Best Middlesex County Grants for Nonprofits in Connecticut

The Traumatic Brain Injury Model Systems Centers aim to enhance TBI rehabilitation through evidence-based research. These centers focus on generating knowledge to improve health, community participation, and employment outcomes for TBI individuals. Funded by the US HHS Administration for Community Living, the grants support site-specific and collaborative research, contributing to a longitudinal database. Each center can receive varying funding amounts, depending on eligible database participants, with a project timeline of 60 months comprising five 12-month budget periods.

The Lifespan Respite Care Program invites state agencies to apply for grants aimed at enhancing respite services for caregivers of individuals with disabilities or chronic conditions. This initiative supports both new states and those re-establishing their programs, focusing on collaboration, training, and outreach to address the respite needs of diverse populations. Approximately ten cooperative agreements will be funded over three years, aligning with federal requirements for lifespan respite care.

The National Breastfeeding Support Initiative aims to enhance maternity care quality by engaging diverse partners and providing training to healthcare organizations. It focuses on implementing evidence-based practices to support breastfeeding, ensuring safe and effective maternity care in hospitals across the U.S. and territories. By fostering collaboration and utilizing data for quality improvement, the initiative seeks to create a sustainable impact on maternal and infant health.

Request for Proposals: Launchpad Funds

Background

Coefficient Giving is increasing its giving, primarily to prepare for the billions of dollars in new philanthropic capital that may become available in the coming years. Our increased giving in global health and wellbeing is a temporary surge, with two objectives: to smooth funding and pull forward initiatives we expect to be cost-effective, and to help create an ecosystem of regrantors and implementers with the capacity to allocate this new money as cost-effectively as possible. Additional context on our scaling is provided in this blog post. 

With new potential capital on the way, we want to increase the supply of actionable and fundable plans to address some of the world’s hardest problems. We’re looking for specific, credible strategies to convert funding into measurable progress. Our ideal funds are:

However, we are also open to funds that are thematic and don’t have a quantified goal — for example, a fund organized around a promising type of intervention. Such funds still need to be led by a single, identifiable person who is accountable for the fund’s direction.

Through this request for EOIs, we aim to seed or scale Launchpad Funds that can grow to $100m+ over the next few years. We don’t seek scale for its own sake; it is a proxy for the ambition of the fund, and a signal that the problem is large and tractable enough to justify deploying significantly more capital over time.

What we will fund

• We expect to support established ideas that have either not yet secured anchor support or could significantly scale beyond their existing level of funding.
• This funding can cover operating expenses, but we expect most of it to be used for activities that make progress on the fund’s goals — whether through regranting or direct implementation.
• For exceptional proposals, we may consider funding levels beyond $50m. We anticipate higher funding levels will involve more thought partnership from our team.
• While we don’t expect to make grants longer than 36 months, funded proposals may later be considered for additional funding beyond the initial period.

Historic Restoration Fund (HRF) Grants

What can the HRF program fund:

• Maintenance and repair of historic building fabric and character defining features.

What types of buildings can the HRF program be used on:

• Buildings that are listed on the State or National Register of Historic Places either individually or as a contributing resource to a district.

What is the size of the grants:

• Grant awards range from $5,000 to $200,000.

Is there a required match:

• Yes, a one-to-one match is required. Grants are paid on a single-payment reimbursement basis following project completion. Federal funds and other non-state funds can be used as a match.

This is a very competitive grant program with a yearly budget of $1 million. If your organization is not awarded a grant, we welcome you to apply in a subsequent year. HRF grants are awarded in January of each year.

The OJJDP FY 2026 Mentoring for Youth Impacted by Opioids and Other Substance Use program aims to provide high-quality mentoring services to youth affected by substance use. This funding opportunity supports various mentoring formats, including one-on-one, group, and peer mentoring, to assist those currently using substances or at risk due to familial influences. The initiative seeks to enhance the well-being of these youth through supportive relationships and guidance.

Who We Are

Broad Street Children's Foundation is committed to providing financial support to privately funded children's homes caring for the orphaned, abandoned and broken children right here in the United States.

Grant Seekers

Broad Street Children's Foundation supports self-sustaining children's homes across the United States that actively foster the development of strong, well-rounded children in their care.

Since the start of the Foundation, over $1,000,000.00 in grants have been donated to children's homes across the country. Additionally, through the Bill and Jackie Hazelgrove Scholarship Program, we have been able to assist a number of young people to continue their education and work towards a college or vocational degree.

Today, the Broad Street Children's Foundation is continuing the dream of it's original founders through the second generation. Equally as dedicated to changing the lives of children in need across America and striving to break the cycle of abuse and neglect for other children and their families.

The Easement Restoration and Stewardship program, funded by the USDA NRCS, focuses on restoring and managing Wetland and Floodplain Easements. It includes developing restoration plans, conducting assessments, and implementing stewardship activities to enhance ecological health. Awardees will collaborate with NRCS personnel to ensure effective restoration design and maintenance strategies, fostering sustainable landscapes. This initiative addresses critical habitat conditions and promotes long-term environmental benefits for protected lands.

The Deployed Warfighter Protection FY27 program aims to safeguard military personnel from disease-carrying arthropods, including ticks and mosquitoes. It seeks innovative research to develop new insecticides, improve existing formulations, and enhance personal protection technologies. The initiative also focuses on effective pesticide application equipment, addressing both current and emerging arthropod threats. This program is crucial for maintaining the health and safety of deployed military forces.

The National Institute of Allergy and Infectious Diseases (NIAID) is advancing Type 1 diabetes research by exploring the innate immune system's role in disease onset. This initiative aims to identify genetic and environmental factors contributing to Type 1 diabetes through multidisciplinary teams. By employing innovative methodologies, the program seeks to determine how immune responses affect pancreatic tissues, potentially leading to early detection and prevention strategies for at-risk individuals.

The Collaborative Centers in Children’s Environmental Health Research and Translation program aims to establish a national network of research centers focused on improving children's health through innovative research and public health strategies. By fostering collaboration within the children’s environmental health community, these centers will lead the way in translating scientific findings into actionable practices, ensuring a healthier future for children while addressing emerging environmental threats.

The Immune Drivers of Autoimmune Disease (IDAD) network, supported by NIAID, aims to uncover early triggers and mechanisms of autoimmunity to prevent disease. Key initiatives include developing predictive tools and biomarkers, fostering preclinical cohorts, and utilizing AI and big data. The network will leverage shared infrastructure for collaborative research, managed by the IDAD Network Coordinating Center, which ensures coordination and resource sharing among awardees. This initiative is crucial for advancing understanding and prevention of autoimmune diseases.

The NLM Grants for Scholarly Works in Biomedicine and Health (G13) program invites applications to support the creation of book-length manuscripts and scholarly works that are vital for U.S. health professionals and scientists. This initiative aims to foster critical reviews and analytical syntheses that enhance understanding of biomedical and public health challenges, ultimately contributing valuable resources for education, research, and clinical practice.

The LAST MILE program, initiated by the NIAID, aims to enhance the implementation and effectiveness of HIV prevention and treatment strategies through real-world effectiveness trials. By fostering collaborations and focusing on diverse populations, this initiative seeks to translate clinical findings into practical applications. The program supports research across various disciplines, aligning with the NIH's mission to improve HIV/AIDS outcomes and address associated comorbidities. This multifaceted approach promises to bridge the gap between clinical trials and community-based interventions.

The National Institute on Aging (NIA) is announcing a funding opportunity to support the Exceptional Longevity Data Management and Coordinating Center (EL DMCC). This initiative aims to enhance the management of large, diverse datasets and facilitate collaborative research across NIA projects. Core functions include data integration, AI/ML infrastructure development, and maintaining the ELITE Portal for secure data access. This NOFO encourages innovative approaches to longevity research, though applications are not currently being solicited.

The National Institute of Allergy and Infectious Diseases (NIAID) aims to enhance the development of diagnostic tests for infectious diseases through strategic partnerships between academia and industry. By fostering collaborations, NIAID seeks to overcome barriers to commercialization, ensuring promising diagnostics reach the market effectively. This initiative aligns with NIH's mission to advance innovative technologies that improve treatment and prevention strategies for infectious diseases, ultimately contributing to public health advancements.

About

Originally conceived by Dr Bruce Mesara in 1990 as a means to carry on his philanthropic efforts beyond his lifetime, the Mesara Family Foundation was re-envisioned by his two children Amy and Douglas in 2014, and received their 501(c)(3) status from the IRS in 2015. Amy and Douglas sought out the assistance of their cousins to build upon the charitable principals on their parents, aunts and uncles.

The foundation is headquartered in Kalamazoo Michigan.

Mission

The mission of the Mesara Family Foundation is to honor the philanthropic principles of the Mesara and Pauch families by supporting carefully selected organizations that share similar values. Our focus is to provide support toward education, conservation and other causes of special family interest where our funding will make a genuine difference.

The BJA FY 2026 John R. Justice Formula Grant Program offers loan repayment assistance to local and state prosecutors and public defenders who commit to three years of service. Administered by state agencies, this program aims to alleviate the financial burden on legal professionals dedicated to public service. Applications are due by November 10, 2026, providing a crucial opportunity for eligible beneficiaries to secure support for their educational loans.

The National Oceanic and Atmospheric Administration (NOAA) is inviting proposals for projects that enhance coastal flood protection through public-private partnerships, innovative insurance products, and improved sediment management. This initiative aims to utilize natural infrastructure to bolster flood preparedness and resilience. Funding of up to $2,000,000 is available for selected projects, supporting research teams that collaborate with regional stakeholders. Proposals must be submitted via Grants.gov, ensuring accessibility to critical resources and information.

The OJJDP FY 2026 Second Chance Act Youth Reentry Program aims to provide critical support for moderate- to high-risk youth transitioning back into their communities after confinement. This funding opportunity encourages collaboration among state agencies, local governments, Tribes, and community organizations to deliver comprehensive reentry services and assist youth in overcoming challenges related to recidivism. Applications are due by November 9, 2026, at 8:59 p.m. ET.

The OJJDP FY 2026 Internet Crimes Against Children (ICAC) Task Force Program Support aims to fortify a national network of 61 multiagency task forces dedicated to combating child sexual exploitation facilitated by technology. This funding opportunity enhances training, prevention, and outreach efforts while fostering collaboration among law enforcement entities. Applications are due in JustGrants by November 9, 2026, at 8:59 p.m. ET, ensuring timely support for critical initiatives to protect children.

The CDC is offering funding to enhance collaboration among tuberculosis control programs and various partners in the U.S. This initiative aims to strengthen relationships with national TB control entities, federal agencies, academia, and community organizations. The goal is to promote health and quality of life by preventing, controlling, and eventually eliminating tuberculosis in the United States, building on previous funding opportunities.

The Advanced Rehabilitation Research Training (ARRT) Program aims to enhance the research capabilities of individuals with advanced degrees, focusing on disability and rehabilitation research related to employment outcomes. Funded by the US HHS Administration for Community Living, this grant offers a 36-month project period, supporting multidisciplinary training for researchers, including those with disabilities, to contribute to high-quality research in the field.

MIND (Maximizing Innovation in Neuroscience Discovery) Prize

The Pershing Square Foundation’s (PSF) brain initiative funds cutting-edge research that revolutionizes our ability to predict, prevent, and treat neurodegenerative diseases (NDDs). Advancing our fundamental understanding of the brain and cognition to ultimately combat neurodegeneration and related diseases is a goal of increasing urgency. Breakthroughs in basic scientific and translational research will yield critical tools for and knowledge of NDDs, including Alzheimer’s Disease and Dementia, which affect millions of people worldwide.

The MIND (Maximizing Innovation in Neuroscience Discovery) Prize supports and empowers early-to-mid-career investigators to rethink conventional paradigms around NDDs. Modeled after the Pershing Square Sohn Prize for Young Investigators in Cancer Research, the MIND Prize catalyzes interdisciplinary approaches and facilitate collaborations across academic departments and institutions. It fuels the groundbreaking research that will accelerate our understanding of NDDs at every level.

Projects may range from the invention of novel tools, techniques, and technologies for mapping and analyzing the brain to bold approaches that demonstrate extraordinary therapeutic potential. Research domains may include—but are not limited to—neurobiology, brain imaging and mapping, machine learning, drug delivery, and synthetic biology. Applicants are encouraged to propose bold, hypothesis-driven, high-risk, high-reward research with the potential for transformative impact. Tool and technology development are permitted when they support the testing of a clearly defined biological hypothesis. Screening may be part of the proposed work, but should not be the sole focus. Clinical components are permitted, but proposals should not center on clinical trials or medical device testing in humans.

MIND Prize winners each receive $250,000/year for three years, and they become part of a unique network of researchers associated with PSF. Generally, at least six prizes will be awarded annually. Benefits include:

• Facilitated partnerships with like-minded researchers within and across institutions
• Networking programs such as collaborations and discussions with industry mentors, introductions to philanthropic and for-profit investors in the business community, special industry networking and entrepreneurship events, and more
• An annual retreat
• Opportunities to present at conferences and events (hosted by PSF and other organizations)

Pershing Square Lotus Award for Ovarian Cancer Research

The Pershing Square Foundation (PSF) has worked across sectors to catalyze innovative approaches to the most difficult problems. Talented individuals have always been at the center of our approach. We aim to support leaders who transform systems, embrace new paradigms, and have an innate drive to make an impact.

PSF has funded pioneering cancer researchers through the Pershing Square Sohn Cancer Research Alliance for over a decade and supported women’s health initiatives in New York City. Through this Request for Proposals (RFP), PSF aims to combine these two priority areas of women’s health and cancer to shine a light on one of the most understudied and underfunded cancers—ovarian cancer. Ovarian cancer is the deadliest gynecologic cancer, with 80% of women diagnosed at an advanced stage. Only 27% of women diagnosed during an advanced stage survive for five years. Ovarian cancer remains a disease with a poor prognosis due to limited early detection and treatment options.

PSF supports research efforts by 

• deploying capital quickly, 
• funding high-risk, high-reward ideas, 
• bringing new perspectives into a field, 
• encouraging collaboration, and 
• leveraging our vast network. We challenge our scientific partners to think creatively and across silos, to spur innovation to fight ovarian cancer.

Through the Pershing Square Lotus Award for Ovarian Cancer Research, PSF is looking for investigators who are either already working on a promising project in ovarian cancer or in another type of cancer that could have an impact on ovarian cancer. Grantees each receive $250,000 a year for three years, totaling $750,000.

Researchers who are not studying ovarian cancer are encouraged to apply and required to find a collaborator with experience in ovarian cancer research.

This award aims to 

• inspire investigators with unique expertise to apply their knowledge to ovarian cancer and 
• empower ovarian cancer researchers to pursue their boldest, most innovative ideas. Facing a disease where too few have survived to-date, PSF ultimately aims to create a culture around ovarian cancer that offers women hope, akin to the breast cancer community. PSF is passionate about changing outcomes for tens of thousands of women a year and is hopeful that future scientific discoveries will allow for more survivors who can share their stories for years to come.

Disabled Veterans National Foundation

The Disabled Veterans National Foundation (DVNF) was established in 2007 to support veterans facing challenges that traditional systems could not fully address. From its earliest days, DVNF has been focused on closing critical gaps in care and providing resources that help veterans rebuild their lives with dignity and stability.

Guided by this commitment, DVNF developed its Health & Comfort programs, offering emergency financial assistance, housing transition support, food assistance, comfort kits, and wellness initiatives. These programs are designed to meet veterans where they are and to provide practical solutions that restore hope and stability. Today, DVNF continues to grow as a trusted national nonprofit. Every day, our team works with a clear purpose: to change lives for the men and women who have served our country.

Veterans Food Assistance Program

It is our goal to ensure that no veteran goes hungry by providing essential food assistance and household support, fostering stability and well-being in the lives of our veterans and their families.

The Veterans Food Assistance Program (VFAP) is designed to provide a one-time grant of essential food and household support to veterans and their families, ensuring no veteran goes hungry. With the rising cost of living, especially food prices due to inflation, this program offers a much-needed lifeline to those who have served our country. Once approved, the DVNF program team will handle the shopping for you.

The Veterans Food Assistance Program provides a one-time grant per household to support different family sizes, given the rising cost of food:

• Married Veterans Grant Allowance
  • Married - No Children up to $250
  • Married - 1 Child up to $300
  • Married - 2 Children up to $450
  • Married - 3+ Children up to $500
• Single Veterans Grant Allowance
  • Single - No Children up to $200
  • Single - 1 Child up to $300
  • Single - 2 Children up to $350
  • Single - 3+ Children up to $450