Best Minneapolis Grants for Nonprofits in Minnesota

The Sons and Daughters Scholarship Program, administered by the Cleveland-Cliffs Foundation, offers a competitive scholarship of $3,000 annually for up to four years for undergraduate studies. This initiative recognizes exceptional academic and extracurricular achievements among high school students. Scholarships are available to those attending accredited colleges or universities in the U.S. or Canada, though children of Cleveland-Cliffs officers are ineligible. The program aims to enhance educational opportunities and support community growth.

The NIDCR Drug, Biologic, Device and/or Procedure Intervention Clinical Trial Planning and Implementation Cooperative Agreement (UG3/UH3) is designed to support clinical trial planning and implementation for dental, oral, and craniofacial conditions. This funding opportunity encourages applications that propose innovative research strategies within the NIDCR mission. Key deadlines span from February 2025 to January 2028, with emphasis on milestone-driven planning phases leading into possible clinical trial phases.

The Livable Communities Development Grants, funded by the Metropolitan Council, aim to enhance housing and job opportunities in Minneapolis. The City will accept sponsorship applications starting in December, requiring a $750 application fee. Up to eight projects may be recommended for funding in the 2026 program year, with a focus on readiness and alignment with city plans. Grant funds will be available only after the Metropolitan Council's approval and can reimburse developers for eligible costs.

The Rita Allen Foundation: Scholars Award in Pain supports early-career researchers in basic pain science. Established in 2009, it offers grants of $150,000 over three years to those investigating innovative pain mechanisms and analgesic development. Eligible candidates should be in the early stages of their faculty careers, demonstrating exceptional promise and a commitment to pain research. This award aims to enhance understanding and treatment of chronic pain, fostering impactful scientific advancements.

The Ken W. Davis Foundation Grant provides essential funding to nonprofit organizations in the U.S. that align with the Foundation's mission of promoting basic human needs and education in line with Constitutional freedoms. With a minimum grant size of $2,500, the Foundation focuses on supporting human service organizations in Tarrant County, Texas, and the Permian Basin of West Texas and Southeast New Mexico, while also offering national support for grants related to Constitutional freedoms.

The ACTA Apprenticeship Program has been supporting California's cultural traditions for nearly 25 years by providing $5,000 contracts to mentor artists for intensive training of eligible apprentices. This program fosters the continuity of traditional arts through one-on-one mentorship, culminating in public presentations and documentation of the learning process. Eligible applicants must submit a collaborative application, demonstrating commitment and quality in their respective art forms. This initiative not only preserves cultural practices but also enhances community engagement.

The Igor Gorin Memorial Award, established in 1993 by the Community Foundation for Southern Arizona, honors the legacy of Igor Gorin by supporting aspiring vocalists. With $382,000 awarded to 49 young talents, this fund provides unrestricted financial assistance for coaching, travel, and auditions. The 2026 award offers up to $12,000, aimed at those overcoming financial barriers to pursue operatic careers, ensuring that exceptional vocalists can thrive in their artistic journeys.

Community Collaboration Challenge

Applications for the 2026 Community Collaboration Challenge are now open! With support from the Leon Lowenstein Foundation, the Challenge provides $5,000 – $10,000 awards to communities and is designed to support collaboration that expands and pilots evidence-based K-12 student supports in the form of high-impact tutoring, mentoring, student success coaching, postsecondary transition coaching, and/or wraparound/integrated student supports.

The Smart Family Fund is a private foundation dedicated to supporting early-stage non-profits that demonstrate the potential for scalable, positive impact. With grants ranging from $25,000 to $100,000, they aim to assist organizations in refining their models and preparing for larger investments. The foundation, guided by three brothers, focuses on mentoring and backing social entrepreneurs facing challenges in securing funding for innovative yet untested ideas, fostering a brighter future for communities.

The Rona Jaffe Foundation Fellowship supports emerging women writers with a fully funded 7-month residency at the Fine Arts Work Center. Established by the Rona Jaffe Foundation, it includes a $2,500 prize to assist with travel and living expenses. Eligible candidates must be U.S. residents, at least 18 years old, and not enrolled in a degree program during the fellowship year. This prestigious fellowship aims to nurture exceptional literary talent.

This funding opportunity invites renewal applications for existing NINDS-supported clinical trial cooperative agreements (U01) that require additional time and resources. The National Institute of Neurological Disorders and Stroke (NINDS) expects applicants to request only what is necessary for trial completion, without introducing new aims. Discussions with NINDS prior to submission are encouraged. Eligible applications must be renewals of previously approved cooperative agreements under specified NIH funding announcements.

This funding opportunity invites applications for pilot projects focused on understudied proteins linked to rare diseases. The goal is to generate preliminary data and tools related to these proteins, which belong to druggable families with known rare disease associations. By supporting innovative research, this initiative aims to facilitate the characterization of these proteins, ultimately contributing to advancements in understanding and treating rare diseases.

This Funding Opportunity Announcement (FOA) aims to advance the identification and evaluation of candidate biomarkers for neurological and neuromuscular disorders. By facilitating the clinical development of neurotherapeutics, the FOA encourages research that includes both animal studies and preliminary human evaluations. The ultimate goal is to produce biomarkers ready for rigorous analytical and clinical validation, enhancing the effectiveness of treatments in clinical practice.

The Limited Competition: Basic Instrumentation Grant (BIG) Program offers funding to NIH-supported researchers for purchasing specialized instruments or integrated systems, with minimum awards of $25,000 and maximum awards reaching $350,000. Eligibility is restricted to institutions that have not received significant S10 funding in recent years. This program aims to enhance research capabilities by providing access to essential technology, thereby fostering scientific innovation and collaboration within the NIH community.

The Shared Instrumentation Grant (SIG) Program supports NIH-funded investigators in acquiring high-cost, specialized instruments, with a minimum award of $50,000 and a maximum of $750,000. Eligible instruments include light microscopes, mass spectrometers, and DNA sequencers, among others. This program aims to enhance research capabilities by enabling the purchase or upgrade of essential equipment for scientific advancement.

The High-End Instrumentation (HEI) Grant Program, offered by the NIH, invites applications for purchasing or upgrading high-end, specialized instruments, with a minimum award of $750,001 and a maximum of $2,000,000. This program supports NIH investigators aiming to enhance their research capabilities through advanced technologies such as mass spectrometers and electron microscopes. Applications must be submitted by 5:00 pm local time of the applicant organization.

The NIH is seeking innovative computational approaches to enhance the curation of biomedical research assets at scale. This initiative aims to accelerate access to secure datasets and computational models, facilitating transformative discoveries in biomedical science. Key deadlines for applications range from January 2025 to January 2027, covering standard, renewal, and AIDS-related grants. Applicants are encouraged to submit Letters of Intent 30 days prior to application deadlines to ensure a streamlined review process.

The Reboot Representation Tech Coalition aims to significantly increase the number of Black, Latina, and Native American women earning computing bachelor’s degrees. They invite qualified organizations to submit grant inquiries focused on recruiting and retaining these women in tech. Programs that leverage existing resources and operate across multiple regions will be prioritized, and the Coalition seeks initiatives backed by substantial research and community trust.

The Warren Alpert Foundation's Distinguished Scholars Award aims to enhance public health by funding innovative research in basic and clinical neurosciences. Nominations are invited from medical schools and research institutions in the U.S., focusing on candidates with a strong post-doctoral record. The selection process emphasizes scholarly achievements, scientific proposals, and letters of recommendation. A total of five awards will be granted to deserving scholars, fostering significant advancements in neuroscience.

The Watson-Brown Foundation Scholarship offers need and merit-based financial assistance to students from Georgia and South Carolina attending accredited four-year colleges. Established in 1970, the foundation aims to enhance educational opportunities for underprivileged youth, awarding over $2.4 million annually. Eligible students can receive up to $3,000 per semester to cover educational expenses, supporting their academic journey while encouraging responsible scholarship and historic preservation.

The National Scleroderma Foundation's New Investigator Grant aims to support emerging researchers dedicated to scleroderma studies. This three-year grant, totaling $200,000, encourages applicants with doctoral degrees and postdoctoral experience. Eligible candidates are invited to submit proposals that may lead to further research funding. The grant emphasizes innovative research approaches while providing essential financial support for early-career investigators. Note that the grant does not cover certain costs, ensuring focused investment in research advancement.

The Scleroderma-Related Lung Disease— The Debra Lurvey Memorial Research Grant, provided by the National Scleroderma Foundation, aims to support research in scleroderma-related lung disease. With a funding amount of $200,000, the grant encourages established investigators to explore innovative solutions and enhance understanding of this condition, ultimately working towards improving the quality of life for affected individuals and advancing medical knowledge in the field.

The National Scleroderma Foundation supports pediatric scleroderma research with up to $500,000 in funding for new and established investigators. Their mission focuses on advancing medical research and promoting awareness of scleroderma, with the vision of improving the lives of those affected. This initiative aims to encourage innovative research that could lead to better treatments and a potential cure for pediatric scleroderma, enhancing support for affected families.

The Fall Program Grants: PTA Connected: Ready, Tech, Go! aims to support elementary schools by providing $1,500 to 230 local PTAs. This initiative encourages in-person programming focused on digital safety and responsible device use. Funded by AT&T, it facilitates peer discussions among parents and caregivers to address screen readiness and promote healthy technology habits. PTAs must be in good standing and engaged in arts, well-being, or healthy lifestyle programs to qualify.

Blue Meridian Partners Grant aims to transform lives of young people and families in poverty by investing in scalable strategies that enhance economic and social mobility. The organization seeks stand-alone nonprofits with a proven track record, a compelling vision, and strong leadership. With a commitment to performance-based investing, Blue Meridian provides significant capital, often exceeding $100 million, to foster impactful solutions and address pressing social challenges effectively.

EmpowHer Grants, offered by the Boundless Futures Foundation, provide essential financial support and resources to female entrepreneurs in the U.S. who are committed to creating social impact through their businesses. Grants, which can go up to $25,000, are available to those with businesses that are less than three years old and demonstrate revenue generation. This initiative aims to empower women by reducing barriers and fostering a supportive entrepreneurial community.