Best Large Grants for Nonprofit Organizations in Missouri

The Regions Community Engagement Grant aims to foster inclusive prosperity by partnering with nonprofit organizations, local businesses, and government agencies. With over 165 years of experience, Regions Bank and Regions Foundation prioritize economic development, education, and financial wellness. This initiative addresses social and economic challenges, helping communities thrive. By focusing on impactful projects, they strive to create pathways to financial stability and support organizations that align with their mission of building inclusive growth.

The James M. Cox Foundation Grant offers support to nonprofit organizations focused on conservation, early childhood education, family empowerment, and health. Organizations must be 501(c)(3) tax-exempt and located in areas where Cox Enterprises operates. Grant applications are accepted year-round, with deadlines before Trustee meetings. Preference is given to organizations with a history of local engagement. This foundation embodies the philanthropic spirit of its founder, James M. Cox, by giving back to the community.

The XENO PRIZE for Performance Arts, awarded by Franklin Furnace, supports early-career LGBTQ+-identifying performance artists creating new work in 26 states with restrictive gender-affirming laws. This annual prize, established in 2023, offers $5000 to a selected recipient from proposals submitted for the Franklin Furnace FUND for Performance Art. The deadline for submissions is April 1, 2025, encouraging innovative voices in the contemporary performance art landscape.

SC Johnson Grants aim to enhance community welfare through charitable contributions, focusing on health, sustainability, and opportunity. Since 1937, the company has committed five percent of its pretax profits to support registered charities and nonprofit organizations, especially in areas where it operates. The grant program prioritizes initiatives addressing healthcare access, environmental conservation, and educational equity, ensuring that efforts align with the values of community service and corporate responsibility.

The Conservation Connect Fellowship Program, offered by the National Forest Foundation, invites graduate students to engage in hands-on conservation projects. This fellowship provides practical experience, mentorship from conservation professionals, and training in collaborative leadership. Fellows will gain a deep understanding of forest management and expand their professional networks. With a focus on developing future conservation leaders, the program seeks students passionate about public lands and community engagement.

The Shelter Operations Support (SOS) Grant Program aims to enhance emergency shelter operations in Missouri, prioritizing assistance to programs that serve veterans. It is designed for established non-profits and community organizations with a track record of at least two years. The program provides operating and administrative funds to ensure safe temporary housing for residents facing crises, while maintaining compliance with funding restrictions and eligibility criteria.

The CSA Midwest Region: Otto Thieme Memorial Internship provides a unique opportunity for students to engage in a hands-on curatorial experience with costume collections at Midwestern museums, historical societies, or universities. Awarded a $2000 stipend for an eight-week internship, students will gain valuable mentorship and training in the field of costume. This program honors Otto Charles Thieme, an influential figure in costume scholarship, enhancing students' academic pursuits while fostering appreciation for historic costumes.

The Dollar General Literacy Foundation offers Family Literacy Grants to nonprofit organizations that support family literacy initiatives. Eligible applicants must provide services such as adult education, children's education, and parent-child engagement activities. Organizations must be located within 15 miles of a Dollar General store and have a valid IRS tax ID. This funding aims to enhance literacy skills for families, empowering individuals to achieve their educational goals.

The US Department of Health & Human Services announces a competitive funding opportunity for the Head Start/Early Head Start programs across various states. This initiative aims to enhance services for low-income families and children, promoting their social and economic well-being. With approximately $818.3 million available, the program seeks to expand access to quality early childhood education, thereby strengthening community stability and prosperity. Interested applicants can seek further information through the OHS Operations Center.

The NAACP X Society Awards Scholarship

The NAACP x Society Awards Scholarship is one of many funding opportunities available to students through NAACP's Inspire Initiatives. We offer scholarships to outstanding and qualified students pursuing undergraduate degrees. Through the generosity of our donors, we advance efforts to ensure equity in educational opportunity that prepares students for success in school, work, and life.

Scholarship amount: $1,000 to $5,000

This is a non-renewable scholarship opportunity.

The Windgate Charitable Trust Grant supports contemporary craft and visual arts in the U.S. It offers funding for fellowships, residencies, educational outreach, and materials for craft programs. The foundation prioritizes strengthening visual arts in colleges and expanding K-12 art-integrated programs, providing opportunities for artists and educators to enhance their skills and foster creativity among students. Organizations with previous funding from Windgate can apply through the grantee portal.

The NCR-SARE Youth Educator Grant Program supports educators in the North Central Region to innovate ways of teaching sustainable agriculture. With funding up to $6,000, this program encourages educators to engage youth and promote sustainable practices. By sharing their experiences, grantees can create a ripple effect among peers, enhancing the reach and impact of sustainable agriculture education. This initiative aims to foster creativity and collaboration in teaching sustainable practices to the next generation.

The Norfolk Southern Corporate Giving: Thriving Communities Grant Program supports initiatives that promote sustainability, workforce development, and community resilience across a 22-state network. With grants ranging from $1,000 to $50,000, the program aims to foster economic development and ensure equal access to basic necessities. Eligible organizations include tax-exempt nonprofits, government entities, and public schools, emphasizing diversity and inclusion in their community-focused efforts.

The Ralph J. Torraco Fine Arts Scholarship, offered by the UNICO Foundation, awards two $2,500 scholarships to U.S. students studying Fine Arts, including Performing, Visual, or Technical Arts. Eligible applicants must be U.S. citizens with a minimum GPA of 3.0, enrolled full-time in an accredited college, and planning to continue their studies into the 2025-2026 academic year. This scholarship aims to support and promote Italian American culture and heritage through the arts.

The NHLBI Career Transition Award (K22) supports postdoctoral fellows and research trainees in the NHLBI Division of Intramural Research, facilitating their transition to independent research roles at extramural institutions. Key deadlines for applications include October 12, 2024, and February 12, 2025, among others, providing ample opportunity for qualified investigators to advance their careers.

Bristol Myers Squibb is dedicated to enhancing healthcare and advancing scientific knowledge through its Corporate Giving program. By supporting various organizations, BMS aims to improve health equity and access to essential medicines for underserved populations. Their focus includes charitable donations, medical education, and community support initiatives. This commitment reflects BMS's goal to make a positive impact on patients' lives and foster strong communities where their employees work and live.

The NCR-SARE Professional Development Program Grant supports agricultural educators through competitive grants aimed at enhancing training in sustainable agriculture. This initiative promotes cross-agency collaboration, utilizing farmers as educators to address pressing issues within the farming community. Projects funded are expected to demonstrate measurable outcomes, fostering knowledge and behavioral changes that lead to sustainable practices in agriculture and food systems. The program encourages diverse participation, ensuring a comprehensive approach to professional development.

Bell's Brewery Small Grassroots Grants support projects focusing on water stewardship across the Great Lakes watershed. With grant amounts ranging from $500 to $5,000, eligible organizations can apply for funding to improve ecosystem health, enhance public health through better water resource management, and promote resilience against climate-related water risks. This initiative highlights Bell's commitment to environmental stewardship and community support in all 50 states and DC.

The Fence Authority Scholarship offers a $1,000 award to students pursuing a bachelor’s degree in fields that enhance community beautification, such as architecture, civil engineering, and environmental sciences. Applicants must be U.S. citizens, enrolled full-time, and involved in community service. This scholarship aims to empower students to contribute positively to society while furthering their education in impactful disciplines.

The Clifford Willard Gaylord Foundation, established in 1948, is dedicated to supporting non-profit organizations in Missouri across various sectors including education, health, social services, and the arts. Founded by industrialist Clifford Willard Gaylord, the foundation aims to enhance community well-being through grants that foster scientific research, historic preservation, and cultural initiatives. Gaylord's legacy continues to impact many lives through this philanthropic effort.

The American Electric Power Foundation provides grants to 501(c)(3) organizations focused on educational improvement, particularly in STEM fields, and basic human services such as hunger and housing. Organizations must operate within AEP's service territory or have a broader beneficial purpose. The Foundation also supports social justice initiatives and environmental protection efforts. Eligible applicants must affirm compliance with anti-discrimination policies and demonstrate commitment to diversity and inclusion.

The Osage Chapter Service Scholarships, funded by the Association for Women Geoscientists, support undergraduate and graduate students in geosciences. These scholarships of $500 aim to promote the participation of underrepresented groups in the field. Eligible applicants must be AWG members and enrolled in a university within the Osage region. The program encourages outreach and community service while honoring the contributions of Sean S. Thomson to the Osage Chapter.

The JFNY Grant for Arts & Cultural Exchange supports U.S. non-profit organizations aiming to enhance understanding of Japanese arts and culture. Eligible projects include performances, workshops, and exhibitions, with priority given to those with additional funding and in areas with limited access to cultural events. Applications must be submitted at least one month prior for online projects and three months for others. The grant covers expenses like travel, publicity, and artist fees, and is reimbursed upon project completion.

Lutheran School Mini Grants

The Foundation continues to encourage congregations to reach out to their surrounding communities through organized, effective social service outreach ministry efforts. We also recognize congregations are looking for innovative ways, outside the traditional social service outreach model, to build relationships and engage their communities.

We look to accomplish this in two ways:

• Supporting congregations as they work to engage and serve their neighbors and community through planning and program implementation grants.
• Strengthening the ability of congregations to engage in community engagement efforts through coaching assistance, mentoring, and training (through Send Me St. Louis).Examples of Possible Ministry Projects

Congregation Community Engagement is defined for this Funding Focus Area as activities, services, or efforts designed to reach out to others on a local level (St. Louis metropolitan region). Examples include both serving the immediate needs of people and efforts to engage and build relationships with the community. The focus is on bringing the care of Jesus Christ into the lives of hurting people in the community, rather than serving the congregation’s own members. This funding focus area is not meant to support “Word and Sacrament” activities.

• Health care/mental health services
• Fitness/healthy living programs
• English as a second language
• After-school mentoring/tutoring
• Social activities for seniors
• Community revitalization
• Recreation activities
• Home repair/beautification
• Partnerships with local schools/other institutions
• Social enterprise/business that benefits the community and/or creates space for relationships
• One-time events (run by the congregation) to meet a need in the community

Idea Exploration

Congregations should know what they want to do and have an idea of how to get started. If you are not at this point, coaching services to assist your congregation are offered through Lutheran Foundation’s relationship with Send Me St. Louis. Services include coaching and guidance on:

• mapping the congregation’s and community’s assets, 
• researching opportunities for social service outreach ministry, and/or
• planning for a social service outreach ministry.

There are no grant deadlines for the Congregation Mini Grants. Application can be made at any time of the year.

The Ralph J. Torraco Scholarship for Seminarian Studies, funded by UNICO Foundation Inc, offers four scholarships worth $1,000 each to full-time seminarians attending accredited Catholic seminaries in the U.S. Eligible applicants must be U.S. citizens, at least 18 years old, and either reside in specific states or have a UNICO sponsor. This scholarship supports the educational journey of seminarians, reflecting UNICO's commitment to serving the community and promoting Italian American heritage.

The rootEd Community College Transfer Scholarship supports students transitioning from Missouri community colleges to accredited four-year institutions. This renewable scholarship awards up to $12,000 annually, aiming to enhance educational access for those in rural areas. Established by the rootEd Alliance in 2018, it addresses the unique challenges faced by these students, ensuring financial barriers do not hinder their academic aspirations.

The US Department of Health & Human Services, through the NIH, invites applications for innovative approaches to implement SBIRT/P for addressing alcohol, tobacco, and other drug use in adults facing health disparities. This funding opportunity encourages research that tests screening, brief interventions, and referrals for treatment or prevention services. Applications are due on specified deadlines from February 2024 through March 2027, fostering collaboration with healthcare and community partners to enhance public health outcomes.