars, with a focus on at least one Asian recipient. The $1000 honorarium promotes access to funding for groundbreaking research in theatre and performance studies and encourages recipients to engage with the ASTR community through conferences and mentoring.

About us

SIR Foundation is a scientific foundation dedicated to fostering research in interventional radiology for the purposes of advancing scientific knowledge, increasing the number of skilled investigators, and developing innovative therapies that lead to improved patient care and quality of life. The foundation is committed to fostering the development and enhancement of innovative, minimally invasive, image-guided therapies from inception to mature clinical application and to conduct educational programs in the service of its mission.

Research Scientist Award

Recognizes the contributions and accomplishments of PhD scientists and engineers at all levels of training for their basic and preclinical research on the topic of interventional radiology.

Award

Up to two recipients will receive complimentary registration and a travel stipend of $1,000.

About us

SIR Foundation is a scientific foundation dedicated to fostering research in interventional radiology for the purposes of advancing scientific knowledge, increasing the number of skilled investigators, and developing innovative therapies that lead to improved patient care and quality of life. The foundation is committed to fostering the development and enhancement of innovative, minimally invasive, image-guided therapies from inception to mature clinical application and to conduct educational programs in the service of its mission.

Resident Research Award

Provides residents and fellows an opportunity to attend and present their scientific research at the SIR Annual Scientific Meeting. The intent is to expose young researchers who wish to further their careers in interventional radiology.

Award

Up to two recipients will receive complimentary registration and a travel stipend of $1,000.