Best Large Grants for Nonprofit Organizations in Minnesota

The Minnesota Department of Education is offering grants for remodeling, constructing, or repurposing gender-neutral single-user restrooms. This initiative supports safe and healthy school environments, aiming for improved accessibility and student health. Grant amounts can reach up to $150,000, with a maximum of $75,000 allocated per site. At least 80% of funds must be dedicated to restroom projects, while 20% may be used for engagement and implementation activities, ensuring a comprehensive approach to student safety.

Bristol Myers Squibb Foundation Inc supports independent medical education to enhance healthcare professional competence and improve patient health outcomes. Their mission is to be a global leader in innovative medical education, focusing on evidence-based activities that address critical gaps in knowledge. By fostering excellence in healthcare, they aim to ensure measurable improvements in performance and patient outcomes across various disease areas.

The Bonnycastle Fellowship for Wetland and Waterfowl Research supports graduate students in advancing conservation efforts. Offered by Ducks Unlimited, this fellowship provides up to $17,000 annually for research and personal support. The fellowship emphasizes the importance of research originality, ecological contributions, and feasibility. It is open to all North American graduate students, with a preference for doctoral candidates. The award is renewable for PhD students up to two years, and once for Master's students, contingent on satisfactory progress.

Project Lead The Way is offering a rolling grant for schools to implement the PLTW Biomedical Science program for the 2026-2029 academic years. Eligible schools can receive up to $14,000 to cover participation fees and training costs. This grant encourages public, private, and charter schools across the U.S. to enhance their science curriculum, supporting students with engaging, hands-on learning experiences. Schools must commit to offering specific courses during the grant period to qualify for funding.

About Us

advancing the science of water ®

Who We Are

The Water Research Foundation (WRF) is the leading research organization advancing the science of all water to meet the evolving needs of its subscribers and the water sector. WRF is a 501(c)(3) nonprofit, educational organization that funds, manages, and publishes research on the technology, operation, and management of drinking water, wastewater, reuse, and stormwater systems—all in pursuit of ensuring water quality and improving water services to the public.

5416 - Innovative Approaches to Extend Lifetime and Minimize O&M for Nature-based Installations

Grant Information

• Identify and evaluate innovative design, construction, and management approaches that extend the functional lifetime of nature-based installations and reduce ongoing operations and maintenance (O&M) requirements.
• Develop practical guidance on key factors affecting nature-based solution (NbS) longevity, including hydraulic optimization, engineered media selection and replacement, plant selection, sediment management, and construction-phase best practices.
• Survey utilities and other NbS owners to document current maintenance practices, costs, and hours, and establish benchmarks to inform targets for improvement.

The CHS Foundation supports initiatives that benefit the agriculture industry, focusing on 501c3 organizations within specific states. Their funding is aimed at empowering cooperative growth and sustainable practices. Local projects may also be eligible through the CHS Seeds for Stewardship program. However, funding is not available for individuals, sports teams, or religious groups, ensuring that the support remains directed towards community and cooperative development.

The McKesson Foundation Grant provides funding up to $25,000 for organizations focused on improving health outcomes in underserved communities. Established in 1943, the foundation prioritizes health equity through strategic partnerships aimed at reducing cancer burdens, preparing healthcare professionals, and enhancing crisis response efforts. Eligible applicants include national and local nonprofits targeting specific regions in the U.S. and Canada. The foundation emphasizes projects that align with its mission and demonstrate significant community impact.

The George Family Foundation's Authentic Leadership Grants aim to foster transformative leadership by supporting organizations that align with their mission. The foundation focuses on developing authentic leaders who demonstrate integrity and commitment to social change. They prioritize funding for programs that encourage leadership development across diverse sectors and ensure equitable access to opportunities in higher education, particularly in Minnesota and select areas. Their approach is rooted in building compassionate communities and addressing systemic challenges.

The EDA Chicago FY 2016–FY 2019 Planning Program and Local Technical Assistance Program aims to enhance regional economic development through comprehensive planning and technical assistance. By supporting the development and implementation of Comprehensive Economic Development Strategies (CEDS), EDA empowers designated organizations, including Indian Tribes, to create jobs and foster economic resilience in distressed areas. This initiative focuses on strategic investments to facilitate effective economic development practices, ensuring sustainable growth and prosperity across regions.

Teacher Mentorship and Retention Grant (TMRG) – FY27 – State Funds

The Minnesota Department of Education makes this funding available to Minnesota School Districts, Tribally Controlled Schools, Charter Schools, Cooperative Units, and Coalition of Teachers for the purpose of developing, sustaining, and expanding mentorship programs in order to increase retention and effectiveness of teachers in their first three years of teaching, especially teachers from underrepresented racial and ethnic groups.

Total amount available:

• $3,395,000

The PFund Foundation offers a Sponsorship Fund for events primarily serving LGBTQ+ communities in the upper Midwest. With sponsorship amounts ranging from $500 to $1,000, organizations can apply once per calendar year. Applications must be submitted at least 60 days prior to the event and include information on the event's impact and how funds will be used. PFund aims to foster equity and strengthen networks within its focus areas.

The MHS State Capital Projects Grants-in-Aid Program provides vital funding for the preservation of publicly owned historic buildings in Minnesota. With a minimum grant of $10,001 and no cap on requests, the program encourages projects that restore and rehabilitate these significant structures. Applicants must be political subdivisions eligible for state bond funds, ensuring that the funds are used for public purposes and comply with state regulations. Matching funds are required at a 1:1 ratio.

The Day-End Dough-Nation® Program by Panera Bread exemplifies community generosity through the donation of unsold bakery products to local charities. This impactful initiative supports various organizations that distribute food to those in need, including shelters, health centers, and youth programs. By partnering with thousands of non-profits nationwide, Panera Bread not only reduces food waste but also plays a crucial role in addressing hunger and promoting equality within communities.

The Physician and Advanced Practice Clinician Fellowship Program at Aspirus Wausau Hospital offers a 12-month, full-time opportunity for recent family medicine graduates and practicing physicians. This program aims to enhance skills in hospital medicine, with flexible start dates and two fellowship spots available annually. Aspirus Health, a nonprofit health system in Wisconsin, operates multiple facilities and employs a large team of healthcare professionals, ensuring comprehensive training and support for fellows.

Minnesota Department of Agriculture 

The Minnesota Department of Agriculture (MDA) has served our state for more than 125 years. The work we do touches every Minnesota citizen every day.

Our mission is to enhance all Minnesotans’ quality of life by equitably ensuring the integrity of our food supply, the health of our environment, and the strength and resilience of our agricultural economy.

Our three general areas of responsibility include:

• Protecting our food supply;
• Protecting our natural resources; and,
• Cultivating our agricultural economy.

Cream of the Crop Awards

The Minnesota Grown Cream of the Crop Awards recognizes school districts, early care centers, and family day cares that go above and beyond to promote foods grown and raised by Minnesota farmers and producers. Whether it’s through locally sourced meals served in your cafeteria, community events to connect families and farmers, or food focused classroom lessons, we want to celebrate all the creative ways you connect your students and kids to Minnesota Grown food!

Award Categories

1) Cream of the Crop Winners

One winner from each category will be selected. Scoring will be based on applicants’ promotion and procurement of Minnesota grown and raised foods during the 2025-2026school year.

• School District of the Year
• Early Care Center of the Year
• Family Day Care of the Year

2) Outstanding in the Field Honors

Additional applicants will be honored across three levels:

• Golden Drumstick Honorees
• Silver Squash Honorees
• Bronze Berry Honorees

3) Producer Appreciation Pick

Applicants will have the opportunity to nominate a Minnesota Grown producer that has been an outstanding partner in their Farm to Kids program. Reviewers will randomly select a nominated producer to be the 2026 Producer Appreciation Pick.

The Advanced Practice Clinician (NP or PA) Fellowship Program at Aspirus Health offers a unique 6-month rotation designed for new graduates to excel in hospital medicine. Aspirus Health, a nonprofit system located in Wisconsin and serving parts of Minnesota and Michigan, operates 18 hospitals and numerous outpatient locations. With a dedicated team of nearly 14,000, including 1,300 employed physicians and advanced practice clinicians, this fellowship is also open to experienced APCs transitioning between departments.

The Aspirus Scholars Program, developed by Aspirus and community partners, addresses healthcare needs in Wisconsin, Minnesota, and Michigan. This initiative offers scholarships up to $175,000 to medical students at the MCW-CW Campus in exchange for a service commitment with Aspirus. The program aims to alleviate the debt burden of future medical providers while fostering a commitment to primary care and community connection, ensuring quality healthcare for generations to come.

The Dental Safety Net Grant, funded by the Minnesota Department of Health, aims to support dental providers serving uninsured patients under 21. Annually, up to $113,000 is allocated based on the number of uninsured patients treated. Each provider can receive between 2% and 30% of the total funding. Grants will be distributed over a three-year period, ensuring that financial assistance reaches those most in need.

The Anderson Niskanen Scholarship Fund, established by Suama Niskanen Anderson in 1998, supports graduates from Duluth public high schools in financial need who wish to attend the University of Minnesota Duluth or Twin Cities. This initiative, backed by the Boreal Waters Community Foundation, emphasizes community values and educational access, honoring the legacies of Elmer Anderson and Saima Niskanen. Eligible applicants must have a GPA of 2.5 or higher and demonstrate leadership potential.

The Jeffris Heartland Fund Grant, provided by the Jeffris Family Foundation, supports significant historic preservation projects across several Midwestern states, including Iowa and Wisconsin. Grants range from $5,000 to $50,000, covering 50% of costs for Historic Structure Reports, requiring a dollar-for-dollar match. Eligible applicants include 501(c)(3) organizations and government agencies, focusing on projects with historical significance, architectural merit, and strong community ties. Applications are accepted anytime, with decisions made approximately 30 days after submission.

The University of Minnesota, in collaboration with the Minnesota Department of Health, offers the BRIIDGE program to prepare international medical graduates (IMGs) for residency. This competitive nine-month program includes comprehensive training through inpatient, outpatient, community, and classroom experiences. Participants are selected based on eligibility criteria and personal motivations, ensuring readiness for residency. Accepted applicants must maintain personal health insurance and may not enroll if they match for residency in mid-March. Multiple applications are permitted.

The St. Croix Valley Foundation serves six counties bordering the St. Croix River through local partnerships and place-based philanthropy. We serve:

• Minnesota: Chisago County, Washington County
• Wisconsin: Burnett County, Pierce County, Polk County, St. Croix County

Since our founding in 1995, we’ve:

• Grown to 500+ charitable funds and $100M+ in assets
• Facilitated $100M+ in grants and scholarships, including $5.8 million in 2024
• Partnered with local community affiliates led by volunteers who help guide grantmaking, grow local endowments, and connect donors to opportunities close to home.

Humane Organization Grant Program 

Mission

To enhance the quality of life of shelter/ rescue animals and to increase their chances for adoption. 

The St. Croix Valley Foundation (SCVF) Humane Organization grant program funded by the Compassionate Animal Fund, is accepting applications (invitation only) from Managed Open Admission humane organizations located in the upper Midwest. The grants, ranging up to $3,000, can cover items on your “wish list” including food, supplies, infrastructure needs, and veterinary cost. 

Funding Criteria

Grants are intended to provide funds for items such as food, supplies, medicine, spay/neuter programs (for in-house animals to aid in adoption) newsletters, or other needs and/or programs that most benefit the humane organization.

​We understand that shelters may differ in the services or alternatives they offer during the waiting period prior to intake. If your facility is at capacity, you must provide a clear statement outlining how emergency surrenders and stray animals are handled, including the procedures your organization follows to operate as an Open Admission shelter.  

The UMN Graduate School's MAGS Distinguished Master's Thesis Competition invites nominations for outstanding master's theses in Biological & Life Sciences and Humanities for 2026. Eligible nominees must be pursuing their first graduate research degree and have received their Master's degree between July 1, 2023, and June 30, 2025. The award includes a $500 honorarium and recognition at the MAGS annual competition. Programs may nominate one student to represent their institution.

Benefitting people in the places making the AI future possible

The Future is for Everyone Fund

Meta is investing directly in education, community enhancement, workforce development and sustainability projects in locations where we have a data center in the United States.

The AI future we are building is for everyone. That starts with making sure everyone in the places that are home to a Meta data center feel the benefits in their communities. We want students to have bright futures, small businesses to flourish and communities to be prosperous.

Our commitment to the communities we call home.

The Future is for Everyone Fund supports investments and programs that address local community priorities in the United States, where we have a Meta data center:

We invest in the people and shared spaces that help a community thrive. That includes the parks, trails, and gathering places where neighbors come together, the technology and access that keep them connected, and first responders - like police officers, firefighters, and paramedics — who keep our communities safe.

We support the people and organizations that power local economies - helping workers gain the skills, certifications, and hands-on experience the modern economy rewards, and backing initiatives that create jobs and give a community its character.

We fund the programs, spaces, and tools that help learners of every age discover what they're capable of - from early literacy and the arts to hands-on science, technology, and problem-solving - and we equip the educators who make it happen with the resources to bring their most ambitious lessons to life.

We invest in the long-term health of the land, water, and wildlife that make our communities home - supporting things like habitat restoration and resource conservation that connects people to the natural world.

What is the Future is for Everyone Fund?

The Future is for Everyone Fund is Meta’s $1 billion commitment to invest directly in the U.S. communities that are home to a Meta data center. The Fund supports local schools, nonprofits, and community organizations and is organized into four focus areas that reflect local priorities: Community Enhancement, Economic Vitality, Education, and Sustainability. It builds on the over $70 million in grant funding we’ve provided to our data center communities since 2011.

The Shavlik Family Foundation Grant focuses on funding innovative technology projects that enhance the operational efficiency of nonprofits and Tribal governments in Minnesota. With a commitment to transparency and continuous improvement, the foundation aims to support impactful projects that demonstrate measurable benefits. Eligible organizations must be recognized as 501(c)(3) public charities or Tribal governments, working to improve the lives and environment of Minnesota residents. The grant process encourages discussion of proposals with foundation staff.

The Wold Foundation Grant, established in 1985, aims to support charitable, scientific, literary, and educational projects primarily benefiting Wyoming citizens and youth. It prioritizes initiatives in education, human services, cultural activities, healthcare, and scientific endeavors that promote conservation and outdoor recreation. Eligible organizations must be 501(c)(3) classified and operate in the U.S. The foundation does not fund individuals or projects that discriminate based on sex, age, or religion.

The Raftelis Leadership Scholarship, offered by the American Water Works Association, supports undergraduate and graduate students pursuing a consulting career in water utilities. With a value of $5,000, this scholarship aims to foster relationships with diverse, promising students who demonstrate leadership and strong academic performance. Applicants from various academic backgrounds, including business and finance, are encouraged to apply, emphasizing initiative and a desire to contribute positively to the community.