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Best Large Grants for Nonprofit Organizations in Missouri

Find the perfect Large Grants for Nonprofit Organizations in Missouri on Instrumentl. 10,000+ Large Grants for Nonprofit Organizations in Missouri in the United States.

10,000+

Available grants

$2.59B

Total funding

$5K

Median grant

10,000+ grants
$2.59B total
$5K median

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9,663 Results based on applied filters

Nold, Chad R Family Scholarship: Graduating High School Seniors

Community Foundation Of Northwest Missouri
Private
Missouri
US $1,000

Community Foundation of Northwest Missouri

The Community Foundation of Northwest Missouri Inc. was established in 2009 as a 501(c)3 public charity to help donors support their favorite charities while receiving maximum tax advantage.

We serve as a vehicle for charitable giving, helping donors give to the causes they care about. Donor gifts will strengthen nonprofits increasing programs and services. 

Nold, Chad R Family Scholarship

This fund was established in memory of Chad Nold by his family to provide academic scholarships to students pursuing a Business degree at Missouri Western State University.

Education - Higher Education Business Education

Nationwide Fishing Trap, Removal, Assessment, and Prevention (TRAP) Program

Virginia Institute of Marine Science (VIMS)
State/Local Government
American Samoa, Guam +7 more
US $50,000 - US $200,000
The Nationwide Fishing Trap Removal, Assessment, and Prevention (TRAP) Program aims to eliminate derelict fishing traps nationwide. Focused on collaboration, it emphasizes standardized data collection, quantifying impacts, and comprehensive data sharing. With an annual budget of up to $1,475,000, the program supports 6 to 15 projects, providing grants ranging from $50,000 to $200,000 for 18-month initiatives. This effort significantly enhances marine resource conservation by reducing bycatch mortality and removing abandoned traps.
Carcinology (Crustaceans) Habitat & Ecosystem Restoration Marine / Ocean Conservation +2 more

Nold, Chad R Family Scholarship: Undergraduates

Community Foundation Of Northwest Missouri
Private
Missouri
US $1,000

Community Foundation of Northwest Missouri

The Community Foundation of Northwest Missouri Inc. was established in 2009 as a 501(c)3 public charity to help donors support their favorite charities while receiving maximum tax advantage.

We serve as a vehicle for charitable giving, helping donors give to the causes they care about. Donor gifts will strengthen nonprofits increasing programs and services. 

Nold, Chad R Family Scholarship

This fund was established in memory of Chad Nold by his family to provide academic scholarships to students pursuing a Business degree at Missouri Western State University.

Education - Higher Education Business Education

FDH Scholarship

Community Foundation Of Northwest Missouri
Private
Missouri
Unspecified amount

Community Foundation of Northwest Missouri

The Community Foundation of Northwest Missouri Inc. was established in 2009 as a 501(c)3 public charity to help donors support their favorite charities while receiving maximum tax advantage.

We serve as a vehicle for charitable giving, helping donors give to the causes they care about. Donor gifts will strengthen nonprofits increasing programs and services. 

FDH Scholarship

This fund was established in honor of FDH by his family to provide academic scholarships to graduating seniors of high schools within the 18- county region of The Community Foundation pursuing degrees in Agriculture, Business, or Health Care.

Scholarships will be awarded on an annual basis and disbursed in equal payments in August and January.

Education - Higher Education Vocational & Trade Education

MFA Oil Foundation Grant

Mfa Oil Foundation
Private
Arkansas, Indiana +6 more
Up to US $2,000
The MFA Oil Foundation Grant offers cash support to nonprofit organizations focused on enhancing communities where MFA Oil operates. With a mission to bolster rural areas, the foundation prioritizes initiatives that develop youth leadership, agricultural education, and community problem-solving. Eligible applicants include tax-exempt nonprofits and accredited educational institutions. However, grants are not available for operating expenses, political lobbying, or individual support. This initiative seeks to empower organizations that create sustainable change in their communities.
Education Youth Services Civic Affairs

St Joseph School District Foundation Day, Roger Scholarship

Community Foundation Of Northwest Missouri
Private
Missouri
US $500

Community Foundation of Northwest Missouri

The Community Foundation of Northwest Missouri Inc. was established in 2009 as a 501(c)3 public charity to help donors support their favorite charities while receiving maximum tax advantage.

We serve as a vehicle for charitable giving, helping donors give to the causes they care about. Donor gifts will strengthen nonprofits increasing programs and services. 

St Joseph School District Foundation Day, Roger Scholarship

This fund was established in memory of Roger Day’s dedication to Hillyard Technical Center and his life-long contribution to education. The fund provides academic scholarships to Hillyard Technical Center students in the welding program.

Education - Higher Education Vocational & Trade Education

Food and Agricultural Sciences National Needs Graduate and Postgraduate Fellowships

USDA: National Institute of Food and Agriculture (NIFA)
Federal Government
United States
US $78,000 - US $705,000
The Food and Agricultural Sciences National Needs Graduate and Postgraduate Fellowships program, managed by the USDA's NIFA, aims to enhance the training of new graduate students in food and agricultural sciences. It provides essential funding for master's, DVM, and doctoral students, focusing on developing the next generation of experts to address critical needs in agricultural sciences. This initiative supports U.S. citizens and residents in achieving their educational goals and contributing to the USDA's mission.
Agriculture Forestry Nutrition & Healthy Eating +4 more

St Joseph School District Foundation Barton, Elmer Scholarship

Community Foundation Of Northwest Missouri
Private
Missouri
US $500

Community Foundation of Northwest Missouri

The Community Foundation of Northwest Missouri Inc. was established in 2009 as a 501(c)3 public charity to help donors support their favorite charities while receiving maximum tax advantage.

We serve as a vehicle for charitable giving, helping donors give to the causes they care about. Donor gifts will strengthen nonprofits increasing programs and services. 

St Joseph School District Foundation Barton, Elmer Scholarship

This scholarship program was initiated to recognize the leadership of Mr. Elmer Barton in the field of Industrial Technology. One scholarship recipient will be selected annually to receive a $500.00 scholarship. 

Education - Higher Education Vocational & Trade Education

Diann Bomkamp Leadership Scholarship

American Dental Hygienists’ Association (ADHA)
Private
Missouri
US $1,000
The Diann Bomkamp Leadership Scholarship, offered by the American Dental Hygienists’ Association (ADHA), supports students pursuing an Associate Degree in Dental Hygiene in Missouri. Eligible applicants are required to demonstrate leadership within their Student ADHA Chapter and show active community volunteerism. A minimum GPA of 3.0 is necessary, along with enrollment in an accredited dental hygiene program, ensuring students have the resources to excel in their education and future careers.
Dental Health Medical Education & Professional Training

MO Agricultural Conservation Easement Program (ACEP): Wetland Reserve Easements (WRE)

USDA: Natural Resources Conservation Service of Missouri
State/Local Government
Missouri
Unspecified amount
The MO Agricultural Conservation Easement Program (ACEP) offers Wetland Reserve Easements (WRE) to assist landowners in restoring and protecting wetlands that have been degraded by agricultural practices. This program enhances habitat for wildlife, improves water quality, and mitigates flooding, while providing landowners with financial support for easement acquisition and restoration efforts. NRCS prioritizes applications that significantly benefit migratory birds and other wildlife, ensuring ecological sustainability and resilience against climate change.
Land / Habitat Conservation

MO Environmental Quality Incentives Program (EQIP)

USDA: Natural Resources Conservation Service of Missouri
State/Local Government
Missouri
Unspecified amount
The MO Environmental Quality Incentives Program (EQIP) is a key initiative by NRCS aimed at assisting farmers and forest landowners in integrating conservation practices into their operations. EQIP offers both financial and technical support to address vital natural resource issues including water quality, soil health, and erosion control. Applications are accepted year-round, and special provisions exist for historically underserved producers, ensuring equitable access to vital resources for sustainable agricultural practices.
Farms & Farming

MO Conservation Stewardship Program (CSP)

USDA: Natural Resources Conservation Service of Missouri
State/Local Government
Missouri
Unspecified amount
The MO Conservation Stewardship Program (CSP) empowers agricultural producers to enhance their conservation practices and improve resource management on their lands. This program offers financial incentives based on conservation performance, encouraging sustainable agriculture across 70 million acres in the U.S. All producers, regardless of operation size, can apply, ensuring inclusivity. CSP contracts last five years, with the option to renew, promoting long-term stewardship of land while benefiting local ecosystems and communities.
Farms & Farming

Advancing HIV/AIDS Research within the Mission of the NIDCD (R21 Clinical Trial Optional) (358080)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $275,000
The NIDCD is offering funding to advance HIV/AIDS research, particularly focusing on areas related to communication disorders. This initiative supports low-risk clinical trials and encourages researchers to align their proposals with high priority topics identified by the NIH Office of AIDS Research. Applications must be submitted by the local deadline, with optional Letters of Intent due 30 days prior to the proposal deadline. This opportunity aims to enhance understanding and treatment in this crucial health area.
HIV / AIDS Hearing Disorders & Audiology Communication Disorders +1 more

SEARCH - Special Evaluation Assistance for Rural Communities and Households Grant

USDA: Rural Development (RD)
Federal Government
United States
Unspecified amount
The SEARCH Grant provides essential support for very small, financially distressed rural communities by funding predevelopment feasibility studies and technical assistance for water and waste disposal projects. Eligible applicants include state and local governments, nonprofits, and federally recognized tribes. Funds can be used for feasibility studies, design analysis, and technical help in securing financial assistance, ensuring improvements in rural infrastructure and community health.
Sanitation & Clean Drinking Water Waste Management Water Resource Management +2 more

Arts Fund Grants

American Australian Association
Private
Australia, United States
US $5,000
The Arts Fund Grants provide vital support for emerging artists from Australia and the USA, facilitating their artistic development through grants of up to $5,000. This funding can be used for travel, living expenses, tuition, and other related costs. Eligible applicants must be citizens or permanent residents of either country and have a formal offer from an accredited institution. The program emphasizes merit-based opportunities across various artistic fields, fostering international collaboration and cultural exchange.
Music Writing & Literature Theater +8 more

Water and Waste Facility Loans and Grants to Alleviate Health Risks for Colonias

USDA: Rural Development (RD)
Federal Government
United States
Unspecified amount
The USDA Rural Development program provides essential loans and grants to improve water and waste disposal services in low-income communities, specifically targeting Colonias recognized before 1989. This initiative aims to alleviate health risks associated with inadequate access to safe drinking water and waste management. Eligible applicants include federally-recognized tribes and local governments, with funds supporting the construction of vital infrastructure to ensure community health and sustainability.
Sanitation & Clean Drinking Water Epidemiology & Public Health Waste Management +3 more

Lozier Foundation Program Application

The Lozier Foundation
Private
Alabama, Indiana +4 more
Unspecified amount

The Lozier Foundation

The Lozier Foundation is a private family foundation based in Omaha, Nebraska, funded by Allan and Dianne Lozier. The Foundation supports nonprofit organizations working to expand opportunity, strengthen communities, and improve quality of life for people and families who have historically had less access to resources.

The Foundation’s grantmaking is grounded in a long-term commitment to Omaha and the surrounding region. We are especially interested in work that helps level the playing field, supports people during important moments of need or transition, and gives individuals and families greater ability to make choices about their own lives and futures.

The Foundation’s support has historically focused on established nonprofit organizations working in areas such as education, human services, youth development, health, family stability, and community well-being. While those areas describe much of our grantmaking, they are not intended to serve as fixed categories or a comprehensive list.

The Foundation is selective in its grantmaking. We generally support organizations with a meaningful operating history, capable leadership, sound governance, financial discipline, and a demonstrated ability to serve the community effectively. The Foundation does not typically support early-stage organizations, small projects or organizations with limited reach, or requests that fall outside our geographic and charitable priorities.

The Foundation also considers whether a request reflects a clear understanding of the existing community landscape. We are generally skeptical of efforts that duplicate services already being provided effectively by other organizations, particularly when collaboration, coordination, or partnership would better serve the community. Organizations seeking support should be prepared to explain how their work fits within the broader field, who they collaborate with, and why the proposed work is needed.

Grants

Grantseekers wishing to apply to the Lozier Foundation should begin by reviewing the Mission, Values, Funding Priorities and Funding Eligibility Statements.

The Lozier Foundation grant applications include: Capital Application; Education Application; General Application; and Program Application.

Organizations may receive general operating, program, and capital grants. While The Lozier Foundation prefers to provide ongoing general operating support, organizations can receive a program and/or capital grant in the same calendar year.

Lozier Foundation Program Application

Funding Priorities

  • Education
  • Women & Girls
  • North Omaha Initiatives
  • Human Services

The Program Application follows the foundation guidelines provided here.

Education Women & Girl Services Human & Social Services

Pilot Studies of Biological, Behavioral and Social Mechanisms Contributing to HIV Pathogenesis Within the Mission of NIDDK (R21 Clinical Trial Not Allowed) (358082)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $275,000
This funding opportunity invites innovative pilot studies focused on biological, behavioral, and social mechanisms related to HIV pathogenesis, aligning with NIDDK's mission and NIH HIV/AIDS research priorities. Topics may include exploring pathophysiological mechanisms of HIV comorbidities and coinfections, understanding HIV reservoirs in relevant tissues, and examining social determinants affecting health outcomes. Applications are due by 5:00 PM local time of the applicant organization.
HIV / AIDS Diabetes Kidney Diseases +1 more

The Standard's Corporate Giving Program

The Standard Charitable Foundation
Corporate
United States
US $500 - US $25,000
The Standard's Corporate Giving Program emphasizes community support and employee engagement, reflecting its foundational mission to enhance financial well-being. Established in 1906, the program focuses on Healthy Communities, Disability and Empowerment, Cultural Development, and Education. With a funding range of $500 to $25,000, it aims to make a substantial impact in the lives of individuals and families facing challenges. The Standard Charitable Foundation, launched in 2006, further extends this commitment by supporting organizations that align with its philanthropic goals.
Workforce Preparation & Job Readiness Education - Preschool / Early Learning Basic Human Needs +12 more

Exchange Bank Scholarship

Community Foundation Of Northwest Missouri
Private
Missouri
Unspecified amount

Community Foundation of Northwest Missouri

The Community Foundation of Northwest Missouri Inc. was established in 2009 as a 501(c)3 public charity to help donors support their favorite charities while receiving maximum tax advantage.

We serve as a vehicle for charitable giving, helping donors give to the causes they care about. Donor gifts will strengthen nonprofits increasing programs and services. 

Exchange Bank Scholarship

This fund was established by John Nixon to provide academic scholarships to graduating seniors of Mound City High School, MO. John is a 1958 graduate of Mound City High School and was one of the original recipients of the Exchange Bank Scholarship. It is his desire to provide scholarships for deserving young people to further their education just as he did

Education - Higher Education Vocational & Trade Education

Water and Waste Facility Loans and Grants to Alleviate Health Risks on Tribal Lands

USDA: Rural Development (RD)
Federal Government
United States
Unspecified amount
The Water and Waste Facility Loans and Grants program aims to provide safe drinking water and waste disposal services to low-income communities on Tribal lands, addressing significant health risks. Eligible applicants include federally-recognized Tribes, state and local governments, and nonprofit organizations. Funding can be used for constructing essential water and waste systems, and while matching funds are typically required, a full grant is possible under certain conditions. Applications are accepted year-round.
Sanitation & Clean Drinking Water Waste Management Water Resource Management +3 more

Allen, Mollie J and Nelson G Scholarship: Scholarship 2

Community Foundation Of Northwest Missouri
Private
Missouri
Up to US $5,000

Community Foundation of Northwest Missouri

The Community Foundation of Northwest Missouri Inc. was established in 2009 as a 501(c)3 public charity to help donors support their favorite charities while receiving maximum tax advantage.

We serve as a vehicle for charitable giving, helping donors give to the causes they care about. Donor gifts will strengthen nonprofits increasing programs and services. 

Allen, Mollie J and Nelson G Scholarship

This fund was established to provide academic scholarships to graduating seniors of Northwest Missouri intending to pursue a degree in education at a 2 or 4-year college/university or a Vocational degree/certificate at a 2-year college or Vocational/Technical School.

There are two types of this scholarship: Scholarship 1 and Scholarship 2

One recipient will be chosen for each scholarship. Scholarship 1 is awarded on an annual basis and is renewable for up to 4 years with disbursements in August and January. Scholarship 2 is awarded on an annual basis and is renewable for up to 2 years if needed. 

Scholarship 2

The students eligible shall be graduating seniors of a high school within the 18-county region of The Community Foundation intending to pursue a certificate/degree through an accredited two-year college or Vocational/Technical School. Students must submit a reference letter from a school staff or community member.

Scholarship 2 renewing students must have a GPA of 2.5 or higher to be eligible.

Education - Higher Education Vocational & Trade Education

Allen, Mollie J and Nelson G Morgan County R-II Scholarship

Community Foundation Of Northwest Missouri
Private
Missouri
Up to US $20,000

Community Foundation of Northwest Missouri

The Community Foundation of Northwest Missouri Inc. was established in 2009 as a 501(c)3 public charity to help donors support their favorite charities while receiving maximum tax advantage.

We serve as a vehicle for charitable giving, helping donors give to the causes they care about. Donor gifts will strengthen nonprofits increasing programs and services. 

Allen, Mollie J and Nelson G Morgan County R-II Scholarship

This fund was established by Mollie and Nelson Allen to provide academic scholarships to graduating high school seniors in the Morgan County R-II School District.

Education - Higher Education Vocational & Trade Education

A+ Scholarship Program (MO)

Missouri Department of Higher Education and Workforce Development
State/Local Government
Missouri
Unspecified amount
The A+ Scholarship Program, managed by the Missouri Department of Higher Education and Workforce Development, offers financial assistance to graduates of A+ designated high schools who enroll in participating community colleges or vocational schools. This merit-based scholarship covers tuition and fees after non-loan federal aid has been applied, and eligibility requires maintaining academic standards and fulfilling certain attendance and mentorship criteria. It supports students in achieving educational and career success.
Education - Higher Education Vocational & Trade Education

Asian Cultural Council: Graduate Fellowship

Asian Cultural Council Inc
Private
United States
US $15,000
The Asian Cultural Council's Graduate Fellowship provides financial support for travel and living expenses to graduate students from Asia studying in the U.S. It offers $15,000 for one academic year, potentially renewable for another year, covering essential costs while pursuing full-time coursework. This initiative fosters international cultural exchange and enhances academic training in the arts. Eligible applicants must be enrolled full-time in accredited graduate programs and commit to at least two consecutive semesters of study.
Art Conservation Archaeology Museums & Cultural Institutions +9 more

Patterson Foundation: Assistance Dog Program Grants

Patterson Dental Foundation
Private
Alabama, Alaska +46 more
Up to US $35,000
The Patterson Foundation offers Assistance Dog Program Grants to support organizations providing service animals to veterans and individuals with disabilities. Funding is available for projects that expand capacity, personnel costs related to puppy training, and program support aimed at improving client experiences. Eligible organizations must be 501(c)(3) non-profits and can request grants up to $35,000 for capital projects or $10,000 for program support. Applications are accepted through a two-step process.
Service Animals

Innovation Grant to Expand a Child Care Program (MO)

Missouri Department of Elementary and Secondary Education
State/Local Government
Missouri
Unspecified amount
The Innovation Grant to Expand a Child Care Program in Missouri aims to enhance access to quality child care for families by providing funding to licensed providers. This initiative, supported by the Child Care Development Fund, encourages business partnerships and community contributions to address the child care shortage. Eligible providers can utilize the funds for expansion, staff training, and facility improvements, ensuring compliance with state health and safety standards and promoting a robust workforce in early childhood education.
Child Care Services

Large Grants for Nonprofit Organizations in Missouri Highlights

Looking for large grants for nonprofit organizations in Missouri?


Read more about each grant below or start your 14-day free trial to see all large grants for nonprofit organizations in Missouri recommended for your specific programs.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Large Grants for Nonprofit Organizations in Missouri

Grant Availability

How common are grants in this category?

Common — grants in this category appear regularly across funding sources.

100+ Large Grants for Nonprofit Organizations in Missouri grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

37 Large Grants for Nonprofit Organizations in Missouri over $25K in average grant size

29 Large Grants for Nonprofit Organizations in Missouri over $50K in average grant size

25 Large Grants for Nonprofit Organizations in Missouri supporting general operating expenses

100+ Large Grants for Nonprofit Organizations in Missouri supporting programs / projects

600+ Grants on Instrumentl focused on Food Access & Hunger

3,000+ Grants on Instrumentl focused on Education

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Large grants for Nonprofit Organizations in Missouri?

Most grants are due in the first quarter.

Q1
33.7%
Q2
26.8%
Q3
18.7%
Q4
20.8%

Typical Funding Amounts

What's the typical grant amount funded for Large Grants for Nonprofit Organizations in Missouri?

Grants are most commonly $13,750.

$375 $375 Min.
$13,750 $13.8 K Median
$587,301 $587.3 K Average
$40,331,313 $40.3 M Max.

Average Grant Size

What's the typical amount funded for Missouri?

Grants are most commonly $101,542.

$101,542

Total Number of Grants

What's the total number of grants in Large Grants for Nonprofit Organizations in Missouri year over year?

In 2024, funders in Missouri awarded a total of 44,064 grants.

2022 39,922

2023 39,688

2024 44,064

Top Grant Focus Areas

Among all the Large Grants for Nonprofit Organizations in Missouri given out in Missouri, the most popular focus areas that receive funding are Philanthropy, Voluntarism & Grantmaking Foundations, Education, and Human Services.

1. Philanthropy, Voluntarism & Grantmaking Foundations

2. Education

3. Human Services

Funding Over Time

How is funding for Large Grants for Nonprofit Organizations in Missouri changing over time?

Funding has increased by -15.61%.

2022 $4,698,402,122

2023 $5,287,874,816
12.55%

2024 $4,462,369,205
-15.61%

Missouri Counties That Receive the Most Funding

How does grant funding vary by county?

St Louis County, Jackson County, and St Louis City receive the most funding.

County Total Grant Funding in 2024
St Louis County $2,185,711,864
Jackson County $1,234,679,326
St Louis City $1,054,441,922
Greene County $223,079,775
Clay County $178,423,081