Best Large Grants for Nonprofit Organizations in Minnesota

The Grand Rapids Area Community Foundation, established in 1994, aims to enhance the quality of life in the Greater Itasca Area through philanthropic efforts. Governed by a dedicated Board of Directors, the foundation awards grants to nonprofits addressing local needs across various sectors, including education and the arts. With over 30 years of experience, it connects generous donors with community needs, fostering collaboration and compassion to create lasting, positive change.

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Mission, Vision & Values

To enhance our community through philanthropy.

We aspire to co-create diverse, meaningful and innovative charitable giving that yields an exponential positive impact within local communities and beyond.

Dale & Thomasina Trout Memorial Fund

About the fund

The Trout Scholarship is awarded to Benton County high school graduates who have excelled in academics and school activities or athletics.

The Mission Boost Grants (MBG) by the American Cancer Society aim to enhance cancer research by funding projects that translate into human testing. These grants support investigators at all levels, offering resources for innovative clinical projects. The program consists of two funding stages: Stage I focuses on developing clear milestones for new treatments, while Stage II supports patient testing, ultimately contributing to advancements in cancer care and treatment.

The Community Foundation of Marquette County distributes over $130,000 annually in scholarships to benefit aspiring students in Marquette County.

Brian Watson Scholarship

Awarded to a graduating senior of Gwinn Area Community Schools pursuing higher education, who is pursuing a degree in one of the STEM fields and demonstrates a financial need.

Distribution Process

• CFMC scholarship recipients will be contacted in June requesting student enrollment verification
• Scholarships can only be distributed once student’s information is received
• Scholarships will be distributed to the college/school/university indicated by student
• The scholarship must be used for tuition and fees required for the enrollment or attendance of the student at a qualifying educational institution; fees, books, supplies, and equipment required for courses of instruction at such an educational institution; and room and board, within the first semester of first year of students enrollment
• That year’s recipient must claim the scholarship within that fiscal year to be distributed (by 12/31/xx)

The BRAIN Initiative's funding opportunity aims to support the establishment of facilities at minority-serving and IDeA-eligible institutions for the production and distribution of brain cell type-specific reagents. These reagents will enhance neuroscience research by enabling precise manipulation and access to brain cell types, facilitating advancements in understanding circuit functions in various species. The initiative encourages collaboration among awardees to optimize the use of these essential resources across the neuroscience community.

The Community Foundation of Marquette County distributes over $130,000 annually in scholarships to benefit aspiring students in Marquette County.

Lowell A. Larson Scholarship

Provides scholarships to MSHS graduating students pursuing secondary education in the trades including, but not limited to construction, welding, automotive, hvac, etc.

Distribution Process

• CFMC scholarship recipients will be contacted in June requesting student enrollment verification
• Scholarships can only be distributed once student’s information is received
• Scholarships will be distributed to the college/school/university indicated by student
• The scholarship must be used for tuition and fees required for the enrollment or attendance of the student at a qualifying educational institution; fees, books, supplies, and equipment required for courses of instruction at such an educational institution; and room and board, within the first semester of first year of students enrollment
• That year’s recipient must claim the scholarship within that fiscal year to be distributed (by 12/31/xx)

The Community Foundation of Marquette County distributes over $130,000 annually in scholarships to benefit aspiring students in Marquette County.

Negaunee Environmental Scholarship Fund

Provides financial assistance for students who attend Negaunee Public Schools and are pursuing a career in an environmental related field, or as the Foundation may determine. 

Distribution Process

• CFMC scholarship recipients will be contacted in June requesting student enrollment verification
• Scholarships can only be distributed once student’s information is received
• Scholarships will be distributed to the college/school/university indicated by student
• The scholarship must be used for tuition and fees required for the enrollment or attendance of the student at a qualifying educational institution; fees, books, supplies, and equipment required for courses of instruction at such an educational institution; and room and board, within the first semester of first year of students enrollment
• That year’s recipient must claim the scholarship within that fiscal year to be distributed (by 12/31/xx)

The Gilead Research Scholars Program in Oncology supports innovative research from emerging investigators worldwide, focusing on scientific understanding and progress in cancer treatment. Launched in 2008, it offers financial support of up to $180,000 over two years to junior faculty who meet eligibility criteria. The program emphasizes diversity and aims to reduce barriers for underrepresented groups in research, fostering a more inclusive landscape in addressing unmet medical needs.

The Seeding Critical Advances for Leading Energy Technologies (Scaleup) Ready initiative by ARPA-E invites applications for funding to advance transformative energy technologies. This program supports innovative projects that demonstrate potential for significant market disruption and emphasizes rigorous project management and technology risk mitigation. Eligible organizations must have inventions conceived during an ARPA-E award, reported in the iEdison system, and hold relevant U.S. patent applications. For further details, visit ARPA-E's website.

The Coors Light Líderes Grant Program honors exceptional Latino leaders across the U.S. and Puerto Rico, awarding five individuals with a $10,000 grant each for their nonprofit organizations. This initiative, active for 17 years, aims to empower emerging leaders who demonstrate significant community impact through innovative programs. Eligible nominees must be between 21-39 years old, associated with a 501(c)(3) nonprofit, and committed to fostering positive change in their communities.

The OVC FY 2026 Enhanced Collaborative Model (ECM) Task Force to Combat Human Trafficking aims to strengthen responses to human trafficking through multidisciplinary collaboration. This initiative provides essential resources for victim identification, service delivery, and case investigations, all supported by the U.S. Department of Justice. By fostering cooperative efforts, the program seeks to enhance the effectiveness of local jurisdictions in combating this critical issue and ensuring the safety and rights of affected individuals.

Knights of Pythias Scholarship Fund

In 1950, the membership roster for the Corvallis lodge of the Knights of Pythias, Valley Lodge No. 11 had more than 250 names, but membership declined over the years and the club subsequently disbanded. In 1992, as remaining members began discussions about how to distribute the assets of the lodge, Benton Community Foundation (BCF) emerged as a natural choice.

“We felt it would be best to keep the money in the community where our members lived and worked,” said Bob Bareinger, a member in the organization since 1943 and an officer since 1954. The lodge tried to give BCF the entirety of assets, including the deed to the building, but the Oregon Chapter that has jurisdiction over it stepped in and required the assets to be distributed differently. BCF received one-third of the lodge assets, which means that the Knights of Pythias will continue to serve the youth of Benton County in perpetuity by providing annual scholarships to graduates of Benton County high schools.

The purpose of America’s Healthy Food Financing Initiative (HFFI) is to improve access to healthy food in underserved areas, to support food supply chain resiliency, to create and preserve quality jobs, and torevitalize low-income communities by providing financial and technical assistance, either directly orthrough other partners and intermediaries, to eligible fresh, healthy food retailers and enterprises toovercome the higher costs and initial barriers to entry in underserved areas. HFFI offers fundingopportunities and technical assistance to eligible applicants.

The Community Foundation of Marquette County distributes over $130,000 annually in scholarships to benefit aspiring students in Marquette County.

Marquette Senior High School Class of 1977 Scholarship Fund 

Provides scholarships to MSHS graduating students who best represent the character, ideals and drive of the Class of 1977. The recipient shall use the scholarship to pursue a college degree or vocational education program of their choice. 

Distribution Process

• CFMC scholarship recipients will be contacted in June requesting student enrollment verification
• Scholarships can only be distributed once student’s information is received
• Scholarships will be distributed to the college/school/university indicated by student
• The scholarship must be used for tuition and fees required for the enrollment or attendance of the student at a qualifying educational institution; fees, books, supplies, and equipment required for courses of instruction at such an educational institution; and room and board, within the first semester of first year of students enrollment
• That year’s recipient must claim the scholarship within that fiscal year to be distributed (by 12/31/xx)

The Hennepin County Youth Activities Grants program, in partnership with the USA Swimming Foundation, aims to enhance youth access to aquatic safety through Swim Lessons Grants. These grants support free or low-cost swim lessons and transportation to lesson locations, addressing disparities in youth drowning rates. Since its inception in 2009, the program has allocated over $31.2 million to various youth activities, including sports and arts, providing vital opportunities for the county's youth.

The Make a SPLASH! Grant Contest invites municipal entities and non-profits in the U.S. to apply for the Inclusive Design Award. This award recognizes splash pads that prioritize inclusivity and accessibility. Winners will receive a customized Life Floor safety surface, valued at $50-65k, promoting community engagement and safety. With two opportunities to win, this initiative aims to enhance splash pad designs, ensuring they cater to all individuals. Join us in making splash pads safer and more accessible for everyone!

The Hennepin County Youth Activities Grants program provides financial support for youth activities, including lifeguard services for individuals aged 21 and younger. With grants up to $50,000, the initiative addresses the youth lifeguard shortage through innovative recruitment, training, and retention strategies. This program has awarded over $31.2 million since its inception in 2009, funded by the Twins ballpark sales tax, ensuring more youth have access to essential water safety training and opportunities.

The Family Medicine Cares USA Free Health Clinic Grants support existing clinics in providing care to the uninsured. Grants of up to $10,000 are available if funds permit, prioritizing clinics with AAFP members in leadership roles. The program emphasizes the involvement of Family Medicine residents or medical students as volunteers, aiming to enhance healthcare access in underserved communities.

KKR Event Sponsorships supports collaborations and programs that address current needs while fostering future growth. The Corporate Citizenship program emphasizes philanthropy, employee engagement, and sustainable community initiatives. Through KKR Cares, employees contribute their skills and time to benefit communities globally. The program focuses on economic opportunity and security, aiding small businesses, social enterprises, and underserved communities through grants, ultimately driving positive outcomes and resilience.

The Fertility Grants (VIVA Program) by the Bob Woodruff Foundation offer vital financial support to wounded veterans facing infertility challenges due to their service-related conditions. Since its inception, the program has assisted over 100 veteran families in starting their own, highlighting a commitment to ensuring veterans have access to necessary fertility treatments. This initiative addresses the unique needs of veterans, recognizing that they experience infertility at nearly double the rate of the general population.

The Frances A. and Joseph B. Levy Family Scholarship Fund, established by the Dallas Jewish Community Foundation, offers a $1,255 scholarship to Jewish doctoral students in veterinary medicine. This fund honors the Levy family's passion for animals and aims to support future veterinarians in their education. Eligible candidates must be enrolled in accredited veterinary programs nationwide, helping them advance their skills to ensure the health and welfare of animals and their communities.

The BISCUITS Grant, offered by Southern Vision Alliance, provides up to $5,000 to organizations with budgets under $300,000 that focus on building power through organizing and collective action. Recipients gain access to a supportive cohort and networking opportunities. Participation in two virtual gatherings and a $500 wellness stipend is included. This grant is aimed at new applicants or those who have submitted their final QMF reports, ensuring support for emerging grassroots organizations.

The NIDCR Dentist Scientist Career Transition Award (K22) supports dentists transitioning from NIH postdoctoral roles to tenure-track faculty positions. It provides two years of mentored research training in the NIH Intramural Research Program, followed by three years of independent research funding at an extramural institution. Key deadlines for grant applications include February 12, 2025, and subsequent dates in June and October 2025, with additional deadlines for renewal and AIDS-related applications.

The Boustany Foundation's Sport 4 Children Award aims to enhance children's lives through sports, fostering happiness, health, and social skills. Open to organizations globally, the award supports projects that utilize sports for children's well-being. With a funding of 50,000 Euros, it encourages innovative and inclusive initiatives that promote participation in sports, aiming to create positive behavioral changes and community engagement. The foundation believes in the transformative power of sports to build responsible and healthy adults.

Seattle Foundation

Seattle Foundation is an agent of change, igniting powerful, rewarding philanthropy to make Greater Seattle a stronger, more vibrant community for all.

At Seattle Foundation, we believe that community is more than a place. It’s the shared understanding that our joy and well-being are tied to one another. Every day we work with nonprofits, philanthropists, and partners like you to strengthen community by igniting powerful philanthropy and advancing long-term solutions. Because it takes all of us to create a joyful region where every person can thrive.

Nora Stone Smith Scholarship

The Nora Stone Smith Scholarship honors and gives financial support to deserving immigrant high school seniors and students who have graduated in the past year and have participated in an ESL/ELL program at some point in their lives. This scholarship is available for all ESL/ELL students, regardless of their citizenship status. Undocumented students are encouraged to apply. This scholarship is $2,000 and renewable for 2 or 4 years.

The Pulitzer Center offers U.S. Local News Reporting Grants aimed at supporting freelance and staff journalists in producing in-depth investigative reporting for local news outlets. This initiative seeks to amplify underreported stories crucial to community engagement, particularly those addressing systemic issues. The grants are available on a rolling basis, encouraging diverse voices in journalism. Applicants must provide a project description, budget estimate, and distribution plan to qualify for funding that covers essential reporting costs.

The DTRF + Thurgood Marshall College Fund Scholarship, offered by the Descendants Truth & Reconciliation Foundation, provides annual need-based scholarships of up to $10,000 for Certified Descendants of Jesuit slaveholding. This initiative aims to support educational advancement at Historically Black Colleges and Universities (HBCUs) and other post-secondary institutions, while promoting racial healing and minimizing the wealth gap within the Descendant community.