Best Large Grants for Nonprofit Organizations in Missouri

The Lenora Jane Perdue Scholarship, offered by the North East Community Foundation, supports graduating seniors from Westfield Academy, Ripley Central School, and North East High School pursuing a degree in education. Applicants must maintain a GPA of 3.0 or higher. This scholarship aims to encourage and assist students dedicated to a career in teaching, fostering the next generation of educators in their community.

The ASTRO-AAPM Physics Resident/Post-Doctoral Fellow Seed Grant supports early-career scientists in radiation oncology physics research. Jointly funded by AAPM and ASTRO, this grant aims to foster innovation in the field, with up to two awards of $50,000 each available. Eligible applicants include medical physics residents and post-doctoral fellows who are active members of ASTRO and AAPM. This initiative strives to enhance the next generation of researchers, ensuring a commitment to advancing radiation oncology.

The CHEERS Open Period 2 initiative invites white papers from researchers in various technical fields, focusing on projects that align with the objectives of the Continuing Enabling, Enhancing, Restoring, and Sustaining (CHEERS) MAA. This funding opportunity, backed by the US DOD's Air Force Materiel Command, is aimed at advancing national defense capabilities through innovative research and development in areas such as ordnance, telecommunications, and medical supplies.

The NABG Scholarships support full-time undergraduate and graduate students in Geoscience programs at accredited institutions, with over $300,000 in funding raised through donations and events. Candidates must exhibit academic excellence, aiming to equip them for future careers in the geosciences. This initiative, backed by the National Association of Black Geoscientists, fosters diversity and prepares the next generation of professionals in the field.

Committee of 100 Academic Scholarship

Awards:

• One time award of $5,000.

About

Paul Newman was born and raised in Ohio by parents who owned a successful sporting goods store. He enlisted in the Navy and completed his military service as a radioman/gunner in the Pacific during World War II. Seeing his father’s business ethic during the Great Depression and experiencing the war fueled his desire to help others in need.

In 1958, Paul made his acting debut on Broadway in “Picnic,” where he also met his future wife, Joanne Woodward. Paul started a successful race car driving career inspired by training for the film Winning. He went on to win second place in the 24 Hours of Le Mans, the world’s oldest endurance race event. After years of acting and being recognized for his achievements on screen and stage, he received many accolades including an Oscar for Best Actor in The Color of Money.

Paul used his fame for good. He was dedicated to civil rights–attending the March on Washington in August 1963–women’s rights, and gay rights. He used his platform to advocate for equal pay for his female co-stars. He was a vocal political advocate committed to ending the nuclear arms race and determined to elect opponents of war and militarism. President Jimmy Carter appointed him to a United Nations General Assembly session on nuclear disarmament.

In 1982, Paul Newman and his friend Hotch founded a food company on a bit of a lark. They turned a profit selling salad dressing that first year, and did something truly radical when they decided to “give it all away” to good causes.

Paul established Newman’s Own Foundation to ensure the continuation of his philanthropic legacy after his passing. 40+ years since its founding, his first of its kind food company and its innovative business model are still going strong.

Garden Grants

Through Whole Foods Market’s Garden Grant program, schools turn outdoor spaces into powerful hands-on learning gardens that connect kids with food, spark their curiosity and support classroom curriculum.

The Smart Growth Grants program, managed by the National Association of Realtors, aims to enhance community development through educational initiatives aligned with Smart Growth Principles. Available in three levels, the grants support REALTOR Associations in promoting sustainable land use, community planning, and stakeholder engagement. Maximum awards range from $3,000 to $15,000, depending on the grant level. Note that the program is currently not accepting applications for 2025 and will reopen in January 2026.

The Chan Zuckerberg Initiative is calling for transformative research proposals through the Advancing Technologies for Spatiotemporal Omics in Live Tissue program. This initiative seeks to combine innovative engineering with biological research to explore the complex molecular dynamics of health and disease. By fostering collaboration among scientists and AI experts, this funding aims to unlock new high-precision interventions, significantly advancing our understanding and management of health issues.

Community Foundation of the Holland/Zeeland Area

Our Mission

The Community Foundation of the Holland/Zeeland Area seeks to ensure that our community thrives today, tomorrow, and forever by building our Community’s Endowment to support high impact charitable projects, helping donors achieve their charitable goals, and leading and partnering in community-level initiatives.

Scholarships

CFHZ awards over $1 million in scholarships each year for students to attend schools of higher education throughout the nation. Our scholarships are possible thanks to the generosity of donors who invest in our community’s future by furthering the education of others.

All Holland/Zeeland area individuals interested in post-secondary education are encouraged to apply for CFHZ scholarships.

The Foundation proudly administers over 100 scholarships, each with unique eligibility criteria that must be met before a candidate can be considered.

Peter and Huberdina Weller Scholarship

• Graduating senior, graduating early college student, or current college student from a high school within the greater Community Foundation service area
• Enrolling/enrolled at an accredited post-secondary school within the United States
• Financial need (must submit the page of the FAFSA Submission Summary showing the Student Aid Index amount)
• GPA of 3.0 or greater
• Intention to pursue educational opportunities and a career in horticulture or the biological sciences with an emphasis on botany
• All other qualifications being equal, tie-breaking consideration will be given to students of color
• Previous recipients of the award are encouraged to reapply.

The Infrastructure Capacity for Biological Research Program, supported by the National Science Foundation, aims to enhance research capabilities across various biological disciplines. This program encourages proposals for developing and improving research tools and services in areas such as Cyberinfrastructure and Biological Collections. It also welcomes planning activities to foster collaboration among researchers. Projects must ensure broad accessibility and significant scientific outcomes for the wider research community.

The BJA FY 2026 Prosecuting Cold Cases Using DNA program aims to enhance public safety and justice by supporting prosecutors in the investigation and prosecution of violent cold case crimes with developed DNA profiles. This funding opportunity, provided by the US DOJ's OJP Bureau of Justice Assistance, facilitates crucial investigative and forensic activities to increase successful prosecutions and provide resolution for victims and their families. Full applications are due by November 5, 2026.

The Collins Medical Trust Grant, established in 1956, supports health-related research and professional education for tax-exempt organizations. Eligible applicants include institutions with approved tax status and a commitment to equal opportunity. Early career investigators are encouraged to apply, but funds cannot be used for individual benefits or political activities. The Trust prioritizes projects in Oregon and does not support product development for industry. Applications are accepted thrice yearly, with specific deadlines for timely consideration.

The BRAIN Initiative aims to advance innovative neurotechnologies by funding early-stage clinical studies for devices that record or stimulate the human central nervous system. This initiative encourages collaborations between clinical researchers and device manufacturers to facilitate groundbreaking studies. By addressing the challenges of obtaining safety and utility data, this program supports both non-invasive and significant risk devices, providing essential insights into their functionality and design. Applications are currently not being solicited, allowing time for meaningful project development.

National Main Street Center Inc.

Main Street America (MSA) leads an inclusive, impact-driven movement dedicated to reenergizing and strengthening older and historic downtowns and neighborhood commercial districts through place-based economic development and community preservation. We work in collaboration with thousands of local partners and grassroots leaders across the nation who share our commitment to advancing shared prosperity, creating resilient economies, and improving quality of life.

Main Street America was founded in 1980 as the National Main Street Center®, a program of the National Trust for Historic Preservation. Over the past 40 years the MSA network has helped to generate over $115.27 billion in local reinvestment, rehab 345,801 buildings, create 815,894 new jobs, and start 181,647 new businesses in over 2,000 communities. 

Great American Main Street Awards

Main Street America celebrates communities whose successes serve as a model for comprehensive, preservation-based revitalization efforts in their historic downtowns and commercial corridor districts with the Great American Main Street Awards (GAMSA).

Winners represent the diversity of communities in the Main Street America network — small towns, mid-sized communities, and urban commercial districts from every region in the country — and demonstrate the power of the Main Street Approach™. Since the inception of the Great American Main Street Awards in 1995, 118 Main Street programs have been honored.

Selection Criteria: Semifinalists and winners are selected from a nationwide pool of applicants by a jury of Main Street professionals and leaders in the fields of community and economic development and historic preservation. Criteria for winning GAMSA include: strength of the Main Street program in spurring community transformation, commitment to historic preservation, innovative programming, implementation of cross-sector partnerships, community outreach and stakeholder engagement, and ensuring their downtown districts are for everyone. 

Accolades & Ceremony: Semifinalists are promoted through Main Street America’s digital channels and receive media relations support. Winners also receive a short documentary film, a plaque, communications and media relations support, prominent placement on the Main Street America website for two years, and recognition at the 2027 Main Street Now Conference in Detroit, Michigan.

About Community Foundation of Henderson County

• Mission: Helping people who care make lasting contributions to causes that matter.
• Vision: Community Foundation of Henderson County is a highly visible, philanthropic leader directed by an engaged and committed board, staffed by qualified employees, empowering donors at all levels to invest in professionally managed charitable funds that address community needs.

Elizabeth DeVilling Environmental Odyssey Scholarship

This scholarship provides support to graduating seniors or graduates of any Henderson County public, private or parochial high school seeking to further their education beyond high school. Recipients of this scholarship must be accepted to an accredited degree granting college or university and be actively pursuing an undergraduate degree in the field of environmental science or a related field. Preference will be given to those who have expressed a desire to pursue work which relates to environmental preservation and/or conservation and have financial need for assistance. Extra-curricular and extra participation in activity relevant to earth sciences/environmental sciences will be given added priority.

The Patient-Centered Outcomes Research Institute (PCORI) is funding Cycle 3 to enhance patient-centered comparative clinical effectiveness research (CER). This initiative targets critical methodological gaps, focusing on improving the use of artificial intelligence, study design, data research networks, and ethical protections. By addressing these areas, PCORI aims to strengthen the quality of evidence in CER, thus promoting better outcomes in healthcare decision-making.

Innovation in Religion and Spirituality Seed Grants Call for Proposals

The Religion and the Public Sphere program at the Social Science Research Council aims to foster research on the wider implications of new forms of religious and spiritual life. This program is offered with the support of the Luce Foundation, the John Templeton Foundation, and the Templeton World Charity Foundation.

Overview

In recent years, scholars have noted that religious and spiritual life is being substantively reshaped. “Innovation” is one way of framing these changes, but it remains a partial and contested analytic lens, and is popularly associated with the sudden emergence of a “new” element introduced into an otherwise static tradition. Scholarship on religion and spirituality, however, points to a more complex set of processes. The essays in an ongoing forum for The Immanent Frame have set out some initial parameters of these dynamics: rather than invention ex nihilio, what we often see is the strategic recombination of existing elements within a broader context of social, political, and cultural change.

Research Themes

This request invites proposals that examine the dynamics of religious and spiritual change that fall within the frame of “innovation.” Possible topics include, but are not limited to: 

• Explorations of innovations within transnational or diasporic religious and/or spiritual communities within the United States, particularly related to the circulation of ideas and culture from or to the Global South.   
• Gendered knowledge of innovation. 
• Studies of the process by which an innovation attains—or does not attain—legitimacy, relevance, or authority within a given community or institution. 
• The relationship between contemporary economic conditions—poverty, economic insecurity, and competitive pressures for time and money—and innovations in religion and spirituality. 
• Historical studies of innovations in religion and spirituality; the creation, reception, transformation, and longevity of an innovation over time.  
• Civic participation and the social mobilization of new or innovative religious identities, as well as the reinterpretation of religious or spiritual traditions or ideas in the service of particular political or ideological projects.

Program Terms 

The program offers research support over a period of up to 6 months. The grant funds will be up to $10,000 per award.

The Rehabilitation Engineering Research Center on Recreational, Sport, and Exercise Technologies for People with Disabilities aims to enhance rehabilitation services through innovative technological solutions. This initiative focuses on promoting health and exercise among individuals with disabilities by addressing unique rehabilitation challenges. Funded by the US HHS Administration for Community Living, the project spans 60 months, involving advanced research and development to create effective support mechanisms and overcome environmental barriers.

The BJA FY 2026 Upholding the Rule of Law and Preventing Wrongful Convictions Program aims to enhance justice by strengthening the capacity of entities that review wrongful convictions. By supporting partnerships among criminal justice and victims' services, the program seeks to effectively manage post-conviction claims of innocence and prevent future errors. This initiative will help identify actual perpetrators and ensure justice for victims, contributing to public safety and the integrity of the legal system.

The National Cancer Institute (NCI) invites applications for the Toward Translation of Nanotechnology Cancer Interventions (TTNCI) program. This funding opportunity focuses on advanced pre-clinical research aimed at developing nanotechnology-based cancer diagnostics and therapeutics. TTNCI awards will support the maturation of innovative nanomedicines using nanoparticles and nano-devices, enhancing cancer treatment efficacy. Successful projects will progress towards further NCI translational programs, such as the NExT initiative.

The Arnold Ventures RFP invites proposals for causal research on community safety and the criminal justice system. This initiative aims to generate evidence that informs effective policies to enhance safety and fairness in justice. Applicants should propose robust research designs capable of isolating treatment effects, focusing on real-world outcomes in the U.S. Preference is given to interventions with potential for policy adoption and led by early-career researchers or those without previous funding from Arnold Ventures.

The Eugene C. Figg, Jr. Civil Engineering Scholarship, established by Figg Engineering Group in 2002, honors the legacy of Gene Figg, who was renowned for his artistic bridge designs. This scholarship aims to support undergraduate civil engineering students with a passion for bridge design and construction, facilitating their education in an ABET-accredited program. Eligible candidates must be U.S. citizens and Student Members of the American Society of Civil Engineers in good standing.

The Edward C. Roy Jr. Award for Excellence in K-8 Earth Science Teaching, established by the American Geosciences Institute, honors educators who demonstrate exceptional leadership in earth science education. This prestigious award includes a $2500 prize for the winning teacher and a $1500 grant to attend the National Science Teaching Association's annual conference. The award celebrates the legacy of Dr. Edward C. Roy Jr., promoting innovation and excellence in teaching for future generations.

The B. Charles Tiney Memorial ASCE Student Chapter Scholarship, established in 1980 by Mrs. Hazel M. Tiney, provides financial support to deserving undergraduate civil engineering students. This scholarship aims to assist with tuition expenses for those enrolled in ABET-accredited programs. Recipients are chosen based on their commitment to the civil engineering field and must be members in good standing of the American Society of Civil Engineers and their respective student chapters.

Communities Foundation of Oklahoma

The Communities Foundation of Oklahoma stems from the vision of Tom McCasland Jr., and Gene Rainbolt. Two decades ago, these gentlemen formed a shared vision to create a single philanthropic organization to serve the charitable needs to rural communities across the great state of Oklahoma. Today, CFO has grown to assist hundreds of efforts in more than 45 counties.

Scholarship Opportunities

CFO offers over 100 diverse scholarship opportunities, empowering students across the state to pursue their educational goals. Each scholarship is tailored to meet unique needs, making higher education more accessible for all.

Ashley Parks Creative Scholarship

Supports continued education in the arts or creative fields for non-traditional students.

The Survivor Fellowship Program for Students, initiated by Everytown for Gun Safety in 2015, empowers individuals directly affected by gun violence. This year-long volunteer advocacy training helps survivors share their narratives, fostering awareness and mobilizing communities to combat gun violence. Participants must be at least 18 years old and enrolled in an educational institution, with a personal connection to gun violence, ensuring diverse experiences are represented in this impactful initiative.

The Social Psychology Program at NSF advances knowledge in social psychology by supporting innovative research and infrastructure. It encourages diverse projects that enhance understanding of human social behavior, addressing topics such as social cognition, group dynamics, and emotions. Proposals must demonstrate intellectual merit and broader societal impacts, with a focus on interdisciplinary approaches. The program prioritizes research that benefits society and strengthens national security, while also ensuring representation across various demographics.