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Best Large Grants for Nonprofit Organizations in Missouri

Find the perfect Large Grants for Nonprofit Organizations in Missouri on Instrumentl. 10,000+ Large Grants for Nonprofit Organizations in Missouri in the United States.

10,000+

Available grants

$2.59B

Total funding

$5K

Median grant

10,000+ grants
$2.59B total
$5K median

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9,667 Results based on applied filters

Open Ocean Research Grant Program

Global Fishing Watch Inc
Private
Algeria, Andorra +155 more
Up to US $20,000
The Open Ocean Research Grant Program, funded by Global Fishing Watch Inc, aims to enhance ocean governance through data sharing on human activity at sea. It invites researchers to improve technologies for better governance, offering up to $10,000 for individuals and $20,000 for small groups. This initiative strengthens the community of practice and optimizes Global Fishing Watch datasets to maximize their impact on ocean conservation efforts.
Oceanography Marine / Ocean Conservation Marine Biology

Peer Education Grant

Organization For Autism Research
Private
United States
US $500 - US $10,000
The Peer Education Grant, offered by the Organization for Autism Research, aims to enhance autism acceptance among children by providing educational resources and funding for initiatives. Grants of up to $10,000 support school-wide projects, with smaller grants available for other activities. Eligible applicants include educators and community organization leaders focused on autism awareness, particularly in low-income areas. This initiative fosters inclusive relationships and understanding between children and their autistic peers.
Autism

Cultural Capital (CC) Fellowship

First Peoples Fund
Private
United States
US $10,000
The Cultural Capital Fellowship offers $10,000 grants to Native artists and culture bearers dedicated to community outreach and cultural preservation. This fellowship strengthens the Collective Spirit of First Peoples artists, emphasizing the importance of passing on ancestral knowledge and maintaining cultural sharing. Eligible applicants must have strong ties to their Native community and be committed to sustaining cultural practices. The fellowship aims to support those who promote generosity, wisdom, and integrity within their communities.
Community Culture & Heritage Folk Art / Traditional Art Native American Culture & Heritage

Jennifer Easton Community Spirit Award

First Peoples Fund
Private
United States
Up to US $50,000
The Jennifer Easton Community Spirit Award honors Native artists who have dedicated their lives to sharing cultural knowledge and ancestral gifts. With a grant of $50,000, this award supports artists deeply rooted in their communities, fostering healing and resilience. Nominations are open for practicing artists across various mediums, including music, dance, and storytelling, ensuring the continuation of Indigenous traditions and the enrichment of Native culture.
Native American Culture & Heritage Arts / Culture Access & Participation Folk Art / Traditional Art

Native Performing Arts Fellowship (NPA) Fellowship

First Peoples Fund
Private
United States
Up to US $10,000
The Native Performing Arts Fellowship (NPA) supports Native artists in enhancing their craft through grants of up to $10,000. This fellowship prioritizes personal artistic development over project-based funding, encouraging applicants to focus on growth through classes, workshops, and professional mentorship. Eligible candidates must be U.S.-based, 18 years or older, and enrolled members of recognized tribes. The program emphasizes Indigenous values in performing arts, fostering resilience and cultural expression.
Performing Arts Native American Culture & Heritage Arts / Culture Access & Participation

Ollie Hinkle Heart Foundation: Technology Grant

Ollie Hinkle Heart Foundation
Private
United States
Unspecified amount
The Ollie Hinkle Heart Foundation's Technology Grant aims to improve pediatric heart care outcomes through innovative collaborations. By focusing on predictive technologies for early recognition, precision for personalized care, and preventive measures for quality of life, the foundation seeks to transform care for heart children and their families. Their mission emphasizes community support, education, and advocacy to ensure no family faces unmet needs alone, creating a legacy of love and courage in the heart community.
Cardiovascular Diseases & Systems Children’s Health & Pediatrics Medical Technology, Devices, and Equipment

VFW's Sport Clips Help A Hero Scholarship

Veterans Of Foreign Wars Of
Private
United States
Up to US $5,000
The VFW's Sport Clips Help A Hero Scholarship offers financial support of up to $5,000 to eligible veterans and service members pursuing their educational goals. This initiative, backed by the Veterans of Foreign Wars organization, aims to alleviate the burden of student debt for those who have served our country. By partnering with Student Veterans of America and Sport Clips, the VFW ensures that veterans receive the assistance they deserve to succeed in their academic endeavors.
Military & Veterans Services Educational Access & Equity Education - Higher Education

ASF Family Fund Grant

Angelman Syndrome Foundation
Private
United States
Up to US $5,000
The ASF Family Fund Grant, offered by the Angelman Syndrome Foundation, provides crucial financial assistance to families of individuals with Angelman syndrome. This rare neuro-genetic disorder affects approximately 500,000 people globally. The fund aims to enhance the quality of life for affected individuals, allowing caregivers to apply for up to $5,000 to cover essential needs. Limitations include restrictions on certain expenses and prior grant awards. This initiative aims to support families through education and necessary resources.
Family Services Disability Care & Services Intellectual / Developmental Disabilities

CFF/NIH R01-Unfunded Award

Cystic Fibrosis Foundation
Private
United States
Up to US $125,000
The CFF/NIH R01-Unfunded Award, offered by the Cystic Fibrosis Foundation, supports exceptional CF-related research projects that have been submitted to NIH but lack funding. This program aims to bridge the gap for meritorious projects, providing up to $125,000 per year for two years. By facilitating research in cystic fibrosis, the foundation helps ensure that innovative ideas can continue to progress toward improving care and outcomes for individuals affected by this disease.
Cystic Fibrosis

CF Foundation/NIH K-Unfunded Award

Cystic Fibrosis Foundation
Private
United States
Up to US $125,000
The CF Foundation/NIH K-Unfunded Award aims to support exceptional research projects in cystic fibrosis (CF) that have been approved by the NIH but lack funding. This award provides temporary financial assistance of up to $80,000 per year for two years to ensure that promising CF research continues without interruption. The initiative focuses on fostering a new generation of researchers dedicated to advancing CF studies while encouraging the NIH to provide long-term support.
Cystic Fibrosis

Cystic Fibrosis Foundation: Student Traineeship Award

Cystic Fibrosis Foundation
Private
United States
Up to US $4,000
The Cystic Fibrosis Foundation's Student Traineeship Award supports students in engaging with cystic fibrosis research through hands-on projects. With a maximum funding of $4,000 for one year, the program aims to inspire students to pursue careers in CF research or care. Eligible applicants must be enrolled in a degree program and collaborate with a faculty mentor on a relevant project. This initiative also emphasizes the importance of maintaining interest in CF-related research among new generations.
Cystic Fibrosis

Cystic Fibrosis Foundation: Travel Award Supplement

Cystic Fibrosis Foundation
Private
United States
Up to US $3,000
The Cystic Fibrosis Foundation offers a Travel Award Supplement aimed at supporting Ph.D. students, postdoctoral fellows, and junior faculty. This funding of up to $3,000 enables trainees to participate in off-site workshops or training programs to enhance their research skills. Eligible applicants must be active researchers in CF projects, with a minimum of one year of experience. The program excludes conference attendance and for-profit entities, ensuring focused support for advancing cystic fibrosis research.
Cystic Fibrosis

Harry Shwachman Clinical Investigator Award

Cystic Fibrosis Foundation
Private
United States
Up to US $133,000
The Harry Shwachman Clinical Investigator Award, offered by the Cystic Fibrosis Foundation, supports clinically trained physicians transitioning to independent researchers in cystic fibrosis. It provides up to $133,000 per year for three years to facilitate research tailored to individual interests. The funding covers personnel costs and supplies, promoting a strong mentorship during this critical stage of their academic careers.
Cystic Fibrosis

Path to a Cure (PTAC) - Postdoc-to-Faculty Transition Award

Cystic Fibrosis Foundation
Private
United States
Up to US $86,000
The Path to a Cure (PTAC) - Postdoc-to-Faculty Transition Award by the Cystic Fibrosis Foundation supports postdoctoral fellows in advancing their research careers in cystic fibrosis. This program offers up to five years of funding, including 3 years for research training and 2 years for transitioning to an independent faculty position, with a maximum support of $110,000 per year. It aims to foster innovative research that develops new therapies for cystic fibrosis.
Cystic Fibrosis

Path to a Cure (PTAC) - Postdoctoral Research Fellowship Award

Cystic Fibrosis Foundation
Private
United States
Up to US $76,000
The Cystic Fibrosis Foundation offers the Path to a Cure (PTAC) Postdoctoral Research Fellowship Award to support innovative research training in cystic fibrosis (CF). Aimed at enhancing scientific knowledge and facilitating the transition to independent careers, this program funds projects targeting the development of new therapies for CFTR variants. Awards can reach up to $75,000 in the first year and $76,000 in the second year, fostering foundational research that could lead to breakthroughs in CF treatment.
Cystic Fibrosis

Financial Assistance & Scholarships for Education

Pizza Hut Foundation
Private
United States
US $500 - US $5,000
The Pizza Hut Foundation is offering scholarships for students demonstrating financial need and community leadership. Eligible applicants must be U.S. residents aged 17-26, enrolled in accredited post-secondary education for Spring 2026, and maintain a minimum GPA of 2.5. Scholarship amounts range from $500 to $5,000, with distribution to be made in Spring 2026. The application period runs from July 8 to September 5, 2025, with notifications for recipients by November 17, 2025.
Vocational & Trade Education Academic Scholarship Programs College Success / Persistence

Exhibitions Abroad Support Grant Program

Japan Foundation, New York
Private
Africa, Americas +14 more
Unspecified amount
The Exhibitions Abroad Support Grant Program, initiated by the Japan Foundation in New York, offers financial aid to U.S. museums and art institutions organizing exhibitions that showcase Japanese art and culture internationally. This program supports a range of events, including biennials and triennials featuring Japanese artists. Eligible applicants are non-profit organizations from designated states, with a focus on promoting cultural exchange and understanding through art.
Asian Art Asian / Pacific Island Culture & Heritage

Karl A. Bickel and Madira Bickel Journalistic Scholarship Fund Grant

Karl A Bickel Charitable Trust
Private
United States
Approximately US $40,000
The Karl A. Bickel and Madira Bickel Journalistic Scholarship Fund Grant supports journalism students at accredited colleges and universities. Established under Karl A. Bickel's Last Will and Testament, it awards approximately $40,000 annually. Eligible organizations must have journalism programs and qualify as 501(c)(3) exempt entities. While there are no geographical restrictions, preference is given to institutions in Florida. The fund is administered by Wells Fargo Bank, ensuring that deserving students receive necessary financial support.
Education - Higher Education Journalism Academic Scholarship Programs

Anna B. Glauser Trust Grants

Anna B Glauser Trust Will Nect
Private
United States
US $2,500 - US $5,000
The Anna B. Glauser Trust Grants provide financial support to organizations aiding physically handicapped individuals, particularly blind residents in Delaware County, PA. Established in memory of Willis K. Glauser, the trust awards 1-2 grants annually, ranging from $2,500 to $5,000. Eligible organizations must be 501(c)(3) certified, while funding for salaries is typically excluded. This initiative reflects Anna Glauser's lifelong commitment to assisting the visually impaired community.
Vision Impairment Care & Services Physical Disabilities

William C. Risser Charitable Trust Grants

William C Risser Irrev Trust 1865-4019875730
Private
United States
US $25,000 - US $55,000
The William C. Risser Charitable Trust Grants support mental health research, particularly in Schizophrenia. This private foundation assists 501(c)(3) nonprofit organizations across the U.S. with grants typically ranging from $25,000 to $55,000. Administered by Wells Fargo, the Trust awards 1-2 grants annually, focusing on program support for scientific and educational research. Eligible organizations must meet IRS exemption requirements.
Schizophrenia

Delta Scholarship

Jewish Community Foundation Of San Diego
Private
United States
Up to US $40,000
The Delta Scholarship aims to support college-bound minority students in San Diego County who are dedicated to pursuing higher education. Established in memory of Jim Lewis, a passionate community leader, this scholarship offers up to $10,000 per student annually for four years, based on financial need. Eligible applicants must be graduating high school seniors with a minimum GPA of 3.0, planning to attend an accredited college or university.
Education - Higher Education Career / College Preparation Academic Scholarship Programs

ESA Youth Scholarship Program

Electronic Security Association
Association/Society
United States
US $2,500 - US $15,000
The ESA Youth Scholarship Program, by the Electronic Security Association, provides financial support to children of first responders, having awarded over $941,500 to date. Eligible applicants are high school seniors with parents who are full-time active first responders. Each scholarship winner receives $1,000 and a chance to compete for larger awards of $14,000 for first place and $5,000 for second place. Applications are welcomed from students in participating states.
Emergency Medical Care & Services Academic Scholarship Programs First Responders

NIGMS Institutional Biomedical Undergraduate Research Training Program

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The NIGMS Institutional Biomedical Undergraduate Research Training Program aims to enhance the training of undergraduate students in biomedical research. By supporting institutions with limited NIH funding, the program provides trainees with 2–3 years of full-time research training. This initiative fosters a skilled workforce prepared for advanced biomedical degrees, addressing national health-related research needs through comprehensive educational and developmental programs.
Biology Biotechnology Biochemistry +2 more

National MS Society: Harry Weaver Scholar Awards

National Multiple Sclerosis Society
Association/Society
United States
Unspecified amount
The National MS Society offers Harry Weaver Scholar Awards to support emerging researchers in multiple sclerosis. This prestigious award honors Dr. Harry Weaver's legacy and aims to facilitate independent research careers. Eligible candidates must have a doctoral degree and relevant postdoctoral training. The funding is designed to provide salary and grant support for five years, allowing awardees to establish competence in their research area. Applications should align with the Society's Pathways to Cures Roadmap.
Multiple Sclerosis

Clinician Scientist Development Awards

National Multiple Sclerosis Society
Association/Society
United States
Unspecified amount
The National MS Society's Clinician Scientist Development Awards aim to cultivate promising young investigators in multiple sclerosis research. This program supports postdoctoral fellows with three years of comprehensive training in academic medicine focused on MS. Applicants must hold a clinical degree and be licensed in the U.S. The Society prioritizes research that aligns with its Pathways to Cures Roadmap, which emphasizes stopping disease progression, restoring function, and preventing MS.
Multiple Sclerosis

Young Investigator Grants

Breast Cancer Alliance Inc
Private
United States
US $125,000
The Young Investigator Grants, offered by the Breast Cancer Alliance, aim to support early-career researchers focused on breast cancer. This two-year grant provides up to $125,000 in funding, split across the duration, to facilitate independent research projects. Applicants must be affiliated with U.S. institutions and should not have held major grant support previously. This initiative fosters innovation in breast cancer research, ultimately enhancing survival rates and quality of life for affected individuals.
Breast Cancer

Exceptional Project Grants

Breast Cancer Alliance Inc
Private
United States
US $100,000
The Breast Cancer Alliance offers Exceptional Project Grants aimed at enhancing survival rates and quality of life for individuals affected by breast cancer. This grant, amounting to $100,000 over one year, supports innovative research and projects in the contiguous United States. Eligible applicants include clinical doctors and research scientists at any career stage. The funding covers salary and project costs, with indirect costs capped at 8% of direct costs, ensuring comprehensive support for impactful research.
Breast Cancer

Large Grants for Nonprofit Organizations in Missouri Highlights

Looking for large grants for nonprofit organizations in Missouri?


Read more about each grant below or start your 14-day free trial to see all large grants for nonprofit organizations in Missouri recommended for your specific programs.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Large Grants for Nonprofit Organizations in Missouri

Grant Availability

How common are grants in this category?

Common — grants in this category appear regularly across funding sources.

100+ Large Grants for Nonprofit Organizations in Missouri grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

37 Large Grants for Nonprofit Organizations in Missouri over $25K in average grant size

29 Large Grants for Nonprofit Organizations in Missouri over $50K in average grant size

25 Large Grants for Nonprofit Organizations in Missouri supporting general operating expenses

100+ Large Grants for Nonprofit Organizations in Missouri supporting programs / projects

600+ Grants on Instrumentl focused on Food Access & Hunger

3,000+ Grants on Instrumentl focused on Education

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Large grants for Nonprofit Organizations in Missouri?

Most grants are due in the first quarter.

Q1
33.7%
Q2
26.8%
Q3
18.7%
Q4
20.8%

Typical Funding Amounts

What's the typical grant amount funded for Large Grants for Nonprofit Organizations in Missouri?

Grants are most commonly $13,750.

$375 $375 Min.
$13,750 $13.8 K Median
$587,301 $587.3 K Average
$40,331,313 $40.3 M Max.

Average Grant Size

What's the typical amount funded for Missouri?

Grants are most commonly $101,542.

$101,542

Total Number of Grants

What's the total number of grants in Large Grants for Nonprofit Organizations in Missouri year over year?

In 2024, funders in Missouri awarded a total of 44,064 grants.

2022 39,922

2023 39,688

2024 44,064

Top Grant Focus Areas

Among all the Large Grants for Nonprofit Organizations in Missouri given out in Missouri, the most popular focus areas that receive funding are Philanthropy, Voluntarism & Grantmaking Foundations, Education, and Human Services.

1. Philanthropy, Voluntarism & Grantmaking Foundations

2. Education

3. Human Services

Funding Over Time

How is funding for Large Grants for Nonprofit Organizations in Missouri changing over time?

Funding has increased by -15.61%.

2022 $4,698,402,122

2023 $5,287,874,816
12.55%

2024 $4,462,369,205
-15.61%

Missouri Counties That Receive the Most Funding

How does grant funding vary by county?

St Louis County, Jackson County, and St Louis City receive the most funding.

County Total Grant Funding in 2024
St Louis County $2,185,711,864
Jackson County $1,234,679,326
St Louis City $1,054,441,922
Greene County $223,079,775
Clay County $178,423,081