Best Large Grants for Nonprofit Organizations in Missouri

The Patient-Centered Outcomes Research Institute (PCORI) intends to issue a Broad Pragmatic Studies (BPS) PCORI Funding Announcement (PFA) on Aug. 4, 2026, seeking to fund high-impact, patient-centered comparative clinical effectiveness research (CER) projects. This preannouncement provides potential applicants additional time to identify collaborators; obtain patient and stakeholder input on potential studies; and develop responsive, high-quality applications. 

Patient-centered CER compares at least two available health treatments, services or care delivery strategies. PCORI seeks proposals that compare clinical interventions (e.g., pharmacological and nonpharmacological treatments, screening and diagnostic approaches) and healthcare delivery system interventions (e.g., workforce, technologies, healthcare service delivery designs) to evaluate potential benefits and harms of different treatment and care delivery options, thus generating evidence that empowers patients, caregivers and the broader healthcare community with information to make informed choices that reflect their needs and preferences. 

The Wellness Across the Lifespan Grant supports the health of communities by providing access to nutritious food and essential nutrition education. Grants ranging from $5,000 to $10,000 are awarded to 501(c)(3) nonprofits in areas where Sprouts Farmers Market operates. This funding emphasizes health and nutrition education, as well as programs that promote healthy lifestyles and nutrition security, ultimately benefiting adults and vulnerable populations.

The Missouri Bar Foundation empowers justice and elevates the legal profession through charitable initiatives. By supporting law-related community projects and educational programs across Missouri, the foundation ensures equitable access to legal resources. Key initiatives include funding legal services for low-income individuals, educational conferences for teachers, and scholarships for law students. With a mission to enhance public appreciation for the rule of law, the foundation plays a crucial role in strengthening the legal community and fostering civic engagement.

The HOME program, administered by the Missouri Housing Development Commission, provides critical funding for affordable housing initiatives targeting low and very low-income families. This federally funded program supports activities such as rental housing acquisition, rehabilitation, and new construction. Eligible developers, including both for-profit and non-profit entities, must demonstrate relevant experience and financial capacity, ensuring that projects meet local housing needs and comply with affordability criteria.

The Norfolk Southern Trades on Track SkillPointe Scholarship offers $5,000 scholarships for students pursuing trades education related to the rail industry. Eligible candidates must be enrolled in a post-secondary institution and focused on railway-related trades. With over 1,000 scholarships funded and a mission to close the skills gap, this initiative empowers individuals towards high-demand careers without requiring a four-year degree, ultimately strengthening the workforce and economy.

The Affordable Housing Assistance Program (AHAP) in Missouri provides tax credits to incentivize donations for affordable housing initiatives. Eligible donors can receive a one-time credit of up to 55% of their donation value, supporting construction, rehabilitation, and rental assistance. With $10 million in production credits and $1 million in operating assistance credits available annually, the program aims to boost affordable housing in distressed communities. Interested organizations can apply for these credits until June 30, 2025.

The Affordable Housing Assistance Program (AHAP) by the Missouri Housing Development Commission incentivizes affordable housing production through tax credits. This program allocates up to 55% of the total donation value as a one-time credit for eligible donors, supporting non-profits in providing housing assistance in distressed communities. With $10 million available in production credits and $1 million for operating assistance annually, AHAP aims to enhance community development and improve living conditions in Missouri.

About PCORI

PCORI funds patient-centered comparative clinical effectiveness research (CER).

Our Mission

PCORI helps people make informed healthcare decisions, and improves healthcare delivery and outcomes, by producing and promoting high-integrity, evidence-based information that comes from research guided by patients, caregivers, and the broader healthcare community.

Broad Pragmatic Studies PCORI Funding

The Patient-Centered Outcomes Research Institute (PCORI) intends to issue a Broad Pragmatic Studies (BPS) PCORI Funding Announcement (PFA), seeking to fund patient-centered comparative clinical effectiveness research (CER) projects. 

Research Initiative Highlights

CER compares at least two available health treatments, services or care delivery strategies. PCORI seeks proposals that compare clinical interventions (e.g., pharmacological and nonpharmacological treatments, screening and diagnostic approaches) and healthcare delivery system interventions (e.g., workforce, technologies, healthcare service delivery designs) to evaluate potential benefits and harms of different treatment and care delivery options, thus generating evidence that empowers patients, caregivers and the broader healthcare community with information to make informed choices that reflect their needs and preferences.

Special Areas of Emphasis

For Cycle 2 2026, PCORI is particularly interested in submissions that address the following Special Areas of Emphasis (SAE) within the BPS funding opportunity. The purpose of identifying these SAEs is to encourage submissions to these areas, rather than limiting submissions to these topics. Applicants addressing one of the below SAEs should identify the area that is best associated with their research approach:  

• Addressing Obesity
• Diabetes Prevention, Care and Treatment
• Management of Urogynecological and Pelvic Pain
• Pain Management for Individuals Living With Sickle Cell Disease

In PCORI-funded research, patients and other research partners are expected to meaningfully contribute their lived experience or professional expertise to ensure studies are patient-centered, relevant and useful for healthcare decision making. Applicants must address PCORI’s Foundational Expectations for Partnerships in Research — an evidence-based framework supported by tools and resources to guide effective engagement strategies. Applicants are also strongly encouraged to consider the inclusion of a broad range of patient-centered burdens and economic outcomes. 

Broad Pragmatic Studies PFA: Category 1, Category 2 and Category 3 Study Specifications

PCORI will commit up to $120 million in direct costs through this funding opportunity. This funding opportunity contains three categories for funding:

• Category 1: Category 1 will support research projects with direct costs up to and including $5 million.

• Category 2: Category 2 will support research projects with direct costs greater than $5 million and up to a maximum of $12 million. Applications for funding under Category 2 will be required to provide additional information in the Letter of Intent (LOI) and application to justify the size and scope of the proposed research projects and to explain how additional funds are necessary with respect to the scale, scope and complexity of personnel and material resources needed to address the research question.

• Category 3: Category 3 will support research projects with direct costs up to $12 million that utilize PCORnet® to conduct observational studies and/or pragmatic trials that are national in scale. Category 3 PCORnet Studies® must include two or more Clinical Research Networks and share study progress, performance metrics and best practices with the network to promote continuous learning and improvement. PCORnet Studies® will leverage the PCORnet Common Data Model® as appropriate. Additional details about Category 3 can be found on the PCORI website.  

Enterprise Community Partners

Enterprise Community Partners (Enterprise) is a national nonprofit that exists to make a good home possible for the millions of families without one. We support community development organizations on the ground, aggregate and invest capital for impact, advance housing policy at every level of government, and build and manage communities ourselves. Since 1982, we have invested $80.9 billion and created 1 million homes across all 50 states, the District of Columbia, Puerto Rico and the U.S. Virgin Islands – all to make home and community places of pride, power and belonging.

Midwest Asset Management University Program

Operating, maintaining, and preserving affordable housing is complex and requires a specialized set of skills and a deep organizational commitment to asset management. Today, affordable housing providers face a variety of economic, operational, and compliance challenges, including rising operating costs, rental arrears, staffing shortages, and an aging portfolio.

Enterprise is launching its first Asset Management University (AMU) Program in the Midwest (Illinois, Indiana, Wisconsin, Missouri, and/or Minnesota) in March 2026 to support mission-aligned, affordable housing providers in meeting these challenges in their efforts to provide housing stability to residents and preserve the long-term affordability of properties.

The Midwest AMU is a comprehensive, five-month training program that seeks to strengthen the asset and property management capabilities of participating housing providers, improving organizations’ capacity to oversee the financial, physical, and operational health of their housing portfolios.

Midwest Asset Management University Cohort 

Enterprise is excited to offer this application for participation in the Asset Management University (AMU) Cohort (the “Cohort”). Up to fifteen (15) eligible organizations will be selected for this Cohort and will receive access to online training offered by the Consortium of Housing and Asset Management (CHAM), peer learning opportunities, and post-training technical assistance.

The Gravelin Nursing Scholarship, offered by the Community Foundation of the Ozarks, provides a $450 grant for undergraduate nursing students at Missouri colleges or universities. Applicants must maintain a GPA of at least 3.3 and demonstrate financial need using a FAFSA-SAI form. This scholarship aims to support future healthcare professionals and requires submission of a transcript and personal essay as part of the application process.

The Deluxe Corporation Foundation's ERG Grant Program supports diverse and inclusive initiatives by empowering employee resource groups (ERGs) to partner with nonprofits addressing relevant social issues. Each of the ten ERGs will award a $25,000 grant to a selected organization, fostering community impact and collaboration. The foundation, established in 1954, has invested over $109 million in charitable causes, focusing on financial literacy, education, and community support to enhance lives and promote entrepreneurship.

Service Objects In-Kind Grants support non-profit organizations dedicated to environmental conservation and sustainability. By leveraging their data validation services, they aim to assist projects that promote ecological health and responsible resource management. The program prioritizes applications with clear, measurable objectives and impactful outcomes within one to three years. Organizations with 501(c)(3) status in the U.S. are eligible, while initiatives lacking detailed plans or focusing on generalized education will not qualify. This grant fosters community involvement in environmental stewardship.

Asia-Pacific Network for Global Change Research

The Asia-Pacific region, home to over half the world's population, faces challenges due to its development goals, which strain natural resources, communities, and cultural heritage. These issues are exacerbated by adverse environmental changes. While research has shed light on these problems, it's clear that more challenges lie ahead. The Asia-Pacific Network for Global Change Research (APN) is well-positioned to generate new knowledge and solutions for these evolving global change and sustainability issues by supporting collaborative research and scientific capacity development activities, particularly those aimed at training the next generation of early career professionals.

APN 2025 Call for Proposals: CAPaBLE Programmes

CAPaBLE, our scientific capacity development programme, aims to enhance the capacity of scientists, policymakers and practitioners to assess global change issues, and explore options to resolve issues towards achieving sustainability. Through CAPaBLE, we support activities that enhance capacity at individual, organizational and systemic levels.

Activities of interest under the CAPaBLE Programme

APN supports CAPaBLE activities that enhance existing capacities of developing countries at three levels of individual-based capacity development; group, organisation, network-based capacity development; and societies, governance, and system level capacity development. APN accepts CAPaBLE proposals that engage 1 or more member/approved countries. Proposals must address one or more of the following activities:

SCIENTIFIC CAPACITY DEVELOPMENT ACTIVITIES that promote the following approaches related to one or more of the six thematic areas of APN:

• Utilising and strengthening existing capacity, 
• Creating opportunities to use/instil capacity, 
• Developing new capacity through innovative approaches.

AWARENESS-RAISING AND DISSEMINATION activities through policy- and decision-making communities, civil society, and/or the general public.

SCIENCE-POLICY interfacing in the context of the priority topics.

CAPACITY DEVELOPMENT PARTNERSHIP ACTIVITIES that contribute to the capacity development components of the evolving global change arena, including the UNFCCC Paris Agreement, IPCC, IPBES, post-2015 Sustainable Development Goals, Sendai Framework for Disaster Risk Reduction, and the UN Decade of Ocean Science, and ongoing and new global change and sustainability research programmes.

Activities geared towards using SCIENCE COMMUNICATION to disseminate knowledge generated from projects, particularly to non-science audiences.

The Great Apes and Gibbons Program Grant, administered by the Arcus Foundation, supports conservation efforts for great apes and gibbons across 24 priority landscapes in Africa and Asia. The program emphasizes sustainable coexistence between humans and wildlife, having awarded over 2,000 grants to more than 500 organizations globally. Funding is not available for individuals or specific lobbying activities, ensuring resources are directed towards impactful conservation initiatives.

Our Mission

The Community Foundation’s mission is to improve the quality of life in Greater Kansas City by increasing charitable giving, educating and connecting donors to community needs they care about, and leading on critical community issues.

Scholarships

We offer hundreds of different scholarships for students in and around Kansas City.

Parkville Fine Arts Association

The Parkville Fine Arts Association (PFAA) Scholarship Fund provides annual scholarships to graduating seniors of Park Hill School District. The scholarships are intended to assist students who are pursuing higher education in the field of fine arts. Fine arts are defined as music, drama or the visual or performing arts.

The Artistic Innovations Grant Program, supported by the Mid-America Arts Alliance, provides up to $15,000 to artists and arts organizations in the M-AAA six-state region. This initiative fosters creativity by funding the development and premiere of original works, encouraging innovative projects that engage local audiences. Eligible applicants include individual artists and nonprofit organizations, promoting a vibrant arts community through financial support for artistic exploration.

The Great American Cleanup Grants, offered by Keep America Beautiful, aim to enhance community beautification and environmental efforts across the U.S. This initiative encourages KAB affiliates to remove litter, plant greenery, and restore public spaces, contributing to the larger goal of cleaning up 25 billion pieces of litter by 2026. With cash grants available, this program fosters collaboration among communities, promoting sustainable practices and a cleaner, greener future for all.

The Cigna Group Foundation is launching the Improving Youth Mental Health Grant, committing $9 million over three years to enhance mental health support for youth aged five to 18. This initiative targets post-pandemic challenges, offering resources to parents, caregivers, and youth service professionals. Nonprofits are encouraged to apply for funding between $100,000 and $150,000 to develop programs that promote social-emotional skills, enhance caregiver support, and improve access to mental health interventions in underserved communities.

Community Foundation of the Quincy Area

My Community Foundation (also known as The Community Foundation Serving West Central Illinois & Northeast Missouri) is a tax-exempt 501(c)(3) nonprofit organization dedicated to improving quality of life in the communities it serves by connecting compassionate donors with meaningful causes. The foundation works with individuals, families, businesses, and nonprofit partners to gather charitable contributions, grow those funds through professional investment strategies, and grant the earnings in ways that address local needs now and into the future. It builds and manages permanent endowments tailored to donors’ goals, ensuring their philanthropic visions—whether honoring a loved one, establishing a legacy, or supporting community needs—are realized. Serving a 12-county region across West Central Illinois and Northeast Missouri, the foundation acts as a steward of charitable assets, helping donors make a lasting impact through customized giving opportunities, community grants, and strategic support for nonprofit organizations.

Delford M. & Portia K. Richter Agriculture Scholarship

Delford M. & Portia K. Richter Agriculture Scholarship provides financial support to students pursuing education in agriculture-related fields. Selection is based on academic achievement and promise, demonstrated financial need, the likelihood that the recipient will return to Pike County or Calhoun County to engage in farming, the applicant’s ability to successfully complete their chosen program, and how well the educational program aligns with the applicant’s ongoing course of study. Awards are made annually in the spring.

The National Forest Foundation's Matching Awards Program connects communities to forests by funding stewardship activities that promote engagement with National Forests and nearby public lands. This program aims to create lasting impacts, ensuring that all communities can benefit from the rich resources of these natural areas. By supporting various projects, the program fosters a deeper relationship between people and the environment, ultimately enhancing conservation efforts and community well-being.

The Express Health Information Outreach Awards aim to enhance public health by increasing access to biomedical information for U.S. health professionals and the general public. These awards support projects that improve health information literacy among consumers and caregivers, ensuring they can effectively find and utilize health information. Focused on partnerships and outreach to underrepresented communities, the initiative seeks to promote healthy behaviors, prevent illness, and improve health outcomes through informed decision-making.

The Ethnic Minorities and Women’s Internship Grant supports entry-level athletics administrative positions for one academic year, promoting diversity in NCAA Division II. It provides $30,000 for intern salaries and $3,000 for professional development, benefiting six schools annually from a total budget of $180,000. Eligible applicants must be active NCAA members, with a focus on enhancing ethnic minority and gender representation in athletics administration. This initiative encourages professional growth and compliance in diverse environments.

The Nixa Affiliate Grantmaking Program, managed by the Nixa Community Foundation, seeks to enhance community well-being through strategic funding. It supports innovative projects that address pressing local needs, encourages collaboration among organizations, and prioritizes areas such as culture, economic development, education, environment, family, and health. Eligible applicants include 501(c)(3) organizations and other IRS-approved entities serving the Nixa area, with grants available up to $10,000.

The Cardinals Fly Together Worship Wednesday Grant Program offers matching grants to Southwest Missouri area churches and faith-based organizations, enabling them to bring groups to Springfield Cardinals home games during the 2025 season. This initiative aims to strengthen community bonds through shared experiences, including pre-game worship and fellowship. Grants can cover 50% or 25% of ticket costs, depending on the request. Applications are reviewed within 14 days, ensuring timely support for community engagement.

The Marvin R. and Pearl E. Patterson Family Fund Scholarship, offered by the Grand Haven Area Community Foundation, supports students aspiring to study graphic or fine arts, as well as those interested in environmental sciences. Open to high school graduates from the Tri-Cities area, this scholarship considers leadership, community involvement, and academic achievements, although financial need is not a requirement. Applicants must provide transcripts and relevant documents to qualify for this opportunity.

The Sumners Foundation Grant aims to engage and educate the public about self-government through various programs, including civic education, democracy reform, and teacher training. Grants are available to qualified 501(c)(3) organizations primarily in Texas, New Mexico, and Oklahoma, supporting activities that foster civic engagement and understanding of democratic principles. The Foundation emphasizes direct involvement in the political process and does not fund political activities or provide individual grants.

The Urban Agriculture Cost-Share Grant Program supports small agribusinesses in urban Missouri, offering funding for projects that enhance agribusiness sustainability and economic growth. Eligible projects include business plan development, community gardens, and training programs for workforce development. Grants cover up to 75% of project costs, with a maximum award of $10,000, aimed at fostering local agricultural initiatives and infrastructure. This program encourages innovation in urban farming and aims to strengthen local economies.